host pathogen interactions in tuberculosis
Báo cáo y học: " First Dominique Dormont international conference on "Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections" pdf
... postinfection The following observations were made in SIVagm-infected AGMs: 1)A significant increase in TGFb1 and Foxp3 gene expression beginning in the first week after infection, coinciding ... targets in co-infected tissue This study highlighted the crucial role of the cytokine/chemokine network in interactions between microbes in the human host Early induction of an anti-inflammatory ... whereas HIV research is gradually turning to the investigation of more intrinsic interactions between host and viral proteins Session 4: Viral infection and innate immunity Chairs: C Soderberg-Naucler...
- 10
- 308
- 0
Blastocystis investigations on host pathogen interactions using in vitro model systems
... non-transformed rat intestinal cell line 5.2.2 Parasite culture and preparation of lysate 5.2.3 Inoculation protocol and experimental planning 5.2.4 Phalloidin-FITC staining of F-actin 5.2.5 Tight ... study was to investigate the pathogenic potential of Blastocystis, by studying the interactions of Blastocystis with intestinal epithelial cell lines This study reports that B ratti WR1 induces apoptosis ... secretory immunoglobulin A (SIgA) by the intestinal protozoan Blastocystis Research work presented in Combined Scientific Meeting 2005, Singapore xviii CHAPTER 1: INTRODUCTION 1.1 INTRODUCTION Blastocystis...
- 251
- 202
- 0
Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 1) docx
... significant human pathogen By 2006, H5N1 avian influenza, having spread rapidly through poultry farms in Asia and having caused deaths in exposed humans, had reached Europe and Africa, heightening fears ... atherosclerosis may have an infectious component In contrast, there are data to suggest that decreased exposures to pathogens in childhood may be contributing to an increase in the observed rates of ... deepening understanding of pathogenesis at the most basic molecular level Even in developed countries, infectious diseases have made a resurgence Between 1980 and 1996, mortality from infectious...
- 5
- 322
- 1
Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 2) docx
... seemingly minor alteration in a travel itinerary can dramatically influence the likelihood of acquiring chloroquine-resistant malaria If such important details in the history are overlooked, inappropriate ... risk of acquiring an infection in several ways: (1) through contact with pathogens during hospitalization, (2) through breaching of the skin (with intravenous devices or surgical incisions) or ... of microbe and host and inevitably affects both In most cases, a pathogenic process consisting of several steps is required for the development of infections Since the competent host has a complex...
- 13
- 243
- 0
Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 4) docx
... cytokines (e.g., interferon) that directly inhibit the growth of pathogens or stimulate killing by host macrophages and cytotoxic cells Cytokines also augment the host' s immunity by stimulating ... function of an invading organism, neutralize secreted toxins and enzymes, or facilitate the removal of the antigen (invading organism) by phagocytic cells Immunoglobulins participate in cellmediated ... production of immunoglobulins Antigen-presenting cells and T cells communicate with each other via a variety of signals, acting coordinately to instruct the immune system to respond in a specific fashion...
- 5
- 238
- 1
Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 5) doc
... cytokines such as tumor necrosis factor α and interleukin The binding of these selectin molecules to specific receptors on PMNs results in the adherence of the PMNs to the endothelium Cytokine-mediated ... malaria (Chap 203) The elevation in body temperature in fever (through resetting of the hypothalamic setpoint mediated by cytokines) must be distinguished from elevations in body temperature from other ... the bedside with cursory instructions Gram's stains of specimens should be interpreted carefully and the quality of the specimen assessed The findings on Gram's staining should correspond to...
- 5
- 260
- 1
Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 6) docx
... active against the range of potential infectious agents consistent with the clinical scenario In contrast, good clinical judgment sometimes dictates withholding of antimicrobial drugs in a self-limited ... benefit in the adjunctive treatment of bacterial meningitis and in therapy for Pneumocystis pneumonia in patients with AIDS The use of these agents in other infectious processes remains less ... recently, CMV immune globulin has been recognized as important not only in preventing the transmission of the virus during organ transplantation but also in treating CMV pneumonia in bone marrow transplant...
- 9
- 246
- 0
Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
... of antituberculosis combinations comparing rifabutin with rifampicin in the treatment of HIV-1 associated tuberculosis: a singleblind randomized evaluation in Ugandan patients with HIV-1 infection ... rifampin induces the activity of the CYP2C19 and CYPD6 isozymes The rifamycins vary in their potential as CYP450 inducers, with rifampin being most potent, rifapentine intermediate, and rifabutin ... K, Gerstoft J, Pedersen C Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIVinfected patients Clin Infect Dis Feb 2004;38(3):426-429 Ribera...
- 20
- 374
- 0
Báo cáo y học: " Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions" pps
... stood out for being involved in important functional processes In total, 14 are involved in transcriptional processes, including RNA polymerases or proteins involved in the transcription of tRNAs, ... importance of O bayeri proteins absent in other microsporidia Perhaps the most intriguing finding of the present study is the identification of 80 O bayeri proteins sharing homology with eukaryotes ... reported in the ones that are larger and less compact [34,37,38,52], so in this case our study simply corroborates previous findings The remainder of these eukaryotic proteins stood out for being involved...
- 12
- 400
- 0
báo cáo khoa học: " Gut microbiome-host interactions in health and disease" pdf
... species than healthy individuals, suggesting a possible new role for the gut bacteria in the mechanism of CRC Bacterial genes involved in regulation of NF-κB signaling in intestinal epithelial cells ... for increasing energy uptake by the large intestine in obese persons [95] It is difficult to definitively ascertain whether the surgical trauma, the bypass or the altered oral intake is definitively ... taurine and betaine levels than other gut regions HBF mice showed lower taurine and myo-inositol levels in the colon, and all ex-germfree animals had higher taurine, choline and ethano amine...
- 12
- 333
- 0
Báo cáo y học: "Computational models in plant-pathogen interactions: the case of Phytophthora infestans" pdf
... conserved machinery for transport of effector proteins, a finding otherwise hard to achieve Protein-protein interactions One approach to study protein-protein interactions is by using yeast two ... [89,93] Since an important phase in host- pathogen interactions involves protein-protein recognition [94,91], efforts to elucidate networks of such interactions are of special interest in phytopathology ... anhydrase Proteinase inhibitor II Peroxiredoxin 2-Cys peroxiredosin Proteinase inhibitor I Superoxide dismutase Peroxidase Aspartic proteinase inhibitor Cystein proteinase inhibitor Cysteine protease...
- 11
- 318
- 0
Host viral interactions host factors in coronavirus replication and coronaviral strategies of immune evasion
... VIRUS -HOST INTERACTIONS (I) 1.2.1 Host factors in coronavirus replication…………………………………………… … 24 1.2.1.1 1.2.1.2 Polypyrimidine-tract binding (PTB)……………………………………… 26 1.2.1.3 Poly (A) binding protein ... regulatory protein 1, is a RNA binding protein that coordinates the expression of ferritin and transferrin receptor during iron metabolism by binding to iron-responsive elements in the 5’ and 3’ ... systems involving viral RNA and replicase remains the choice approach for identifying cellular proteins to be involved in coronavirus infection, an increasing number of cellular proteins have...
- 220
- 328
- 0
Computational studies of host pathogen protein protein interactions a case study of the h sapiens m tuberclulosis H37RV system
... computational studies on host- pathogen interactions including: prediction and analysis of host- pathogen protein-protein interactions; basic principles revealed from host- pathogen interactions; and database ... and integration” 1.2 Host- pathogen protein-protein interactions prediction Host- pathogen protein-protein interactions play an important role between the host and pathogen, which may be crucial in ... host- pathogen interaction databases Current host- pathogen interaction databases contribute a lot to host- pathogen interaction studies in the form of collecting and integrating valuable host- pathogen...
- 211
- 310
- 0
Host cell pathogen interactions between erythrocytes and p falciparum apoptotic mimicry
... phosphatidylcholine (PC) and sphingomyelin (SM), are predominantly localised in the outer layer while amine-containing phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), are mainly ... Determining Phosphatidylserine Externalisation 2.2.1 Annexin V assay for phosphatidylserine externalisation Annexin V-fluorescein isothiocyanate (Annexin V-FITC; Biovision) bind to phosphatidylserine ... with ml of Annexin V binding buffer (Biovision) containing Ca2+ necessary for Annexin V binding Ten µl of stock Annexin V-FITC was added to every ml of cells at 1% hematocrit A final concentration...
- 149
- 148
- 0
Discovery of host lipid biomarkers for tuberculosis infection in mice
... coordinating and conducing the animal experiment for us In the lab at NUS, I would like to thank everyone for taking me into the group and for giving me a great experience in Singapore In particular ... for TB Infection in Mouse” International Symposium on Emerging Trend in Tuberculosis Research: Biomarkers, Drugs and Vaccines December 1-3, 2008 New Delhi, India XI Introduction 1.1 1.1.1 Tuberculosis ... regulated during infection and reverted to the healthy state upon rifampicin treatment Interestingly, the list of these biomarker lipids included mainly phosphatidylserines and phosphatidylcholines We...
- 88
- 144
- 0
Tài liệu Chapter 10: Host-guest chemistry in aqueous organometallic catalysis pdf
... molecules in aqueous organometallic catalysis An overview of the literature on the application of host- guest interactions in aqueous organometallic catalysis reveals the following: in most cases ... cyclodextrins were used as hosts, majority of the reactions in such systems were catalyzed by complexes bearing a sulfonated phosphine ligand, and majority of the above reactions involved higher olefins ... in acidic aqueous solutions (pH adjusted to 1.8) in the presence of various chemically modified cyclodextrins (Scheme 10.11) [18] As in most cases, the best results were obtained with In an interesting...
- 11
- 435
- 2
Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx
... electrostatic interactions [60] (d) For the Transient RNA–protein interactions in RNA folding human mRNA-binding protein hnRNP A1 [61], the Xenopus laevis protein X1rbpa [54], the trypanosome guideRNA-binding ... RNA–protein interactions in RNA folding M Doetsch et al Tat peptide induced a change in the population of coexisting and interchanging RNA conformations The lack of intermolecular NOE connectivities indicated ... molecules during their folding process or during their assembly into RNP complexes Static versus transient interactions RNA folding reactions can be modulated either by tight binding to proteins, establishing...
- 9
- 600
- 1
Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx
... cob(I)alamin from CH3-H4-folate, generating H4-folate and the methylcob(III)alamin form of MS During primary turnover, the homocysteine-binding domain (dotted barrel) and the CH3-H4-folate binding-domain ... enzyme from cobalamin–agarose resin Inset: SDS polyacrylamide gel (8%) analysis indicating the purity of hMS recovered from the cobalamin–agarose resin Protein was visualized by staining with Coomassie ... form of hMS During reactivation of hMS, the FMN domain of MSR (light grey) and the C-terminal activation of hMS (grid-barrel) interact with the cobalamin-binding domain For more information on...
- 10
- 698
- 0
Tài liệu Báo cáo khoa học: Plant–pathogen interactions: what is proteomics telling us? doc
... origin directly involved in mounting the plant defence against infection by protecting against the oxidative burst inside the plant cell Such a burst can be caused in plant cells by invading ... homologue Calreticulin precursor Tropomyosin Myosin regulatory light chain ATP synthase b chain Chaperonin protein HSP-60 H schachtii H schachtii Ml incognita Ml incognita Ml incognita Ml incognita Ml ... graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum F graminearum Ph ramorum Ph ramorum...
- 16
- 446
- 0
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... the hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the hinge ... homologous to the RNases investigated in this study, have been isolated from human eosinophils, namely eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) They are RNases ... cationic proteins, with high isoelectric point values Thus we investigated the effects Table Natural and engineered RNases investigated in this study IC50 is the RNase concentration producing half-maximal...
- 11
- 643
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25