i hate the tomb of giants

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Ngày tải lên: 05/11/2014, 21:52

... twisting and writhing themselves in the dust of commonplace, which also expect to find a reading public.’ ‘Oh,’ exclaimed the clerical gentleman smiling, ‘there is much wit in them; besides ... taken their ships while in the roadstead; and 34 of 260 the Councillor, before whose eyes the Herostratic* event of 1801 still floated vividly, agreed entirely with the others in abusing the ... thatched roof. forced, in spite of his opposition, to drink with the rest. They took hold of the worthy man; who, hearing on every side that he was intoxicated, did not in the least doubt the truth...

Ngày tải lên: 07/11/2013, 07:15

... approach for the notion of complexity of real numbers, by emphasizing the quantitative aspect of the notion of calculability introduced by Turing [42]. According to them, a real number is said to be ... set of states, Σ k is the input alphabet, : Q ì k Q is the transition function, q 0 is the initial state, ∆ is the output alphabet and τ : Q → ∆ is the output function. Annals of Mathematics ... quantita- tive version is established (in the sense that one bounds explicitly the number of exceptional subspaces). We now turn to the proof of Theorem 5. Keep the notation and the assumptions of...

Ngày tải lên: 16/02/2014, 06:20

... KLF4 is required for the expression of VSMC differentiation marker genes induced by all-trans retinoic acid [4]; KLF4 could induce inhibition of proliferation of VSMC, which is mechanistically linked ... shown in Fig. 3C. Further- more, this transactivation was almost abolished upon further point mutations of the corresponding KLF4 binding site. The specificity of transcriptional activity of KLF4 ... the proliferation, migration, differentiation and activation of cells are always highlights for researchers. Kru ă ppel-like factor 4 (KLF4) was first identified in the epithelial lining of the gut and skin,...

Ngày tải lên: 18/02/2014, 04:20

... to the plasma membrane. The E3-ubiquitin ligase c-Cbl is directly involved in the ubiquitylation of several RTKs [24–26,32] and may participate in the downregulation of FGFR1 via an indirect interaction ... ⁄ PmlI sites or PmlI ⁄ MluI sites. Wild-type and mutant FGFR3 cDNAs were then transferred from pBSII to pcDNA3.1 at the HindIII ⁄ EcoRI restriction sites. Single-point mutations in the intracellular ... mutations causing TDI induce variable constitutive phosphorylation of the receptor, which partially colocalizes with the ER marker PDI. (A) Constitutive phosphorylation in the absence of ligand of...

Ngày tải lên: 19/02/2014, 00:20

... make him relinquish. All the defence which Vane could make was fruitless. The court, considering more the general opinion of his active guilt in the beginning and prosecution of the civil wars, ... obliged, by the late law, either to relinquish their livings, or to sign the articles required of them. A combination had been entered into by the more zealous of the Presbyterian ecclesiastics ... prevailed so far with the convention parliament as to make them restore the king with strict limitations, there is no question but the establishment of Presbyterian discipline had been one of the...

Ngày tải lên: 19/02/2014, 05:20

... role in promoter activity in the 5Â-upstream region of DNASE1 exon 1a. Results Mapping of transcription initiation sites in the human DNASE1 gene To identify the transcription initiation sites of DNASE1 ... Division of Legal Medicine, University of Fukui, Japan 4 Third Division of Internal Medicine, University of Fukui, Japan Deoxyribonuclease I (DNase I, EC 3.1.21.1) is an enzyme that preferentially ... delineation of the transcriptional regulation of human DNASE1 may provide clues to the mechanisms underlying ischemia-induced elevation of DNase I activity in vivo. Here, we describe the identification...

Ngày tải lên: 19/02/2014, 06:20

... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible. From ... from the dissociation of the intact complex I with mutated s ubunits during the solubilization for blue native gel electrophoresis. It remains to be seen whether the 20 subunits of the integral ... Molecular Biology Section, University of California, San Diego, California, USA The ESSS protein is a recently identified subunit of mam- malian mitochondrial complex I. It is a relatively small integral...

Ngày tải lên: 19/02/2014, 16:20

... phase of evolution, in which the indi- vidual specificities of the peroxidase families distinguished were already formed. Evidence is presented that class I of the heme peroxidase superfamily is ... oxidative activation of isoniazid (isonicotinic acid hydrazide) [3], still the most widely used antitubercu- losis drug. All heme peroxidases have important features of their catalytic mechanism ... feature in this region. The iron of the prosthetic heme group is invariantly co-ordinated by the a bove essential proximal h istidine (Fig. 4A,C,D). However, in all C-domains of catalase– peroxidases,...

Ngày tải lên: 19/02/2014, 16:20

... of the South- ern hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns are shown as in Fig. 2A. Positions of the ... activity of region IV did not correlate with the activity observed in transient transfection assays. These observations demonstrate that regions II, III, and IV are involved in the transcription of the Ig-b ... without Bsr gene. Position of the probe (0.9 kb; )10.1 kb HindIII to )9.2 kb AccI fragment) for hybridization is indicated by a black rectangle. Size and position of the HindIII fragment hybridizable...

Ngày tải lên: 19/02/2014, 16:20

... amino acid substitution, Leu130Ile, might be involved in an evolutionally critical change in the thermal stabilities of vertebrate DNases I. Amphibian DNasesIhaveaSer205insertioninaCa 2+ -binding ... [13]. These findings indicate that the thermal stabilities of DNase I in vitro might reflect the enzyme activities in vivo.We found that amphibian DNases I are characterized by a C- terminal end with ... considerably from those of other vertebrate DNases I, comprehensive characterization, including determination of thermal stabilities, of reptilian DNases I is required, not only to elucidate the...

Ngày tải lên: 20/02/2014, 23:20

... pragmatic interpretation. Each piece of information is a thresholding device with memory. It has an activity value, initially at a resting state, that is modified over time depending on the input, ... strictly linguistic analysis. The remainder of the paper focuses on our initial work in the adaptation (Gigley, 1984). As the research is currently underway, the discussion will raise several ... activation of all meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon 9 meanings...

Ngày tải lên: 21/02/2014, 20:20

... perfectly match the in vivo conditions. Because GBSSI is known to be the major determinant of amylose synthesis we are confident that the semi in vitro system is a good reflection of the in vivo situation. Fig. ... surface of the granule. The apparent polarized growth of the granules is consistent with either an aniso- tropic distribution of GBSSI or a filling of the amorphous regions of the granule leading ... detailed characterization of amylose synthesis both in vivo and in vitro. We show that GBSSI is capable of synthesizing a significant number of crystalline structures within starch. Quantifications of amount and type of...

Ngày tải lên: 22/02/2014, 07:20