immune vascular and stromal cells in the tumor environment
Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
... detected in patients with PTB in this study may therefore indicate the contribution of NK cells in the host immune response against MTB infection The immune response after MTB infection and disease ... the patients in this study Immunity against MTB comprises of a predominant cellular response and majority of researchers have dismissed the participation of B cells in defending against the infection ... response against MTB by increasing the infection inoculum (Vordermeier et al., 1996; Maglione et al., 2007) In addition the protection of mice against MTB infection by administration of intravenous...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... dynamic immune response when the body is threatened by infection or injury In this setting T cells will become activated, and will recruit other T cells and other inflammatory cells and mediators ... whether the CD4+CD25– T cells capable of differentiating into TR cells following activation are derived from a separate lineage of CD4+ T cells, and whether their induction is a result of the initial ... fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, or whether they return to their previous...
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Báo cáo khoa học: "Comparative study of endocrine cells in the principal pancreatic islets of two teleosts, Silurus asotus (Siluridae) and Siniperca scherzeri (Centropomidae)" potx
... study of the endocrine cells within the pancreas, intestine, and stomach of the gar Gen Comp Endocrinol 1997, 106, 1-16 Guyot, E., Diaz, J P., Romestand, B and Connes, R Insulin during the early ... PP-immunoreactive cells Insulin is synthesized in the B cells of the pancreatic islets and regulates the serum glucose levels (Hsu and Crump, 1989) The regional distribution and relative frequency of the insulin-immunoreactive ... chromogranin containing cells in the porcine gastroenteropancreatic endocrine system Jpn J Vet Sci 1987, 50, 395-404 11 Jansson, L and Sandler, S L The influence of cyclosporin A on the vascular...
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Báo cáo khoa học: " An immunohistochemical study of chromogranin A and Sp-1 immunoreactive cells in the gastrointestinal tract of ovariectomized rats" pdf
... lanoitubirtsid eht ,hguohtlA ]8,3[ sllec enircodneoruen lla fo ”srekram“ nommoc yltnacifingis a ,stneitap aitreni cinoloc nI slamina fo sutats evitsegid ot detaler ylraelc erew sllec RI-GC fo segnahc eht ... enircodne ni A ninargomorhc fo noitartsnomed lacimehcotsihonummI T aganawI ,N arahianaY ,F otaS ,H ikhO ,Y otomihsaH 01 892-782 ,25 ,9891 lotyC lotsiH hcrA saercnap enircodne eninac eht ni II ninargoterces ... yltnacifingis a ,noitidda nI ]5[ esaesid s’nhorC dna ]5[ sitiloc evitareclu ,]41[ romut ,]61[ noitapitsnoc cinorhc htiw stneitap fo mutcer eht ni desaercni osla yeht dna ]43[ asocum cinoloc ni...
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Báo cáo khoa học: "Changes of gastrointestinal argyrophil endocrine cells in the COLO205 tumor-implanted Balb/c-nu/nu mice" pps
... enircodne cinoloC L suilemirG ,R gnilnetS ,A nossleinaD ,M yhlaS-lE 943-143 ,772 ,4991 seR eussiT lleC ,gorf neerg eht fo tcart yratnemila eht fo sllec enircodne eht ni B dna A ninargomorhc ... nI stluseR 962 giF ecnereffid tnacifingis a deredisnoc saw 50.0 naht ssel fo eulav-p a dna )ASU ,SSPS ;3.1.6 esaeleR( swodniW rof SSPS htiw atad fo ecnacifingis eht ezylana ot desu saw )tset ... dezimotceiravo eht ni detroper erew sllec lihporygra IG fo esaerced yltnacifingis a ,noitidda nI ]62[ aimena suoicinrep dna ,]3[ aimenirtsagrepyh ,]1[ sitirtsag cihporta ,]7[ esaesid s’nhorC...
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Báo cáo khoa học: "Autologous somatic cell nuclear transfer in pigs using recipient oocytes and donor cells from the same animal" pdf
... viability in vitro and in vivo [4,12,39], but there are few reports on autologous SCNT in pigs The objective of the present study was to examine the feasibility of producing autologous porcine SCNT ... cell cycle is an important factor in the development of SCNT embryos [6,38] Cells in the G0/G1 phases are superior to cells in other phases of the cycle in terms of their ability to support NT embryo ... different since the CCCs were cultured for only 18 h and were probably in the actively growing phase However, this probable difference in the cell cycle was not reflected in the development of the SCNT...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... proliferation and the cell cycle progression in nucleus pulposus cells, (2) determine if c-Myc transcription inhibitor obstructed the effect of TGF1, and (3) determine the role of ERK1/2 in stabilizing the ... treatment The cell cycle distribution in TGF1treated cells (Figure 5b) indicates a large increase in cells in the S phase, associated with the suppression of p21 and p27 which belong to the Cip/Kip ... Competing interests The authors declare that they have no competing interests 14 Authors' contributions TN and DS conceived of the study and performed the experimental work DS and JM participate in...
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Báo cáo y học: "Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production" docx
... supporting the importance of intercellular contacts in the pathogenic mechanisms underlying RA Indeed, the importance of these cell-cell interactions in the synthesis and release of pro-inflammatory ... CD48, than in monocytes that express both CD48 and CD244 Thus, our findings show that NK cells can engage and stimulate monocytic cells, resulting in the synthesis of TNF This finding opens the possibility ... PR-N obtained purified NK cells EF-R and DS participated in the design of the study and helped to draft the manuscript FS-M participated in the design of the study and its coordination and helped...
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Báo cáo y học: " The inflammatory response seen when human omental adipose tissue explants are incubated in primary culture is not dependent upon albumin and is primarily in the nonfat cells" pps
... cells Interestingly over the 48 h incubation there was a marked increase in 11b HSD-1 gene expression in nonfat but not in fat cells [Figure 4] The increases in IL-8 release and mRNA in non-fat cells ... 48 h was examined in the studies shown in figure There were significant additional increases in the mRNAs for IL-8, HIF1a, and 11b HSD1 in the nonfat cells over the 48 h incubation There was also ... studies and analysis of mRNA DT and AM selected the donors, obtained the samples of fat and aided in the interpretation of the data All authors read and approved the final manuscript Competing interests...
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Báo cáo y học: "Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review." doc
... colonize the gut and express and release the immunogen in the intestine DCs in the mucosal site will then capture the immunogen via DC-binding peptide motifs They internalize the immunogen, process and ... antigen-specific B cells [29] T- and B-cell interaction results in the clonal expansion of B cells, which takes place in the plasma foci of the T cell rich area [30] and in the germinal centers [31] T- and ... to immune component cells [66-68] facilitate rapid internalization of the immunogen into DCs DCs will then process and present it to T cells residing in the gut These cells will be activated and...
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Báo cáo y học: " Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study" pptx
... cross-sectional, have examined the relationship between vascular risk factors and SMC, with conflicting results [3,17] Neither of these studies examined the SMC -vascular risk factor association as their primary ... with vascular risk factors This finding adds some support to the concept of vascular depression [43] and emphasises the need for clinicians to take SMC seriously in their patients, as a common indicator ... conceived the study and wrote the first draft NSG helped with the study design, statistics and editing the manuscript SLN provided input into the study design and helped draft the manuscript TAD...
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Báo cáo y học: "Alterations of alveolar type II cells and intraalveolar surfactant after bronchoalveolar lavage and perfluorocarbon ventilation. An electron microscopical and stereological study in the rat lung" pdf
... obtained at baseline, thereafter treatment according to randomization was initiated In the Lavaged-Gas group conventional mechanical ventilation was continued with the same ventilatory setting In ... between the T piece of the ventilator and the endotracheal tube Measurements were performed prior to lavage, at baseline and 30 and 60 minutes of therapy Fixation, sampling and processing All ... from collapsing during the fixation procedure The abdominal cavity was opened and animals were exsanguinated After opening the thoracic cavity, the pulmonary artery was canulated and the lung was...
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Báo cáo y học: "Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia" ppsx
... these Lin- PCs migrated into the airspaces (approximately 3.1% of all the cells remaining in the lung), therefore approximately 14.6% of the initially infused Lin- PCs homed to lung tissues and ... when cells for resolution and repair are required Alternatively, these cells may remain in the less hostile intravascular milieu to proliferate and mature, to home and migrate into the inflammatory ... regeneration and repair These findings showed firstly that very few progenitor cells migrate into the airspaces to participate in airspace inflammation but the majority of cells remain in the lung...
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Báo cáo y học: "Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver" pptx
... staining in the perisinusoidal spaces throughout the parenchyma b) HSC stain positive, producing a thin irregular positive band lining the sinusoids c) HSC stain positive A positive cell containing ... consistently in all slides In the portal areas, the terminal and sublobular hepatic veins, and in Glisson's capsule identical staining was observed In the hepatic parenchyma moderate positive staining ... between slides In the portal area, vimentin showed positive staining cells in smooth muscle cells of portal vasculature, most spindle-shaped stromal cells and neural cells (Fig 1a) Cells in Glisson's...
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Báo cáo y học: "Discovery of estrogen receptor α target genes and response elements in breast tumor cells" ppsx
... From these observations the number of direct target genes involved in initiating hormone response in breast tumor cells might represent only 0.47% (89/18,912) of the genes in the human genome The ... predicted in either organism; conservation of the 20 bases flanking the 5' and 3' ends (40 bases total) of the predicted EREs; and the distance between the binding-site sequences and the TSS refereed ... Materials and methods section), defined as the most 5' nucleotide of the reference transcript in the NCBI RefSeq database, of candidate genes and queried them for potential ER-binding sites The size and...
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Báo cáo sinh học: "Combined therapy with cyclophosphamide and DNA preparation inhibits the tumor growth in mice" docx
... efficiency of this therapy [17,21,22] Tumor microenvironments harbor the activity of Tregs, suppressing the immune effect on tumor cells and thus protecting the tumor from immune regression In such a ... transformed into an ascitic form, and maintained in this line LSs are highly sensitive to the apoptosis induced by CP and several other alkylating agents The Krebs-2 tumors were initially Figure ... participated in the design of the study and performed the statistical analysis KEO participated in the design of the study DNS helped in the data interpretation ERC performed the analysis and interpreted...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
... asymmetric division in cell-fate determination, and provided compelling evidence suggesting that the cell fate determinant Numb is critical in determining lineage commitment in the immune system Tannishtha ... two-hybrid screen and identified CTNNBL1 (beta catenin-like protein 1) as an AID-interacting protein Interestingly, he found that an AID mutant deficient in CTNNBL1 binding retains deamination activity ... promoting B-cell development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... resulting in the killing of 39 Chapter 1: Introduction these infected cells Under these circumstances, the dying cells, CD8 T -cells and other APCs such as macrophages and DCs within the inflammatory ... naive T cells (Steinman and Cohn, 1974) These cells are now known as the primary instigators of the adaptive immunity as they are vital for detecting, alerting and priming the adaptive immune ... antigen and is followed by a contraction phase, when 90–95% of the effector cells die in the ensuing days and weeks and the remaining 5–10% become long-lived memory cells (Harty and Badovinac,...
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Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"
... bone graft in the damaged site and on the other hand, it creates an environment with a rich content of HA, with all the advantages deriving from the phenomenon The present study’s clinic and radiologic ... rheological and viscoelastic properties, HA can influence the cell function that modify the surrounding micro and macro environment as a result of complex interactions with the cells and other extracellular ... suggest that integrin-mediated interaction plays a decisive role in 67 the regulation of proliferation, migration, and differentiation of the epithelial cells [2,12,18,19] Following the surgical...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose