image registration in medical imaging applications methods and clinical evaluation

... for Drug Evaluation and Research Food and Drug Administration Silver Spring, Maryland Kinam Park Departments of Pharmaceutics and Biomedical Engineering Purdue University West Lafayette, Indiana ... training grant in nanomedicine science and technology that was co-funded by the NIH and NSF He has two published books, Applied Physical Pharmacy and Polymeric Gene Delivery: Principles and Applications, ... liposomes, allowing them to be used as a means for intracellular drug delivery and delivery of proteins such as antibodies and genes, as well as providing a window for cellular imaging. 17 In addition...

Ngày tải lên: 04/06/2014, 14:30

... and 96 h using MONICA (Mobile Nuclear Imaging Camera, NIH, Bethesda, MD, USA) [35] Images were analyzed using NucLear Mac software (Scientific Imaging, Inc., Crested Butte, CO, USA) PET imaging ... following i.p injection of the panitumumab F(ab’)2 Imaging studies, g-scinitigraphy and PET, of the i.p tumor model using these two injection routes are pending Studies from this laboratory and ... radiolabelings TN performed PET imaging and analysis MWB synthesized the chelate and participated in the design of the studies DEM conceived of and coordinated the studies and assisted with the in vivo...

Ngày tải lên: 21/06/2014, 02:20

... molecular imaging modalities, MRI is one of the best imaging modalities in both research and clinical fields for injury and disease diagnosis as it offers high spatial and temporal information ... designed for the potential applications in targeted and controlled drug delivery 2.3 Biomedical Applications of SPIONs 2.3.1 MRI Molecular imaging, such as optical imaging, MRI, and positron emission ... cisplatin from Pt-Fe-PNs in DI water, PBS, and artificial urine at 37 oC Inset shows the release profile in the first 10 h Figure 6-9 Size increase of a mixture of Pt-Fe-PNs and mucin after incubation...

Ngày tải lên: 09/09/2015, 10:14

... molecular imaging of protein-protein interactions in vivo by PET and fluorescence imaging, we engineered a fusion reporter gene comprising a mutant herpes simplex virus thymidine kinase Imaging Protein-Protein ... 26 In a general sense, molecular imaging is a term used to define in vivo imaging of molecules and stands in contrast to anatomical or physiological imaging In that sense, any type of imaging ... established for investigating protein-protein interactions in cultured cells and several are now being validated for use in living animals, including the two-hybrid system and protein fragment complementation...

Ngày tải lên: 29/06/2014, 11:20

... absorption or scattering and offer promising clinical application especially in the area of cancer imaging by increasingly proving themselves to offer alternative angles in examining the same biological ... time domain OCT system [27] OCT is becoming a standard imaging modality in ophthalmology to image the retina and recent studies have shown promising applications for in situ oncological imaging specifically ... optical imaging modalities are designed for imaging tissue structures rather than their intrinsic molecular events However, with the current growing research interest in clinical molecular imaging, ...

Ngày tải lên: 11/09/2015, 09:02

... that it is nontoxic and non-immunogenic, leading to approved by the FDA for internal use in humans and inclusion in the list of inactive ingredients for oral and parenteral applications While ... similar to FA-NPs, indicating that PEG modification had minor influence on the FA receptor-mediated intracellular delivery process In vivo imaging of different kinds of NPs in animals Same as ... NPs in vitro Ye SF participated in the study of Cell viability assays of MMC loaded NPs, and Xie LY carried out the study of in vivo images in animals and participated in its design and coordination...

Ngày tải lên: 20/06/2014, 22:20

... synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine phosphoribosyltranferase ... hypoxanyhine into xanthine and this latter into uric acid During this reaction an active metabolite, deriving by enzymatic action on allopurinol, oxypurinol, inhibits xanthine oxidase and probably ... half-life and further reduce immunogenicity The PEGylation consists in binding with a covalent link a protein (adenosine-deaminase, asparaginase, interferons, granulocyte colonystimulating factor,...

Ngày tải lên: 31/10/2012, 14:59

... Accumulating evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of ... heparanase in human cancer by focusing on head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion ... been established clinically [23,25,31] and in several in vitro and in vivo model systems, including wound healing [29,57], tumor xenografts [52,55], Matrigel plug assay [57] and tube-like structure...

Ngày tải lên: 15/03/2014, 23:20

... Library module in Lightroom provides robust tools for importing photos; categorizing and applying attributes; comparing similar images in detail; and exporting files to new formats and workflows ... developing raw files in Lightroom (and by extension ACR), and on perfecting those files in different ways using Photoshop CS5 I hope that you will find the breakdown and relative “weighting” of ... professional instructor Dan has authored a series of Adobe training tutorials, including Image Retouching & Adjustment with Photoshop CS5 and Core Lightroom His articles have been featured in photo...

Ngày tải lên: 30/05/2014, 23:16

... particular, we present applications in medical imaging, synthetic aperture radar imaging, millimeter wave imaging, single pixel camera and light transport sensing In Sect 4, we present some applications ... compressive sensing or compressed sensing V.M Patel and R Chellappa, Sparse Representations and Compressive Sensing for Imaging and Vision, SpringerBriefs in Electrical and Computer Engineering, DOI ... sparse representation and compressive sampling and examine several interesting imaging modalities based on these theories We will also explore the use of linear and non-linear kernel sparse representation...

Ngày tải lên: 05/06/2014, 12:05

... two BBN(6-14) ligands and the chelator In vitro GRPR-binding affinities were determined with competitive binding assays on PC3 human prostate cancer cells In vivo stability and biodistribution ... used lysine side chain or a 6-aminohexanoic acid spacer for their homodimer and obtained promising in vitro results We used one and two PEG spacers between the binding sequences to fine-tune ... in vivo by PET Tumor retention was improved in vivo with 64 Cu/NOTA-dimer by applying polyvalency effect and/ or statistical rebinding Keywords: Bombesin; homo-dimer; 64Cu; PET imaging; gastrin-releasing...

Ngày tải lên: 21/06/2014, 17:20

... morphology was predominantly hyaline (> 90%) in five of the biopsy specimens and predominantly fibrocartilage in seven, and the remaining 11 biopsy specimens had areas with both hyaline and fibrocartilage ... meniscus, in contrast, had much staining for types I and III collagens, patchy staining for type II collagen, and a little for type VI collagen Most glycosaminoglycan staining was for chondroitin-4-sulfate, ... Frank LR, Resnick D: Magnetic resonance imaging: state of the art Cartilage imaging techniques Current clinical applications and state of the art imaging Clin Orthop 2001, 391(suppl):S370-S376 54...

Ngày tải lên: 09/08/2014, 01:21

... progression in nonembolized (and also in embolized) segments during the induction period, however, remains unresolved An intervention that would both accomplish tumor control and induce compensatory ... treatment that offers meaningful improvement in survival in patients with colorectal cancer liver metastases (CRCLMs) Indications for surgical resection continue to expand An increasing number of patients ... demonstrated a mild centriacinar steatosis No inflammatory/ fibrotic changes were observed in the central vein region Reticulin stain demonstrated intense fibrotic reaction in the portal tracts Page...

Ngày tải lên: 09/08/2014, 04:21

... in the angiogenesis in RA synovium [13,14] All these VEGF isoforms bind to high-affinity receptors, namely VEGFR-1 (fms-like tyrosine kinase; Flt-1) and VEGFR-2 (kinase insert domain-containing ... in 2× standard saline citrate and twice in 0.2× standard saline citrate and blocking nonspecific binding with blocking solution (DakoCytomation Norden A/S, Glostrup, Denmark), they were incubated ... synovial lining cells, endothelial cells of blood vessels and macrophage-like cells in the sublining layer of the RA synovium (Fig 5a,b), confirming the findings from in situ hybridization No staining...

Ngày tải lên: 09/08/2014, 07:20

... 2a) and the S-I and L-R (Figure 2b) axes Summary statistics are shown in Table 2, in the right-hand columns ("during treatment”) In the figures, any deviation of individual points from the intersection ... Vicini F, Matter R, Brabbins D, Martinez A: Prostate gland motion assessed with cine-magnetic resonance imaging (cine-MRI) Int J Radiat Oncol Biol Phys 2005, 62:406-417 15 Huang E, Dong L, Chandra ... L-R and S-I axes, and mm or larger along the A-P axis, effectively reduced the combined systematic and random error to within mm along the L-R and S-I axes and mm along the A-P axis Our image...

Ngày tải lên: 09/08/2014, 09:20

... Imaging Protocol Magnetic resonance imaging was performed with a 1.5 T MR system (Gyroscan, Intera, Phillips Medical Systems, Best, The Netherlands) employing a SENSE torso surface coil Imaging ... the study and participated in its design and coordination All authors have read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... interval after HDR-BT this difference was not distinct enough to base clinical decisions in individuals exclusively on these findings Perhaps a larger time interval of 1-2 weeks would have been superior,...

Ngày tải lên: 09/08/2014, 09:20

... patients refusing surgery SBRT for lung cancer is under evaluation in clinical trials Japan Clinical Oncology Group (JCOG) conducted a phase II study 0403 of SBRT in operable and medically inoperable ... T1N0M0 or T2N0M0 stage according to the International Union Against Cancer (UICC) 1997 system by CT scans, bone scintigraphy and brain magnetic resonance imaging (MRI), or clinically diagnosed as recurrent ... cm, and 52 Gy in fractions for those larger than The tumor movement was defined as increased and decreased when the amplitude in condition B minus the amplitude in condition C or D exceeded - and...

Ngày tải lên: 09/08/2014, 09:22

... may influence overall survival in head and neck patients, since xerostomia can cause malnutrition, dental infections and other debilitating conditions Some authors comparing ipsilateral and bilateral ... Dempsey JF: Determination and delineation of nodal target volumes for head-andneck cancer based on patterns of failure inpatients receiving definitive and postoperative IMRT Int J Radiat Oncol ... months during the first two years, every months until years, and once yearly until 10 years Radiation oncologists and head and neck surgeons performed a clinical examination A head and neck CT...

Ngày tải lên: 09/08/2014, 10:20

... suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may ... kshedNb,t,i+γfkadhNb,f,i)] where Ds and Db are the doses administered in a single fraction to the spinal and brain compartments, respectively Scenario I In this scenario (Figure 3), results following a standard course ... considered as having two tissue compartments, brain (b) and spine (s), with two phases, solid tumor (t) and cerebrospinal fluid (f), within each compartment (Figure 2) In the model the brain is not...

Ngày tải lên: 09/08/2014, 10:21