identification of functional effectiveness measures

... http://genomebiology.com/2010/11/2/R23 Page 10 of 16 [...]... effects or by the incompleteness of the topology TIF measures the effects of pathway topology on the biological function of individual genes ... invariably omit large bodies of informa- tion on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network ... work by an influence factor, Ψ.Weconstrainthe functional form of Ψ by assuming that the influence of genes i and j on one another will drop as the ratio of the shortest distance between them to their...

Ngày tải lên: 09/08/2014, 20:21

... survival of only 44% The possible reasons for these low survival rates are the high incidence of chemoresistance found with EOC and a lack of consideration of the high degree of heterogeneity of EOC ... Overview of ovarian cancer………………………………………… 1.1.1 Definition of ovarian cancer……………………………… 1.1.2 Epidemiology of ovarian cancer…………………………… 1.1.3 Risk factors of ovarian cancer……………………………… 1.1.4 Cell of ... IDENTIFICATION OF FUNCTIONAL TARGETS IN EPITHELIAL OVARIAN CANCER MIOW QING HAO (B Sci (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY NUS GRADUATE...

Ngày tải lên: 09/09/2015, 11:09

... the diversity of toxic activities deployed by both CDI and Rhs systems Citation: Poole SJ, Diner EJ, Aoki SK, Braaten BA, t’Kint de Roodenbeke C, et al (2011) Identification of Functional Toxin/Immunity ... the VENN sequence of the next cdiA-CT orphan (Figure S4) Orphan cdiA-CT/cdiI Modules Are Functional If orphan cdiA-CT/cdiI modules are merely unused, nonfunctional remnants of full-length cdiA/cdiI ... retain the biochemical features of a functional toxin/immunity module Interchange of cdiA-CT/cdiI Modules All sequenced Y pestis strains share two large blocks of conserved DNA that contain cdi...

Ngày tải lên: 02/11/2022, 11:37

... 10.1186/s12864-016-3455-y RESEARCH ARTICLE Open Access Identification of functional enolase genes of the silkworm Bombyx mori from public databases with a combination of dry and wet bench processes Akira Kikuchi1, ... Department of Science of Biological Production, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Full list of author ... one million species of insects in the world Insects can adapt to any number of environmental conditions because of their small size Studies of insects have contributed a wealth of scientific discoveries...

Ngày tải lên: 04/12/2022, 10:35

... Yeast Functional associations mapped from seven types of functional genomics data in yeast through gene orthology [92] 123,380 3,809 Worm Functional associations mapped from four types of functional ... Fly Functional associations mapped from three types of functional genomics data in fly through gene orthology [56] 139,984 5,966 Mouse-rat Functional associations mapped from three types of functional ... different Si cutoffs Here True positives is the number of seed genes above the Si cutoff, False positives is the number of non-seed genes above the cutoff, True negatives is the number of non-seed...

Ngày tải lên: 09/08/2014, 20:20

... prevalence of 1% [1], characterized by perturbations of cognition and behavior and by abnormal or limited display of emotion Because of the severity of symptoms and the long-term, chronic pattern of ... clinical effectiveness of RLAT on important outcomes such as health-related quality of life, disease severity, patient functionality, and tolerability can be further understood in the context of the ... outcomes and tolerability of RLAT in real-world practice by following patients with schizophrenia initiated on RLAT for Page of 12 years Results of the effectiveness outcomes measures from the SOURCE...

Ngày tải lên: 11/08/2014, 16:20

... reflect the adaptation of influenza virus to the warmer host temperature of avians as compared to swine and humans. Identification of functional motifs and annotation of conserved regions and ... http://www.virologyj.com/content/8/1/44 Page 7 of 10 Identification of highly-conserve d functional motifs an d accessible regions of all sequences was obt ain ed. Eighty- seven conserved regions, nineteen functional motifs, ... categorization of the sequences facilitated the management of the data, allowed the identification of diversity in the sequences based on the host and year isolated, and helped in the determination of conserva-...

Ngày tải lên: 11/08/2014, 21:22

... Ct (target gene of sample) - Ct (refer- ence gene of sample) ΔCt (calibrator) = Ct (target gene of calibrator) - Ct (reference gene of calibrator) Ratio (folds of difference) of sample: calibrator ... reduction of level of cccDNA. Sub-sections of the PRE have different effects on the reporter gene activity To investigate the functional core elements of the PRE, a deletion s eries of the PRE ... Bioinformatic analysis of functional elements The functional elements within the PRE (nucleotides 1151-1684, of Acces sion number AM282986) wer e ana- lyzed using results of CDS-Plotcon and Alidot...

Ngày tải lên: 12/08/2014, 01:21

... facet of the same problem is identification of proteins that have a certain specificity, i.e. refined functional annotation. Most of techniques dealing with the stated problem reduce the problem of ... of the derived predictions for the LacI family applying the Mann-Whitney test to distances of the predicted SDPs to the functional site of the pro- tein compared to all amin o acid resudues of ... stimulated development of approaches aimed at more precise annotation of proteins, that is, prediction of exact specifici ty to a ligand or, more broadly, to a binding partner of any kind. Results:...

Ngày tải lên: 12/08/2014, 17:20

... -score) of a motif, which measures the motif's specificity to the cell-cycle genes. The y-axis is the G- score of a motif, which measures the coherency of the expression profiles of the ... calcu- lated the specificity of each motif to every phase of the cell Distribution of discovered yeast motifs of length 8Figure 3 Distribution of discovered yeast motifs of length 8. The x-axis is ... locations of putative Arabidopsis motifsFigure 6 Distribution of the locations of putative Arabidopsis motifs. The location distribution of the top four putative motifs of length 7 in the promoters of...

Ngày tải lên: 14/08/2014, 16:21

... putative cis-regulatory elements present upstream of functionally related groups of genes and subsequently characterized the function of some of these conserved elements using reporter assays ... the presence of additional copies of this motif likely confers additional strength to the promoter. Genome-wide occurrences of candidate motifs We examined the occurrences of each of the motifs ... seven out of eight motifs iden- Table 2 Genome-wide occurrences of each candidate motif within coding and upstream regions Upstream Coding Motif Number of genes Number of motifs Number of motifs/10...

Ngày tải lên: 14/08/2014, 21:20

... IDENTIFICATION AND FUNCTIONAL VALIDATION OF CALDESMON AS A POTENTIAL GASTRIC CANCER METASTASIS-ASSOCIATED PROTEIN HOU QIAN NATIONALUNIVERSITY OF SINGAPORE 2013 IDENTIFICATION AND FUNCTIONAL ... VALIDATION OF CALDESMON AS A POTENTIAL GASTRIC CANCER METASTASIS-ASSOCIATED PROTEIN HOU QIAN B Sc (Hons.), NTU A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOCHEMISTRY ... Khoo A, Tan IB, Yeoh KG, Chung MC Identification and Functional Validation of Caldesmon as a Potential Gastric Cancer Metastasis-associated Protein vii Table of Contents ACKNOWLEDGEMENTS ...

Ngày tải lên: 10/09/2015, 09:09

... COMPUTATIONAL IDENTIFICATION OF NOVEL MICRORNAS USING INTRINSIC RNA FOLDING MEASURES COMPUTATIONAL IDENTIFICATION OF NOVEL MICRORNAS USING INTRINSIC RNA FOLDING MEASURES NG KWANG LOONG ... examiners Prof. Peter Clote (Biology Department of Boston College), Prof. Vladimir B Bajic (Deputy Director of South African National Biodiversity Institute), and Prof. Peter Stadler (University of Leipzig), ... List of Tables ix List of Figures xi List of Abbreviations xv List of Abbreviations xv List of Mathematical Symbols and Notations xvi Chapter 1. Introduction 1.1. Background of MicroRNAs...

Ngày tải lên: 11/09/2015, 16:05

... activities of the NTP-RCC include the: (i) Assessment of climate change impacts on sectors and local areas and the (ii) Identification of response measures On 13th October 2009, the Ministry of Natural ... flooding Increase of electricity demand The Increase of temperature reduces the cooling performance of the power plants Increase of the price and reduction of the productivity Increase of the water ... The approval of the NTP-RCC is one of the first successful activities of Vietnam’s effort to respond to climate change for the purposes of achieving sustainable development Two of the eight important...

Ngày tải lên: 10/10/2015, 23:27

... brain Table of content I Table of content Table of content I List of figures IV List of tables V List of abbreviations VI List of units ... 55 Fig 12: Functional analysis of the influence of kinesin-1 on the delivery of NCAM∆CT to the cell surface in CHO cells 56 Fig 13: Functional analysis of the influence of peptides ... List of figures IV List of figures Fig 1: The three main isoforms of NCAM Fig 2: Heterophilic interactions and posttranslational modifications of NCAM 11 Fig 3: Schematic model of...

Ngày tải lên: 25/11/2015, 13:27

... intervention measures for community-based prevention and control of hypertension and diabetes - Evaluated effectiveness of several prevention and management measures for patients of hypertension ... 2013 Evaluate effectiveness of several prevention and management measures for the middle aged (40-59) patients of hypertension and diabetes in Dong Son, Thanh Hoa * New contribution of the dissertation: ... National Institute of Hygiene and Epidemiology At: hour on the of in the year of 2015 The dissertation can be retrieved at: - The National Library - The library of National Institute of Hygiene and...

Ngày tải lên: 16/01/2020, 08:28

... part, at the level of crtB transcription A B C D Discussion Identification of EgcrtE and EgcrtB The GGPS of C annuum [24] and the majority of the GGPP synthase family proteins of Arabidopsis thaliana ... transformation of Escherichia coli with plasmids Gene 1990;96:23–8 56 Takemura M, Maoka T, Misawa N Carotenoid analysis of a liverwort Marchantia polymorpha and functional identification of its lycopene ... day after the cultivation, and the degree of inhibition of cell growth increased in a time-dependent manner After days of cultivation, the concentration of cells illuminated at 920 μmol m−2 s−1...

Ngày tải lên: 26/05/2020, 20:40

... properties of these recombinant enzymes This study of the novel activity of the M truncatula and C arietinum acetaldehyde synthases provides insights for a better understanding of the functional ... Despite the identification of plant aldehyde oxidases capable of catalyzing the conversion of indole-3-acetaldehyde to indole-3-acetic acid (IAA) there have thus far been no enzymes capable of generating ... the separate functions of these highly homolgous enzymes Characterization of MtAAS In an effort to evaluate biophysical characteristics capable of differentiating these functionally divergent...

Ngày tải lên: 27/05/2020, 01:18

... UGT74S1 reaction conditions A, Effect of pH; B, Effect of temperature; C, Effect of two concentrations of seven different metal cofactors; D, Effect of enzyme concentration PSPG motif [34] that includes ... the catalysis of the first biosynthetic steps of lignans in many plant species, including flax These enzymes sequentially reduce pinoresinol formed by the coupling of two molecules of coniferyl ... to 1431 bp The size of the amplified spliced cDNA for each of the UGT genes (Additional file 2C) matched very closely with the exon size of the flax genomic DNA The length of the 5′ un-translated...

Ngày tải lên: 27/05/2020, 01:35

... subject of future analysis in an ecological context Functional identification of BrCYP81F4 isoforms for biosynthesis of 1-methoxy-indol-3-ylmethyl GS In order to finally assess BrCYP81F4 isoform ... glucosinolate profiles in sprouts of pak choi (Brassica rapa ssp chinensis) 48 hours after application of different concentrations of methyl jasmonate (MeJA) A, relative changes to control of aliphatic ... BrCYP81F4-1 and BrCYP81F4-2 4fold with highest increase of BrCYP 81F4-2 of more than 64fold after application of mM MeJA This confirms that the two isoforms of BrCYP81F4 are the candidate genes from Brassica...

Ngày tải lên: 27/05/2020, 01:53