hsp105aand hsp105bare mammalian members of the hsp105⁄110 family
Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
Ngày tải lên :
18/02/2014, 04:20
... of biological processes. Here, we have
focused on describing the regulatory mechanisms steer-
ing the different members of the mammalian HSF
family. The family provides an excellent example of
how ... HSF4
promotes the DNA-binding activity of another mem-
ber of the HSF family, through modulating the chro-
matin status [106].
Conclusions and perspectives
Nearly 10% of the genes in the human genome ... features among the HSF
family members
Similarly to most transcription factors, the members of
the HSF family are modular proteins composed of
functional domains (see figure 2 in [4]). The most con-
served...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
Ngày tải lên :
18/02/2014, 06:20
... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were
stained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... with members of the ERF ⁄ AP2 family. (A) Y2H assays demonstrate the assembly of BPM1(1–189) and BPM3
with RAP2.4 and RAP2.13, respectively. (B) Schematic drawing of the BPM1 fragment used for the ... AP2 proteins is restricted to the A-6 subfamily
and, in this case, even to a subset of eight members.
The finding that, within the A-6 subfamily, not all of
its members interact with BPM1 indicates...
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Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx
Ngày tải lên :
19/02/2014, 07:20
... lymphoid cell infiltrates of the lung and fibro-
sis in the liver [110].
Conclusions
The novel members, PDGF-C and -D, of the PDGF
subfamily of the cystine knot family of growth factors
are potent ... 2005 The Authors Journal compilation ª 2005 FEBS
endothelial growth factors (VEGF) and the family is
therefore often referred to as the PDGF ⁄ VEGF
family.
The PDGF family of growth factors
The ... The current information on their
activities points to a wide scope of biological effects;
however further understanding of how these factors
interplay with other members of the cystine knot family
and...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
Ngày tải lên :
07/03/2014, 00:20
... promoters. These results show that
the configuration of nGAAn units in the promoter is
important in determining which hHSF members are
involved in the regulation of the gene.
Footprint analysis of the ... without
changing the magnitude of the heat shock response
(cp3). The mutational analysis of the CRYGA and
CRYGC HSEs suggests that the nucleotide sequences
and configuration of nGAAn-like units ... as judged from the amount and
mobility of the complex (Fig. 1B). Notably, the
amount of complex formed with hHSF4 and HSEgap
or HSEstep was more than 70% that of hHSF4–
HSE3P. Therefore, like...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
Ngày tải lên :
07/03/2014, 05:20
... not the b domain.
The distinguishing feature of members of the meiotic
clade of AAA ATPases is the SRH motif, which dif-
fers from that of other AAA ATPases [24]. The pair of
Arg residues in the ... for the RDF sequence in modulating the function
of the SRH.
The C-terminal region of human VPS4B contains
the b domain (b strands 7 and 8), the final helix of the
AAA domain (a helix 10) and the ... we address the role of the yeast Vps4p C-ter-
minal helix. In the 3D structure of mammalian and
yeast Vps4, this helix lies close to the catalytic domain
[31]. The close proximity of the C-terminal...
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Báo cáo khoa học: Relation between domain evolution, specificity, and taxonomy of the a-amylase family members containing a C-terminal starch-binding domain pot
Ngày tải lên :
08/03/2014, 08:20
... determinations of family members with yet other
specificities are in progress (e.g. [17,18]). Furthermore,
prediction of the presence of this (b/a)
8
-barrel fold in other
family members has been ... illustrating the arrangement of all
domains in the five-domain members of the GH 13, can
be taken as an approximation of the first three domains in
the four-domain members. It also shows the typical
Table ... between the hydrolases and transglycosi-
dases, but rather there may be one between the compact
cluster of Bacillus and Thermoanaerobacter CGTases and
the remaining enzymes. The positions of the...
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Tài liệu Báo cáo khoa học: Bioinformatics of the glycoside hydrolase family 57 and identification of catalytic residues in amylopullulanase from Thermococcus hydrothermalis doc
Ngày tải lên :
19/02/2014, 12:20
... data).
Therefore, in attempt to provide the first elements
towards the understanding of the functionality of the
potentially valuable, heat stable GH-57 enzymes, especially
that of the T. hydrothermalis ... and, in the case of equal lengt hs, a lphabe tically. The division is based on the evolutionary tree s
(Fig. 4). For the amylopullulanase from Thermococcus hydrothermalis (Q9Y8I8_THEHY), the numbering ... half of the family is formed
by ORFs coding for putative proteins of uncharacterized
activity and specificity. A s triking feature of GH-57 is the
sequence and length diversity of the individual members.
Indeed,...
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Tài liệu Báo cáo khoa học: Evolutionary relationships of the prolyl oligopeptidase family enzymes docx
Ngày tải lên :
19/02/2014, 13:20
... ancestor of life. With respect to the
studied enzymes of the POP family, POP seems to be the
most conserved enzyme. Ten conserved amino acids were
found at the active site of the enzyme of each of the ... proposed that the b-propeller
of P. furiosus POP does not perform the same function as
the mammalian enzyme, i.e. the exclusion of large peptides
from the active site [25]. Clearly the role of the b-propeller
has ... sequences of POP family members are located in the
C-terminal third of the alignment [20]. Of these conserved
residues, Ser554, Asp641 and His680 form the catalytic triad
of POP and the small residues...
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Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
Ngày tải lên :
22/02/2014, 07:20
... evolution
and function of the hormonal system. We first cloned the
genes of the CYP11B family of the guinea pig. The 11b-
hydroxylase of the guinea pig showed higher substrate
specificity than the aldosterone ... Thus, the proteins of the CYP11B
subfamily catalysing the last biosynthetic steps are the key
enzymes for the synthesis of both mineralocorticoids and
glucocorticoids.
From molecular cloning of the ... with the size of
the C17 substituent of the substrate. Furthermore, analyses
with the electron transfer protein adrenodoxin indicate dif-
ferential sensitivity of CYP11B1 and CYP11B2 as well as the
three...
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Báo cáo khoa học: Structure analysis of the flavoredoxin from Desulfovibrio vulgaris Miyazaki F reveals key residues that discriminate the functions and properties of the flavin reductase family pdf
Ngày tải lên :
07/03/2014, 02:20
... of the structure of NADP
+
-bound FeR
revealed that the nicotinamide moiety of NADP
+
faces the re-side of the isoalloxazine ring, and that the
2¢-P-AMP moiety is held in the groove between the ... direction along the b10 of the other mono-
mer, forming an anti-parallel intermolecular b sheet
(Fig. 2A). The subsequent residues of the loop (Ala7–
Pro13) turn into the interior of the dimer interface,
and ... fulgidus
FeR is one of the candidates for the ferric ion-binding
residue based on the structure of the mercury-bound
derivative, although a ferric ion was not found at the
site of either the native or...
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Báo cáo khoa học: Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family pot
Ngày tải lên :
07/03/2014, 09:20
... FEBS
To analyze the contribution of protein domains to
the ER anchorage, the localization of the full-length
enzyme was compared with those of five truncated
forms. The pattern of the full-length ... enzymes.
The most significant difference between the amphi-
oxus and the other retinal reductases was, nevertheless,
their preference for the NADH cofactor. To our
knowledge, these are the first ... [29]. The overall analysis, examining
the topology of the phylogenetic tree and the position
of each gene inside the cluster, was informative regard-
ing the orthology relationships of the distinct...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
Ngày tải lên :
19/02/2014, 16:20
... must still be determined whether
its absence in the V79-G18 mutant is the result of the missing
ESSS subunit alone, or whether the absence of ESSS causes
the f ailure of other integral membrane subunits ... and the effect of
the absence of intact complex I, but the results are too
preliminary in this regard.
Heterologous expression of the ESSS-HA subunit
The localization of the ESSS subunit in the ... as a nother identification of
the complex at the position o f the histochemical stain in the
left panel. Antisera against the SDHC subunit of complex II
and against the Rieske protein of complex...
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- tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam
- điều tra đối với đối tượng giảng viên và đối tượng quản lí
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- khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu
- nội dung cụ thể cho từng kĩ năng ở từng cấp độ
- xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct
- phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ
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