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Báo cáo khoa học: Binding of the volatile general anesthetics halothane and isoflurane to a mammalian b-barrel protein doc
... a combination of aliphatic and charged residues, such as arginine or lysine, with the remaining two composed of aliphatic and somewhat polar residues such as serine, phenylalanine, and asparagine ... The other thermodynamic parameters underlying halothane and isoflurane binding to the porcine odorant binding protein are given in Table Halothane displaces 1-aminoanthracene (AMA) bound to the ... treated as a two parameter Table Dissociation constants and thermodynamic data for the binding of halothane and isoflurane to the porcine odorant binding protein The entropy unit (eu) is calÆmol)1Æ...
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Off the Rim Basketball and Other Religions in a Carolina Childhood docx
... as Trinity and Vanderbilt and Sewanee held their own with Georgia and Alabama and Tennessee, when Duke went to the Rose Bowl after hiring away Alabama’s famous coach, Wallace Wade My mother’s first ... Hank Aaron, and Karl Spooner for Vinegar Bend Mizell and came up with a team of players all born in Alabama When I was nine years old my family had taken a trip across country to Yellowstone and ... ground fauna, to Blue Devils and Blue Demons, Sun Devils and Demon Deacons, to Hawkeyes and Buckeyes, Longhorns and Sooners, Tigers and Wildcats and Lions and Cougars and all other breeds of cat In...
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Báo cáo khoa học: Cytochrome P460 of Nitrosomonas europaea Formation of the heme-lysine cross-link in a heterologous host and mutagenic conversion to a non-cross-linked cytochrome c ¢ pot
... converted a unique SspI site on the vector to an EcoRV site The mutagenesis oligonucleotides were 5¢-GTAACTGTAAGAGAACTGGTCAC-3¢ (Lys70 to Arg), 5¢-GTAACTGTAGCAGAACTGGTCA G-3¢ (Lys70 to Ala), and 5¢-GGTAACTGTATATGAA ... mutagenesis kit (Clontech, Inc., Palo Alto, CA, USA) using the method of Deng and Nicloff [19], as directed by the manufacturer The selection oligonucleotide, 5¢-AAATGCTTCAATGATAT CGAAAAAGGAAG-3¢, ... sulfate was then added to the periplasmic extract to 75% saturation and stirred for 45 at °C before centrifugation at 15 000 g for 15 at °C The pellet was discarded, and the supernatant brought to...
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MENTAL EFFICIENCY AND OTHER HINTS TO MEN AND WOMEN docx
... clothes that you have put on that very day and that you know by heart, you are almost always shocked by the realization that you are you And now and then, when you have gone to the glass to arrange ... course, scandalous A man is born as he is born And he can as easily add a cubit to his stature as add kindliness to his heart The feat never has been done, and never will be done And yet we blame those ... like it to be And the years pass, and that beautiful furniture and that system of ventilation are not achieved And then one day they die, and friends come to the funeral and remark: "Dear me!...
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comparative phototoxicity of nanoparticulate and bulk zno to a free-living
... paper demonstrates that phototoxicity of nano-ZnO and bulk-ZnO was dramatically enhanced under natural sunlight illumination as compared to artificial laboratory light illumination This phototoxicity ... Netherlands) was used to characterize particle morphology and measure the primary particle size Approximately 100 particles from four representative images of each material were measured and average ... generation of the nanoparticles; (ii) nano-ZnO will have greater phototoxicity than bulk-ZnO, as smaller particles have a greater surface area per unit mass than larger particles and thus may be...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 1) pps
... chemicals Measurements of solar flux indicate that there is a twentyfold regional variation in the amount of energy at 300 nm that reaches the earth's surface This variability relates to seasonal effects; ... dermis Approximately 3% of radiation below 300 nm, 20% of radiation below 360 nm, and 33% of short visible radiation reaches the basal cell layer in untanned human skin In contrast, UV -A readily ... readily penetrates to the dermis and is capable of altering structural and matrix proteins that contribute to photoaging of chronically sunexposed skin, particularly in individuals of light complexion...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 2) pps
... manifests the dry, leathery appearance of prematurely photoaged skin as well as basal cell and squamous cell carcinomas and melanoma in the first two decades of life Studies ... leads to increased intracellular cyclic AMP and protein kinase A, followed by increased transcription of microphthalmia transcription factor (MITF) that regulates melanogenesis MCIR mutations account ... IL-8, vascular endothelial growth factor, prostaglandin E2, and tumor necrosis factor α Local accumulation of these cytokines occurs in sunburned skin, providing chemotactic factors that attract...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 5) pps
... solar spectrum Treatment of this PLE includes the use of sunscreens and the induction of hardening by the cautious administration of artificial UV-B (broad-band or narrow-band) and/ or UV -A radiation ... prior to initial sun exposure Phototoxicity and Photoallergy These photosensitivity disorders are related to the topical or systemic administration of drugs and other chemicals Both reactions ... clinical manifestations include erythema resembling a sunburn reaction that quickly desquamates, or "peels," within several days In addition, edema, vesicles, and bullae may occur Table 57-3 Phototoxic...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 6) ppsx
... duplicate and one set is irradiated with a suberythema dose of UV -A Development of eczematous changes at sites exposed to sensitizer and light is a positive result The characteristic abnormality ... sensitive to UV-B, UV -A, and visible wavelengths Diagnostic confirmation of phototoxicity and photoallergy can often be obtained using phototest procedures In patients with suspected phototoxicity, ... glucocorticoids may be useful Judicious use of analgesics may be necessary Photoallergic reactions require a similar management approach Furthermore, patients with persistent light reaction and chronic actinic...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 7) docx
... that absolute avoidance of the sun would eliminate these disorders Unfortunately, contemporary life-styles make this an impractical alternative for most individuals, and this has led to a search ... associated features Biochemical confirmation of the diagnosis can be obtained by measurement of urinary porphyrin excretion, plasma porphyrin assay, and by assay of erythrocyte and/ or hepatic uroporphyrinogen ... the patient eliminates exposure to porphyrinogenic agents Erythropoietic protoporphyria originates in the bone marrow and is due to a decrease in the mitochondrial enzyme ferrochelatase secondary...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 8) pot
... therapeutically The administration of UV-B alone or in combination with topically applied agents can induce remissions of psoriasis and atopic dermatitis Photochemotherapy in which topically applied ... furocoumarins that, when intercalated into DNA and exposed to UV -A, form adducts with pyrimidine bases and eventually form DNA cross-links These structural changes are thought to decrease DNA synthesis ... parents and young children about the hazards of sunlight Simply eliminating exposure at midday will substantially reduce lifetime UV-B exposure Phototherapy and Photochemotherapy UV can also be...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 3) doc
... matrix are the major site for sun-associated chronic damage, manifest as solar elastosis, a massive increase in thickened irregular masses of abnormal elastic fibers Collagen fibers are also abnormally ... Exposure: Nonmalignant The clinical features of photodamaged sun-exposed skin consist of wrinkling, blotchiness, and telangiectasia and a roughened, irregular, "weatherbeaten" leathery appearance Whether ... carcinogen, meaning that it can act as both a tumor initiator and a promoter The third and final step in the malignant process is malignant conversion of benign precursors into malignant lesions, a process...
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Báo cáo toán học: "A density result for random sparse oriented graphs and its relation to a conjecture of Woodall" pptx
... T is larger than the maximum cardinality of a family of pairwise disjoint transversals and, therefore, T is a counterexample to this generalized dual statement Thomassen’s tournament is as follows ... is acyclic and each source is joined to each sink by an oriented path Lee and Wakabayashi [5] recently proved the conjecture for series-parallel oriented graphs To relate this conjecture to Theorem ... Woodall’s conjecture may be stated as follows: for any planar oriented graph G, the oriented girth of G is equal to the maximum cardinality of a family of pairwise disjoint transversals In other...
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Báo cáo toán học: "Periodicity and Other Structure in a Colorful Family of Nim-like Arrays" pdf
... verify that a change of seed from to has a minimal effect; other than the top left × block, the pattern of the array A1 is exactly the same as that of A0 The array A0 is well known as the Nim addition ... that Nimaddition may be represented as a recursively generated array [4] The purpose of this paper is to give a detailed combinatorial and graphical description of the members of a family A ... Note the various appearances of striation – patterns arranged linearly – in the colored array Interestingly, the striation in the spindle and tendrils is somewhat parallel to the diagonal, and the...
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báo cáo khoa học: "Metabolome in schizophrenia and other psychotic disorders: a general population-based study" pptx
... cluster values to improve normality Partial correlation network analysis Cluster analysis The data were scaled into zero mean and unit variance to obtain metabolite profiles comparable to each other ... glutamic acid, alpha-ketoglutaric acid, pyruvic acid, alanine, lactic acid, alpha-hydroxybutyrate Arachidonic acid, aminomalonic acid, citric acid Beta-sitosterol MC8 Lipid metabolites 2-Monopalmitin ... variables and Mann-Whitney U test for continuous variables One-way analysis of variance (ANOVA), implemented in Matlab (MathWorks, Natick, MA, USA), was applied to compare the average metabolite...
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Báo cáo y học: "The Autism - Tics, AD/HD and other Comorbidities inventory (A-TAC): further validation of a telephone interview for epidemiological research" docx
... data and performing clinical assessments OS and EC in collecting data and statistical analyses BK and MR in revising the manuscript PL in conceiving and designing the study and statistical analyses ... specifically in relation to ASD symptomatology and associated problems, and (c) in that it has been validated as a telephone interview There are today several instruments that are frequently used as ... site are also translations of the original Swedish A- TAC into English, French, and Spanish (ASD modules only), translated by the authors and/ or back-translated for authors’ approval The A- TAC items...
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grid computing esis analysis of its impact on business and the shift to a services infrastructure
... WHAT IS DRAMATICALLY NEW ABOUT ABOUT GRIDS? a a a a GRIDS BEGIN AS A WAY TO ACCELERATE COMPUTING THEY EVOLVE TO A TECHNOLOGY THAT MAKES APPLICATIONS INFRASTRUCTURE AWARE THIS IMBEDS ... interfaces that address such fundamental issues as authentication, authorization, resource discovery, and resource access – these protocols and interfaces must be standard and open Otherwise, we are ... first to adopt blade servers in large numbers GRID ADOPTION - PHARMAS, AEROSPACE 20 GRID ADOPTION - HEALTH CARE 21 Communications Services Hospitals Financial Services Aerospace Autos Pharmaceuticals...
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managing suppliers beyond tier 1- an exploration of motivations and strategies leading to a normative model
... gratitude to my parents, Linsen Wang and Yonghui Tian, who made me who I am today I am especially obliged to my mother, who nurtured a dream to have a doctor in the family 30 years ago and devoted all ... economics, and strategic management Generally speaking, managing suppliers beyond Tier falls into the area of interorganizational relationship management, and the generic interorganizational relationship ... model that managers can use to manage suppliers beyond Tier Data were collected from both manufacturers and retailers to ensure that the framework is generalizable at 13 certain levels and to provide...
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A teacher's guide to interference and other problems
... (West) Germanic branch of Indo-European, and as such is closely related to Frisian, English, German and the Scandinavian languages It is the standard language in the Netherlands and in Flanders, ... tends to use intonation Typical mistake: *That have I not seen 26 Speakers of Scandinavian languages Position of adverbs In the Scandinavian languages, mid-sentence adverbs are generally placed after ... instance, Like a cabinet minister and As a cabinet minister , as well as mistakes such as *I speak as my mother and problems of style as in He did like he had chosen to Scandinavians have...
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Tài liệu The Little Guide To Beating Procrastination, Perfectionism and Blocks: A Manual for Artists, Activists, Entrepreneurs, Academics and Other Ambitious Dreamers docx
... have the confidence to follow through on an ambitious plan? Go back now and see what you can add to your list. Then, talk to family, friends and mentors and see what they would add to it. You will probably be amazed at all the ... club manager must think I’m a jerk, too. I’m sure he’ll never let me perform there again. I feel like crap. I just can’t stand it. I’m going to get a quart of icecream and rent a bad movie and crawl into bed.” What if, she had instead reacted this way: “What a disaster. I’m such a dope . . . oh, well, I could keep on dwelling on this ... find “humility” listed among the dozens of other paeans to myself. They also see entries such as “loves animals” and “not a slave to fashion” along with the more standard fare such as “smart” and “good with computers.” We typically define success too narrowly, ...
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