hypothetical introduction of bse into the united states
Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt
Ngày tải lên :
19/02/2014, 17:20
... platform spread on the b-sheet from b4 to b2 in the 5¢)3¢ direction More often, the nucleotide at the 5¢ end of the central dinucleotide contacts the loops at the bottom of the b-sheet (loop and ... Specificity of this central dinucleotide recognition is provided by other non conserved elements of the RRMs The two most frequently observed elements are the protein side chains at the surface of the ... 3A) The contacts with these two RNP positions result in a characteristic arrangement of the nucleic acid strand on the b-sheet surface in which the 5¢ end is located on the first half of the b-sheet...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
Ngày tải lên :
05/03/2014, 23:20
... must, then, be present in this preparation Of particular importance is the finding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38 In other words, the ... 0.05) Numbers of observations are in parentheses Enhanced overflow of all purines was observed during EFS BoNTA significantly reduced the EFS-evoked, but not the spontaneous, overflow of ATP in bladders ... release in the bladder tissue in bladders from CD38) ⁄ ) mice (n = 11) (P > 0.05) These values were not significantly different from the ST ) PS amounts of ATP in the absence of cADPR Note that the peak...
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Báo cáo khoa học: Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression pdf
Ngày tải lên :
07/03/2014, 10:20
... in the transfected cells The observed localization of trypsinogen was the same when GFP was fused to the N- or the C-terminal end of the molecule (data not shown) We determined the number of ... the longer isoform (Isoform A) and no traces of the shorter isoform (Isoform B) By contrast, the expression of only Isoform B was detected in the cells transfected with the p28LT4 construct (Fig ... identied leucine as the only N-terminal amino acid of the isolated protein, irrespective of the specicity of the immobilized antibody (Fig 1C) In order to prove the integrity of the isolated protein,...
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Báo cáo sinh học: "The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans" ppt
Ngày tải lên :
06/08/2014, 18:21
... pathfinding of the epaxial nerve fibers (Figure 5n) The epaxial nerve is formed by axons of motoneurons of the MMC These axons leave the spinal cord together with the neurons of the LMC to form the ventral ... phenotype; e911 was the strongest allele among all the nine alleles that we tested For the other unc-76 alleles, the AWCOFF phenotype varied from 6% to 30% Interestingly, the strength of the AWC expression ... structure, with a dendrite extending to the tip of the nose and an axon extending into the nerve ring (Figure 5i) In unc-69(e587) mutants, the axon of the AWC neuron often stopped prematurely (Figure...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
Ngày tải lên :
12/08/2014, 15:22
... basis of the rate of accumulation of joint damage over a specific interval of time, and therefore an effect of I50V on severity may have been overlooked The pattern of IL-17 suppression seen in the ... http://arthritis-research.com/content/13/1/R15 Page of the healthy control group genotypes There was a more pronounced suppression of the percentage of IL-17+ cells in the I/I genotype culture, as shown in the top row of Figure 3A, ... compared to the suppression of IL-17+ cells in the V/V genotype culture, shown in the bottom row In these cultures, the majority of IL-17+ cells were CD4 + , but some CD4-IL-17+ cells were also observed...
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Báo cáo y học: " The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking" doc
Ngày tải lên :
13/08/2014, 09:20
... Figure of either the dileucine- or the tyrosine-based motifs affect the TGN localization of CD25 chimeras Mutation Mutation of either the dileucine- or the tyrosine-based motifs affect the TGN ... mutagenesis (figure 2B) We then analyzed the effects of these mutations on the intracellular localization of the resulting mutated chimeras Mutation of the tyrosine 23 to serine in either MLV and MPMV ... better understand the molecular basis of the intracellular sorting of the viral chimeras, we assessed the ability of the viral CT to physically interact with components of the adaptor protein...
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Design of Biomembrane-Mimicking Substrates of Tunable Viscosity to Regulate Cellular Mechanoresponse
Ngày tải lên :
24/08/2014, 13:45
... temperature, μ is the viscosity of the lipid membrane, μ’ is the viscosity of the surrounding fluid (i.e water), the thickness of the membrane, is is Euler’s constant, and a is the radius of the cylinder ... interest in the lateral structure of membranes and the way they regulate the activity of constituent membrane proteins has prompted the design of cell mimetic surfaces [48] The application of solid ... along the boundaries of specimen and background These are a consequence of the phase-retarding ring of the phase plate also transmitting small amounts of the light diffracted from the specimen While...
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Advanced control strategies for automatic drug delivery to regulate anesthesia during surgery
Ngày tải lên :
14/09/2015, 08:25
... anesthetics Inhaled anesthetics are used by many anesthesiologists for the maintenance of anesthesia while the intravenous anesthetics are used at the start of the surgical procedure as they ... representation of triad combination of anesthesia Hypnosis describes a state of anesthesia which is not only related to unconsciousness of the patient but also to the disability of the patient to ... compared to most other drugs used for the rapid intravenous induction of anesthesia This is one of the most important advantages of propofol compared to other intravenous anesthetic drugs Inhalation...
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Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death docx
Ngày tải lên :
16/03/2014, 04:20
... evaluation of surface expression of the adhesion molecule CD47 are shown in the upper panels Numbers represent the percentage of highly positive platelets In the lower panels, dot plots of the physical ... points The numbers in the boxed areas represent the percentages of cells with hyperpolarized mitochondria The percentages of cells with depolarized mitochondria are shown below the dashed line The ... were observed (see Fig 4), no significant activation of these caspases was detected As a positive control, platelets treated with UÆmL)1 of thrombin 850 for h (in the presence or absence of the...
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Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death potx
Ngày tải lên :
16/03/2014, 04:20
... stabilizes the protein structure to a similar extent as in the case of the wild-type enzyme The mode of hydrolysis of glucosamine oligosaccharides [5,15,16], however, provides insight into the interaction ... enhanced by the addition of the azide ion The effect of the azide concentration on the reaction rate, shown in Fig 4B, clearly demonstrates that the rate enhancement depends upon the azide concentration ... refers to the distance of the first residue from the N-terminus of the mature protein (Csn-N174; chitosanase from B circulans MH-K1) or of the precursor protein as stored in GenBank (other chitosanases)...
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Báo cáo khoa học: Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing docx
Ngày tải lên :
23/03/2014, 03:20
... phosphorylation of Cas [8] PP2 treatment delayed the protrusion of cells toward the wound and disrupted reorientation of the Golgi in the direction of migration, which is consistent with the findings of previous ... on the leading edge Fifty cells on the wound edge in each of three independent experiments were evaluated for the localization of Cdc42 The percentage of these cells with Cdc42 localized on the ... whereas more than 50% of the CasWt cells at the wound edge contained Cdc42 localized on the leading edge, < 10% of the CasKo cells at the wound edge showed localization of Cdc42 on the leading edge...
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Báo cáo khoa học: Transcription factor specificity protein 1 (SP1) and activating protein 2a (AP-2a) regulate expression of human KCTD10 gene by binding to proximal region of promoter pot
Ngày tải lên :
30/03/2014, 02:20
... the start the codon of human KCTD10 and 5¢ cDNA end of UBE3B (Fig 1B) The transcription start site (TSS) of KCTD10 was determined by primer extension assay An antisense primer on the 3¢-end of ... this 271 bp of the 3¢-end showed only a 8.7% increase These results suggested that the functional promoter region was located in the 271 bp region of the 3¢-end (from )241 to +30) Further deletion ... maintain the hypomethylation of CpG islands [13,14], and interacts with some components of the basal transcription complex [15,16]; therefore it plays a critical role in the assembly of the transcription...
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báo cáo sinh học:" Narrowing the gap between eye care needs and service provision: a model to dynamically regulate the flow of personnel through a multiple entry and exit training programme" pdf
Ngày tải lên :
18/06/2014, 17:20
... Within reason, these additional modules can be learnt some time after the completion of the original set of modules In the case of eye care, this permits the definition of a new role of non-physician ... only the four stages of optometry training At the end of the first year, graduates can either enter the workforce as refractionists, move onto Stage of training or will have dropped out of the ... showing the stocks and flows of personnel through training and into and out of the The computable model of an eye care MEES showing the stocks and flows of personnel through training and into and...
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in the crosshairs famous assassinations and attempts from julius caesar to john lennon
Ngày tải lên :
03/07/2014, 16:10
... heart the wisdom of the adage that opined that if you want to kill a dog, you don’t cut off its tail, you cut off its head—and the Southerners were horrified After the failure of the raid, the ... knife wounds, the combined effect of which were fatal Caesar died on the floor of the Senate in front of the statue of Pompey JUDICIAL OUTCOME: Cassius and Brutus spoke to the Senate the day after ... given by the Park Police or the Secret Service (See Marcelino Corniel’s story on page 38.) The First Family’s residence is on the second floor of the White House in the rear The windows of the residence...
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Báo cáo y học: "CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis." ppsx
Ngày tải lên :
11/08/2014, 08:22
... curve (AUC) of the disease scores over the course of the experiment (Figure 7A and 7B, respectively) At the termination of the study, we assessed the number of CD11b+Ly6Chi monocytes in the peripheral ... 4B) Thus, the in vivo effects of MK0812 align well with the predicted potency based on the in vitro characterization of the compound In the course of this experiment, we noted that the circulating ... define the pharmacokinetic pharmacodynamic relationship for this compound We observed a linear relationship between the administered dose of MK0812 and the levels of the compound present in the...
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báo cáo khoa học: " Can NGOs regulate medicines markets? Social enterprise in wholesaling, and access to essential medicines" pdf
Ngày tải lên :
11/08/2014, 14:21
... interviewed, two non-profit and one for-profit firm did their own repeated inspections of manufacturing sites One used only suppliers they had approved themselves At the time of the research, the WHO had ... part of their business The non-profit wholesalers did not sell to the private sector The experience of the charity that became a division of a commercial firm illustrates this point, as the procurement ... ‘they are coming round’ The specialist focus on the ‘social’ market was presented as implicit evidence of lack of profiteering, alongside the explicit social mission The marketing manager of the...
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Báo cáo y học: "Suicide attempts and related factors in patients admitted to a general hospital: a ten-year crosssectional study (1997-2007)" pot
Ngày tải lên :
11/08/2014, 15:22
... function, and that the variance of the dependent variable is a known function Page of 10 of its expectation The parameters of the model are then estimated subsequent to the specification of the intracluster ... population, rather the sub-set of patients who are admitted to hospital Nonetheless, given the magnitude of the problem in this sub-set of patients, we feel that it is relevant to be able to define the ... for the former [44] The possibility of a certain degree of under-reporting of attempted suicide in the present study cannot be excluded Another selection bias is associated with the use of hospital...
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Báo cáo khoa học: "Prevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in questing Ixodes ricinus ticks in relation to the density of wild cervids" pptx
Ngày tải lên :
12/08/2014, 18:22
... destruction by the complement system of a particular host species are lysed early in the midgut of the feeding tick and are thereby eliminated by the host [10] These findings have led to the hypothesis ... in Great Britain in the absence of other reservoir hosts which suggests that I trianguliceps is a competent vector The aim of the present study was to compare the prevalence of B burgdorferi s.l ... over to prevent tick infection and lyse the spirochetes early in the midgut of the feeding tick, and are thereby eliminated by the host [10] Low levels of B burgdorferi s.l in ticks werre found...
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Báo cáo y học: " Tetraspanins regulate cell-to-cell transmission of HIV-1" pot
Ngày tải lên :
12/08/2014, 23:21
... dividing the amount of p24 released by the total amount of p24 produced (cells + supernatant), then normalizing to the mock-treated sample (set to 100%) Data shown represent the mean of independent ... are in line with findings of the Marsh group, who reported that knockdown of CD63 in macrophages did not alter the efficiency of viral release, regardless of whether the knockdown was done prior ... depends on endogenous levels of the tetraspanin at the surface in producer cells, with CD63 displaying the lowest surface fraction of the tetraspanins analyzed in the Page of 13 (page number not for...
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