... therefore the replication of the integrated HIV- 1 genome [16 ,17 ] Because of its important role in HIV- 1 replication, the inhibition of P-TEFb function has been proposed as a potential therapeutic ... cyclin T1 function in macrophage differentiation The functional significance of the induction of cyclin T1 expression upon differentiation of primary monocytes is unknown, in part due to the difficulty ... Research Induction of the HIV- 1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs Wendong Yu1, Yan Wang1, Chad A
Ngày tải lên: 13/08/2014, 09:20
... protective function of U1 snRNA binding is inde- pendent of the recognition of the 3'ss during progression of spliceosome formation. To exclude the possibility that the requirement for U1 snRNA ... if only one of the elements was altered exclusively the increase of the pyrimidine content... ASF/SF2 to the RRE thereby possibly stabilizing the interaction of U1 snRNP with the ... http://www.retrovirology.com/content/3 /1/ 89 Page 8 of 20 (page number not for citation purposes) The intrinsic strengths of the HIV- 1 splice acceptor sites differ largely The observation that the efficiency of the 3'ss
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: " Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission" ppsx
... mb.9 mb .10 mb .11 mb .12 mb .13 ib .1 ib.2 ib.3 ib.4 ib.5 ib.6 ib.7 ib.8 ib.9 ib .10 ib .11 md.8 md.9 md .10 md .11 md .12 md .13 md .14 md .15 md .16 md .17 id.4 id.5 id.7 id .12 id.8 id .11 id.9 id .10 id.2 ... 0.002 C 0. 011 0. 017 0.0 31 0.075 D 0.022 0. 017 0. 011 0.020 E 0. 016 0. 015 0. 015 0.024 F 0.009 0. 011 0.025 0.0 61 H 0.023 0. 016 - - I1H - - 0.0 01 0.0 01 I2H - - 0. 017 0. 017 Total 0. 014 0. 014 0. 015 0.029 ... mf .18 mf.9 mf .12 mf .10 mf .16 mh.2 i2h.6 i2h.7 i2h.2 i2h.3 mh.7 mh.3 mh.6 mh .1 mh.4 mh.5 mh .16 i2h .1 i2h.4 i2h.5 mh.8 mh.9 mh .10 mh .11 mh .12 mh .13 mh .14 mh .15 i1h .1 i1h.2 i1h.3 i1h.4 i1h.5 i1h.6
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: " Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41" pdf
... L593Q Q591L A501C C605Y Q593L Q591L A501C C605Y Q593L L591Q A501C T605C L593Q Q5 91 A501C C605Y L593Q Q5 91 A501C T605C L593 Q5 91 A5 01 T605 L593 Q5 91 wt SOS SOS-X 6 /11 11 /11 2 /11 1/ 11 1 /11 1/ 1 Replication ... Reversion a ASOSSupT 110 - - BSOSSupT 110 - - CSOSSupT 110 - - D A501C SupT1 10 - - ESOSSupT 110 - - F1 SOS SupT1 10 0 .1 - F3 SOS SupT1 10 0.3 - ISOSSupT140 J1 SOS SupT1 40 0 .1 - J3 SOS SupT1 40 0.3 ... engagement [11 ,12 ]. Modeling of the SOS reversions in structure model of the HIV- 1 gp 41 ectodomain [18 ]Figure 6 Modeling of the SOS reversions in structure model of the HIV- 1 gp 41 ectodomain [18 ]. The
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: "Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study" ppsx
... Society of America/American Thoracic Society Schouten et al Critical Care 2 010 , 14 :R145 http://ccforum.com/content /14 /4/R145 10 11 12 13 14 15 16 17 18 19 20 21 consensus guidelines on the management ... (pg/mL) 41 (19 -53) 53 (27 -10 2) 39 (3 .1- 56) 36 (18 - 41) 43 (23-69) 18 (3.7-38) IFN-g (pg/mL) 10 7 (57 -16 5) 69 (56 -18 3) 50 (35-238) 84 (39 -15 5) 58 (47 -14 6) 42 (24 -14 2) IL -10 (ng/mL) 1. 1 (1. 0 -1. 2) 0.9 ... (8.9 -1. 3) 0.8 (0.6 -1. 1) 1. 0 (0.7 -1. 1) 0.9 (0.8 -1. 3) 0.6 (0.4-0.8) MCP -1 (ng/mL) 8.4 (2.6 -10 ) 10 (1. 9 -14 ) 2.8 (1. 6-3.0) 6.3 (2.5-8.9) 9.0 (1. 9 -10 ) 2.6 (1. 3-8.4) KC (ng/mL) MIP-2 (ng/mL) 12 (8.3 -15 )
Ngày tải lên: 13/08/2014, 21:21
Báo cáo y học: "The impact of the neisserial DNA uptake sequences on genome evolution and stability" potx
... recombination in all of the neisserial genomes, and not only in N. meningitidis, reduced the size of the average conversion fragment to 1, 127 nucleotides. The smaller size of the conversion fragments ... association between their spacing and the sizes of con- version fragments. We then computed the distribution of the distances between consecutive DUSs. To control for the selec- tion of close ... studying the conservation of the motif sequences [15 ]. In this study, the M-GCAT global genome alignment allowed precise prediction of the evolution of these elements in each of the aligned positions.
Ngày tải lên: 14/08/2014, 08:20
The impact of the north east transit line on the housing price gradient
... Dummy 0. 013 817 0.033786 -0. 013 627 -0.0766 21 -0 .14 6256 -0 .15 8722 -0. 016 505 -0.0 415 52 0. 013 728 -0.004 318 0.053700 0.087687 0.0993 31 Exponential 0.78297 0.75622 0.8 810 7 1. 08592 0.77222 0.747 01 0.84 519 0.84334 0.83497 0.79403 0.7 814 6 0.795 01 0.82540 1. 118 82 Normalised 10 0.00 96.58 11 2.53 13 8.69 98.63 95. 41 107.95 10 7. 71 106.64 10 1. 41 99. 81 1 01. 54 10 5.42 14 2.89 44 [...]... announcement of the Pioneer MRT station’s ... Dev. 446755.3 7 .15 42 43.304 61 106 .18 64 .49 914 17 .4963974 .17 10847 0.094059 0.24357 0.273455 0 .15 4 418 0.237764 0.369002 0.357546 0.206967 0.23 815 7 0.230546 0.253945 0. 412 945 386. 519 4 Min 15 5000 1 38 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 62 Max 8482840 37 10 16 488 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1700 Counts 2450 18 56 14 2 42 298 383 11 5 283 722 499 205 284 265 326 10 26 - Table ... Percentage 4706 10 0 13 69 29.09 18 89 40 .14 14 88 30.77 Table 2: Percentage of Housing Transactions in each Proximity Zone 16 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 Estate
Ngày tải lên: 06/10/2015, 21:16
Magnetic properties of the spin-1 heisenberg antiferromagnet on an interpolating square – triangular lattice in Popop-Fedotov representation
... principle, the various magnetic phases may appear depending on the type of lattice (square, triangular ), on the magnetic bonds and also on the magnitude of the spin quantum numbers of the atoms on the ... constraint condition The simplest way to resolve the constraint problem is the relaxiation of the local constraint on each lattice site by a so called global constraint, which is fulfilled only ... 1. 25 Again, at T = 0K, (18 ) and (18 ) lead to the same result In one loop approximation we obtain the the contributions of the longitudinal and transverse fluctuations to the energy as follows:
Ngày tải lên: 13/01/2020, 12:09
The impact of the company''s market timing on insider trading of repurchase announcement
... 0.535 -10 . 319 -0.009 14 437.58 -10 .8384 1. 216 132 8.557 0 -11 .996 -0.0 31 49233.5 -9.628 1. 111 7.64 71 338. 71 0.329 -13 . 012 -0.034 811 32.46 -15 .656 1. 070 7.5390 0 -13 .858 -0.054 18 898.5 -14 .756 0.9 71 ... company ? ?1 month ±3 month ±6 month MT 30 81. 1** (2.08) -429 .1 29 71. 2** (2 .11 ) -467.3 2949.0** (2 .10 ) -465.8 ( -1. 35) 62.25 (0.53) 17 1.9 (0.56) 5.349 (1. 17) -76.05 (-0.08) ( -1. 48) 49.73 (0.43) 11 7.2 ... SIZE 219 1.6** (2.56) 206.2 (0.62) -15 8.2 2078.8** (2.44) 214 .2 (0.62) -18 9.0 18 59.9** (2 .12 ) 229.2 (0.66) -18 6.5 IND (-0.97) ( -1. 12) ( -1. 10) Ms The Impact of the Company's Market Timing on BCAR
Ngày tải lên: 01/02/2020, 23:12
The impact of the US-China trade war on FDI in Vietnam
... Trúc Ly 18 50806 51 Task V 10 0% Lê Yến Nhi 18 50 811 80 Support V+Word 10 0% Table of Contents TABLE OF CONTENTS THE IMPACT OF THE US-CHINA TRADE WAR ON FDI IN VIETNAM I - THE BEGINNING ... Department of Customs, the value of Vietnam's exports to the United States reached 47.53 billion USD at the end of 2 018 - an increase of 11 14 .3% compared to 2 017 In the first half of 2 019 , Vietnam's ... relations What is the nature of an FDI project? The essence of FDI is the meeting of the needs of two parties and one side is the investor and the other side is the host country Which includes: There
Ngày tải lên: 06/01/2022, 08:37
Impact of the hoa binh dam vietnam on wa
... 34.9 30 .1 156.3 91. 9 10 3.9 13 1.4 66.8 80.7 549.7 523 .1 265.5 30.9 211 .5 11 7.0 19 6.8 14 6.3 328.6 216 .4 920.7 10 12.7 439 .1 41. 2 538.9 262.2 556.7 3 51. 0 484.7 378.4 18 04.9 2339.9 12 49 .1 91. 4 10 14.0 ... 427 .1 1028.4 717 .1 444.0 474.8 2426 .1 315 0.2 17 87.9 15 3 .1 1383 .1 480 .1 12 91. 1 857.4 399.4 399.2 2908.8 2990.7 17 92.4 14 1.6 14 68.4 606.0 13 69.8 875.6 255.3 255 .1 20 01. 2 2 611 .4 978.8 87.5 10 68.6 ... stations before (19 60? ?19 79) and after (19 89–2 010 ) Hoa Binh dam impoundment River Lo Thao Da Red Duong Period 19 60? ?19 79 19 89–2 010 19 60? ?19 79 19 89–2 010 19 60? ?19 79 19 89–2 010 19 60? ?19 79 19 89–2 010 19 60? ?19 79
Ngày tải lên: 19/01/2022, 15:50
study-of-the-impact-of-the-tobacco-plain-packaging-measure-on-smoking-prevalence-in-australia
... 2, 215 K 2,593 K 11 .66% 15 .00% 14 .38% 11 . 31% 15 .00% 14 . 31% 390 K 2,080 K 2,4 71 K 368 K 2,080 K 2,448 K 11 .66% 14 .09% 13 .64% 10 .99% 14 .09% 13 .52% 390 K 1, 954 K 2,345 K 358 K 1, 954 K 2, 312 K 11 .67% ... Total Population Smokers 3,345 K 390 K 14 ,768 K 2,358 K 18 ,11 3 K 2,748 K 3,345 K 390 K 14 ,768 K 2,358 K 18 ,11 3 K 2,748 K Prevalence 11 .66% 15 .96% 15 .17 % 11 .66% 15 .96% 15 .17 % 390 K 2, 215 K 2,605 ... Implementation of the Tobacco Plain Packaging Act 2 011 and the Competition and Consumer (Tobacco) Information Standard, 2 011 ,” Tobacco Control, Vol 24, 2 015 , pp ii9-ii16 at ii14-ii15 Tobacco Plain
Ngày tải lên: 22/10/2022, 22:50
Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... (0. 61 1. 09) 0.87 (0. 61 1. 23) On ART 0.44 (0. 31 0.62) 0.58 (0.43–0.78) Orphan 0.82 (0. 61 1. 10) 1. 03 (0.67 1. 55)
Ngày tải lên: 25/10/2012, 10:31
Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot
... 61 60 52 61 14 12 0.003 0.0 01 > 10 0 (58%) > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (98%) 21 16 > 10 0 (10 0%) 16 ND 68 10 0 10 0 35 93 92 64 28 0.68 0.2 > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (10 0%) ... Asn103 Tyr1 81 VAL108A VAL106A LEU234A ASN103A TYR188A Tyr1 81 D H O O O K126 Asp 110 VAL108A O O O TYR188A VAL108A O Asp 110 O O O VAL106A Asp186 TYR188A Trp229 Asp186 PHE227A NNRTIbp Asp185 K126 ... 61 K-53 > 10 0 (10 0%) > 10 0 K-54 39 60 KNA-53 21 52 K -12 6 10 0 61 K- 61 > 10 0 ( 91% ) 14 K -11 1 > 10 0 (80%) > 10 0 (10 0%) K-49 13 12 EFV > 10 0.003 0.0 01 a Compound concentration required to...
Ngày tải lên: 22/03/2014, 16:20
Báo cáo khoa học: Structural mobility of the monomeric C-terminal domain of the HIV-1 capsid protein pptx
... of 12 .3 s )1 (range 9 .1 14 .0); the second a-helix presented a mean of 13 .2 s )1 (range 11 .9 14 .2); the third a-helix presented a mean of 11 .3 s )1 (range 8 .19 – 13 .5); and, finally, amino acids in the ... constant of the free space, cN and cH are the gyromagnetic ratios of 15 N ()2. 71 · 10 7 radÆs )1 T )1) and 1H (2.68 · 10 8 radÆs )1 T )1) , h is the Planck constant, xN is the Larmor frequency of the 15 N, ... motions (i.e the internal motions of the bond vectors are independent of the overall rotational movement of the molecule) Furthermore, the internal motions of each bond vector are independent of...
Ngày tải lên: 07/03/2014, 06:20
Báo cáo khoa học: Kinetic study of the HIV)1 DNA 3¢-end processing Single-turnover property of integrase docx
... (19 96) Linear diffusion of the restriction endonuclease EcoRV on DNA is essential for the in vivo function of the enzyme EMBO J 15 , 510 4 511 1 40 Harper AL, Skinner LM, Sudol M & Katzman M (20 01) ... inactivation (T1 2, IN alone ẳ 11 1 min; T1 2, IN+DNA ẳ 15 4 min; T1 2, IN+Mg ẳ 222 min) FEBS Journal 273 (2006) 11 3 711 51 ê 2006 The Authors Journal compilation ê 2006 FEBS M Smolov et al DNA allows the ... preincubation of IN with 11 44 [Product] (nM) 0 .12 0.08 T1/2 = 11 1 15 0.04 0.00 200 400 600 800 10 00 Time (min) B [Product] (nM) Stability of IN during the 3Â-processing reaction A 0 .12 0.08 T1/2 =...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot
... panel: Backbone superimposition of 10 selected structures of (1 96)Vpr, performed on the (15 –33) (38–49) (54–74) a helices The average rmsd of the back˚ bone for the (17 –83) region is 5.0 A Helices ... that maintain the relative orientation of the first and second helices, on one side, and the second and third helices on the other side of the molecule It is reasonable to suggest that these local ... This is one of the main reasons why the aim of this study was to determine the solution structure of the intact monomeric form of this protein One of the main problems encountered with (1 96)Vpr,...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo sinh học: " Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein" docx
... Zasloff M, Stanley EF: Magainin 2, a natural antibiotic from frog skin, Page 12 of 14 (page number not for citation purposes) Virology Journal 2007, 4 :12 3 10 11 12 13 14 15 16 17 18 19 20 21 22 ... http://www.virologyj.com/content/4 /1/ 123 osmolysis The ability of UV-inactivated HIV to cause single cell balloon degeneration in the absence of replication argues for the involvement of a virion component, possibly the ... virion Since the LLP domains are also present in the context of the virion, it is possible that they would have an effect at this stage of the HIV replication cycle There is at least one report of...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo hóa học: " Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein" docx
... Zasloff M, Stanley EF: Magainin 2, a natural antibiotic from frog skin, Page 12 of 14 (page number not for citation purposes) Virology Journal 2007, 4 :12 3 10 11 12 13 14 15 16 17 18 19 20 21 22 ... http://www.virologyj.com/content/4 /1/ 123 osmolysis The ability of UV-inactivated HIV to cause single cell balloon degeneration in the absence of replication argues for the involvement of a virion component, possibly the ... virion Since the LLP domains are also present in the context of the virion, it is possible that they would have an effect at this stage of the HIV replication cycle There is at least one report of...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo y học: "Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase" ppt
... Interaction with LEDGF/p75 +++ D64/D 116 99.4/99.7 DD64, 11 6EA +++ ++ K136 31. 3 K136A +++ ++ K159 99.5 K159P - +/- V165 93.5 V165A - - E170 99.6 H171A +++ - H1 71 98.5 L172A +++ - L172 K173 99.4 ... Journal 2 010 , 7:68 http://www.virologyj.com/content/7 /1/ 68 Page of 14 highlighted the importance of E170A, H171A, LK172,3AA for LEDGF/p75 interaction [11 ,12 ,26] The mutants K136, K159 were also ... EH170,1AA EK170,3AA ++ +++ +++ V176 99.4 HL1 71, 2AA - - A179 99.8 HK1 71, 3AA ++ ++ I182 98.0 V176A - - F185 99.4 A179P - - KR186,7 99.7/99.0 A179I - NA I200 98.3 I182A + ++ I203 96.8 F185A KR186,7AA...
Ngày tải lên: 12/08/2014, 04:20