... augmenting an intel-ligent tutoring system with human- supplied ca-pabilities: Adding Human- Provided EmotionalScaffolding to an Automated Reading Tutor thatListens. In Proc. Intelligent Tutoring ... 2002. Intelligent tutoring systemswith conversational dialogue. AI Magazine.P. W. Jordan, M. Makatchev, and K. VanLehn.2004. Combining competing language under-standing approaches in an intelligent ... emotion labels. Instead, it contains examplesof labeled dialogue excerpts (as in Figure 1, excepton human- human data) with links to correspondingaudio files. The cues mentioned in the discussion...
... Using independent organizations to hold or administer the institution's financial interest.! Including individuals from outside the institution in the review and oversight of financialinterests ... financial interests toCOICs. ! Establishing procedures for disclosure of institutional financial relationships to COICs.! Providing training to appropriate individuals regarding financial interest ... institutional financial interests in research.! Establishing criteria to determine what constitutes an institutional conflict of interest,including identifying leadership positions for which the individual's...
... secondarykinetic isotope effects [19,27–29]. The existence of agem secondary kinetic isotope effect has the effect ofattenuating the rate of C-H bond-breaking, so in prin-ciple the intrinsic kinetic ... coumarin O-deethylation inhuman liver micro-somes. Human P450 1A2 also catalyzed 3-hydroxylation of 7-methoxy(OMe) coumarin at appreciable rates but P450 2E1 did not. Intramolecularkinetic ... catalyzing this reaction in human liver microsomes and indicating that the C-H bond-breaking stepmakes a major contribution to the rate of this P450 (1A2) reaction. Thus,the rate-limiting step...
... thatcould be inhibited by protein kinase inhibitor (PKI). In the presence of cAMP approximately one-third of thePKI-inhibited activity was released into the extract, indi-cating that the precipitated ... potential binding of non-Cb2C-subuints to the R-subunits. The resulting precipitateswere analysed by SDS ⁄ PAGE and immunoblottingusing anti-Cmono (Fig. 2B) and a PKA-specific kinaseassay. ... immunoprecipitates.Indirect immunofluorescenceResting human T cells were allowed to attach to poly(l-lysine) coated cover slips for 30 min at room temperature,S. Ørstavik et al. Novel PKA holoenzymes in human...
... as insulin receptor sub-strates and adiponectin [8,9], resulting in obesity-relatedinsulin resistance [11–13]. In an in vitro model of ERstress induced by proteasome inhibition, the stressinduced ... aputative adaptor protein that interacts with adiponectinreceptors, insulin and adiponectin signaling are nowconsidered to be linked in the peripheral organs ofinsulin action, such as the ... predicted ATF3-binding site in theregulatory region of the human AdipoR2 gene usingchromatin immunoprecipitation (ChIP). This showedspecific in vivo binding of ATF3 to the putativeATF3-binding element...
... contributing to the significantchanges in ligand-binding activity. In addition, the factthat S168T retained its ligand-binding activity cannotexclude the possibility that S168 in IP and S181 in TPlead ... ligand-binding assay (Fig. 5B), in which one mutant, S168A, completely lost its ligand-binding activity, and another mutant, S168T, recov-ered its full ligand-binding activity following bindingto ... may affect signaling without affecting ligandbinding has not been completely excluded. In conclusion, a profile of the residue functions in human IP eLP2 was obtained by Ala scanning muta-genesis....
... suggesting its involvement in theterminal stage of intracellular protein catabolism.Interestingly, DPP-III activity has been reported toincrease in retroplacental serum [8] suggesting that ... immunoprecipitation assays. Mutationsof these binding sites abolished not only binding of the Ets protein, butalso the intrinsic promoter activity. Increased DNA-binding activity ofEts-1 ⁄ Elk-1 by v-Ha-ras ... because of increasedlevels of pElk-1 in v-Ha-ras-expressing cells (CLR), wetreated CLR and CLDR cells with mitogen-activatedprotein kinase kinase ⁄ extracellular regulated kinase(MEK⁄ ERK) inhibitor...
... workers intersect with those of the broader civilservice; and pre-service vocational training, in- servicetraining and continuing professional development engagestakeholders not only in education, ... Agreement (AFTA)is driving a review of health training curricula. Healthpartners and government could use this review as an entrypoint to pursue reforms, including improving clinicalcompetences. ... of nursing graduates alsopoints to the broader issue of inadequate standards in training, which affects all cadres of the workforce.Results and discussion In this section we explore the intersections...
... depending on thepreferred terminology.Close and trusting collaboration between partners is essential in such a chain.No business involved can afford to have even one weak link in the chainBox ... Group Inc. Copying or distributing in print or electronic forms without writtenpermission of Idea Group Inc. is prohibited.IntroductionThe integration of handheld computer technology with human ... by renegotiating the range of tasksexisting employees are expected to undertake. Finally, in order to reduceuncertainty for the company, flexible forms of financial reward linking individual...
... Coaching 179 Counselling 181 Mentoring 183 Dealing with Problem Performers 184 8 Human Resource Planning 187 What is Human Resource Planning? 188 The Process of Human Resource Planning ... For example, making a minimum number ofyear’s continuous service in a particular profession a job requirement may, in certaincircumstances, be held to indirectly discriminate against women because ... Leadership appointed in the United Kingdom.Predominantly interested in military history, Adair used his research to formulate a theory whichwould also have valuable spin-offs as a training vehicle....