identifying qtl for multiple complex traits in experimental crosses

... ancestral genes for economically important traits and adds information to accelerate fine-mapping in the QTL information-sparse species QTL mapping requires robust phenotypes In the case of lactation ... QTL- MLE for the single milk content traits Results Results of the QTL analysis using QTL- MLE for the single milk content traits Drawn are the genome-wide graphs for the single milk contents traits ... composition traits, protein, fat and lactose percentages, is shown in Figure In order to aggregate the QTL information, the integrated QTL scores for each trait are shown in Figure by way of a single QTL...

Ngày tải lên: 14/08/2014, 13:21

... procedures for experimental crosses In this paper, we develop methods that capitalize on the information available in both regression-based and marginal-based tests of linkage for experimental crosses ... that include F2 intercross designs appear in [5] and [20] Nevertheless, marginal-based tests have been Joint tests for experimental crosses 603 underutilized in the development of QTL mapping ... Random and ET2 sampling for the joint test involving multinomial regression with fixed intercepts (M15 ) The results for selective sampling of N = 250 were very similar and for a brevity that was...

Ngày tải lên: 14/08/2014, 13:22

... (OAR19) QTL for carcass lean on chromosome were in coupling phase, whereas all other QTL pairs were in repulsion phase The QTL in repulsion phase were not identified using the single QTL model since ... 14 For muscle traits, eight QTL were detected on seven chromosomes, for fat traits ten QTL on seven chromosomes and for bone traits only two QTL There were no QTL which solely contributed to traits ... genetic progress by incorporating CT traits into selection indices suggest increases in response by 50% or even 100% when combining different measurement methods [6] The sheep in our study were...

Ngày tải lên: 14/08/2014, 13:21

... preferable [4] For example, during quality improvement (QI) projects involving multiple process and/or outcome measures within multiple clinical domains, efforts to improve quality in one area may ... Using a composite measure may also be quite useful within QI projects involving multiple process and/or outcome measures within multiple clinical domains Because efforts to improve quality in ... Mammogram Td vaccine Flu vaccine Pneumococcal vaccine Hep A vaccines (n> = 2) Chlamydia screening Depression screening Alcohol screening Alcohol counseling Tobacco counseling Diagnosing HTN Blood...

Ngày tải lên: 11/08/2014, 05:22

... directly useful for developing breeding materials However, the GY QTL interval (less than 10 cM) in LG20 was associated with a large increase in plant height, resulting in lodging The GY QTL in LG20 ... environment interactions are due to changes in magnitude or are crossover interactions before using MAS to select for QTLs Identifying and selecting the proper allele at QTLs with crossover interactions ... the increasing effect for grain yield was linked to decreasing effect for plant height [13] However, in some cases beneficial QTLs from O rufipogon were associated with undesirable QTLs For example,...

Ngày tải lên: 12/08/2014, 05:20

... SLA complex, which is the most significant QTL found in this study, confirming previous QTL mapping results [4,14] SSC7 is of particular interest to the pig industry since it carries numerous QTL ... We then performed the QTL analysis using combined data of cyclic animals and juvenile animals and found evidence for a genomic region affecting age at puberty QTL for age at puberty in gilts 535 ... affecting diverse economically important traits At the QTL for age at puberty on SSC7, one interesting phenomenon is that the favourable QTL allele originates from the Duroc breed, which is in contradiction...

Ngày tải lên: 14/08/2014, 13:21

... Therefore, the aim of this study was to investigate QTL for LW-related traits, including leg and feet scores, OC and bone mineral traits in a Duroc × Pietrain resource population Methods Experimental ... LW-related traits in growing and finishing pigs are limited A significant number of QTL for performance traits has been reported in pigs [16] but few studies have been devoted to LW-related traits ... [22], as well as QTL for immune traits [38] Lee et al [20] have also reported that most QTL for LW-related traits in a Large white × Meishan cross show dominance In addition, using principal components...

Ngày tải lên: 14/08/2014, 13:21

... commercially, information regarding breeding techniques and advances is lacking No concentrated effort in selection to the efficiency of production (in terms of the number of squabs produced by a breeding ... Variability in weight gain during the 1st wk is ! 28%, declines to 19% at wk 2, and then increases to x5 40% at wk The weight gain from 3-4 wk are not differentiated by sex The heritability estimates for ... by The American King Club (Levi, 1974; PJ Marini, Nicholas Breeding Farms, Sonoma, CA, USA; personal communication) Our F performance data can therefore be treated as providing estimates of purebred...

Ngày tải lên: 14/08/2014, 20:20

... selection intensities for egg laying from the index line were in general smaller than the corresponding values obtained in the independent culling line, while selection intensities for adult ... 12 p 100 for adult weight and egg laying, respectively The selection intensities for egg laying and adult weight in both lines are shown in table In the independent culling line the intensity ... independent culling line The difference between average gains in egg laying was significant (tabl 3) The mean value for adult weight increased in all replicates of the index line, increasing in replicates...

Ngày tải lên: 09/08/2014, 22:22

... al In animal genetics, QTL mapping experiments are either performed in outbred populations, targeting the loci that contribute to the within population variance, or in experimental crosses aiming ... hypothesis before accepting the hypothesis of an imprinted QTL 2.10 Information content mapping In an F2 design, the information content along the used marker map can be measured according to Knott ... We herein report the results of a whole genome scan performed in a Piétrain × Large White intercross to map QTL in uencing growth and carcass traits The identification of an imprinted QTL with...

Ngày tải lên: 14/08/2014, 13:21

... by VCA using simple deterministic (upper line) and MCMC (lower line) methods 90 Y Nagamine et al QTL in outbred pig population 91 Figure (a) QTL position for DGT, daily gain on test, using chromosome ... determined the QTL for growth rate on chromosome 7, using Chinese and European crosses de Koning et al [4] reported a highly significant QTL for back fat around the marker, S0102, where the QTL ... more reliable parameters for breeding plans The confidence interval for QTL position is also important in practice to determine the breeding strategy [30] However, bootstrapping cannot be easily applied...

Ngày tải lên: 14/08/2014, 13:22

... increased binding, methylation of the C-terminal half of the a1(I) resulted in either reduced binding for a1(I) CB7, or a complete loss of the binding for a1(I) CB6 The variation of the binding ... in Table Because our data for collagens I and II did not allow us to obtain meaningful values for both binding sites, we performed linear interpolation on all the data points (Fig 5C,D) obtaining ... whereas fibronectin and a 30-kDa fibronectin fragment having heparin-binding ability showed interaction with tendon decorin (Fig 4) Fibronectin is known to interact with decorin protein core [45]...

Ngày tải lên: 21/02/2014, 15:20

... densities in Kielder were lower in 1996 but increased in 1997 (Fig 1) Sampling of parental animals for the laboratory Voles for breeding in the laboratory and for autopsy were sampled from nine clear-cuts ... 1996 and maintained high densities in 1997, while the population densities in Kielder were lower in 1996 but increased in 1997 (Fig 1) To increase readability we will in the following refer to ... conceived in the laboratory was also related to Breeding performance of the overwintered generation Frequency and timing of breeding in the lab In the laboratory as in the field, the overwintered...

Ngày tải lên: 05/03/2014, 17:20

... function of the increasingly large group of proteins that have been shown to contain intrinsically unstructured regions The intrinsic conformation flexibility that is inherent in this binding mechanism ... activator-binding domains Recruitment of the SWI ⁄ SNF complex via activator interactions with these activator-binding domains is thus critical for normal galactose induction of the tested genes Interestingly, ... Protein A Agarose ⁄ Salmon Sperm DNA incubation for no more than h Beads were washed twice for 15 in lysis buffer containing 150 mm NaCl, followed by a 15-min wash in lysis buffer containing 500...

Ngày tải lên: 07/03/2014, 00:20

... 419-444 Vilain, M and Day, D 1996 Finite-state Phrase Parsing by Rule Sequences, Proc of COLING-96 Vilain, M 1999 Inferential information extraction In Pazienza, M.T & Basili, R., Information Extraction ... Workshop on Information Filtering Lodhi, H., Saunders, C., Shawe-Taylor, J., Cristianini, and N., Watkins, C 2002 Text classification using string kernels Journal of Machine Learning Research, ... they apply to financial texts Much new work is in the offing Many experiments are in progress now to assess performance on other text types (financial news), and to pin down performance on a wider...

Ngày tải lên: 08/03/2014, 21:20

... in Fig 3A for the core domain, with a twofold axis in the middle of the S-shaped region as might be predicted for a heterodimeric complex Interestingly, the S-shape is echoed in the surrounding ... and cyt-c550 in the cyanobacterial PSII complex are indicated Note: protein regions and loops external to the membrane and one extrinsic subunit are not included in 1fe1, explaining the apparent ... threshold for discrimination of protein density The main features of the Ê 140 ´ 100 A core domain correspond closely to those described earlier for negatively stained specimens [14,15] The distinctive...

Ngày tải lên: 17/03/2014, 17:20

... Hematoxylin & eosin together with cyanin R staining in alternate sections of the spinal cord revealed pathology consistent with the clinical score The most conspicuous changes appeared in rats showing ... removed for histology Urine collection and CHEC-9 treatment Urine was collected in metabolic cages from all rats starting 1–2 days before immunization and then every other day for 18 days The urine ... handling of samples for ex vivo monitoring [32] Enzyme activity in urine was found to be much more stable, specifically in those rats tested prior to immunization or in healthy human controls As in...

Ngày tải lên: 19/06/2014, 22:20

... combination The method aims to enforce the pitch continuity in time For this, the fundamental frequencies of each combination C are mapped into music pitches, obtaining a pitch combination C For ... processing stages, shown in Figure 1, are described below 2.1 Preprocessing The analysis is performed in the frequency domain, computing the magnitude spectrogram using a 93 ms Hanning windowed ... method for combining similar information across 23 frames allows to consider different alternative architectures This novel methodology permits interesting schemes For example, the beginnings of...

Ngày tải lên: 21/06/2014, 17:20

... million in plantations The Southern Tree Breeding Association (STBA) does most of the breeding for radiata pine in Australia Most radiata pine resources in Australia are used for producing structural ... Three thinnings at Rennick also increased ring growth initially Thinning at cambial age 13 (1984), 20 (1991) and 26 (1997) had lifted radial growth by between 2–5 mm Thinning at young ages increased ... at rotation age for MFA and MOE and at least 80% effective for wood density Thinning of trials increased ring width and MFA, reduced ring wood density and MOE of remaining trees in the first two...

Ngày tải lên: 07/08/2014, 16:20

... since D = V (G) is such a code Hence we are usually interested in finding an ℓ-ID code of minimum cardinality The most studied case is when ℓ = In this case, D is an 1-ID code if and only if for ... Karpovsky, K Chakrabarty, L.B Levitin, On a new class of codes for identifying vertices in graphs, IEEE Trans Inform Theory 44 (1998) 599–611 the electronic journal of combinatorics 16 (2009), #R113 ... follows In Section we prove the main result This proof consist of stating six discharging rules, and verifying that after the discharging phase, each vertex has charge at least 12/29 Showing that...

Ngày tải lên: 08/08/2014, 01:20