identification of disease related targets moving beyond model systems

... airways of people with this disease; high prevalence of pulmonary tuberculosis in these patients is due to aging (old women) and changes in immune defense mechanisms as a result of inhalation of poisonous ... did not have good ventilation (10) Smoke resulted from burning of wood sticks consisted of a combination of gases and particles of different sizes The reason why dark pigmentations appeared on ... pattern of occupational diseases At present, MATERIALS AND METHODS anthracosis is considered as one of the most In this cross-sectional study data was obtained important occupational diseases,...

Ngày tải lên: 15/02/2014, 12:20

... basis of the ACR (American College of Radiology) code and the computerized disease coding system in use at our institution Among the 335 cases, CT scans were available in 219 After review of the related ... diagnosis of scar cancer: macroscopic evidence of scarring, a central nidus of fibrous tissue suggestive of an old tuberculous granuloma, and anthracotic pigmentation (7) RESULTS The location of tuberculous ... in a known case of pulmonary TB, the diagnosis of dual disease is more difficult than when a diagnosed case of bronchogenic carcinoma is complicated by the presence in sputum of acid-fast bacilli...

Ngày tải lên: 22/03/2014, 18:20

... °C (40 OF) and 40°C (104 OF) passing through a valve and resulting in a pressure loss of 0,1 MPa (1 bar; 14.5 psi) Kv is expressed in 51 units of cubic metres per hour NOTE NOTE Kv is related ... testing of valves Definition of nominal pressure ISO 9606-1, Approval testing of welders ISO 9712, Non-destructive testing - Fusion welding - Part 1: Steels Qualification and certification of personnel ... qualification of welding procedures for metallic materials procedure test - Part 1: Arc and gas welding of steels and arc welding of nickel and nickel alloys Welding ISO 23277, Non-destructive testing of...

Ngày tải lên: 01/04/2014, 11:40

... The subjects were exposed to controlled levels of cooking fumes during the pan-frying of beef in a model kitchen of 56 m3 (2.5 × × 5.6 m) by use of an electric hob for group A and a gas hob for ... rate of up to 600 m3/h The level of cooking fumes in the kitchen was regulated by adjusting the quantity of beef in the pan, the extraction rate of the kitchen ventilator, and the effect level of ... Journal of Occupational Medicine and Toxicology 2009, 4:9 Frying at high temperatures also produces aerosols of fat with small aerodynamic diameters of 20–500 nm which disperse in the air of the...

Ngày tải lên: 20/06/2014, 00:20

... for male patients The mean age of all patients was 63 years (range 20–95 and standard deviation ±17.2) A diagnosis of pulmonary embolism was reported for 66 (16.3%) of the remaining 405 CTPAs The ... that five (7.6%) of these were false positive examinations The positive predictive value of CTPA for pulmonary embolism in this study was 92.4% (95% CI = 82.5%–97.2%) The numbers of performed d-dimer ... x The main anatomical sites of pulmonary embolism are shown in Table Sub segmental embolisms were least common, being described in (6%) of cases The main findings of the CTPAs considered for...

Ngày tải lên: 21/06/2014, 19:20

... capacity of a battery is reported in terms of Ah at a specified discharge rate However, it is often of interest to report electrochemical investigations of battery material utilization in terms of the ... composition of the active material on the surface of the gauntlet as compared to that of the bulk inner core The dipping of the filled tubular electrodes in dilute sulphuric acid for short periods of time ... through the outer gauntlet section of the sample and not through the two open sides of the sample The flat plate electrodes were analysed by removing complete sections of the active material from the...

Ngày tải lên: 05/07/2014, 21:20

... intensity of dyspnea increases (Adapted from Gillette and Schwartzstein.) Motor Efferents Disorders of the ventilatory pump are associated with increased work of breathing or a sense of an increased ... sensation of an inability to get a deep breath or of an unsatisfying breath It is not clear if this sensation arises from receptors in the lungs or chest wall, or if it is a variant of the sensation of ... experiences and provide feedback on the action of the ventilatory pump Afferents also project to the areas of the brain responsible for control of ventilation The motor cortex, responding to...

Ngày tải lên: 06/07/2014, 15:21

... leads to hyperinflation, increased work of breathing, a sense of an increased effort to breathe, and a sense of an unsatisfying breath Assessing Dyspnea Quality of Sensation As with pain, dyspnea ... with pain, dyspnea assessment begins with a determination of the quality of the discomfort (Table 33-1) Dyspnea questionnaires, or lists of phrases commonly used by patients, assist those who have ... describing their breathing sensations Table 33-1 Association of Qualitative Descriptors and Pathophysiologic Mechanisms of Shortness of Breath Descriptor Pathophysiology Chest tightness or constriction...

Ngày tải lên: 06/07/2014, 15:21

... recognized cause of exerciseinduced breathlessness Pericardial disease, e.g., constrictive pericarditis, is a relatively rare cause of chronic dyspnea Low Cardiac Output Diseases of the myocardium ... vascular and interstitial lung disease and pulmonary vascular congestion may produce dyspnea by direct stimulation of pulmonary receptors In these cases, relief of hypoxemia typically has only ... Disorders of the airways (e.g., asthma, emphysema, chronic bronchitis, bronchiectasis) lead to increased airway resistance and work of breathing Hyperinflation further increases the work of breathing...

Ngày tải lên: 06/07/2014, 15:21

... cardiomyopathy or valvular disease Bilateral pleural effusions are typical of congestive heart failure and some forms of collagen vascular disease Unilateral effusions raise the specter of carcinoma and ... work of breathing (supraclavicular retractions, use of accessory muscles of ventilation, and the tripod position, characterized by sitting with one's hands braced on the knees) is indicative of ... motion during inspiration), a sign of diaphragmatic weakness Clubbing of the digits may be an indication of interstitial pulmonary fibrosis, and the presence of joint swelling or deformation as...

Ngày tải lên: 06/07/2014, 15:21

... being studied Pulmonary Edema Mechanisms of Fluid Accumulation The extent to which fluid accumulates in the interstitium of the lung depends on the balance of hydrostatic and oncotic forces within ... movement of fluid into the tissue of the lung Cardiogenic Pulmonary Edema (See also Chap 266) Cardiac abnormalities that lead to an increase in pulmonary venous pressure shift the balance of forces ... consequence of blunt chest trauma Indirect injury is the consequence of mediators that reach the lung via the blood stream The third category includes conditions that may be the consequence of acute...

Ngày tải lên: 06/07/2014, 15:21

... Schwartzstein RM: Mechanisms of dyspnea, in Supportive Care in Respiratory Disease, SH Ahmedzai and MF Muer (eds) Oxford, U.K., Oxford University Press, 2005 Mahler DA et al Descriptors of breathlessness ... shunting and typically persists despite high concentrations of inhaled O2 Further Readings Abidov A et al: Prognostic significance of dyspnea in patients referred for cardiac stress testing N ... effusions are uncommon Finally, the hypoxemia of cardiogenic pulmonary edema is due largely to ventilation-perfusion mismatch and responds to the administration of supplemental oxygen In contrast, hypoxemia...

Ngày tải lên: 06/07/2014, 15:21

... http://arthritis-research.com/contents/7/3/126 Figure Dysfunction of cellular components of the arterial wall and of inflammatory and haemostatic systems are interrelated predicted survivals of 69% and 57%, respectively Although ... the pathophysiology of PAH and RP, particularly in the context of connective tissue disease, inhibition of the renin–angiotensin system may prove effective in RP A pilot study of the angiotensin ... prevent the development of PAH by a combination of mechanisms including vasodilation, reduction of vascular smooth muscle proliferation, reduced collagen deposition and inhibition of NF-ΚB activation...

Ngày tải lên: 09/08/2014, 06:23

... complication of relapsed disease after autologous stem cell transplantation The presence of circulating plasma cells and hyperammonemia are both known to be indicators of advanced disease Plasma ... H&E of BAL; (E) Skin (A) Kappa staining(B) BAL (A) Skin nodules; (B) Wright Giemsa stain, aspirate of skin nodules; (C) Chest CT showing diffuse infiltrates; (D) H&E of BAL; (E) Kappa staining of ... Authors' contributions All authors were involved in the provision of clinical care of the patient and the collection of data and the review of the manuscript RW performed immunohistochemical analysis...

Ngày tải lên: 10/08/2014, 22:20

... indicators of acute lung injury [34] Early in acute lung injury, low oxygenation can be the result of ventilation perfusion mismatch [25] This can develop as a result of an imbalance of the effect of ... production of cytokines, specialized cytokines called chemokines and cell adhesion molecules [9] Chemokines belong to a superfamily of cytokines that promote chemotaxis of leukocytes to areas of infection, ... density of the autoradiograph bands was measured using computer software (Kodak Science 1D) Relative TNF-α, IL-1β, or MIP-2 mRNA levels were estimated as the ratio of the autoradiographic density of...

Ngày tải lên: 11/08/2014, 08:21

... Journal of Medical Case Reports 2007, 1:46 Beta-blockers – the standard medical treatment of portal hypertension – worsen the prognosis of patients with PPHTN [3] Endothelin ... mmHg) After exclusion of other causes of pulmonary hypertension according to current guidelines portopulmonary hypertension was diagnosed in this patient We tested the effect of 10 mg Tadalafil ... indicated a dilation of right atrium and increased right heart pressure Doppler echocardiogram showed right heart enlargement with a PAPsystolic of about 75 mmHg and normal dimensions of the left ventricle...

Ngày tải lên: 11/08/2014, 10:22

... Ford Hospital where he complained of chills and diarrhea The diarrhea was watery and continuous of 1-day duration accompanied by chills He denied shortness of breath or chest pain A 2D echocardiogram ... kept in hospital for the duration of intravenous antibiotics to ensure adherence to therapy and to prevent use of the intravenous access for illicit drug use At day of hospitalization, he underwent ... hospitalization, he remained afebrile and euvolemic without symptoms of heart failure Two weeks Page of (page number not for citation purposes) Journal of Medical Case Reports 2009, 3:6598 http://jmedicalcasereports.com/jmedicalcasereports/article/view/6598...

Ngày tải lên: 11/08/2014, 17:21

... severity of his infection Therefore, our patient's profession and history of alcohol consumption provide some clues to the means of acquisition and spread of S simulans To the best of our knowledge, ... excessive alcohol consumption and alcoholic liver disease All three sets of blood cultures yielded Gram-positive cocci on Gram stain Initial identification of these cocci was based on colony and microscopic ... scarcity of reported human infections caused by Page of (page number not for citation purposes) Journal of Medical Case Reports 2008, 2:183 S simulans is probably due to the infrequent colonization of...

Ngày tải lên: 11/08/2014, 23:21

... Foundation of China and 00-722, 06-834 from China Medical Board of New York to Dr F.Q Wen Author details Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of ... Hospital of Sichuan University, Chengdu, Sichuan 610041, PR China 2Department of Cardiology, Fifth Affiliated Hospital of Xinjiang Medical University Department of Pathology, West China Hospital of ... Inhibitors of chymase as mast cellstabilizing agents: contribution of chymase in the activation of human mast cells J Pharmacol Exp Ther 1999, 291:517-23 40 Takahashi H, Cease KB, Berzofsky JA: Identification...

Ngày tải lên: 12/08/2014, 11:21