immunostimulant antimutagenic and anticancer activity
Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications pot
... defined a-helical and amphipathic peptide [9] A number of synthetically modified citropin peptides have significantly greater anticancer and antibacterial activity (and also nNOS activity) than citropin ... antimicrobial activity Antibacterial and anticancer activity Synthetic modifications of citropin 1.1, shown in Table 1, were made to investigate the relationship between activity and sequence The ... change in activity for Asp4 and Ser11, and (b) significant reduction in the activity for Phe3, Lys7, Lys8 and Leu16; replacement of the following residues with Lys show (a) reduction in activity...
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Cationic drug based self assembled polyelectrolyte complex micelles physicochemical, pharmacokinetic, and anticancer activity analysis
... charge density and binding affinity of individual drugs towards the anionic PAA block Fig Release profiles of (A) MTX and (B) DOX from MTX-PCM and DOX-PCM at pH 5.0 and pH 7.4 MTX-PCM and DOX-PCM ... bladder cancers These anticancer agents act by intercalating DNA and inhibiting topoisomerase II [11] While both DOX and MTX are anthracycline moieties, they differ in number and substitution states ... wavelengths of 609 and 485 nm were selected for measuring MTX and DOX, respectively 2.3 Particle size and -potential analysis Particle size (nm), polydispersity index (PDI), and zeta ()potential...
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Reading DOs and DONTs activity
... answers is wrong She should: A 26 give two answers just in case B 28 rub it out and leave it blank C 30 forget about it and move on ...
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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... three regions between RIZ1 and ephrin receptor (EphR) during sequence analysis (Fig 2) The sequence identity and homology were 34.2% and 68.4%, 37.0% and 81.5%, and 22.9% and 53.1% in the three aligned ... Identical and homologous residues are shown in red and blue, respectively The sequence identity and homology between RIZ1 and EphR were 34.2% and 68.4% in the residues 63-99 region, 37.0% and 81.5% ... showed that the PR domain alone exhibited anticancer activity Materials and Methods Overexpression and purification of PR domain The cloning, overexpression and purification of recombinant His6-tagget...
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INFLUENCE OF STREAMSIDE SURFACE AREA ON AQUATIC BIOTA AND BIOFILM ACTIVITY
... a highly repeatable and easy to measure method for estimating biofilm activity (Hanes and Irvine, 1968) Moreover, it is possible to separate a specific microbial activity and quantify it by adding ... artificial wastewater was fish extract 40 g･l-1, NH4Cl g･l-1, and KH2PO4 g･l-1 (TOC, T-N, and T-P are 16, 7.4, and 2.6 g･l-1, respectively), and a feed pump was used for continuous addition at a rate ... and gravels in a gabion, peeling all attached deposits, and fixing the capacities of brick-filled channel to 0.6 l and the gravel-filled channel to l This was filtered with a mm mesh sieve, and...
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International Taxation and Multinational Activity
... American business and the consequent greater ability to relocate productive operations in response to tax incentives See Razin and Slemrod (1990), Giovannini, Hubbard, and Slemrod (1993), and Feldstein, ... technology and its transmission across borders National tax policies affect the costs and returns to R&D performed by multinational firms, and have the potential to influence the location of innovative activity ... economic activity to its tax treatment The lessons provided by such investigations carry valuable implications for a broad range of domestic and international policies, and deepen our understanding...
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Tài liệu Sport and Physical Activity in Children with Congenital Heart Disease ppt
... based on recommendations from German and international expert societies (e1, 8, e4, e5, 13) and on longstanding experience in the treatment, sports advice, and care provided in sports activities ... peers means improved quality of life and has a strong social and socializing aspect for children and adolescents Being forbidden to participate in sports and/ or limitations to the extent to which ... a child's perceptive and movement-related experiences Fears and worries for the ill child often result in the parents adopting an over-protective educational style Fear and insecurity prevail...
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Tài liệu "Promoting healthy diets and physical activity: a European dimension for the prevention of overweight, obesity and chronic diseases" doc
... European Network on Nutrition and Physical Activity IV.2.1 A network on Nutrition and Physical Activity composed of experts nominated by the Member States, the WHO and consumer and health NGOs has been ... Portugal and Italy report overweight and obesity levels exceeding 30% among children aged 7-11 The rates of the increase in childhood overweight and obesity vary, with England and Poland showing ... ensured in the definition and implementation of all Community policies and activities A number of areas of Community policy are relevant to nutrition and physical activity, and the Council has confirmed...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... relies on both phospholipase C and PI3-K activity PI3-Kb and not PI3-Kc mediates the P2Y12 effect on thrombin-evoked Ca2+ responses In man and mouse, the PI3-Kb (p110b) and PI3-Kc (p110c) isoforms ... prolongation of thrombin ⁄ ADP-evoked phospholipase C activity and Ca2+ mobilization in a way controlled by PI3-Kb Results Autocrine and added ADP increases and prolongs thrombin receptor-induced Ca2+ ... activation and platelet aggregation [18] We and others have shown that both the PI3-Kb and PI3-Kc isoforms contribute to the P2Y12-mediated stabilization of platelet aggregates under static and shear...
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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
... hindrance between peptide and protein, and to relax the hydrogen added to the protein, the peptide and protein were merged and minimized before docking Atomic solvation parameters and fragmental volumes ... temperature probe The one- and two-dimensional NMR experiments were performed and processed on 300 MHz and 500 MHz Bruker DRX spectrometers equipped with a 5-mm broad-band inverse probe, at a proton ... Intensities were assigned as strong, medium and weak with upper and lower boundaries of distance for dNa (i, i), daN (i, i +1) and dNN (i, i +1), 1.9–3.0, 2.2–3.6 and ˚ 3.0–5.0 A, respectively [23] Side...
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Tài liệu Báo cáo khoa học: Molecular characterization and allergenic activity of Lyc e 2 (b-fructofuranosidase), a glycosylated allergen of tomato pdf
... sera to a 9- and a 15-kDa band We could show that the 9-kDa band in the tomato extracts reacts with a specific antibody against the LTP from cherry, Pru av and the 15-kDa band shows reactivity using ... tomato-allergic patients (A, B) Patient 1, showing IgE reactivity to nLyc e and CCD (C,D) Patient 2, showing no IgE reactivity to nLyc e and CCD Standard deviations are shown for each measurement horseradish ... reactivity and allergenic activity of this carrot protein in comparison to the tomato allergen As the IgE reactivity of nLyc e was inhibited by the pineapple stem bromelain glycopeptide MUXF and...
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Tài liệu Báo cáo khoa học: Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans ppt
... cm)1 and ms (PO2–) at 1120 cm)1, respectively [23,30], and the bands at Fig Infrared spectrum in the spectral range 1800–900 cm)1 (A) and – in the range of the negatively charged phosphate band ... by treatment with DNAse/RNAse and proteinase K, and lyophilized and used in the natural salt form The lipopeptide palmitoyl-3-cysteine-serine-lysine-4 (Pam3CSK4) and the macrophage-activating ... hydrated PC, MfGl-II, and LPS Re 1172, 1085, and 1038 cm)1 assigned to glucose ring vibrations [31] As no additional bands in the range of the amide vibrations centered at 1650 and 1550 cm)1 can...
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Women and Physical Activity pot
... have an impact on women and men; Policies and programs affect women and men differently; and Diversity exists between individual women and men and within groups of women and men The framework can ... Nutrition and Physical Activity Strategy The Victorian Aboriginal Nutrition and Physical Activity Strategy acknowledges that high body mass and physical inactivity are ranked the second and third most ... information and support given to women during and after pregnancy regarding the role of physical activity in preventing and managing gestational diabetes is vital Regular exercise before and during...
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Occupational therapy interventions and physical activity interventions to promote the mental wellbeing of older people in primary care and residential care pdf
... for delivery and it is not necessary to cover all themes Beginnings – a celebration of achievements • activity and health • the ageing process and activity • personal time, energy and activity • ... standardised measures of emotional and social wellbeing and quality of life and self-reported outcomes, and how could such measures be used in economic appraisals? What are the most effective and ... skills councils and other organisations responsible for developing training programmes and setting competencies, standards and continuing professional development schemes • NHS and local authority...
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American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention doc
... work, and schools, and decrease access to and marketing of foods and drinks of low nutritional value, particularly to youth • Provide safe, enjoyable, and accessible environments for physical activity ... different types of activity, minute of vigorous activity can take the place of minutes of moderate activity For example, 150 minutes of moderate activity, 75 minutes of vigorous activity, and a combination ... appropriate, enjoyable, and varied, including sports and fitness activities in school, at home, and in the community To help reach activity goals, daily physical education programs and activity breaks...
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Báo cáo khoa học: Improving thermostability and catalytic activity of pyranose 2-oxidase from Trametes multicolor by rational and semi-rational design pdf
... Concomitantly, Phe454 rotates and moves some A to ll the active site and pack against the FAD cofactor In the loop between b-strand B6 in the substrate-binding domain and strand E2 in the hinge domain, ... buffer (pH 6.5) at 60, 70 and 75 C, respectively, and by subsequent measurements of the enzyme activity (A) at various time points (t) using the standard ABTS assay and glucose as the substrate ... substrates, d-glucose and d-galactose, which were varied over the range 0.150 and 0.1200 mm, respectively, using the standard azino-bis-(3-ethylbenzthiazolin-6-sulfonic acid) (ABTS) assay and oxygen (air...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
... ATPase domain and C-terminal helix [36] showing the location of residues that were mutated The TRP, RDF and DEL sequences are shown in green, dark blue and red, respectively The b domain and C-terminal ... as well as the b-domain DEL sequence, for Vps4p ATPase activity, wild-type and mutant Vps4p proteins were purified (Fig 4A) and the ATPase activity of each Vps4p protein was assayed (Fig 4B) Mutant ... SDS ⁄ PAGE and stained with Coomassie Brilliant Blue (B) The purified 6His-tagged wild-type Vps4p and Vps4p mutant proteins were assayed in vitro for ATPase activity at 30 °C ATPase activity is...
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Báo cáo khoa học: Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity docx
... available and obtained from Sigma or Fluka (Buchs, Switzerland) DEAE Sephacel was from Amersham Biosciences, and cellulose phosphate (P11) was from Whatman (Kent, UK) DNA restriction and modification ... system and a likely candidate in a position for the abstraction of hydrogen from the substrate Single-mutant proteins in which Asp367 has been replaced with alanine or asparagine exhibit a 300- and ... bacterial, fungal, plant and protozoan origin, of the crystal structure of the enzyme with bound EPSP and of the flavin cofactor, revealed two invariant serine residues – Ser16 and Ser127 – interacting...
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Báo cáo khoa học: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles pdf
... very low CatE activity, and no CatD activity Moreover, the overall activity in the subcellular fractions of the three cell types tested varied substantially, as did CatE and CatD activity DCs ... E and D activity N Zaidi et al A TAPA Cytosol CatE activity CaD activity Lysosomes Endosomes 20 40 60 80 100 120 pmol MOCAc liberated/min/20µg total protein B TAPA CatE activity Cytosol CaD activity ... specific determination of CatE and CatD activity, CatE was specifically depleted by immunoprecipitation The remaining activity is due to CatD, and the decrease in activity is assigned to CatE This...
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Báo cáo khoa học: Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate potx
... for activity and the activity bands for corresponding peaks are labeled with arrows In this gel, peak appeared as a doublet (band a and b) Each peak was further separated on nondenaturing PAGE and ... coomassie blue and the duplicate half was stained for activity as described for nondenaturing PAGE The pI for each isoenzyme was calculated from the standard curve and the average of the major bands is ... carboxylesterases stained for activity and protein The glycoprotein fraction of microsomal extract and the five activity peaks seen in Fig were individually concentrated and 15 lg of protein from...
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