identity and roles of vitamins and trace minerals
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... with craniofacial defects, thoracoabdominoschisis, and severe skeletal defects in the head and trunk region [17,18] Studies of earlier embryonic stages of these mice indicate a failure of cranial ... functions of AP-2s in physiological processes, they have also crucial roles in pathological processes such as tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the...
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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... of modifier genes that would enhance or diminish the impact of HSF2 deficiency Pending questions for the roles of HSF1 and HSF2 in oogenesis and in early embryos The role of HSF2 in oogenesis and ... basis of incorrect pairing of sister chromatids and of the lack of integrity of the synaptonemal complex in Hsf2) ⁄ ) spermatocytes is a pending question [62] Role of HSF1 in the quality control of ... over-expression of Hsp60 and Hsp70 and exhibit abnormal morphology in correlation with increased proliferation, premature differentiation and elongation, inhibition of denucleation and of loss of organelles...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... physiological role of this interaction is conserved [30,52] Interactions of Vrp1p and Las17p in yeast and WIP and WASP-family proteins in mammalian cells are direct and result in constitutive and apparently ... localization of Hof1p to the bud neck at elevated temperature and this in turn is important for cytokinesis and cell growth under these conditions Interestingly, mutation of K485 and R486 in the ... with a role of F-actin and ⁄ or actin polymerization in the generation or maintenance of a polarized distribution of cortical patches Las17p and type I myosins promote the assembly of actin monomers...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... Roles of the HsRad51 L1 and L2 loops D231W (L1 loop) Table Changes in the fluorescence of tryptophan probes inserted in the L1 and L2 loop upon binding of nucleotides and DNA The fluorescence of ... Camerini-Otero DR & Takahashi M (1999) The L2 loop peptide of RecA stiffens and Roles of the HsRad51 L1 and L2 loops restricts base motions of single-stranded DNA similar to the intact protein FEBS Lett ... Alignment of the HsRad51 sequence to those of MvRadA, Pyrococcus furiosus Rad51 (PfRad51), and ScRad51 around the L1 and L2 loops The L1 and L2 loops, which are invisible in the crystal structure of...
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Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... auto-oxidation rates and catalytic activities of Ec DOS Breakage of the salt bridge between Asp40 and Arg85, and the hydrogen bond network consisting of Asp40, two water molecules and His77, appear ... structure of the cyanide-bound complex of FixL is similar to that of its oxygen-bound complex [10], a cyanide binding study should facilitate elucidation of the structure and catalytic mechanism of ... Fig Soret and visible optical absorption spectra of Fe(III) (solid line), Fe(II) (broken line) and Fe(II)-CO (dotted line) complexes of the Asp40Ala (upper) and Asp40Asn (lower) mutants of Ec DOS...
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Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
... equivalent volumes of M urea solution and then run on SDS ⁄ PAGE Lanes a and d, in the absence of both TnC and Ca2+; lanes b and e, in the presence of TnC and the absence of Ca2+; lanes c and f, in the ... presence (lanes m–q) of equimolar amounts of Akazara scallop TnC Lanes h and m, ATnI-52K; lanes i and n, ATnI-19K; lanes j and o, ATnI1)128; lanes k and p, ATnI130)252; lanes l and q, ATnI232)292; ... absence of both urea and KCl and the presence of 0.5 mm CaCl2, whereas ATnI130)252, RTnI1)116, and RTnI96)181 strongly bound to TnCs These results suggested that the inhibitory region and the...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... architecture of OYE1 and PETN reductase, and (ii) geometry for the binding of steroid compounds and 2-cyclohexen-1-one [2,19] The structure of the Y186F enzyme is essentially identical to that of wild-type ... C1 and C2; the double bond between C4 and C5 is not susceptible to reduction, and thus progesterone and related steroids (e.g 4-androstene3,17-dione), which lack a double bond between C1 and ... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... dysfunction SH3 and SH2 domain dysfunction Deletion of N-terminal, SH3 and SH2 domain of active n-Src Deletion of N-terminal, SH3 and SH2 domain of kinase-dead n-Src of PP3, the inactive form of PP2, ... ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21] After PP2 application, peak amplitudes of ... Institutes of Health (R01 NS053567) to X.-M.Y Plasmids of v-Src, and n-Src and its mutants were kindly provided by Dr T Pawson (Department of Molecular Genetics, University of Toronto, Canada) and Dr...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... diversification of different members of a gene family In previous studies, we examined the expression profiles of all the members of the GH3 and Aux ⁄ IAA gene families and a few members of the SAUR ... these probe sets in control and IAA-treated Results and Discussion Identification and overview of auxin-responsive genes Previously, we identified and characterized members of the early auxin-responsive ... (etiolated and green shoot, root, flower, and callus) by real-time PCR analysis, and showed their specific and overlapping expression patterns [7,18,19] The expression patterns of members of ARF gene...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... letters (A and B), whereas the small t peptides are designated by lower case letters (a and b), so that the wild-type AChE and BChE are Aa and Bb, and the chimeras are Ab and Ba Comparisons of wild-type ... between human AChE and BChE The T variants of human AChE and human BChE are composed of a catalytic domain of approximately 500 residues, followed by small C-terminal t peptides of 40 and 41 residues, ... processing and the activity of AChE and BChE, notably those involving charged residues, the presence in peptide b of an additional tryptophan (W8) and the presence of six instead of five residues...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... development of a new generation of effective and selective MMPIs is an emerging and promising area of research Acknowledgements We thank Professor G N Tzanakakis (University of Crete, Greece) and Dr ... of TGF-b Shedding of HB-EGF Proliferation Cleavage of Fas ligand Shedding of tumor associated major histocompatibility proteins complex class-I Indirect activation of Akt through activation of ... growth and invasion effects, interfering with the expression ratio and activity of several MMPs and TIMPs [77,78] Challenges and future prospects MMPs have well-established complex and key roles...
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The States and Moods of Federalism. Governance, Identity and Methodology (French & English) pot
... states and moods of federalism : governance, identity and methodology Papers presented at an international conference on federalism organized by McGill University and held at Faculty of Law of McGill ... Phenomenology of Federalism and Methodology of Comparative Federalism 52 II Governance and the Complexity of Identity 56 III Representation, Values, and Dispute ... Devolution, the Growth of Identity Politics in the UK and the Unaddressed Question of a Union Identity 424 The Devolution Programme: A New Role for the Judicial Committee and Implications...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... activation of the various intermediates in DIM and PGL biosynthesis has not been analyzed This study was undertaken to dissect the roles of FadD22, FadD26 and FadD29 in the biosynthesis of DIMs and ... knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 ... Schematic representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium tuberculosis The role of the activation enzymes...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... nature and behavior of the financial At the core of this issue are questions about the type of financing need and receive at various stages of their growth, the nature of the private equity and ... alternative of small business finance is a growing of small business finance For example, the impact of the U.S of the early 1990s and the effect of the consolidation of the banking industry on the of ... questions trade credit, and other sources of funds These data allow for tests of research regarding the cost and availability of different types of external finance and how the cost and availability...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... and chondroitin sulfate chains of syndecan-1 and aggrecan [51,52] A recent study also reported that syndecan-4 may regulate activation of ADAMTS-5 via engagement of HS chains and regulation of ... inhibitor of metalloproteinases The catalytic activity of MMPs can be inhibited by the family of tissue inhibitor of metalloproteinases (TIMP), of which there are four members (TIMP1-4) TIMP-1, -2 and ... 43 kDa 22 kDa Fig Schematic of the four vertebrate syndecans Syndecans-1 and -3 core proteins are larger than those of syndecan-2 and -4, and can bear both heparan and chondroitin sulfate chains...
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Báo cáo khoa học: Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase ppt
... expressed and purified from Escherichia coli When ferrochelatase was phosphorylated in E coli, (Fig 4F, lower), the intensity of phosphoferrochelatase of S130A and S303A was decreased, and the band ... were separated into inner and outer membranes and immunoblotting was performed (D) Densitometric quantitation of ferrochelatase, COX IV, ABCB7 and b5-reductase of the inner and outer membranes (E) ... expression of ferrochelatase, which plays a role in the iron-removal reaction of exogenous heme and the change in position of the heme-moiety of hemoproteins The protoporphyrin ring of the heme-moiety...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... chemotherapeutics adriamycin, etoposide and cisplatin), the levels of Itch become reduced and allow the accumulation of p73 [53] p73 displays functions in apoptosis induction, and many of its pro-apoptotic target ... Bernardi R & Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies Nat Rev Mol Cell Biol 8, 1006–1016 Krieghoff-Henning E & Hofmann TG (2008) Role of nuclear ... kinases ATM and ATR ATR and ATM in turn phosphorylation-dependently activate the downstream checkpoint kinases Chk1 and Chk2, respectively, and the tumour suppressor p53 Furthermore, ATM and ATR...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... [55] The volumes of the cavities are ˚ 601, 313, 637 and 1736 A3 for PAO, MAO N, MAO B and LSD1, respectively (B) Overview of the active site surrounding the flavin cofactor in each of the four structures ... Rossmann-fold topology and a substrate-binding domain Evolution has ‘modeled’ the structure of these AOD enzymes to fit different amine substrates and cellular landscapes LSD1 was the subject of a dali search ... peptide (residues 1–16 of the N-terminal tail) is in magenta (the two ends of the peptide, residues and 16, are labeled accordingly) The FAD cofactor is in yellow ball -and- stick representation...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... ligand binding kinetics of the PAS domain of Ec DOS, as it does in myoglobin and hemoglobin Examination of the effects of these hydrophobic amino acids on the kinetics of O2 and CO binding to the ... characteristics of O2 and CO binding Finally, we discuss the roles of these hydrophobic amino acids in the structure surrounding heme and the electronic states of heme Results and Discussion Optical ... spectra of the Fe(III)–CO, Fe(II)–CO, and Fe(II)–CO complexes of the Ec DosH mutants The optical absorption spectra of the Fe(III)–CO, Fe(II)–CO, and Fe(II)–CO complexes of the Leu99 and Leu115...
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