hypoxia in head and neck cancers clinical relevance and treatment

... NHS National Institute for Clinical Excellence Guidance on Cancer Services Improving Outcomes in Head and Neck Cancers The Manual Improving Outcomes in Head and Neck Cancers Cancer service ... from head and neck cancers, are discussed in Improving Outcomes in Haematological Cancers. 4 There are marked regional variations in the incidence of head and neck cancers, with rates ranging from ... connective and soft tissues, and various glands Skull base cancers are included among head and neck cancers, but tumours that originate in the skull are very rare; most cancers that invade the...

Ngày tải lên: 22/03/2014, 16:21

... modulated radiathion therapy in head and neck cancers: an update Head and Neck 2007, 29:387-400 Popovtzer A, Eisbruch A: Advances in radiation therapy of head and neck cancer Expert Rev Anticancer ... high-risk Clinical Target Volume (CTV1) was defined as GTV (guided by clinical criteria and FDGPET imaging whenever available) plus a margin for microscopic spread, and the low-risk Clinical Target ... the initial clinical experience with head and neck RapidArc patients, in terms of dosimetric analysis and acute toxicity results Methods and materials Patients’ selection This is a single-Institute...

Ngày tải lên: 09/08/2014, 09:20

... against infection and invading connective tissue There are still very few studies applying the methods of tissue engineering to produce tracheal replacements and to examine these in vitro and in ... to develop and establish novel therapeutical options in head and neck surgery in case of delayed wound healing after surgical treatment A main focus of the own biocompatibility testing was the ... intubation over several days as an intratracheal splinting An external splinting by metallic microplates in the surgical tracheal reconstruction was described first time by Zalzal and Deutch in...

Ngày tải lên: 25/10/2013, 08:20

... no staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of ... c-erbB2 and other markers in patients treated with chemotherapy for recurrent head and neck cancer Head Neck 2000, 22:599-608 33 Werkmeister R, Brandt B, Joos U: Clinical relevance of erbB-1 and ... membranous staining and Her3 (b, membranous and cytoplasmic staining, and c, predominant cytoplasmic staining) 400 × magnification Takikita et al Journal of Translational Medicine 2011, 9:126...

Ngày tải lên: 18/06/2014, 22:20

... strong (3+), and 26% showed no TLR4 staining (Figure 1; Table 3) TLR4 staining (all scores) showed a diffuse and fine granular cytoplasmatic pattern Distinct membrane staining was observed in some ... CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and AS wrote the manuscript All authors read and approved the final ... methods for genotyping (e.g direct sequencing, pyrosequencing or TaqMan-genotyping) were not considered Figure TLR4 immunohistochemistry in head and neck squamous cell carcinomas (A) Strong (score...

Ngày tải lên: 18/06/2014, 22:20

... no staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of ... c-erbB2 and other markers in patients treated with chemotherapy for recurrent head and neck cancer Head Neck 2000, 22:599-608 33 Werkmeister R, Brandt B, Joos U: Clinical relevance of erbB-1 and ... membranous staining and Her3 (b, membranous and cytoplasmic staining, and c, predominant cytoplasmic staining) 400 × magnification Takikita et al Journal of Translational Medicine 2011, 9:126...

Ngày tải lên: 20/06/2014, 04:20

... strong (3+), and 26% showed no TLR4 staining (Figure 1; Table 3) TLR4 staining (all scores) showed a diffuse and fine granular cytoplasmatic pattern Distinct membrane staining was observed in some ... CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and AS wrote the manuscript All authors read and approved the final ... methods for genotyping (e.g direct sequencing, pyrosequencing or TaqMan-genotyping) were not considered Figure TLR4 immunohistochemistry in head and neck squamous cell carcinomas (A) Strong (score...

Ngày tải lên: 20/06/2014, 04:20

... research and clinical purpose in order to determine the global functional outcome of speech and voice after the treatment of head and neck cancer It allows quantifying the intelligibility also in severely ... Scottish Intercollegiate Guidelines Network (SIGN), Diagnosis and management of head and neck cancer A national clinical guideline, Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network ... a low intelligibility and hence a low recognition rate and vice versa The agreement between WR and the mean scores of the perceptual ratings is very high in both patient groups and is in the...

Ngày tải lên: 21/06/2014, 20:20

... Cummings B, Dawson L, Keller A, Kim J, Ringash J, Yu E, Hendler A, Waldron J: Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers Int ... volume delineation in head- and- neck cancer using CT and PET/CT fusion Int J Radiat Oncol Biol Phys 2006, 65:726-732 Black QC, Grills IS, Kestin LL, Wong CY, Wong JW, Martinez AA: Defining a radiotherapy ... DE, Andrade RS, Flickinger J, Johnson J, Agarwala SS, Wu A, Kalnicki S, Avril N: Hybrid PET-CT simulation for radiation treatment planning in head- and- neck cancers: a brief technical report Int...

Ngày tải lên: 09/08/2014, 09:20

... patient-reported and objective observer-assessed instruments Patient-reported clinical swallowing function was evaluated using the “European Organization for Research and Treatment of Cancer (EORTC) head- and- neck ... swallowing dysfunction after curative radiotherapy in head and neck cancer Radiotherapy and Oncology 2009, 90:189-195 Joke W, Kim De R, Duprez F, et al: Acute Normal Tissue Reactions in Head- and- Neck ... outside the PTVs in all cases This sparing structure has been defined prospectively in January 2002, when we implemented IMRT clinically, and was provided to be used in all midline areas where...

Ngày tải lên: 09/08/2014, 09:20

... head and neck: interdisciplinary collaboration between head and neck surgeons in 305 cases Ann Plast Surg 1996, 36:37-43 Amarante J, Reis J, Costa-Ferreira A, Malheiro E, Silva A: Head and neck ... were often seen in patients suffering from head and neck cancer [31] However, in many cases surgical treatment is not sufficient and adjuvant therapy might be necessary [1,2] In these cases neoadjuvant ... 2) and patients treated with neoadjuvant chemoradiation (40 Gy and cisplatin or carboplatin and paclitaxel, group3) Intima of the veins (A, * p < 0.05 vs group1 and group 2), media of the veins...

Ngày tải lên: 09/08/2014, 09:20

... Urba S, Lin A, Schipper MJ, Wolf GT: Recurrences near base of skull after IMRT for head- and- neck cancer: implications for target delineation in high neck and for parotid gland sparing Int J Radiat ... function sparing in patients with head- and- neck cancers receiving intensitymodulated or three-dimensional radiation therapy: initial results Int J Radiat Oncol Biol Phys 2001, 49:907-916 Vineberg ... D, Dawson K, Dinardo L, Reiter E: Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head- and- neck squamous cell carcinomas: II clinical results Int J Radiat Oncol...

Ngày tải lên: 09/08/2014, 10:20

... range of inhibitors currently under investigation [3] Promising preclinical studies have prompted the development of clinical trials testing EGFR inhibitors as singleagent therapy or in combination ... Her-2, Her-3, and Her-4) These receptors are composed of an extra-cellular ligand-binding domain, a hydrophobic transmembrane segment, and an intracellular tyrosine kinase domain Binding to EGFR ... regarding overall survival [29] Tyrosine kinase inhibitors (TKI) and RT In preclinical studies, when gefitinib was combined to RT, strikingly greater than additive effects were observed in vivo...

Ngày tải lên: 09/08/2014, 10:20

... has been defined by contouring the anatomic region of the initial primary and nodal GTV, considering the preoperative diagnostics and the clinical and histological findings The PTV1 includes the ... Approximately weeks after completion of treatment all patients were also seen regularly in our joint clinics at the Department of Head and Neck Surgery or Head, Neck and Maxillofacial Surgery Further ... postoperative radiotherapy and weekly cisplatin infusion for locally advanced squamous cell carcinoma of the head and neck: preliminary report of a randomized trial Int J Radiat Oncol Biol Phys...

Ngày tải lên: 09/08/2014, 10:21

... ataxia-telangiectasia-mutated (ATM) improved radiosensitivity in rodent head and neck cancer models [14-16] In addition, superior imaging in head and neck cancers resulted from the use of superparamagnetic ... Harrison PR: Profiling early head and neck cancer Nat Rev Cancer 2005, 5:127-135 Marur S, Forastiere AA: Head and neck cancer: changing epidemiology, diagnosis, and treatment Mayo Clin Proc 2008, ... the head and neck Bmj 1994, 308:961-966 Amir Z, Kwan SY, Landes D, Feber T, Williams SA: Diagnostic delays in head and neck cancers Eur J Cancer Care (Engl) 1999, 8:198-203 Hunter KD, Parkinson...

Ngày tải lên: 11/08/2014, 00:23

... clinical monitoring (92% and 75% respectively) When comparing retrospectively the three monitoring schemes, i.e clinical monitoring alone, bone scans alone and clinical and bone scan monitoring together, ... techniques, including clinical observation, hand-held Doppler ultrasonography, surface temperature probes and pinprick testing, was highly effective in non-buried free flaps but had not been reliable in ... vein providing the skin pedicle Bone scintigraphy was normal (score 2) and the ensuing clinical course was uncomplicated Revision surgery was performed within the first postoperative days in...

Ngày tải lên: 11/08/2014, 23:22

... which included 17 genes with p53 binding sites in cluster A and 26 genes with NF-κB binding sites in cluster B In cluster A genes with p53 binding sites, putative models containing three and four ... from clinical studies in more complex tissue specimens in independent studies at our and other institutions, supporting the biologic and clinical relevance of genes within clusters identified in ... signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines Int J Cancer 2002, 99:538-548 Yu M, Yeh J, Van Waes C: Protein kinase...

Ngày tải lên: 14/08/2014, 07:21

... interdisciplinary platform The last meeting of the SCBS was held in 2005 in Maastricht/Netherlands during the "Xth International Facial Nerve Symposium (Chairman: Hans Manni)" with election of Rainer ... Jacqueline Diels (USA), Secretary; Paul Mulkens (Netherlands), Treasurer, Mihael Podvinec (Switzerland) is Webmaster and Kedar Adour (USA) President-Emeritus The next meeting will be held in Rome ... Head & Face Medicine 2007, 3:24 http://www .head- face-med.com/content/3/1/24 Ј Evaluation of grading systems An important aspect of the SCBS is that these problems are discussed on an interdisciplinary...

Ngày tải lên: 11/08/2014, 23:22

... Head & Face Medicine 2008, 4:5 http://www .head- face-med.com/content/4/1/5 Table 1: Diseases treated with botulinum toxin type A in head and face medicine with high interdisciplinary relevance ... [23,27]) and became the first line treatment option in these patients To get an optimal outcome, we recommend marking of the sweating area by Minor's test and then dividing the sweating area in "boxes" ... application of botulinum toxin type A is a helpful and minimally invasive treatment option in different functional disorders improving the quality of life in patients with head and face disorders...

Ngày tải lên: 12/08/2014, 00:20

Ngày tải lên: 15/02/2014, 04:20