human immunodeficiency virus hiv

... contact  HIV is a fragile virus Tip of the Day: Use condoms and clean needles! HIV- 1 and HIV- 2   HIV- 1  Binds to CCR5 co-receptor  Most common strain of the Human Immunodeficiency Virus  ... multinucleated giant cells that produce huge amounts of virus HIV Infection Mechanism Co-receptor CCR5 Permits HIV- 1 Entry •CCR5 is the major co-receptor used by HIV- 1 and is expressed on key T-cell subsets ... when they reference HIV HIV-2  Binds to CXCR4 co-receptor  Uncommon; mostly found in Western Africa or individuals of whom are in the later phases of disease progression Higher HIV- 2 prevalence-rates...

Ngày tải lên: 15/03/2014, 12:57

... Urinary Tract FDC Fixed Dose Combination HAART Highly Active Antiretroviral Therapy HIV Human Immunodeficiency Virus MDH Muhas Dar es Salaam City Harvard Collaborative Project MoHSW Ministry of ... the TB infection In recent years TB has become prevalent among people living with human immunodeficiency virus (HIV) which poses a major public health problem especially in Sub-Saharan Africa including ... prevalence; more than 75% of cases of TB are HIV- associated Southern Africa has the highest prevalence of HIV infection and had the highest incidence of TB before the HIV/ AIDS era (Badri et al, 2002; WHO,...

Ngày tải lên: 22/03/2014, 18:20

... of Surgical Oncology 2009, 7:99 The impact of HIV on the South African healthcare system has been profound The total number of persons living with HIV in South Africa increased from an estimated ... to 5.2 million by 2009 For 2009, an estimated 10.6% of the total population is HIV positive [5] The scourge of HIV in sub-Saharan Africa has contributed to the unusual clinical presentation and ... biopsy of a cervical lymph node which demonstrated features of a metastatic epithelioid angiosarcoma HIV Elisa was positive with a CD4 count of 360 cells/μl Computed Tomography (CT) scan revealed a...

Ngày tải lên: 09/08/2014, 04:21

... precursors on human immunodeficiency virus replication Chem Biol Interact 1994, 91(2-3):217-224 Ho WZ, Douglas SD: Glutathione and N-acetylcysteine suppression of human immunodeficiency virus replication ... Fullerton, CA) on days 3, 7, 10, 14 and 17 Results Anti -HIV- 1 activity and cytotoxicity of WR1065 in human TCBs In HIV- 1-infected human TCBs, the HIV- 1 titers, determined in the absence of drug, ranged ... experiments in which we exposed HIV- 1-infected human TCBs to amifostine to compare the anti -HIV- 1 activity of this compound with its active metabolite WR1065 Because cultured human cells lack alkaline...

Ngày tải lên: 10/08/2014, 05:21

... Abbreviations HIV: human immunodeficiency virus; Vpr: viral protein R; HAD: HIV- associated dementia; AIDS: Acquired immunodeficiency syndrome; ND: non-demented; PKR: Protein kinase R; HF μj: human fetal ... of human immunodeficiency virus type Vpr J Virol 1997, 71:6339-6347 Levy DN, Refaeli Y, MacGregor RR, Weiner DB: Serum Vpr regulates productive infection and latency of human immunodeficiency virus ... from human immunodeficiency virus type forms ion channels and kills neurons J Virol 1999, 73:4230-4238 van de Bovenkamp M, Nottet HS, Pereira CF: Interactions of human immunodeficiency virus- 1...

Ngày tải lên: 13/08/2014, 01:20

... simian -human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques Virology 2005, 339:56-69 Maldarelli F, Chen MY, Willey RL, Strebel K: Human immunodeficiency virus ... gene of HIV- 1, vpu, and its 16-kilodalton product Science 1988, 241:1221-1223 Bour S, Strebel K: The human immunodeficiency virus (HIV) type envelope protein is a functional complement to HIV type ... The HIV- 1 Vpu protein: a multifunctional enhancer of viral particle release Microbes Infection 2003, 5:1029-1039 Bour S, Geleziunas R, Wainberg MA: The human immunodeficiency virus type (HIV- 1)...

Ngày tải lên: 18/06/2014, 18:20

... of human immunodeficiency virus in the brain: correlations with dementia Ann Neurol 1995, 38(5):755-762 Johnson RT, Glass JD, McArthur JC, Chesebro BW: Quantitation of human immunodeficiency virus ... Jablonska J, Kibler K, Wilkinson J, Adair D, Rakela J: Human immunodeficiency virus facilitates infection/ replication of hepatitis C virus in native human macrophages Blood 2004, 103(10):3854-3859 ... of human CD4+ T lymphocytes by HIV- 1 and HHV-6 Nature 1989, 337(6205):370-373 Asada H, Klaus-Kovtun V, Golding H, Katz SI, Blauvelt A: Human herpesvirus infects dendritic cells and suppresses human...

Ngày tải lên: 18/06/2014, 18:20

... He T, Talal A, Wang G, Frankel SS, Ho DD: In vivo distribution of the human immunodeficiency virus/ simian immunodeficiency virus co-receptors: CXCR4, CCR3, and CCR5 J Virol 1998, 72:5035-45 Bleul ... that stably produces functionally active HIV- 1 envelope protein (BH-10 clone of HIV- 1 LAI) [30] 293/CD4+ (human embryonic kidney 293 cells which over express human CD4), obtained through the AIDS ... are used by primary isolates of human immunodeficiency virus type as co-receptors with CD4 J Virol 1998, 72:4065-71 Paxton WA, Liu R, Kang S, et al.: Reduced HIV- 1 infectability of CD4+ lymphocytes...

Ngày tải lên: 18/06/2014, 22:20

... of human immunodeficiency virus in the brain: correlations with dementia Ann Neurol 1995, 38(5):755-762 Johnson RT, Glass JD, McArthur JC, Chesebro BW: Quantitation of human immunodeficiency virus ... Jablonska J, Kibler K, Wilkinson J, Adair D, Rakela J: Human immunodeficiency virus facilitates infection/ replication of hepatitis C virus in native human macrophages Blood 2004, 103(10):3854-3859 ... of human CD4+ T lymphocytes by HIV- 1 and HHV-6 Nature 1989, 337(6205):370-373 Asada H, Klaus-Kovtun V, Golding H, Katz SI, Blauvelt A: Human herpesvirus infects dendritic cells and suppresses human...

Ngày tải lên: 20/06/2014, 01:20

... Homogeneous Human Immunodeficiency Virus Type in Exposed Seronegative Individuals J Virol 2003, 77:6108-6116 Koning F, van der Vorst TJ, Schuitemaker H: Low Levels of Human Immunodeficiency Virus Type ... immunity against HIV infection: has nature done the experiment for us Immunol Today 1996, 17:21-24 Beretta A, Weiss SH, Rappocciolo G, Clerici M: Human immunodeficiency virus type (HIV- 1) seronegative ... anti -HIV IgG antibodies in serum Methods To examine the potential presence of HIV DNA in seronegative children born to HIV- 1-infected mothers of the Mexico City Reference and Diagnostic Unit HIV...

Ngày tải lên: 20/06/2014, 01:20

... He T, Talal A, Wang G, Frankel SS, Ho DD: In vivo distribution of the human immunodeficiency virus/ simian immunodeficiency virus co-receptors: CXCR4, CCR3, and CCR5 J Virol 1998, 72:5035-45 Bleul ... that stably produces functionally active HIV- 1 envelope protein (BH-10 clone of HIV- 1 LAI) [30] 293/CD4+ (human embryonic kidney 293 cells which over express human CD4), obtained through the AIDS ... are used by primary isolates of human immunodeficiency virus type as co-receptors with CD4 J Virol 1998, 72:4065-71 Paxton WA, Liu R, Kang S, et al.: Reduced HIV- 1 infectability of CD4+ lymphocytes...

Ngày tải lên: 20/06/2014, 04:20

... .NNSQGSIGAQVSQNYPIVGGSGTDSLAV RPSQQSAGSIVSQNYPIVQNL α peptide B C pCHIV pCHIV.MAα pCHIV pCHIV.MAα - - + - + + - + 2.5 pCHIV pCHIV.MAα 2μM LPV - + - + 2μM LPV 2.0 Gag.MAα Gag 50 37 Gag.MAα 50 37 ... substrates for human immunodeficiency virus type protease FEBS Lett 1991, 278:199-203 Shoeman RL, Honer B, Stoller TJ, Kesselmeier C, Miedel MC, Traub P, Graves MC: Human immunodeficiency virus type ... HIV- 1 gag-pol polyprotein results in intracellular activation of HIV1 protease and inhibition of assembly and budding of virus- like particles Virology 1993, 193:661-671 Kräusslich HG: Human immunodeficiency...

Ngày tải lên: 13/08/2014, 01:20

... to target the HIV- 1 genome, restricting virus expression [17] Our observed down modulation of these two miRNAs in T-cells (Figure 6) would suggest an in vivo setting which favors HIV- 1 replication ... cellular miRNAs could be co-opted by viruses to enhance propagation Thus, it has been reported that human miR-122 interacts with the 5' UTR of hepatitis C virus (HCV) RNA MiR-122, rather than ... and approved the final manuscript Materials and methods Patients and cells Normal and human immunodeficiency virus- infected patient PBMCs were obtained from the NIH blood bank and Saint Michael's...

Ngày tải lên: 13/08/2014, 05:21

... Retrovirology 2009, 6:4 Background Virus- host relationships in human immunodeficiency type virus (HIV- 1) infection are characterized by a great complexity The virus is strictly dependent on the ... complex HIV- 1-host relationships, but also for planning new immune-based strategies against HIV- 1 infection Methods Patients and sequences Seven HIV- positive patients, never treated for HIV infection, ... CJ, et al.: Neutralizing antibody responses drive the evolution of human immunodeficiency virus type envelope during recent HIV infection Proc Natl Acad Sci USA 2005, 102(51):18514-18519 Clementi...

Ngày tải lên: 13/08/2014, 05:21

... Walker BD: Comprehensive epitope analysis of human immunodeficiency virus type (HIV- 1)specific T-cell responses directed against the entire expressed HIV- 1 genome demonstrate broadly directed responses, ... Altfeld MA, Sun Y: Inter-clade cross-reactivity of HIV- 1-specific T cell responses in human immunodeficiency virus type infection in China Curr HIV Res 2007, 5(2):251-259 Lichterfeld M, Yu XG, ... Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type (HIV- 1) proteins reveal imprints of immune evasion on HIV- 1 global variation J Virol 2002, 76(17):8757-8768...

Ngày tải lên: 13/08/2014, 05:22

... diverse human immunodeficiency viruses support the hypothesis that the relative replicative fitness and the prevalence of viral types and subtypes are related It was shown that HIV- 1 group O and HIV- 2 ... and HIV- 2 in the pandemic [27] Furthermore, lower replicative fitness of HIV- 2 isolates compared to HIV- 1 group M viruses could be related to the delayed disease progression observed with HIV- 2 ... al.: Genetic analysis of human immunodeficiency virus in Abidjan, Ivory Coast reveals predominance of HIV type subtype A and introduction of subtype G AIDS Res Hum Retroviruses 1999, 15:3-9 Laurent...

Ngày tải lên: 13/08/2014, 09:20

... Tsg101 control of human immunodeficiency virus type Gag trafficking and release J Virol 2003, 77:9173-9182 Ono A, Freed EO: Cell-type-dependent targeting of human immunodeficiency virus type assembly ... detergent-resistant membrane during the assembly of human immunodeficiency virus type J Virol 2003, 77:3973-3984 Krausslich HG: Human immunodeficiency virus proteinase dimer as component of the viral ... Helm K, Nitschko H: In vivo processing of Pr160gag-pol from human immunodeficiency virus type (HIV) in acutely infected, cultured human T-lymphocytes Virology 1995, 214:624-627 Almog N, Roller...

Ngày tải lên: 13/08/2014, 09:21

Ngày tải lên: 15/02/2014, 13:20

... Adenovirus Encephalitis B virus Poliovirus I Size, shape and structure B Shape: Tobacco mosaic virus: rodshaped Poxvirus: brick-shaped HIV Spherical VSV (Vesicular stomatitis virus) : bullet-shaped ... (e.g., tobacco mosaic virus) • Icosahedral symmetry (e.g., adenovirus)  Complex symmetry (e.g., poxviruses ) Influenza virus Unconventional viruses • Viroid – plant disease – Human Hepatitis D a ... Assembly Naked virus: capsid + viral genome → nucleocapsid (virion) Enveloped virus: nucleocapsid + envelope → virion Site: a DNA viruses (except poxvirus): cell nucleus; b RNA viruses and poxvirus:...

Ngày tải lên: 15/03/2014, 13:00