hypoxic ischemic encephalopathy intracranial hemorrhage and seizures

... neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors Nat Med 2, 788–794 153 Gary DS, Bruce-Keller AJ, Kindy MS & Mattson MP (1998) Ischemic and ... cells and leukocytes, which promote the adhesion and transendothelial migration of leukocytes [13,35,36] By this mechanism, activated neutrophils and platelets accumulate in cerebral capillaries and ... cyclooxygenase-2 (COX-2), IL-1b and TNF-a, contributing to postischemic brain damage [64–66] Enzymes Both in human stroke and in animal models, neutrophils, vascular cells and, most notably, neurons,...

Ngày tải lên: 07/03/2014, 03:20

... neuroprotection against the hypoxic- ischemic brain injury Our results indicate that pretreatment with ceftriaxone in neonatal rats can reverse hypoxic- ischemic induced morphological and functional alterations ... loss, and = cystic infarction and gliosis Eight brain regions (hippocampus: CA1, CA2, CA3, dentate gyrus; anterior and middle regions of cortex; striatum and thalamus) were evaluated, scored, and ... p < 0.05 Saline group refers to animals received hypoxic- ischemic procedures and saline administration Figure Ceftriaxone attenuated hypoxic- ischemic white matter injury in neonatal rats A, the...

Ngày tải lên: 10/08/2014, 10:20

... traumatic intracranial hemorrhage Materials and methods Probabilities and utilities We searched Medline (OVID Technologies, New York, NY, USA; 1950 to March 2008) for studies concerning intracranial hemorrhage ... safety and efficacy of using anticoagulant prophylaxis in patients with traumatic brain injury and intracranial hemorrhage Key messages • Patients with traumatic brain injury associated with intracranial ... contributions DCS, JRC, JTG and ASD conceived of and designed the manuscript DCS, JRC, VA and DW were responsible for data acquisition DCS, JRC, DW and ASD were responsible for analysis and interpretation...

Ngày tải lên: 13/08/2014, 20:21

... between major bleeding and anti-Xa levels was found Therefore, if LMWH does not accumulate even in the face of severe renal insufficiency, the likelihood that it will accumulate and precipitate bleeding ... migration of the filter [9], and increased risk for DVT [10], must be contemplated before its placement Despite these considerations, the lack of concrete evidence from a randomized controlled trial ... risk stratification tool to select those patients who are at low risk for ICH progression and would be ideal candidates for DVT prophylaxis at 24 hours In the meantime, while Page of we await more...

Ngày tải lên: 13/08/2014, 20:22

... Neonatal intracranial hemorrhage Pathophysiology, neuropathology, and clinical features Clin Perinatol 4:77– 102, 1977 36.  Vople JJ (ed): Intracranial hemorrhage: germinal matrix–intraventricular hemorrhage ... patients, major motor disturbance in 4, and vegetative state in (Table 4) Discussion Intracranial hemorrhage in the neonatal period is a well-recognized and frequent occurrence Spontaneous neonatal ... defined according to the etiology and the age at hemorrhage onset: early VKDB (occurs within 24 hours of birth), classic VKDB (occurs between and days after birth), and late VKDB (occurs more than...

Ngày tải lên: 31/08/2015, 13:08

... films independently and assigned a grade for intracranial hemorrhage as follows: 0, no hemorrhage; I, hemorrhage limited to the periventricular area; II, intraventricular hemorrhage without ventricular ... neonatal intracranial hemorrhage. 16 The first studies of antenatal phenobarbital therapy showed that it was effective in decreasing the frequency of neonatal intracranial hemorrhage and death.5-9 ... lower risk of neonatal intracranial hemorrhage than male sex.18 In previous studies, there were differences in sex and other characteristics that affect the risk of intracranial hemorrhage, such as...

Ngày tải lên: 31/08/2015, 13:09

... response; and neonatal seizures. 1,11–13 Clinical neonatal seizures are reported in 17% of infants with GM-IVH and in up to 40% of infants with PVHI,14 mostly described as generalized tonic seizures ... Cytokines and Vasoactive, Angiogenic, and Growth Factors The role of cytokines and of vasoactive, angiogenic, and growth factors in the pathogenesis of GM-IVH is not well understood and their ... as risk modifiers for GM-IVH and PVL.60,61 Triggers of cytokine generation in the context of GM-IVH could be maternal and placental infection and inflammation and hypoxic ischemia-reperfusion...

Ngày tải lên: 31/08/2015, 17:13

... RE, Anderson GW Clinical and pathologic concepts of gross intracranial hemorrhage in perinatal mortality Obstet Gynecol Surv 1956; 11:179- 204 13 Tsiantos A, Victorin L, Relier Jr, et al Intracranial ... sequelae occur, and the infants go on to live a developmentally and neurologically normal life Grades III and IV, however, are associated with subsequent development of hydrocephalus and carry a ... ultrasonography of neonatal intraventricular hemorrhage and comparison with computed sonography Radiology1981; 139:687-691 Mack LA, Wright K, Hirsch JH, et al Intracranial hemorrhage in premature infants:...

Ngày tải lên: 31/08/2015, 17:13

... Major Types of Intracranial Hemorrhage in the Term Infant  Subdural Hemorrhage  Primary Subarachnoid Hemorrhage  Intracerebellar Hemorrhage  Intraventricular Hemorrhage  Miscellaneous ... month of life and presents as intracranial hemorrhage Primary intracerebral and subarachnoid hemorrhage are most common Serious long-term deficits usually occur (70%-90% severe handicap rate) ... factors Risk of Intracranial Hemorrhage with Asphyxia and Acidosis It is not uncommon for infants (premature > term) to suffer intracranial hemorrhages if they are asphyxiated at birth and/ or are...

Ngày tải lên: 18/11/2020, 14:00

... hypovolemia and anemia  Seizures may occur in up to half of neonates with SDH, particularly with SDH over the cerebral convexity Diagnosis  suspected on the basis of history and clinical signs and ... anticonvulsant therapy for seizures INTRAPARENCHYMAL HEMORRHAGE (iph)  Rare  Intracerebral or intracerebellar variety  More commonly a secondary event  Hypoxic ischemic brain injury, venous ... ECMO therapy, large ICH in another compartment  Presentation and management similar to SDH  MRI – extent and age of hemorrhage and other associated parenchymal lesions  LP to rule out meningitis...

Ngày tải lên: 18/11/2020, 14:00

... among both males (2.3 years for ICH and years for ischemic stroke) and females (1 year for ICH and 1.3 years for ischemic stroke) Conversely, in the older age bands (> 65 years) for males the QALYs ... people with and without stroke or health experts [8]) including the type and range of tool used; timing of elicitation between the event and the assessment; differences in age and gender; and the ... utility loss varied by age and time since stroke and ranged between 0.025 and 0.514 Our summary QoL weight estimate at 12 months was 0.19 and at years 0.25 (adjusted for age and population size) These...

Ngày tải lên: 20/06/2014, 16:20

... miscarriages, and livedo reticularis Materials and Methods We focused on the secondary prevention of stroke with APS, and compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation ... stroke in patients with ischemic stroke or transient ischemic attack and with antiphospholipid antibodies (aPL), antiplatelet therapy is reasonable for cases of cryptogenic ischemic stroke or TIA ... positive aPL On the other hand, oral anticoagulation with a target INR of to [4] is reasonable for patients with ischemic stroke or TIA who meet the criteria for APS with venous and arterial occlusive...

Ngày tải lên: 26/10/2012, 09:48

... language and culture and address the following (See Table 1): Table 1: Febrile Seizure Information and Education Clinical Information What is a febrile seizure? The link between fever and febrile seizures ... anxiety-provoking events for parents and caregivers It is important that health care providers understand potential parental misconceptions, anxieties and fears about fever and febrile seizures so that they ... excessive anxiety and worry about low-grade fevers [66] The occurrence of febrile seizures can potentially disrupt the familial quality of life and the parents may experience anxiety and fear whenever...

Ngày tải lên: 26/10/2012, 10:03

... Immunofluorescence staining of total cellular and chromatin-bound PCNA T24 were grown and incubated on coverslips Two sets of hypoxic cells and of cells reoxygenated for 10 and 30 were prepared One set of ... complex, after medium renewal before and at the end of hypoxic gassing as well as under normoxic conditions As shown in Fig MCM3 and Cdc6 are not, and MCM2 and Cdk2 are barely, detectable on chromatin ... MCM2, MCM3, Cdc6 and Cdk2 from normoxic and hypoxic T24 cells Chromatinbound proteins were prepared after the indicated incubation conditions (for details see Materials and methods) and equal amounts...

Ngày tải lên: 21/02/2014, 00:20

... tumors in the following manner: “Other specified intracranial and intraspinal neoplasms excluding pineoblastoma (IIIe)” and “Unspecified intracranial and intraspinal neoplasms (IIIf)” were combined ... (IIIc)” category was expanded to include intracranial neuroblastoma (these were also reported with ICCC IV) and pineoblastoma Finally, the ICCC system places intracranial and intraspinal germ cell ... history of seizures may differ by type of brain tumor and/ or type and circumstances of seizures 13,18,27 Family history of mental retardation Increased risk observed in one study of adults and one...

Ngày tải lên: 06/03/2014, 02:21

... control hypoxic cells at 320 nM (EA320nM) The results are expressed as means ± 1SD (n ¼ 3) *, ** and ***, P < 0.05, 0.01 and 0.001 versus normoxia (*), (**) and (***), P < 0.05, 0.01 and 0.001 ... 1SD (n ¼ 3) *, ** and ***, P < 0.05, 0.01 and 0.001 versus normoxia (*), (**) and (***), P < 0.05, 0.01 and 0.001 versus hypoxia [*] and [**], P < 0.05 and 0.01 versus PMA alone (E) The table summarizes ... inhibited both basal and PMA-stimulated c-myc transcriptional activity (Fig 2C) AP-1 activity was also low in unstimulated HepG2 cells PMA enhanced this activity and, under normoxic and hypoxic conditions,...

Ngày tải lên: 16/03/2014, 05:20

... GK Collection and assembly of data AD Collection and assembly of data AK Data analysis and interpretation, collection and assembly of data CP Conception and design, data analysis and interpretation ... Conception and design, provision of patients, data analysis and interpretation, manuscript writing PA Conception and design, data analysis and interpretation, manuscript writing HA Data analysis and ... delivered, and the most suitable route for cell delivery Design of a large multicenter randomised controlled trial with a standardized protocol is imperative in order to assess the safety and efficacy...

Ngày tải lên: 18/06/2014, 16:20

... and designed the research; analyzed and interpreted the data; performed statistical analysis, handled funding and supervision and drafted the manuscript RRG, DB, OM, have acquired, analyzed and ... (MMP-9) and cellular fibronectin (cFn) as markers of blood brain barrier disruption after ischemic stroke Patients and methods Study population and patients characteristics One hundred and ninety ... treatment for ischemic stroke patients In this respect, combined thrombolytic and neuroprotective therapy continues to be one of the most interesting approaches for ischemic stroke This and future...

Ngày tải lên: 18/06/2014, 19:20

... expressions of Bcl-2 and PGC-1a in group than in other groups and markedly lower in group and than in group and 5, but no difference between group and and between group and † vs other groups, ... of caspase (C) and Bax (D) in group than in other groups, and significantly higher in group and than in group and 5, but no notable difference between group and or between group and † vs other ... metabolism and biogenesis, was notably lower in group than in other groups and significantly lower in groups and than in groups and 5, but it did not differ between groups and or between groups and...

Ngày tải lên: 18/06/2014, 22:20

... levels of IL-1b and HMGB1 (A), IL1b and IL-6 (B), IL-1b and TNF-a (C), and IL-6 and TNF-a (D) in febrile patients (N = 82) IL-1b levels are significantly correlated with HMGB1, IL-6, and TNF-a levels ... IL-6 and HMGB1 levels These results together suggest that active inflammation does occur in febrile seizures and pediatric epilepsy, and it may play a common pathologic role in febrile seizures and ... febrile seizures persist for < 15 minutes, are generalized tonicclonic, and only occur once within 24 hours; and atypical types for whom seizures persist for > 15 minutes, or are partial seizures, ...

Ngày tải lên: 19/06/2014, 22:20