hypoxia oxidative stress and the pathophysiology of contrast media induced nephropathy

... factors The CYP2E1-mediated myocyte apoptosis may be associated with the progress of DCM, such that the inhibition of CYP2E1 may mitigate the progression of DCM In summary, we report that the CYP2E1 ... heart tissues of WT mice and cTNTR141W transgenic mice at and months of age, representing the early stage of DCM (data not shown); therefore, we propose that the up-regulated expression of CYP2E1 ... Expression of CYP2E1 in mouse heart tissue and the generation of transgenic mice Protein translational levels of CYP2E1 in heart tissue from mice at embryonic age 16.5 days and at 1, 2, and weeks of...

Ngày tải lên: 22/03/2014, 16:20

... principally on the significance of these findings in the context of our current understanding of BMP receptor biology, and relate the data to our knowledge of inheritance patterns and disease pathophysiology ... includes the three mammalian TGF-β isoforms, the activins and inhibins, and over 30 members of the BMP subfamily [7,8] Unlike the mammalian TGF-β isoforms, BMPs are secreted in an active form and, ... conditions Other structural studies indicate that the plexiform lesions of PPH are composed of monoclonal foci of proliferating endothelial cells [31], and microdissection of endothelial cells from these...

Ngày tải lên: 12/08/2014, 18:20

... acetaminophen -induced liver injury, before the development of overt liver injury and hypoxia [56], and in aged well-fed animals [57] The role of HIF stimulation during oxidative stress therefore needs further ... control of HIF synthesis, HIF controlling PHD synthesis, putative competing/intervening impacts of HIF-3α and PHD-3, cross-talk of HIF and other key regulators of gene expression (STAT, p-300 and others), ... others), further modification of HIF-α activity at the level of DNA hypoxiaresponsive elements by small ubiquitin-like modifiers (SUMO) and factor inhibiting HIF (FIH), and the effect of reactive...

Ngày tải lên: 14/08/2014, 07:21

... associated with the risk of CIN Acknowledgment Prof De Luca had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis ... 2 Introduction Contrast Induced Nephropathy (CIN) is one of the most common complications of procedures that require the use of contrast media [1,2] and is commonly defined as an ... far few studies have investigated the role of uric acid in the occurrence of CIN Therefore, the aim of the current study was to evaluate whether high level of serum uric acid in patients undergoing...

Ngày tải lên: 24/08/2016, 14:06

... reductase, catalase T and catalase A, did not alter the growth, either after the single treatments or after the associations of both treatments (Fig 1) On the other hand, the deficiency of sulfiredoxin, ... transcription [8,15] The involvement of mitochondria in the response of yeast to oxidative stress is not well understood, despite the fact that these organelles are the primary cellular source of ROS In ... ROS Therefore, they have been widely used as indicators of oxidative stress [41–43] To determine whether TSA1 deletion and the mitochondrial dysfunction can generate stressful conditions, the...

Ngày tải lên: 16/03/2014, 14:20

... indicating that ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal proton conductance ... selectively down-regulate ANT1 and ANT2 isoforms The siRNAs were tested for their ability to reduce the expression of their cognate mRNAs by absolute real-time quantification of ANT1 and ANT2 specific transcripts ... effect on cell viability might be a result of the onset of a programmed cell death process, we analyzed the effect of siRNA in the presence of the protein synthesis inhibitor puromycin As shown in...

Ngày tải lên: 29/03/2014, 09:20

... level and the urinary excretion of 8OHdG can be considered as a measure of the whole-body oxidative stress [20-22] The presence of 8OHdG in urine seems to originate mostly from the oxidation of the ... with the concentrations of the particle-related variables OC, NO x , and possibly the particulate copper content The increase of the oxidative stress marker was accompanied by an increase of urinary ... (Institute for Work and Health) for their help in the metal/creatinine analysis, and comments on the manuscript The medical team of the Institute for Work and Health (Prof Marcel-André Boillat, Dr...

Ngày tải lên: 20/06/2014, 00:20

... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and ... proximity of the N5 atom A putative flipping motion of the progesterone molecule along an axis parallel to the FMN plane aligns the C1-C2 with the 4666 plane of the isoalloxazine ring and in close ... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework of the enzyme or the active site The active sites of the enzymes are shown in stick format with the sigmaA...

Ngày tải lên: 20/02/2014, 02:21

... hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis The ApoE-/- mice are generated on a C57BL/6 background, and ... (Figures 2A and 2B) and iBAT (Figures 2C and 2D), respectively, and the analyses of mitochondria number (Figure 2E) and area (Figure 2F) In the PM2.5-exposed group, the mitochondrial number and area ... cycle They were fed ad libitum on standard laboratory mouse chow and had free access to water The investigation conforms to the Guide for the Care and Use of Laboratory Animals published by the...

Ngày tải lên: 06/03/2014, 19:20

... 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide Preincubation of cells with benzamide prevented the peak activity observed during oxidative ... death in response to oxidative stress and hence are used as therapeutic molecules to control oxidative stress- related diseases [12] However, the consequences of the blockade of cell death by PARP ... in the case of 5614 LA (h) 0.0 1.0 2.0 3.0 4.0 2.5 mM HA-5min To investigate the germination efficiency of spores and the fate of the germinated amoebae, spore revival was attempted Control and...

Ngày tải lên: 23/03/2014, 07:20

... detachment [7,52,57] Nevertheless, independently of the resulting effect of the thermal stress, all mechanisms point to the involvement of oxidative stress in the early stages of symbiosis breakdown ... antioxidant defenses and bleaching in animal tissue of A viridis The occurrence of oxidative stress in the animal tissue (ectoderm and gastroderm) and freshly isolated zooxanthellae of A viridis was ... shows the increase of endlabeling DNA after 48 h of thermal stress (25 °C) DNA fragmentation occurred largely in the gastrodermal tissue harboring the zooxanthellae (Fig 6B) Effect of heat stress...

Ngày tải lên: 30/03/2014, 10:20

... The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice Journal of ... adhered to the principles stated in the guide-book of laboratory animal care and user committee of the International Medical University and in accordance with the declaration of Helsinki The mice ... proportional to the amount of corticosteronetracer bound to the well The amount of free corticosterone present in the well was inversely proportional to the amount of emission The purification of serum...

Ngày tải lên: 20/06/2014, 00:20

... was found for the audience of our study, because these models are developed to evaluate psychosocial stress in general irrespective of the mode of work or the profession The focus of our study ... type of work, weekly working hours and the number of years of professional work • „Over the past few years, my job has become more and more demanding.“ (ERI6) • „During my work I am afraid of injuries ... asked about their attitudes to their profession More than two thirds reported that they suffered considerable stress from work and that they had difficulty in combining their professional and personal...

Ngày tải lên: 20/06/2014, 00:20

... to either the inhibition of GSH synthesis or increased utilization of GSH for detoxification of toxicant induced free radicals [33] The decrease in SOD, blood GSH and GSH-Px suggests that the ... ability to handle excessive free radicals [2] However, an increase in catalase activity enhances the scavenging ability of erythrocytes to handle the hydrogen peroxide to molecular oxygen and water ... [24] Similarly, GST catalyzes the conjugation of the reduced glutathione to electrophiles and protects cellular components from oxidative damage [16] Increased activity of GST was reported in Drosophila...

Ngày tải lên: 07/08/2014, 23:22

... levels than the other professional groups With the aging of the population there will be a growing demand to recruit health care professionals -especially in oncology On the other hand birth rates ... on the other side have produced a negative influence on the workplace environment and are potential sources of stress and burnout of cancer care workers in radiotherapy [12] The impetus for the ... deliverance of bad news and dealing with patient's death and suffering [11] These imbalances with increasing demand of human and material resources on the one hand side and a lack of sufficient...

Ngày tải lên: 09/08/2014, 09:22

... effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells Respir Res 2006, ... available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright ... Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in...

Ngày tải lên: 12/08/2014, 15:21

... status and the amount of 4-HNE is formed IL-8 and IL-6 are important in the recruitment and activation of inflammatory cells The induction of these proinflammatory mediators is regulated by the ... were harvested, and supernatants were collected for the measurement of IL-8 and IL-6 levels by sandwich ELISA CSE treatment dose-dependently induced the release of both IL-8 and IL-6 from human ... model for understanding the mechanisms of proinflammatory effects of cigarette smoke exposure To this extent, we studied the effect of CSE on oxidative stress (reduced glutathione and 4-hydroxy-2nonenal),...

Ngày tải lên: 12/08/2014, 16:20

... in the thickness of the interstitium, thinning of the epithelium and separation of the terminal air units This stage also marks the terminal differentiation stages of alveolar ATI and ATII epithelial ... on the 16th/17th week and continuing to the 25th-27th weeks of gestation The enlargement of the lumina of bronchi and terminal bronchioles characterizes the canalicular stage, in addition to the ... main bronchi The embryonic stage is marked by the formation of the lobular and segmental sections of the respiratory tree as columnarepithelium-lined tubes evident by the end of the fifth or...

Ngày tải lên: 12/08/2014, 18:20

... occupational stress disrupt the physical and mental health of the caregivers, but it also disrupts their quality of life (QOL) If medical institutions understand the stress experienced by their staff and ... showed that the QOL was higher when the number of daily work hours was between and 10, rather than between 11 and 12, and was higher when the number of patients cared for during the day and night ... to evaluate the different personal backgrounds and job responsibilities of these Vietnamese care attendants, as well as the occupational stress they had experienced and their QOL Further, stepwise...

Ngày tải lên: 08/08/2015, 19:23

... the food stocks, and the mood of the garrison The tactics of the Daily Mail captured the attention of the nation; the newspaper dramatized the situation of the town by emphasizing the danger that ... examine both the role of the press in the formation of public opinion about imperialism and the role of the press in the formation of the concept of public opinion itself Mafeking Night marks the powerful ... powerful beginning of the New Journalism at the same time as it marks the beginning of the end of the New Imperialism The coincidence of these occasions arises from the nature of the South African...

Ngày tải lên: 21/09/2012, 10:54