i ii clinical trial for patients with acute liver failure

... progress in the DSM-IV criteria “unstable and intense interpersonal relationships”, “identity disturbance” and “impulsivity” These criteria were explicitly discussed in the multi family skills training ... Wilcoxon signed rank test Effect size was calculated according to the following formulae: - SKID -I (Structured Clinical Interview for DSM-IV, German version, [13]) - SKID -II (Structured Clinical ... the beginning of therapy; especially in the dimensions Phobic Anxiety, Paranoid Ideation and Psychoticism Similar to the SCL 90-R, the YSR showed significant amelioration in all global indices...

Ngày tải lên: 13/08/2014, 18:21

... clinical efficacy Therefore, it will be desirable to examine the clinical efficacy of rh-HGF in additional clinical trials involving patients with less severe conditions Systemic administration ... Pharmaceuticals for Human Use (ICH)-Good Clinical Practice (GCP)-registered phase I/ II clinical trial of rh-HGF As this application is the first clinical trial to administer rh-HGF to humans, we performed ... extremely serious condition This life-threatening condition was influenced by the degree of impaired hepatic reserve and varying complications Indeed, in this trial, all eligible patients with FH or...

Ngày tải lên: 18/06/2014, 19:20

... psychological functions leading to difficulties in familiar, vocational and social reintegration which diminishes * Correspondence: jgil@upv.es Instituto Interuniversitario de Investigación en Bioingeniería ... play in standing or in sitting position to improve balance control in both conditions In standing position the patients are required to maintain their soles on the WBB In sitting position, the patients ... dementia or aphasia; 2) patients whose visual or hearing impairment does not allow possibility of interaction with the system; 3) patients with hemispatial neglect; 4) patients with ataxia or...

Ngày tải lên: 19/06/2014, 08:20

... feasibility of progesterone in women with TBI, in spite of the limited number of female patients in the trial It is recognized that the pathophysiology of TBI is a multifactorial process involved ... dissolved in the same camellia oil and taken daily for days by patients with acute TBI Those patients administered progesterone experienced significant improvements in functioning outcome, indicating ... but no high-density or mixed-density lesions > 25 cm3, with bone fragments and foreign bodies; III, cisterns compressed or absent, shift ≤ mm, with no high-density or mixed-density lesions > 25...

Ngày tải lên: 13/08/2014, 11:22

... that identifying barriers and tailoring intervention to these barriers may improve clinical practice compared to no intervention and to guideline dissemination In their meta analysis including eight ... on a website and examine the possibilities for designing the guiding patient registration forms on this website as well Tailored delivery of the implementation intervention The intervention group ... visitor is an educational facilitator trained in supporting behaviour change in practices The pilot study also demonstrated that there was little multidisciplinary clinical activity in the improvement...

Ngày tải lên: 10/08/2014, 10:23

... therapy is particularly important in situations in which IRA patency is critical for survival, such as in patients with cardiogenic shock In addition, both the Randomized IABP [10] and PAMI -II [12] ... This was an unexpected finding, since patients in PAMI -II were generally older and had poorer LV function than those in the Randomized IABP Trial Critical appraisal of randomized clinical trials ... using IABP Only high-risk patients were included in PAMI -II, and no patients in Kono et al's trial received rescue angioplasty The therapeutic maneuver in these trials, specifically insertion and...

Ngày tải lên: 12/08/2014, 18:20

... most patients enrolled in ALI/ ARDS datasets are sedated with minimum activity, receive minimal nutrition and are out of the initial shock phase, if present Another important limitation is that ... measured in clinical practice • In mechanically ventilated patients with ALI and ARDS, Vd/Vt can be estimated from routinely available clinical data (arterial blood gas analysis and minute ventilation) ... predicts mortality in ALI patients in a dose-response manner and modified alveolar gas equation allows for its rapid bedside estimation, utilizing routinely collected clinical data Future studies are...

Ngày tải lên: 13/08/2014, 21:21

... respiratory failure While early diagnosis is often difficult to perform in ICU patients presenting with acute respiratory failure, this finding may be of major clinical importance Roughly one-third of ... malignancy was associated with an increased risk and oral beta-blocker treatment prior to admission with a decreased risk of in-hospital mortality in ICU patients with acute respiratory failure ... heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet 1999, 353:2001-2007 27 The Cardiac Insufficiency Bisoprolol Study II (CIBIS -II) : a...

Ngày tải lên: 13/08/2014, 21:21

Ngày tải lên: 14/08/2014, 07:21

... Not significant Perforated viscous 2 Not significant Infarcted gut Not significant Gastrointestinal bleeding Not significant Neurological disease 11 0.03 Liver transplantation Not significant ... critically ill patients with ARF and compared our findings with those seen in two control groups: 40 APACHE II score-matched patients without ARF, and 60 unmatched critically ill patients also without ... these fulfilled the predefined criteria for the diagnosis of ARF ARF compared with APACHE II- matched controls R62 Compared with the APACHE II- matched group, patients with ARF had mild acidemia and...

Ngày tải lên: 12/08/2014, 19:22

... tracheostomy in patients with acute respiratory failure Physician belief in the utility of tracheostomy, patient selection and the lack of blinding may introduce bias, leading to difficulties in comparing ... association between ET and a shorter period of weaning was similar in patients with and without TBI Thus, while the inclusion of patients with TBI did not appear to bias our results, it will be ... physiologically based and clinically relevant time point at which tracheostomy should be considered in critically ill patients requiring MV Before considering the implications of our observations,...

Ngày tải lên: 12/08/2014, 20:20

... than in those without ARF, particularly in patients with oliguria and those treated with RRT Cox regression showed that age, SAPS II, heart failure, liver cirrhosis, medical admission, mean fluid ... according to urine output and treatment with RRT In oliguric patients and in patients treated with RRT, mean fluid balance was significantly more positive than in non-oliguric and non-RRT patients, ... unit; SAPS II, Simplified Acute Physiology Score II; SOFA, sequential organ failure assessment Outcome Patients with ARF had higher mortality rates than patients without ARF (60-day mortality 35.7%...

Ngày tải lên: 13/08/2014, 11:22

... characteristics, Simplified Acute Physiology Score (SAPS) II, duration of mechanical ventilation prior to inclusion and outcome for patients included in normal and increased IAP groups All patients ... abdomen in surgical ALI/ARDS patients was associated with an improved oxygenation [23] We did not find differences in ITBVI, EVLWI and hemodynamics between ALI/ARDS patients with and without IAH ... cmH2O in ALI/ARDS patients without IAH and from 12.6 ± 4.2 to 15.5 ± 3.4 mmHg with IAH, respectively This relatively small PEEP-induced increase in IAP is in keeping with previous findings by...

Ngày tải lên: 13/08/2014, 19:20

... Matti Reinikainen, Tanja Eiserbeck, Helena Jyrkönen; Seinäjoki Central Hospital - Dr Kari Saarinen, Dr Matti Viitanen, Niina Siirilä, Johanna Soini; South Karelia Central Hospital - Dr Seppo Hovilehto, ... mellitus, immunodeficiency, neuromuscular disease ARF, acute respiratory failure; NIV, non-invasive ventilation; SAPS II, Simplified Acute Physiology Score; SD, standard deviation; QALY, qualityadjusted ... Helsinki, Finland, 2Department of Intensive Care Medicine, Tampere University Hospital, Teiskontie 35, FI-33520 Tampere, Finland, 3Division of Intensive Care, Kuopio University Hospital, Yliopistonranta...

Ngày tải lên: 13/08/2014, 20:21

... Acknowledgements iv Summary vii List of Abbreviations x List of Figures xiv List of Tables xix Publications arising from material in the thesis 1.1 ii Table of contents Chapter i xxii Introduction Acute ... characteristics of study and control patients (APACHE II Acute Physiology and Chronic Heatlh Evaluation II; SAPS II Simplified Acute Physiology Score II; CVVH continuous veno-venous haemofiltration; ... Acute- on-chronic renal failure ALF Acute liver failure AoCLF Acute- on-chronic liver failure Acute PD Acute peritoneal dialysis AMI Acute myocardial infarction AN69 Polyacrylonitrile membrane aPTT Activated...

Ngày tải lên: 16/09/2015, 17:14

... hepatocellular recovery In the management of late presenters with APAP poisoning and APAPinduced liver failure, clinicians may have to consider individual case scenarios in tailor-making duration and dose ... APAP-induced ALF patients could be in the direction of monitoring for biomarkers (for example, sFas and HGF) [19] for liver regeneration or apoptosis in order to establish whether there is a ‘tipping ... NAC metabolic pathways 10 Issues related to clinical practice The current clinical literature recommends the prolonged administration of NAC in patients with APAP-induced ALF and in those who...

Ngày tải lên: 13/08/2014, 16:20

... surgical patients ventilated with conventional tidal volumes compared with those in patients ventilated with lower tidal volumes [12] The increase in lung-injury score in the conventionaltidal-volume ... 49 patients had to be included in each group As we studied patients without ALI/ARDS, we chose to study twice as many patients, resulting in a total of 200 patients Lung injury diagnosis for interim ... by using SPSS, version 14.02 (SPSS Inc., Chicago, IL) Results Patients A flow diagram summarizing patient inclusion, allocation, and analysis is given in Figure At the second interim analysis,...

Ngày tải lên: 13/08/2014, 20:21

... Sunitinib, an oral multitargeted tyrosine kinase inhibitor with antiangiogenic activity in vivo, has been investigated in advanced HCC within several phase II trials [13-15], and a phase III trial ... resistance to VEGF-A pathway inhibition, and no such association was seen in a phase I/ II study in which patients with metastatic RCC were treated with sunitinib in combination with gefitinib ... role in HCC disease progression, and that inhibition of this receptor may result in improved clinical outcome in a subset of patients with this disease, following treatment with sunitinib In support...

Ngày tải lên: 18/06/2014, 22:20

... Sunitinib, an oral multitargeted tyrosine kinase inhibitor with antiangiogenic activity in vivo, has been investigated in advanced HCC within several phase II trials [13-15], and a phase III trial ... resistance to VEGF-A pathway inhibition, and no such association was seen in a phase I/ II study in which patients with metastatic RCC were treated with sunitinib in combination with gefitinib ... role in HCC disease progression, and that inhibition of this receptor may result in improved clinical outcome in a subset of patients with this disease, following treatment with sunitinib In support...

Ngày tải lên: 20/06/2014, 04:20