hypothermia hyperthermia and rhabdomyolysis
báo cáo khoa học: " Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis" potx
Ngày tải lên :
10/08/2014, 10:20
... left kidney, and about 200 mg of the anterior edge of the liver were sampled and kept at -80° C until the platinum assay The comparison of groups and should assess the effect of hyperthermia; ... cavity (kidney and thoracic muscle), the accumulation of platinum was lower in group (adrenaline) than in groups (control) and (HIPEC) (p = 0.05 and p = 0.001, for the kidney and the thoracic ... locoregional hyperthermia [27] This could have modified both blood concentrations and vascular permeability, and may explain why plasmatic cisplatin was about times greater at 41°5 than at 38°C and why...
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Báo cáo y học: "New onset diabetes complicated by haemolysis and rhabdomyolysis: a case report and review of the literature" pot
Ngày tải lên :
11/08/2014, 23:21
... and creatine kinase in the early identification of G6PD deficiency and rhabdomyolysis Case presentation A 54-year-old Kenyan man presented with a 3-day history of reduced appetite, weakness and ... electrolytes and renal function normalised but CRP increased to 350 mg/l and ceftriaxone and metronidazole were started for presumed aspiration pneumonia Clinically the patient improved and began ... transfusions and all medication was stopped apart from the intravenous insulin and intravenous fluids His haemoglobin increased, reticulocytes count rose and serum creatine kinase and bilirubin...
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báo cáo hóa học:" Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)" pptx
Ngày tải lên :
20/06/2014, 07:20
... mouse/cage) and monitored for recovery and discomfort Immediately (0 h) and 24 h after perfusion, mice were euthanized and tumors, kidneys, liver, spleen, heart and brain were dissected and snap ... sodium arsenite and hyperthermia modulate mechanisms of cisplatin resistance in vivo We developed murine models of HIPEC treatment and metastatic human EOC to investigate if NaAsO and hyperthermia ... NER by inhibiting induction of p53 and XPC and to activate MMR by maintaining high levels of MSH2 and enhancing platinum accumulation in tumors NaAsO2 and hyperthermia might not produce added...
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Báo cáo hóa học: " Synthesis of Bio-Compatible SPION–based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia" docx
Ngày tải lên :
21/06/2014, 07:20
... substrate and the base liquid was allowed to evaporate Magnetic Hysteresis loops of SPIONs were measured at room temperature and at a low temperature of K and are depicted in Fig Field-cooled (FC) and ... particle is functionalized and introduced for hyperthermia application So, the power loss and hence the heat generated becomes a function of domain magnetization, anisotropy and volume of the particle ... electrostatic and steric effects and could easily get conjugated to iron oxide particles Iron oxide is most recommended because of its higher magnetization values, lesser toxicity [19] and the ease...
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Chapter 017. Fever and Hyperthermia (Part 1) docx
Ngày tải lên :
06/07/2014, 12:20
... ovulation and remains at that level until menses occur Body temperature can be elevated in the postprandial state Pregnancy and endocrinologic dysfunction also affect body temperature Fever versus Hyperthermia ... infections and rapid breathing Lower-esophageal temperatures closely reflect core temperature Tympanic membrane (TM) thermometers measure radiant heat from the tympanic membrane and nearby ear canal and ... raised, neurons in the vasomotor center are activated and vasoconstriction commences The individual first notices vasoconstriction in the hands and feet Shunting of blood away from the periphery...
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Chapter 017. Fever and Hyperthermia (Part 2) docx
Ngày tải lên :
06/07/2014, 12:20
... prescription psychotropic drugs and illicit drugs Drug-induced hyperthermia may be caused by monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and amphetamines and by the illicit use of ... increased thermogenesis It is important to distinguish between fever and hyperthermia since hyperthermia can be rapidly fatal and characteristically does not respond to antipyretics In an emergency ... response to halothane and other inhalational anesthetics or to succinylcholine Elevated temperature, increased muscle metabolism, muscle rigidity, rhabdomyolysis, acidosis, and cardiovascular instability...
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Chapter 017. Fever and Hyperthermia (Part 3) pot
Ngày tải lên :
06/07/2014, 12:20
... cytokine is encoded by a separate gene, and each pyrogenic cytokine has been shown to cause fever in laboratory animals and in humans When injected into humans, IL-1 and TNF produce fever at low doses ... acute-phase proteins, and generalized symptoms of malaise Pyrogenic Cytokines Cytokines are small proteins (molecular mass, 10,000–20,000 Da) that regulate immune, inflammatory, and hematopoietic ... of 1–10 µg/kg is required for fever production A wide spectrum of bacterial and fungal products induce the synthesis and release of pyrogenic cytokines, as viruses However, fever can be a manifestation...
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Chapter 017. Fever and Hyperthermia (Part 4) potx
Ngày tải lên :
06/07/2014, 12:20
... infection.[newpage] APPROACH TO THE PATIENT: FEVER OR HYPERTHERMIA Physical Examination Attention must be paid to the chronology of events and to other signs and symptoms preceding the fever The temperature ... CNS Several viral diseases produce active infection in the brain Glial and possibly neuronal cells synthesize IL-1, TNF, and IL-6 CNTF is also synthesized by neural as well as neuronal cells What ... receptors are called Toll-like receptors and are similar in many ways to IL-1 receptors The direct activation of Toll-like receptors also results in PGE2 production and fever Production of Cytokines...
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Chapter 017. Fever and Hyperthermia (Part 5) pdf
Ngày tải lên :
06/07/2014, 12:20
... of an unusual febrile disease For example, the usual times of peak and trough temperatures may be reversed in typhoid fever and disseminated tuberculosis Temperature-pulse dissociation (relative ... brucellosis, leptospirosis, some drug-induced fevers, and factitious fever In newborns, the elderly, patients with chronic renal failure, and patients taking glucocorticoids, fever may not be ... period and then a relapse of days of fever In the Pel-Ebstein pattern, fever lasting 3–10 days is followed by afebrile periods of 3–10 days; this pattern can be classic for Hodgkin's disease and...
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Chapter 017. Fever and Hyperthermia (Part 6) doc
Ngày tải lên :
06/07/2014, 12:20
... malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome Dantrolene at similar doses is indicated in the neuroleptic malignant syndrome and in drug-induced hyperthermia ... neuroleptic malignant syndrome and in drug-induced hyperthermia and may even be useful in the hyperthermia of the serotonin syndrome and thyrotoxicosis The neuroleptic malignant syndrome may also ... et al: Beneficial response to anakinra and thalidomide in Schnitzler's syndrome Ann Rheum Dis 65:542, 2006 Dinarello CA: Infection, fever, and exogenous and endogenous pyrogens: Some concepts...
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Chapter 020. Hypothermia and Frostbite (Part 1) potx
Ngày tải lên :
06/07/2014, 12:21
... lead to hypothermia Hypothyroidism—particularly when extreme, as in myxedema coma—reduces the metabolic rate and impairs thermogenesis and behavioral responses Adrenal insufficiency and hypopituitarism ... surface-to-mass ratio and their lack of effective shivering and adaptive behavioral responses In addition, malnutrition can contribute to heat loss because of diminished subcutaneous fat and because of ... loss), reduces thermogenesis and gluconeogenesis, and may impair judgment or lead to obtundation Phenothiazines, barbiturates, benzodiazepines, cyclic antidepressants, and many other medications...
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Chapter 020. Hypothermia and Frostbite (Part 2) pot
Ngày tải lên :
06/07/2014, 12:21
... the presentation is often more subtle and other disease processes, toxin exposures, or psychiatric diagnoses should be considered After initial stimulation by hypothermia, there is progressive depression ... level of consciousness in a patient with mild hypothermia should raise suspicion of an overdose or CNS dysfunction due to infection or trauma Table Hypothermia 20-2 Physiologic Changes Associated ... n; oxygen triiodot apathy; vasoconstri consumptio hyronin n; e and ia; increase in bronchorrhe thyroxin impaire cardiac d output and bronchospa increase judgme blood in a; ased increase preshiverin...
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Chapter 020. Hypothermia and Frostbite (Part 3) doc
Ngày tải lên :
06/07/2014, 12:21
... past 33°C should be predicated on the type and severity of the precipitants of hypothermia There are no validated prognostic indicators for recovery from hypothermia A history of asphyxia with secondary ... survival Diagnosis and Stabilization Hypothermia is confirmed by measuring the core temperature, preferably at two sites Rectal probes should be placed to a depth of 15 cm and not adjacent to ... facilitate monitoring of cold-induced diuresis Dehydration is commonly encountered with chronic hypothermia, and most patients benefit from a bolus of crystalloid Normal saline is preferable to lactated...
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Chapter 020. Hypothermia and Frostbite (Part 4) pot
Ngày tải lên :
06/07/2014, 12:21
... secondary hypothermia Active external rewarming is best accomplished with forced-air heating blankets Other options include radiant heat sources and hot packs Monitoring a patient with hypothermia ... catheters with outflow suction Like peritoneal dialysis, standard hemodialysis is especially useful for patients with electrolyte abnormalities, rhabdomyolysis, or toxin ingestions Extracorporeal blood ... coupled with rhabdomyolysis There is no evidence that extremely rapid rewarming improves survival in perfusing patients The best strategy is usually a combination of passive, truncal active, and active...
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Chapter 020. Hypothermia and Frostbite (Part 5) pdf
Ngày tải lên :
06/07/2014, 12:21
... cause of hypothermia, the relaxation phase of the Achilles reflex is prolonged more than the contraction phase Hypothermia obscures most of the symptoms and signs of infection, notably fever and leukocytosis ... with standard therapy The administration of parenteral levothyroxine to euthyroid patients with hypothermia, however, is potentially hazardous Because laboratory results can be delayed and confounded ... Preexisting ventricular ectopy may be suppressed by hypothermia and reappear during rewarming None of the class I agents has proved to be safe and efficacious When available, bretylium tosylate...
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SỐT (Fever and hyperthermia) potx
Ngày tải lên :
05/08/2014, 20:22
... trước thị giác vùng đồi thị Interleukin-1 kích thích trình tổng hợp prostaglandin nhóm E từ acid arachidonic Prostaglandin E mà đặc biệt PG-E1 kích thích trình tổng hợp adenyl monophosphat vòng ... tăng sản xuất prostaglandin E làm tăng trình sinh nhiệt ngược lại (aspirin dẫn xuất có tác dụng hạ sốt thông qua chế ức chế men cyclooxygenaza ngăn cản tổng hợp prostaglandin E1, E2 Glucocorticoid ... hạ nhiệt thông qua chế ức chế sản xuất interleukin-1 v.v ) Prostaglandin đặc hiệu CSN ngoại sinh CSN nội sinh (IL-1) Prostaglandin Acid arachidonic AMP vòng Hypothalamus (Dưới đồi) TB bắp tăng...
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báo cáo khoa học: "Inflammatory myopathy and severe rhabdomyolysis induced by leuprolide acetate therapy for prostate cancer: a case report" pot
Ngày tải lên :
10/08/2014, 23:20
... strength in both his hands and his feet, but active lifting of his head, legs, and arms was barely possible while he was supine, and his speech was slurred His reflexes, eye movements, and cranial nerve ... creatinine 51 μmol/L, BUN 6.4 mmol/L, sodium 122 mmol/L, and potassium 4.3 mmol/L His serum 25OH vitamin D level and thyroid gland function were normal, and his human immunodeficiency virus test was negative ... Histological and immunohistochemical tests (inflammation marker, membrane attack complex, and major histocompatibility complex class I) showed signs of muscle necrosis (Figure 1, Figure 2) and diffuse...
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báo cáo khoa học: " Hypothyroidism in a five-year-old boy with rhabdomyolysis and recent history of cardiac tamponade: a case report" pptx
Ngày tải lên :
10/08/2014, 23:20
... anti-double-stranded DNA results were negative and serum complement (C3 and C4) levels were within normal limits HIV rapid test and serum antibody (IgM) tests for cytomegalovirus and Epstein Barr ... doctor in charge of our patient and revised the case report ER revised the case report CL and SS were consulting physicians and revised the case report All authors read and approved the final manuscript ... psychomotor development, and vaccinations had been given on schedule On physical examination, his vital signs were within normal limits and he was not febrile His weight was 13.6 kg and his height 98...
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Báo cáo y học: " Near fatal posterior reversible encephalopathy syndrome complicating chronic liver failure and treated by induced hypothermia and dialysis: a case report" pps
Ngày tải lên :
11/08/2014, 17:21
... intubated for airway protection and to facilitate endoscopy He was resuscitated with crystalloids, 5% albumin, packed cells and fresh frozen plasma and treated with vancomycin and piperacillin/ tazobactam ... induced hypothermia has been shown to reduce cerebral edema following cardiac arrest and in patients with acute liver failure [15,16] The mechanisms by which hypothermia reduces neuronal injury and ... ammonia 151mmol/L (normal 11 to 35mmol/L) and lactate of 6.1mmol/L (normal 0.6 to 1.7mmol/L) His blood urea nitrogen (BUN) and creatinine were 9mmol/L and 124mmol/L, respectively The patient was...
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