identification standardization and validation of effective biomarkers

... Problem of Overweight and Obesity .5 Treatment Guidelines Assessment and Classification of Overweight and Obesity Assessment of Risk Status 11 Evaluation and ... Study of Obesity (NAASO) and the National Heart, Lung, and Blood Institute (NHLBI) It is based on the Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity ... adopted by the Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults and endorsed by leading organizations of health professionals, are shown in Table...

Ngày tải lên: 14/02/2014, 09:20

... However, the age and maturity of the child and the preferences of the child and the parents should be taken into account 1.2.2 Identification and classification of overweight and obesity 1.2.2.1 ... rice and pasta • Eat at least five portions of a variety of fruit and vegetables each day, in place of foods higher in fat and calories • Eat a low-fat diet and avoid increasing your fat and/ or ... obesity in adults and children in England and Wales The guidance aims to: • stem the rising prevalence of obesity and diseases associated with it • increase the effectiveness of interventions...

Ngày tải lên: 21/02/2014, 11:20

... However, the age and maturity of the child and the preferences of the child and the parents should be taken into account 1.2.2 Identification and classification of overweight and obesity 1.2.2.1 ... rice and pasta • Eat at least five portions of a variety of fruit and vegetables each day, in place of foods higher in fat and calories • Eat a low-fat diet and avoid increasing your fat and/ or ... obesity in adults and children in England and Wales The guidance aims to: • stem the rising prevalence of obesity and diseases associated with it • increase the effectiveness of interventions...

Ngày tải lên: 22/03/2014, 09:20

... Steps and 4, 39 more times Amplification of transcripts for the genes of interest in each sample was compared to the same assay run on a "standard curve" consisting of a dilution series of cDNA ... elevation of ABCA1 and ABCG1 mRNAs reflected the potency of agonists to activate LXR receptors, rats were treated with a range of doses of GW3965 (Figure 2D) or LXR-623 (Figure 2E) Since the potency of ... with 0, 15 and 50 mpk/day of LXR-623 for days (n = per dose group) Blood was collected on day of dosing, and RNA was prepared from whole blood for gene expression analysis of ABCA1 and ABCG1 qPCR...

Ngày tải lên: 18/06/2014, 15:20

... Management, and Experience of Side Effects and a theoretical model of the impact of AOM on patient functioning and well-being was developed (Figure 1) Based on this theortetical model, and relying ... reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance ... The goal of this first validation study was to determine the initial measurement model and fundamental reliability and validity of the TRIM-Weight The cross sectional and web based nature of the...

Ngày tải lên: 18/06/2014, 19:20

... the validation data and contributed to the writing of the manuscript JB designed and managed the valuation survey, analysed and reported on the valuation data and contributed to the writing of ... (CAMPHOR): A measure of health-related quality of life and quality of life for patients with pulmonary hypertension Qual Life Res 2006, 15:103-15 Rasch G: On general laws and the meaning of measurementin ... analyses) were candidates for exclusion However, it was the aim to include a reasonable spread of items in terms of the degree of severity they represented The logit severity of the selected...

Ngày tải lên: 18/06/2014, 19:20

... 66.0 vs 64.3 ± 15.5, p < 0.01), and for SF36 on dimensions VT and GHP Measures of RTQ and SF36 were neither influenced by the kind of dialysis, nor the duration of dialysis, nor a possible rejection ... RTR, members of the national association of End-Stage Renal Disease patients The group confirmed the pertinence of the five dimensions, and the relevance of the items The dimension of "Medical ... time Most of time A good bit of the time Some of the time A little of the time None of time 35 36 37 38 39 40 41 42 43 44 45 Is taking medications a constraint for you? Are you scared of the possible...

Ngày tải lên: 18/06/2014, 19:20

... domains of the short-form of BPH-QLS and SF-36 were significantly correlated (p < 0.01) with CCs of 0.267~0.773, most of which were > 0.300 The disease domain of the new scale and that of the ... 0.424 for disease and physical; 0.515 for physical and social; 0.777 for social and psychological; and 0.612 for psychological and satisfaction Criterion validity of the short-form of BPH-QLS is ... Health and Quality of Life Outcomes 2009, 7:24 development of shorter questionnaires The aim of this study was to construct and validate the short-form of BPHQLS and to compare its...

Ngày tải lên: 18/06/2014, 19:20

... conceptualisation and design of the original web-based survey FJS, SES and FP assessed the quality of the data collected and participated in the design of the validation study and the development of the statistical ... mean scores of the insulin-treated patients are on three of the four positive items (3, and 17) pertaining to improved Page of (page number not for citation purposes) Health and Quality of Life Outcomes ... Health and Quality of Life Outcomes 2007, 5:69 quencies, means and standard deviation on all measures Differences in demographic, clinical and questionnaire scores between the insulin naïve and...

Ngày tải lên: 18/06/2014, 22:20

... responsiveness and sensitivity of WE-CARE to changes over time, and in the incorporation of WE-CARE into routine clinical assessments and trials to improve understanding and interpretation of individual ... depression and parental life satisfaction [4,16] We acknowledge that validation of any instrument is an ongoing process and our validation of WE-CARE is an essential first step toward a fuller validation ... summary of the SF-36 and with the impact of the child's health on parent's time and emotions and on the family, as measured by the CHQ-PF50 Because both the psychosocial domain of WE-CARE and the...

Ngày tải lên: 18/06/2014, 22:20

... perception of health status (50% healthy ones and 50% unhealthy ones), gender (50% female) and age (60–69 years of age, 70–79 years of age and over 79 years of age) Subjective perception of health ... Cross-cultural adaptation and validation of health status measures Scand J Reumathol 1995, 24(2):61-3 Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central ... adaptation of quality of life measures and was used for the development of the WHOQOL-OLD module [18,19] Regarding development of new measures or validation of existing ones, new approaches have...

Ngày tải lên: 18/06/2014, 22:20

... and qualitative work with carers and reviewed by a panel of "expert carers" [12,16,26,27] The panel was made up of a psychiatrist (one of the authors of this paper), a clinical nurse leader and ... strength of association between subscale scores of the final version of the EDSIS and the general aspects of caregiving (ECI), psychological distress (GHQ-12) and the global severity of the illness ... individual (CGAS) and social functioning of carers (EDSIS) and the total score of the scale (EDSIS) A significant positive correlation size was also found between EDSIS and GHQ-12 Page of (page number...

Ngày tải lên: 18/06/2014, 22:20

... version of the Manchester Foot Pain and Disability Index Greek language version of the Manchester Foot Pain and Disability Index Page of (page number not for citation purposes) Health and Quality of ... the validation of the instrument in English-speaking older people Increased use of this instrument in both epidemiological studies and clinical trials will further develop our understanding of ... length of the foot [18] Ankle flexibility was measured in degrees using a modified version of the weightbearing lunge test The lateral malleolus and head of the fibula was first located and marked...

Ngày tải lên: 18/06/2014, 22:20

... 59 and 75 for depression, and 61 and 61 Lastly, we computed means for men and women and each subscale as a function of cancer type Only those types of cancer were listed where at least men and ... of Health and Human Services, Centers for Disease Control and Prevention Andresen E, Catlin T, Wyrwich K: Retest reliability and validity of a surveillance measure of health-related quality of ... continued inclusion of these two sets of QoL items Anxiety and depression were predictably intercorrelated (r = 71 and r = 55 in sample and respectively) and explain about 30–50% of each other's...

Ngày tải lên: 20/06/2014, 15:20

... (WEMWBS): development and UK validation Health Qual of Life Outcomes 2007, 5:63 Watson D, Clark LA, Tellegen A: Development and validation of brief measures of positive and negative affect: The ... questions, PMH items and the general health and happiness items, regardless of which version of the questionnaire they received Due to the number Page of 18 of validity measures and their expected ... Table Missing data and floor and ceiling effect Missing data and floor and ceiling effect were investigated from frequency distributions of responses and Table Brief description of validity measures...

Ngày tải lên: 20/06/2014, 15:20

... between some of the IDEEL dimensions and the SF-36 (such as “impact on work” of IDEEL and “role physical” of SF-36; “emotional impact” of IDEEL and the mental component (or some of the related ... leisure and social impact, visual-aid impact, tiredness/sleep, appearance/aesthetics and general impacts; and treatment experiences and satisfaction in terms of inconvenience, effectiveness and frequency ... and effect of treatments [3,50] Existing PRO instruments focus on the ability to identify and diagnose dry eye, assess the prevalence of the condition, and assess the severity and frequency of...

Ngày tải lên: 20/06/2014, 15:20

... for the Level of well-being) [17] The scale integrates both affective and cognitive components of well-being, and measures levels of physical and social well-being Cronbach’s alpha of the SPF-IL ... number of missing items and each item’s mean and standard deviation To verify the factor structure of the questionnaire and to test whether the relationship between observed variables and their ... approval of the version to be published MS: Preparation of the paper; analyses and interpretation of data; final approval of the version to be published PV: Preparation of the paper; acquisition of...

Ngày tải lên: 20/06/2014, 16:20

... Get on and off the toilet Reach and get down a five pound object Bend down & pick up clothing from floor Open car doors Open jars which have been opened Turn faucets on and off Run errands and shop ... the topic of addressing content generality and specificity of PRO items Differing approaches to structural validation of PROs based on MCI and MEI models Moderate to high correlations and high ... particular set of items are more appropriately described using a MEI or MCI model, and whether inclusion of both types of items provide a better estimate of the construct Construct validation of single...

Ngày tải lên: 20/06/2014, 16:20

... conceptualisation and design of the original web-based survey FJS, SES and FP assessed the quality of the data collected and participated in the design of the validation study and the development of the statistical ... mean scores of the insulin-treated patients are on three of the four positive items (3, and 17) pertaining to improved Page of (page number not for citation purposes) Health and Quality of Life Outcomes ... Health and Quality of Life Outcomes 2007, 5:69 quencies, means and standard deviation on all measures Differences in demographic, clinical and questionnaire scores between the insulin naïve and...

Ngày tải lên: 20/06/2014, 16:20

... responsiveness and sensitivity of WE-CARE to changes over time, and in the incorporation of WE-CARE into routine clinical assessments and trials to improve understanding and interpretation of individual ... depression and parental life satisfaction [4,16] We acknowledge that validation of any instrument is an ongoing process and our validation of WE-CARE is an essential first step toward a fuller validation ... summary of the SF-36 and with the impact of the child's health on parent's time and emotions and on the family, as measured by the CHQ-PF50 Because both the psychosocial domain of WE-CARE and the...

Ngày tải lên: 20/06/2014, 16:20