immune basis for the second order bystander effect

... theorem, Ma established the following theorem Theorem 1.2 Let H1 , (H2), (H3), and (H4) hold Assume that for some k ∈ N, λk λk < f∞ f0 1.6 Then i if r ∈ λk /f∞ , λk /f0 , then 1.1 have at least ... considered in , and satisfies the general hypotheses imposed in that paper Then by 9, Theorem 1.6 and Corollary 1.8 together with Lemmas 2.3 and 2.4 in Section 2, there ν exists a continuum Dk ... case, there exists a neighborhood O ⊂ M of λk , ∞ such that μ, u ∈ Dk ∩ O ν and μ, u / λk , ∞ implies μ, u ∈ R × Tk ν On the other hand, by 3.5 and the continuity of the operator L−1 : Y → E, the...

Ngày tải lên: 22/06/2014, 06:20

... for conditions of coefficient matrices for which the operator is Fredholm of zero index (section 2) and the second is characterizing the set of all right-hand side functions y ∈ Z for which the ... the operator In the rest of paper we use the following notations is zero matrix of order d × d and θ is zero element of d Id : the identity matrix of order d ν z(t) := t (t − s)ν−1 z(s)ds, for ... ∈ Im , } Proof The proof of this Lemma is straightforward and we will omit the details Theorem 2.1 The operator • zero if dim (Im + Im • positive if dim (Im is Fredholm Moreover the index of is...

Ngày tải lên: 14/10/2015, 08:45

... Page of second- order nonlinear coefficients focusing in the role played by the Coulomb interaction Conclusions are summarized in final section Theory The effective-mass Hamiltonian for the electron-hole ... the other hand, the Coulomb potential defines the effective Bohr radius a∗ and the effective Rydberg energy R∗ of the electron-hole interaction, 4π εh2 ¯ , μe2 a∗ = (3) where M = m∗ + m∗ is the ... situation for ω0 = × 1014 s-1, Table This is because the mean spatial separation between the electron and the hole increases, and therefore the Coulomb interaction decreases, as the energy of the quantum...

Ngày tải lên: 21/06/2014, 04:20

... of cards for each item in the librarys collection The first type has the authors name or other persons or institutions The second has the title of the book or other item on the top line the third ... cards for each item in the librarys collection The first type has the authors name or other persons or institutions that contributed to the work on the top line The second has the title of the ... study This is the reason why the topic Designing an ESP syllabus for the second year students of library study at the NTTC is the subject matter chosen for my thesis Aims and Objectives The study...

Ngày tải lên: 07/11/2012, 14:36

... seeks their opinions about the content of the material Part C asks for their opinions about the methodology Part D requires them to offer suggestions for the material’s further improvement The ... mistakes in the statements; read the text and numbering the sentences or the paragraphs; read the text and find the similar words in the reading text; read the text and find the best title for the passage ... the source for much of the language practice that occurs in the classroom Richard further explains that materials provide basis for the content of the lesson, balance of skills taught, and the...

Ngày tải lên: 07/11/2012, 14:50

... GE in the first year, the students have to study Business English in the second year The kind of English is quite new for all of them because they have never studied it before or what they have ... design In order to design a speaking syllabus for the second year students of Business Administration at HUI, the researcher considers the business – related topics, the skills needed for their future ... role The measure of success for students learning English for hotel waiters, or the English for food technology, is whether they can perform convincingly as hotel waiters in English or 42 whether...

Ngày tải lên: 25/12/2013, 20:21

... discussed the results of the needs analysis conducted to create the basis for proposing an appropriate reading syllabus for the second- year students at the Urban Planning Faculty The setting for the ... syllabus for the second- year students at the Urban Planning Faculty, HAU” as the topic of my thesis Aims and objectives of the study This study aims at designing an ESP reading syllabus for the second- year ... planning The questionnaire for the subject teachers at the Urban Planning Faculty, HAU, only seeks for their opinions on the necessary topics to be included in the syllabus Like the teachers of the...

Ngày tải lên: 29/01/2014, 14:39

... element basis In fact such a basis follows from the Proper Forcing Axiom, a strong form of the Baire Category Theorem The elements ∗ are X, ω1 , ω1 , C, C ∗ where X is any suborder of the reals ... interested in the suborder ∂H(K) = {p ∈ ∂(K) : Xp ∈ H(K)} which seems to be the correct modification of H(K) from the point of view of forcing the conclusion of the main theorem In order to aid in the presentation ... cardinality ℵ1 , then X serves as a single-element basis for the class of uncountable separable linear orders PFA is a strengthening of the Baire Category Theorem and is independent of the usual axioms...

Ngày tải lên: 06/03/2014, 08:21

... site formation after substrate binding Interestingly, the disorder of the lid region appears to be increased in the product rather than in the substrate complexes In the VioC•hArg complex, the ... interactions in the active site of the product complex of VioC The involved residues are specified by their number in the peptide chain and by the secondary structure element from which they are ˚ ... molecules of l-serine (Fig 1A) Another striking feature of these NRPSs is related to the C-terminus of the synthetase VioG Although there is no need for a further condensation reaction, this NRPS...

Ngày tải lên: 16/03/2014, 02:20

... (Table 3) The effects of the K103N mutation on the hydrophobic interactions reveal individual differences among the three compounds Though the electron density for the amide part of the residue ... by the K103N mutation The electron density for Cc of the K103N mutant structures is well defined but the quality of the map does not allow assessment of the orientation of the amide plane There ... subnanomolar range for all three inhibitors PNU142721 and MSC194 show a 3–10-fold reduction in efficacy for the K103N mutant The effect of the mutation is more pronounced for Efavirenz where there is a...

Ngày tải lên: 18/03/2014, 01:20

... Coalition for Affordable Housing & the Environment 483 Coalition for Affordable Housing & the Environment 1402 Coalition for Brain Injury Research 365 Coalition for Natural Health 1192 Coalition for ... Limited The 1098 Fund for Animal 1192 G Tech Corp 551 Page 25 of 75 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR GOVERNMENTAL AFFAIRS AGENTS BY REGISTRATION NUMBER FOR THE SECOND ... ORGANIZATIONS AND THEIR GOVERNMENTAL AFFAIRS AGENTS BY REGISTRATION NUMBER FOR THE SECOND QUARTER 2005 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER Assist America Inc 26 Assn for Children of...

Ngày tải lên: 22/03/2014, 21:20

... complexes [34] Therefore, we conclude that the reason for the difference in energetics of the )1 subsite between PAL and A must be due to details in the interaction between the protein and the carbohydrate ... in the monosaccharide binding site, severe steric clashes are observed between the mannose residue and the protein for all conformations due to the b(1–2) linkage A second possibility is that the ... binding in the global minimum conformation Neither in the GlcNAcb(1–2)Man complex, nor in the complexes with M592 or GlcNAcb(1–2) Mana(1–3)ManaMe is there any evidence for two conformations despite...

Ngày tải lên: 23/03/2014, 11:20

... Figure 4A shows the 20 lowest-energy conformers from the selected cluster modelled using the Haddock docking calculations The rmsd values for the 20 lowest-energy conformers of the best cluster ... 0.71 ± 0.11 A for the backbone and 1.11 ± 0.09 A for the heavy atoms The mean total energy of the ensemble is )8146 kcalÆmol)1, being )314 kcalÆmol)1 the intermolecular contribution The corresponding ... used for the peptide (C) Lowest-energy conformer of the family, using ribbon and stick representations for the protein and the peptide, respectively Selected side chains with important roles in the...

Ngày tải lên: 29/03/2014, 09:20

... is therefore a particularly attractive candidate for the medical gene therapy applications mentioned above, as well as for industrial synthesis of d(d)NTPs and their analogs [6,15] To further ... phosphorylation of the natural substrates of the double mutant with the single mutant, it seems that the mutation N45D in the double mutant counteracts the negative effect( s) of the N64D mutation For phosphorylation ... bound to the 3¢-OH group of the substrate while there is no density for that interaction in the mutant structure (Fig 2B) Structural basis for altered properties of the N64D mutant The LID region...

Ngày tải lên: 30/03/2014, 20:20

... two theorems about the set of semantically equivalent parses that a CCG parser will generate for a given string (see (Eisner, 1996) for proofs and discussion of the theorems): (31) Theorem : For ... Wallace) ate)? Finally, the unary combinator basis for CCG provides an interesting additional specification for generating CCG rules Like the CTL basis, the unary combinator basis can produce a much ... This shows another instance of the schema in (1), which is undefined for any of the combinators in (3): The preceding data motivates adding D rules (we return to the distribution of the modalities...

Ngày tải lên: 31/03/2014, 00:20

... by others [31], and the thrusting forward of subdomain with respect to the rest of the monomer In this report we study the pH-dependence of the actin– cofilin interface and provide evidence for ... fragment Another histidine is located in the 38–52 fragment, but this sequence was previously excluded from the interfaces [33] The possible effect of pH on the actin site was first tested using the C-terminal ... suggesting that the actin–cofilin complex impedes the interaction of cofilin with the actin peptide The complex formation between the C-terminal sequence of actin with cofilin was then investigated...

Ngày tải lên: 31/03/2014, 09:20

... infinitely many periodic solutions for system (1.1) using the Fountain theorem, the Dual Fountain theorem, and the Symmetric Mountain Pass theorem The rest of the article is divided as follows: ... j satisfies the (PS)∗ c condition, then j satisfies the (PS)c condition Main results and proofs of the theorems Theorem 3.1 Let F(t, x) satisfies the condition (A’), and suppose the following ... r2 centered at Proof The proof of Proposition 3.2 is the same as the proof of the condition (A2) in the proof of Theorem 3.1 We have proved the functional j satisfies all the conditions of Lemma...

Ngày tải lên: 20/06/2014, 22:20

... I, s Î I The proof is complete Similar to the proof of Theorem 3.1, we can prove the following results Theorem 3.2 Assume that (H) holds, P is normal and for any x Î P, A(f)0 >Bf∞ Then problem ... (3.1), there exists ε > such that 1 such that ||f(t, x)|| ≤ (f0 + ε)||x||, for ||x|| ≤ r1, x Î P, and t Î I Therefore, for t Î ... nonnegative, θ is the zero element of E The main features of this article are as follows First, the author discusses the existence results in the case q Î C[0, 1], not q(t) = as in [1] Second, comparing...

Ngày tải lên: 21/06/2014, 00:20