implications for targeted therapy development

... 1000 1083 1003 4458 The functional form chosen for the stochastic frontier function for all the countries is the translog form The translog functional form for the ith farmer in a particular ... Production in West and Central Africa: Implications for Cocoa Sector Development, Working Papers Series N° 104, African Development Bank, Tunis, Tunisia AFRICAN DEVELOPMENT BANK GROUP Technology ... dominant role in the provision of food, raw material for industries, employment for the majority, and foreign earnings, which are used in financing development activities In the course of the last...

Ngày tải lên: 18/03/2014, 02:20

... in a latent form in about one-third of the world’s population (http://www.who.int/tb/en) A combination of several factors, such as the requirement of long-term multidrug therapy for the treatment ... ª 2008 FEBS A role for the D-arabinose lipid carrier B A Wolucka Despite the efforts of many research groups, the biosynthesis of d-arabinose in mycobacteria was an enigma for many years until ... subsequently undergoes an enolization to form l-ascorbic acid (or d-erythroascorbic acid) It is probable therefore that the Rv3790 subunit(s) is directly responsible for the conversion of decaprenyl-phospho-ribose...

Ngày tải lên: 30/03/2014, 04:20

... publication provides information about biofuels for use in helping to understand technology-related implications of biofuels development It seeks to provide some context for (a) understanding ... publication provides information about biofuels for use in helping to understand technology-related implications of biofuels development It seeks to (a) provide some context for understanding the ... produced) with concerted development efforts [74] While historically there have been relatively low levels of research and development support provided for energy crop development, recent major...

Ngày tải lên: 01/04/2014, 00:20

... group … 3.3 Orientation for development of the ecosystems of Viet Tri city for maximal development of ecological services [1, 3, 4-6] - Residential ecosystem should be created for full use of all ... Ecological services Forest on land Planted forest, perennial fruit trees Grass River Lakes, Agricultural Residential Industrial area land area and river port ponds fields ecosystem Forest resources ... including mountains belong The Hung Temple Nation Forest which is historic cultural - environmental forest in the system special - using in Vietnam Therefore, this Table Ecological services of main...

Ngày tải lên: 24/06/2015, 08:16

... their development partners have agreed on in order to maximize the effectiveness of external aid for development at national or sector levels It is a subset of development coordination • Development ... development triangle Formulating special preferential policies for the development triangle Simplifying procedures to facilitate the flows of goods and people in the triangle 23 CONCLUSION For ... institutions are involved? What are the local efforts from international agencies and donor communities for aid effectiveness efforts in Laos? Does the local development community support the local government...

Ngày tải lên: 03/11/2016, 22:29

... regulatory sequences of the H19 gene for the development of DNAbased therapy for human ovarian cancer related ascites The successful development of anti-tumor gene therapy depends on the use of a ... The polymerase chain reaction (PCR) was carried out for 30 cycles (98°C for 15 sec, 58°C for 30 sec, and 72°C for 40 sec and finally 72°C for min) The integrity of the cDNA was assayed by RTPCR ... approach aimed at targeted delivery and specific expression of effective antitumor agents Various gene therapy strategies for the treatment of ovarian cancer are currently under development and...

Ngày tải lên: 18/06/2014, 15:20

... ISH was performed on successive slides of TCC tissue for H19 and IGF2-P4 transcripts The intensity of hybridization signal was indicated as (0) for no staining, (+1) for weak, (+2) for moderate ... patient Cancer Therapy 2005, 3:249-266 Cooper MJ: Noninfectious gene transfer and expression systems for cancer gene therapy Semin Oncol 1996, 23:172-187 Kouraklis G: Gene therapy for cancer: from ... or HT-1376(B) cell lines, “C": negative control for PCR The sizes of the PCR products are 300 bp for human H19, 119 bp for IGF2-P4 and 213 bp for Histone 3.3 internal control, respectively Amit...

Ngày tải lên: 18/06/2014, 16:20

... Week (± 1) CD4 Not performed Not performed 234 195 Not performed Week 12 (± 2) CD4 15 250 40 33 Week 24 (± 2) CD4 Not performed 112 294 Not performed (deceased) Not performed Baseline HIV viral ... performed Not performed 132 84 Not performed Week 12 (± 2) viral load 1,356 Undetectable Undetectable 195 Undetectable Week 24 (± 2) viral load Not performed Undetectable Undetectable Not performed ... Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution AIDS Research and Therapy...

Ngày tải lên: 10/08/2014, 05:21

... was used to collect data for all the three types of services: a fastfood restaurant for pure service, an airline for mixed service, and a longdistance telephone company for quasi-manufacturing ... almost a consensus among the participants Therefore the summary of their discussion does not pinpoint a particular service type Implications for management development Most of the participants agreed ... and provide the implications of the relation between service quality and its dimensions on management development To the authors’ knowledge no one has yet attempted to assess the implications of...

Ngày tải lên: 28/01/2013, 10:57

... Therefore, these manifestations point to PLCs as a nucleus for sorting and channelling signals that determine auxiliary cardiac circulatory function, providing a regulatory feedback route for ... argues for the existence of a1-AR as a purposeful and productive resource for adaptive regulation of contractility in response to cardiac disease Although there is hardly any direct evidence for ... for a defunct b1-AR, the mobilization of Ca2+ required for the PIE is attainable most probably by a mechanism that bypasses the Gs-AC pathway, and signalling via PLC is one important option for...

Ngày tải lên: 21/02/2014, 15:20

... products, from the more formal and licensed to the less formal and unregulated The financial system in Ghana falls into three main categories: formal, semi- formal, and informal: • Formal financial ... of the World Bank Africa Region’s strategy for supporting the Millenium Development Goals for poverty reduction Convenient and affordable instruments for savings, credit, insurance, and payment ... International Development Agency Department for International Development (UK) ENOWID FFH GHAMFIN GCSCA GTZ IDA IFAD MFIs MOF MSEs NBFIs NBSSI NGOs NRCD Enhancing Opportunities for Women in Development...

Ngày tải lên: 22/03/2014, 21:20

... this article as: De Backer et al.: Microcirculatory alterations: potential mechanisms and implications for therapy Annals of Intensive Care 2011 1:27 Submit your manuscript to a journal and benefit ... or several of the mechanisms involved in the development of these microvascular alterations Nevertheless, most interventions that are currently used for their impact on systemic hemodynamics also ... to measure and is the most reproducible At the present time, both SDF and NIRS are mostly used for research purposes Microcirculatory alterations are observed in severe sepsis Multiple investigations...

Ngày tải lên: 21/06/2014, 01:20

... of 14.7 per cent compares with per cent for Malaysia, per cent for Indonesia, 11 per cent for the Philippines, 14 per cent for Thailand and 19 per cent for Vietnam in 1997 Lao PDR agricultural ... minimum reforms required for membership – bearing in mind that the accession process offers a unique opportunity to use it for political cover to introduce reforms that otherwise would face formidable ... below the bound rates, and for each tariff item the tariff rate must be the same for all WTO members.7 Secondly, Article V of the GATT provides for freedom of transit for products traded by any...

Ngày tải lên: 09/07/2014, 08:19

... monoclonal antibody therapy in first line treatments for metastatic CRC The aforementioned studies demonstrated the predictive value of KRAS for outcomes of EGFR -targeted monoclonal antibody therapy in ... predictive marker for responsiveness to EGFR monoclonal antibody targeted therapy, it was well known that skin rash was a very good surrogate marker for responsiveness to EGFR targeted therapies ... status Rationale of KRAS Status as a Predictor of Response to EGFR Targeted Therapy The EGFR signaling pathway and targeted therapies for CRC EGFR is a member of the HER (ErbB) family of human epidermal...

Ngày tải lên: 10/08/2014, 22:20

... who were not candidates for intensive chemotherapy [90] Fifty eight patients were enrolled Forty patients received the combination therapy There was only 5% response rate for this group of patients ... three patients received CI-994 orally for 2–10 weeks [46] Thrombocytopenia was the DLT The MTD was mg/m2/day for weeks One refractory lung cancer patient had PR for over years, additional patients ... advanced solid tumors [48] CI-994 dose ranged 4–6 mg/m2 for one or two weeks Thirty patients were enrolled The MTD was mg/m2 for days for the combination regimen CI-994 was evaluated in another...

Ngày tải lên: 10/08/2014, 22:20

... profile have provided strong rationale for the development of smallmolecule inhibitors of MEK1/2 for chemotherapeutic intervention in cancer [62] Clinical development of MEK1/2 inhibitors PD98059 ... challenges Despite strong rationale for the clinical development of drugs targeting the ERK1/2 MAP kinase pathway in cancer, the effectiveness of this approach in cancer therapy remains to be validated ... and results of ongoing trials are anxiously awaited As for other targeted therapies, several outstanding questions remain to be addressed before MEK1/2 inhibitors join the arsenal of anticancer...

Ngày tải lên: 10/08/2014, 22:20

... fluorescent dye (Invitrogen) PCR cycling conditions were 94°C for min, followed by 40 cycles of 94°C for 15 s, 60°C for 30 s and 72°C for 30 s For MtSERK3 and MtSERK6 PCR reactions the annealing temperature ... conditions were a denaturation step of at 95°C, 40 cycles of 95°C for 30 s, 52°C for 30 s and 72°C for 60 s, and then cycle of 72°C for PCR products were cloned into pGEM Easy vector (Promega) and ... -3.’ The degeneracy was 256-fold for the forward primers and 1024-fold for the reverse primers, with a predicted amplicon size of around 446 bp Degenerate PCR was performed on cDNA and genomic DNA...

Ngày tải lên: 11/08/2014, 11:21

... an excellent opportunity to investigate the ontogeny of pollen development and its evolutionary implications In this work, pollen development is characterized in A cherimola, one of the species ... the most developmentally advanced anthers placed in the outermost rows and the different stages of anther and pollen development present within the same flower This fact was helpful for establishing ... number not for citation purposes) BMC Plant Biology 2009, 9:129 showed only a faint staining for the presence of unesterified pectins (Figure 2F) Pollen cohesion Following tetrad formation, callose...

Ngày tải lên: 12/08/2014, 03:21

... treatment for 48 weeks (41.4 ± 7.9 l pre -therapy vs 40.8 ± 9.5 l post -therapy; p < 0.01; Figure 3B) whereas no significant alterations could be observed for HCV genotype patients (40.3 ± 10 l pre -therapy ... shown in Figure 3C, PA did not differ before and after antiviral therapy in HCV patients with genotype (5.3 ± 0.7° before therapy versus 5.4 ± 0.7° after therapy; p > 0.05) whereas in genotype ... either HCV genotype (28.1 ± 4.4 l before and 27.7 ± 5.2 l after therapy; p > 0.05) nor in HCV genotype patients (27.4 ± 5.2 l before and 28.1 ± 6.0 l after therapy; p > 0.05) Similarly, no significant...

Ngày tải lên: 12/08/2014, 04:20

... because of its labile nature in T cells (unintegrated forms persist in the cytoplasm of these cells for only one day and cannot account for the formation of long-term latently-infected CD4+ T-cell ... implications for the development of therapeutic strategies Biochem Pharmacol 2004, 68:1231-1238 219 Quivy V, De Walque S, Van Lint C: Chromatin-associated regulation of HIV-1 transcription: implications ... modifications function sequentially or act in combination to form the "histone code" and serve as extremely selective recruitment platforms for specific regulatory proteins that drive different biological...

Ngày tải lên: 12/08/2014, 23:22