impaired glucose tolerance obesity and inflammatory mediators

... macaque IGT model 14 male macaques were randomized into two groups, NGT (Normal glucose tolerance) and IGT (Impaired glucose tolerance) NGT group was given the standard lab diet (Laboratory Fiber-Plus ... insulin -glucose metabolism at the gene expression level, physical and biochemical characteristics in nutrition-mediated IUGR and impaired glucose tolerance (IGT) cynomolgus macaques Studies on IUGR and ... PEPCK and GR expression level was higher in IUGR Fasting hyperglycemia, reactive hyperglycemia and hyperinsulinemia observed Fasting hyperglycemia and glucose intolerance observed PEPCK and IGFBP-1...

Ngày tải lên: 02/10/2015, 17:14

... macaque IGT model 14 male macaques were randomized into two groups, NGT (Normal glucose tolerance) and IGT (Impaired glucose tolerance) NGT group was given the standard lab diet (Laboratory Fiber-Plus ... insulin -glucose metabolism at the gene expression level, physical and biochemical characteristics in nutrition-mediated IUGR and impaired glucose tolerance (IGT) cynomolgus macaques Studies on IUGR and ... PEPCK and GR expression level was higher in IUGR Fasting hyperglycemia, reactive hyperglycemia and hyperinsulinemia observed Fasting hyperglycemia and glucose intolerance observed PEPCK and IGFBP-1...

Ngày tải lên: 04/10/2015, 16:03

... macaque IGT model 14 male macaques were randomized into two groups, NGT (Normal glucose tolerance) and IGT (Impaired glucose tolerance) NGT group was given the standard lab diet (Laboratory Fiber-Plus ... insulin -glucose metabolism at the gene expression level, physical and biochemical characteristics in nutrition-mediated IUGR and impaired glucose tolerance (IGT) cynomolgus macaques Studies on IUGR and ... PEPCK and GR expression level was higher in IUGR Fasting hyperglycemia, reactive hyperglycemia and hyperinsulinemia observed Fasting hyperglycemia and glucose intolerance observed PEPCK and IGFBP-1...

Ngày tải lên: 04/10/2015, 16:12

... morbidity and mortality following CPB is of importance It is well documented that CPB is associated with a systemic inflammatory response, which involves the synthesis of various cytokines and inflammatory ... example, a systematic review by Liakopoulos and colleagues [10], which included randomized controlled trials (RCTs), and 16 observational studies (3 prospective and 13 retrospective), reported outcomes ... therapy, compared with placebo or standard of care, decrease the inflammatory response after CPB? Materials and methods This systematic review was conducted and reported in accordance with available...

Ngày tải lên: 13/08/2014, 19:20

... intake and weight loss associated with smoking Low-grade inflammation is a key feature of obesity and links obesity to insulin resistance, impaired glucose tolerance and even diabetes Features of obesity- induced ... efforts, obesity and obesity- related disorders remain at epidemic proportions and the etiology of ulcerative colitis remains unclear Since the inflammatory response is an integral process in both obesity ... into those with predominantly pro -inflammatory actions and those with anti -inflammatory actions Pro -inflammatory cytokines include TNFa, interleukin (IL)-1b, IL-6, and IL-8 TNF-a is a pleiotropic...

Ngày tải lên: 18/06/2014, 22:20

... Figure 8A shows immunoblots for p-Pkb/Akt proteins Samples (1 and 7) correspond to control, (2 and 8), (3 and 9), (4 and 10), (5 and 11), (6 and 12) correspond to cells treated with LPS + Aβ +/- mM ... (Thr-172 of the α1/α2 subunits) and Figure C to phosphorylated AMPK (Ser 108) of AMPK β subunit In Figures B and C samples (1) control (2 and 5), (3 and 6) and (4 and 7) correspond to cells treated ... data for iNOS and MnSOD, and for all phosphorylation blots are expressed on an arbitrary scale Results AICAR attenuates LPS- and Aβ peptide-induced expression of cytokines and iNOS, and NO production...

Ngày tải lên: 19/06/2014, 22:20

... intake and weight loss associated with smoking Low-grade inflammation is a key feature of obesity and links obesity to insulin resistance, impaired glucose tolerance and even diabetes Features of obesity- induced ... efforts, obesity and obesity- related disorders remain at epidemic proportions and the etiology of ulcerative colitis remains unclear Since the inflammatory response is an integral process in both obesity ... into those with predominantly pro -inflammatory actions and those with anti -inflammatory actions Pro -inflammatory cytokines include TNFa, interleukin (IL)-1b, IL-6, and IL-8 TNF-a is a pleiotropic...

Ngày tải lên: 20/06/2014, 04:20

... IL-6, IL-8 and nitric oxide by hSFs and hACs: effects of IL-1F8 and IL-1β Shown is an analysis of the effects of IL-1F8 and IL-1β on IL-1β production of (a) IL-6 and (c) IL-8 by hSFs, and of (b) ... is required for IL-1F8 signalling [5,16] Both hSFs and hACs produced inflammatory mediators in response to IL-1F8, and stimulation of IL-6 and IL-8 production was somewhat stronger in hACs than ... synovial fluid and serum samples JLB and MJHN produced the recombinant IL-1F proteins DM, GP, SB, PAG, MJHN and CG participated in the design of the study, data analysis, and drafting and reviewing...

Ngày tải lên: 09/08/2014, 08:22

... Figure Rutoside and rat macrophage inflammatory mediators ex vivo To confirm the anti -inflammatory effects of RU and the role of macrophages, we tested the levels of selected mediators in the ... human and murine cells and in vivo DM contributed to the conception and design of the study and to manuscript drafting JR and AA-K contributed to the acquisition of data in human cells SB and DT ... treatment on rat inflammatory mediators (a) Sera were collected at day 50 after immunization and tested for their concentramediators tions in tumor necrosis factor-alpha (TNF-α), prostaglandin E2 (PGE2),...

Ngày tải lên: 09/08/2014, 10:22

... of SF mediators and markers over the time course of week The panel included several inflammatory mediators and enzymes implicated in altered joint homeostasis in arthritic disease (prostaglandin ... characterized the induced inflammatory response through SF analysis of inflammatory mediators and painrelated (neuro)peptides The observed increase in prostaglandin E2 was sharp and short-lived, which ... effects with accurate timing and quick recovery of joints In addition, LPS is known to induce IL-1 and various other cytokines and mediators, such as TNF and prostaglandin E2, implicated in naturally...

Ngày tải lên: 09/08/2014, 13:22

... Figure Basal glucose transport and glucose transporter-1 protein in normal and osteoarthritis chondrocytes (a) 2-Deoxy-D -glucose (2-DG) transport into chondrocytes normal (n = 6) and osteoarthritis ... Rosa et al Figure Stimulation of glucose transport and glucose transporter-1 expression by IL-1β in normal and osteoarthritis chondrocytes (a) 2-Deoxy-D -glucose ( 2and osteoarthritis chondrocytes ... have been shown to adjust to high and low glucose concentrations, mimicking hyperglycemia and hypoglycemia episodes, by changing the GLUT-1 content and the rate of glucose transport [26-28] Moreover,...

Ngày tải lên: 09/08/2014, 14:21

... FCA and (b) contralateral 8) and high and µg; n = those injected14 Levels of IL1α, = joints of IL10(500rats and in (a) ipsilateralwith Figure days earlier Levels of IL1α, IL1β, IL6, IL10 and ... collection, then read and edited the manuscript after completion AGR assisted with the total inflammatory cell count studies and reviewed and edited the article IPC, AJR and DSM contributed intellectually ... temporomandibular joint and its relation to pain, mobility, and anterior open bite J Oral Maxillofac Surg 1998, 56:1059-65; discussion 1066 Chang H, Israel H: Analysis of inflammatory mediators...

Ngày tải lên: 11/08/2014, 08:21

... systemic inflammation and postoperative organ dysfunction [3] Several circulating inflammatory mediators, including proinflammatory and anti -inflammatory cytokines [4] and chemokines [5], could ... expression of inflammatory adhesion receptors and cellular activators, and circulates in response to cardiac surgery with CPB [16] IL-6 is a cytokine with recognized pro -inflammatory and antiinflammatory ... was involved in the conception and design of the study and in the analysis and interpretation of data KCP, MF and DASAV conducted immunoassays and data acquisition and drafted the manuscript MLFM...

Ngày tải lên: 12/08/2014, 23:22

... responder and nonresponder, †P < 0.05 between baseline and before INO Endotoxin also caused a rapid release of inflammatory mediators and vasoactive substances Prostanoids, LTB4, ET-1, nitrates and ... vasoactive inflammatory mediators and subsequent INO administration We previously developed an experimental model of endotoxin infusion in pigs and tested the degree of response to INO hours and hours ... plasma concentrations of endotoxin and IL-8 (ρ = 0.62, P < 0.01) Further positive correlations were seen between MPAP on one hand and IL-8 (ρ = 0.72, P < 0.01) and ET-1 (ρ = 0.68, P < 0.01), on...

Ngày tải lên: 13/08/2014, 11:23

... suggested that small intestinal [12] and gallbladder motility [13] may be inhibited by a hyperglycaemic state Glucose control may thus be important for optimal tolerance and absorption of nutrients in ... absorptive capacity of the gut is indeed impaired during critical illness and to determine the causes and mechanisms of this With this aim in view, further development and validation of tools Page of ... Another observation from Chapman and colleagues’ study is the finding that gastric emptying was inversely related to baseline blood glucose, such that elevated blood glucose levels were associated...

Ngày tải lên: 13/08/2014, 19:20

... improvement of glucose tolerance in L.s.-infected DIO mice depended on eosinophils Glucose tolerance tests in both L.s.-infected and uninfected ΔdblGATA mice showed a worsened glucose tolerance in ... L.s infection on glucose tolerance is dependent on the time point of infection, which provided at 7-8 wpi and 11 wpi the best improvements of glucose tolerance (Fig 10 and 11) Inflammatory immune ... subcutaneous and visceral adipose tissue (VAT) and results in obesity Obesity is a major risk factor to develop T2D and is associated with low grade chronic inflammation Adipocyte hypertrophy and tissue...

Ngày tải lên: 26/11/2015, 10:00

... Portugal and Italy report overweight and obesity levels exceeding 30% among children aged 7-11 The rates of the increase in childhood overweight and obesity vary, with England and Poland showing ... schools and the media Council conclusions on obesity, op cit Council conclusions on obesity, op cit Opinion of the European Economic and Social Committee on Obesity in Europe – role and responsibilities ... Building overweight and obesity prevention and treatment into health services Health services and health professionals have a strong potential for improving patients’ understanding of the relations...

Ngày tải lên: 14/02/2014, 13:20

... inflammation of adipose tissue in obesity and related insulin resistance [15] Here, we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ... ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases The expression of ANGPTL2 and ANGPTL6 ⁄ AGF is induced in obese conditions ANGPTL2 induces chronic adipose tissue inflammation and ... serum levels and amelioration of diet-induced obesity and insulin resistance [14] Taken together, these findings suggest that ANGPTL6 ⁄ AGF in the circulation counteracts obesity and related insulin...

Ngày tải lên: 14/02/2014, 22:20

... the link between obesity and ED by focusing on the potential pathophysiological links including obesity- related androgen deficiency and obesity- induced endothelial dysfunction Obesity promotes ... and these anthropometrical measurements Andersen et al [83] investigated the relationship between obesity and ED in a younger cohort of Danish men between aged 20–45 years and reported that obesity ... dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens in vascular health and erectile function Summary and conclusions Visceral obesity, in...

Ngày tải lên: 18/02/2014, 06:20

... inhibitor and with higher and more physiologically relevant total adenylate concentration (2 mm) We determined how palmitoyl-CoA (5 and 10 lm) affects the ATPtotal ⁄ ADPtotal ratio and [AMP]total ... ratio by ATP synthesis and proton leak, and decreased the control by the Q-reducing module with both respiratory substrates, and the control by the QH2-oxidizing module and hexokinase with succinate ... multifactorial diseases such as obesity and type diabetes Both starvation and incubation with fatty acids have been shown to cause a concomitant decrease in cytosolic ATP ⁄ ADP ratios and an increase in total...

Ngày tải lên: 19/02/2014, 05:20