implications for heart disease
Understanding how mutations and stress factors contribute to parkin dysfunction implications for parkinsons disease
Ngày tải lên :
14/09/2015, 12:20
... only a predominant cause of familial parkinsonism but also a formal risk factor for the more common, sporadic form of Parkinson’s disease (PD) However, how parkin becomes dysfunctional was not ... aberrant polyglutamine proteins in cells is typical not only for PD, but also for some other neurodegenerative diseases such as Huntington’s disease and spinocerebellar ataxias Tsai and coworkers demonstrated ... which suggests common pathogenic mechanisms in disease pathogenesis Therefore, understanding the function of the genes linked to different monogenic forms of PD could provide us with a better knowledge...
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Advances in StentTherapy for Ischaemic Heart Disease
Ngày tải lên :
26/01/2013, 11:02
... Pharmacologic agent Mak Heart Drug-eluting Stent Drug carrier vehicle Stent Platform Optimal Geometry “Closed Cell” “Open Cell” 1.0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 Mak Heart Stent-based Drug ... Mak Heart Popma J TAXUS IV Angiographic Results 2003 2.50 Late Loss: TLR Probability for TLR 1.0 Late loss
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
Ngày tải lên :
25/10/2013, 05:20
... At sacrifice, colons were evaluated for ACF formation, for inhibition of inducible nitric oxide synthase (iNOS) and proliferating cell nuclear antigen, and for effects on mucin glycoprotein (MUC2) ... assay after injection of carrageenan For the abdominal constriction test, inhibition observed for the extract was almost as potent as that for indometacin In the formalin test, the V corymbosum extract ... risk of aging, chronic disease, or cancer chemoprevention and treatment in the general population 11.3 Parkinson’s Disease Parkinson’s disease (also known as Parkinson disease or PD) is a degenerative...
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Tài liệu Báo cáo Y học: Receptor crosstalk Implications for cardiovascular function, disease and therapy ppt
Ngày tải lên :
21/02/2014, 15:20
... practical significance for human disease conditions The second category of cardiac diseases comprises disorders, such as left ventricular dysfunction from valvular heart diseases or hypertension ... experimental heart failure and in human disease strongly argues for the existence of a1-AR as a purposeful and productive resource for adaptive regulation of contractility in response to cardiac disease ... hypertrophy Studies in animal disease models have provided important leads for the relevance of crosstalk in therapeutic management of heart failure, hypertension and ischemic heart diseases One of the...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
Ngày tải lên :
16/03/2014, 11:20
... generating toxic radicals, as is the case for the cytochrome P450 system [9] Even though the ADHs are known to be involved in both retinoid transformation and formaldehyde scavenging, their physiological ... including investigations in human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity ... Institute for Medical Research Support for construction of the B6.Adh1– ⁄ – congenic strain was provided by NIH grant AA11828 10 11 12 References 13 Farrer MJ (2006) Genetics of Parkinson disease: ...
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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
Ngày tải lên :
23/03/2014, 07:20
... of acetylcholinesterase involved in amyloid formation In 1996, we found that acetylcholinesterase was able to accelerate Ab fibril formation [11], forming a high molecular complex with Ab fibrils ... showed that hAChE increases the b-conformation content in Ab prior to fibril formation Also, studies with several acetylcholinesterase inhibitors effects were performed The peripherical anionic site ... have shown that this peptide aggregates and forms amyloid fibrils similar to the filaments found in the brains of Alzheimer’s disease patients [39] For example, the single mutation Val18 fi Ala...
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Báo cáo sinh học: " Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases" pot
Ngày tải lên :
19/06/2014, 08:20
... and, therefore, viral forces, have fallen by 102–3 hence, immune forces Ic must fall by >102–3 from A to B for equilibrium to develop There is no evidence this happens serum or liver for 4–7 weeks ... concentration and, therefore, viral forces fall between points A and B to D by 102–3 geq/ml (observation 1), the immune forces must also fall by >102–3 between A and B to D for equilibrium to develop ... or know it, we call the disease autoimmune [75]" fully reflects recent explosive growth of information and the deeper questions this information poses 10.0 Virus receptor disease RNA virus quasispecies...
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báo cáo hóa học: " The contribution of activated astrocytes to Ab production: Implications for Alzheimer’s disease pathogenesis" pot
Ngày tải lên :
19/06/2014, 22:20
... Rockville, MD) for making oligomers, or with 10 mM HCl at room temperature for making fibrils Before treating cells, the 100 μM Ab42 stocks, and vehicle controls lacking Ab42, were incubated for 24 h ... horseradish peroxidase (HRP)conjugated goat anti-mouse (for APP, 1:5000; for GFAP, 1:30,000; for IL-1b, 1:5000; h at RT) or goat anti-rabbit (for BACE1, 1:5000; h at RT) secondary antibodies Finally, ... vicious cycle [62,63] Such an astrocytic feed-forward mechanism could have important implications for both pathogenesis and therapeutic strategies for AD Conclusions In summary, we demonstrate...
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báo cáo hóa học:" Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases" doc
Ngày tải lên :
20/06/2014, 04:20
... and, therefore, viral forces, have fallen by 102–3 hence, immune forces Ic must fall by >102–3 from A to B for equilibrium to develop There is no evidence this happens serum or liver for 4–7 weeks ... concentration and, therefore, viral forces fall between points A and B to D by 102–3 geq/ml (observation 1), the immune forces must also fall by >102–3 between A and B to D for equilibrium to develop ... or know it, we call the disease autoimmune [75]" fully reflects recent explosive growth of information and the deeper questions this information poses 10.0 Virus receptor disease RNA virus quasispecies...
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báo cáo hóa học:" Disease Progression Among Untreated HIV-Infected Patients in South Ethiopia: Implications for Patient Care" pot
Ngày tải lên :
20/06/2014, 08:20
... agents, for their excellent work in tracing and recording patient information Tamirat Seyoum, Tolosa Tomas, and Tadele Roba did most of the counseling The apparent high risk for change in disease ... within the same WHO stage The WHO now recommends initiation of ART for all patients in stage III if there are no facilities for performing CD4+ cell counts.[8] In settings with scarce resources, ... part of the standard package of care for Ethiopian HIV-infected patients Funding Information The HIV/AIDS project of AMH was funded by the Norwegian Agency for Development Cooperation (NORAD)...
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Báo cáo y học: "Maternal Smoking in Pregnancy: Do the Effects on Innate (Toll-Like Receptor) Function Have Implications for Subsequent Allergic Disease" pps
Ngày tải lên :
08/08/2014, 21:20
... rate of respiratory disease4 0 and infection2 in infants of smoking mothers is well recognized These Prescott and Noakes, Implications of Maternal Smoking for Subsequent Allergic Disease effects may ... Noakes, Implications of Maternal Smoking for Subsequent Allergic Disease these groups was the same) Although other studies (discussed above) have noted that infants at high risk of allergic disease ... Prescott and Noakes, Implications of Maternal Smoking for Subsequent Allergic Disease pregnancy, and this is heavily influenced by maternal age,...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
Ngày tải lên :
09/08/2014, 01:23
... polymorphisms have been investigated for linkage with autoimmune diseases The functional consequences have been described for some of these polymorphisms For example, T cells from people carrying ... CD4+ T cells [25], but enhanced surface staining for CTLA-4 performed on naive T cells did not detect CTLA-4 protein [11] The surface CTLA-4 is therefore expressed at very low concentrations (fewer ... engagement [49], PP2A might serve as the mediator for these downstream effects of CTLA-4 However, so far only the opposite role for PP2A as a negative regulator for CTLA-4 function has been described [50]...
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Báo cáo y học: "The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease" potx
Ngày tải lên :
09/08/2014, 10:23
... alginate cultures resulted in the formation of NP cell clusters, which also form through increased cell proliferation in the NP in vivo and have been suggested to form part of an ineffective response ... trypsinisation and viable cell counts were performed using trypan blue The proliferation status of cells was also examined by immunocytochemistry for the proliferation-associated Ki-67 antigen, ... cells for each condition and each sample Collagen immunolocalisation The production of type I and II collagens was examined by immunolocalisation of cytospins, as described [24] In brief, formalin-fixed...
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Implementing electronic clinical reminders for lipid management in patients with ischemic heart disease in the veterans health administration: QUERI Series doc
Ngày tải lên :
11/08/2014, 05:21
... cholesterol-lowering therapy in patients with coronary heart disease A statement for healthcare professionals from the American Heart Association Task Force on Risk Reduction Circulation 1997, 95:1683-1685 ... eligible for this study Patients were identified as having IHD if they had an ICD-9-CM code of 410.xx (acute myocardial infarction), 411.xx (other acute and subacute forms of ischemic heart disease) , ... following diseases were coded as co-morbidities, and each scored one in the count of co-morbid conditions: diabetes, renal disease, chronic heart failure, depression, stroke, peripheral vascular disease, ...
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Báo cáo y học: "Role of vasopressin in the treatment of anaphylactic shock in a child undergoing surgery for congenital heart disease: a case report" docx
Ngày tải lên :
11/08/2014, 11:20
... (amoxicillin/clavulanate potassium) and methylprednisolone (30 mg/kg) were administered as routine before sternotomy incision Before starting cardiopulmonary bypass (CPB), 380 UI/kg of heparin were given and after ... it, and for critical review of important intellectual content SP gave final approval of the version to be published All authors read and approved the final manuscript Consent Written informed ... informed consent was obtained from the patient's relatives for publication of this case report A copy of the Page of (page number not for citation purposes) Journal of Medical Case Reports 2008,...
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báo cáo khoa học: " Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling" ppt
Ngày tải lên :
11/08/2014, 12:20
... additional requirement that proteins were quantified for at least two of the pool pairs for a disease, 346 proteins for CHD and 366 proteins for stroke were included in statistical analyses Of ... Protein set (pathway) analyses For each disease, we focused attention on KEGG pathways for which relative quantification was available for three or more proteins and tested for evidence of a case versus ... Ratios for these protein groups were logarithmically transformed and median-centered at zero for each IPAS experiment Groups that had fewer than four peptide ratios across all experiments for a...
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báo cáo khoa học: "Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease" potx
Ngày tải lên :
11/08/2014, 12:21
... with epigenomic profiling will provide an important tool for uncovering the role of non-coding mutations in human disease For example, if the disease of interest affects a particular cell type that ... These advancements will in turn allow for generation of replacement cells for cellular transplantation approaches and for development of the appropriate disease in a dish’ models Within such ... and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA 2Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA Page...
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báo cáo khoa học: " Implementing electronic clinical reminders for lipid management in patients with ischemic heart disease in the veterans health administration: QUERI Series" ppsx
Ngày tải lên :
11/08/2014, 16:21
... cholesterol-lowering therapy in patients with coronary heart disease A statement for healthcare professionals from the American Heart Association Task Force on Risk Reduction Circulation 1997, 95:1683-1685 ... eligible for this study Patients were identified as having IHD if they had an ICD-9-CM code of 410.xx (acute myocardial infarction), 411.xx (other acute and subacute forms of ischemic heart disease) , ... following diseases were coded as co-morbidities, and each scored one in the count of co-morbid conditions: diabetes, renal disease, chronic heart failure, depression, stroke, peripheral vascular disease, ...
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Báo cáo y học: " MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies" pot
Ngày tải lên :
12/08/2014, 14:20
... (0.3 mg/ml) for 30 minutes, as outlined by [12] For time course studies, BAL fluid was obtained for analysis as described above, at various time points (1, Page of 15 (page number not for citation ... various MMPs and TIMPs in inflammatory airway diseases Information regarding the specific pattern of MMPs/TIMPs involved in "disease" conditions may be useful for the development of novel therapeutics ... from Harlan-Olac (Bicester, UK) and kept for at least days before initiating experiments Food and water were supplied ad libitum UK Home Office guidelines for animal welfare based on the Animals...
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Báo cáo y học: "Displacement and disease: The Shan exodus and infectious disease implications for Thailand" ppt
Ngày tải lên :
13/08/2014, 13:21
... filariasis; in 2004, two Shan migrants in urban Chiang Mai presented for care for symptomatic lymphatic filariasis, the first time this disease entity had been seen in decades [39,40] This finding raises ... Shan, already bear a disproportionate burden of infectious disease morbidity and mortality Tuberculosis is the most common infectious disease diagnosed on health screening of guest worker registrants, ... 1996–2002 Page of (page number not for citation purposes) Conflict and Health 2008, 2:4 infection rates in Thailand [30,31] In Chiang Mai, AIDS is now the most common disease in Shan migrants that...
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