hormone insulin like growth factor i igf i

... 465-472 Ninh NX, Thissen JP, Collette et al 1996 Zinc supplementation increases growth and circulating insulin- like growth factor I (IGF -I) in Vietnamese growth- retarded children Am J Clin Nutr ... (1998) Continuous administration of growth hormone (GH) does not prevent the decrease of IGF -I gene expressionin zinc-deprived rats despite normalization of liver GH binding Growth Horm & IGF Res ... quan đa biến (IGF -I v i tu i gi i) , kết cho thấy tu i gi i có hệ số tơng quan có ý nghĩa (P

Ngày tải lên: 25/03/2014, 03:22

... deserves particular mention is that IGF- II treatment improved significantly lipid metabolism, diminishing cholesterol and triglycerides and increasing free fatty acids circulating levels [6] Since fatty ... the International Union of Biochemistry; IGF: Insulin- Like Growth Factor; MDA: malondialdehyde; MMP: mitochondrial membrane potential; ns: not significant; O: untreated old rats; O +IGF- II: aging ... (Calbiochem-Novabiochem, San Diego, CA) needed for ANT inhibition, the efficiency of Atr was first examined in its classical role, i. e for its ability to inhibit oxidative phosphorylation For analysis, increasing...

Ngày tải lên: 18/06/2014, 22:20

... administering both IGF -I and LPS i. c.v [11], i. c.v IGF -I has anti-depression like activity, but not anti-sickness activity against i. p administered LPS 11 IGF -I does not affect preexisting LPS-induced ... action of IGF -I Mature intact IGF -I has antidepressant activity, but it is still not known if des-(13) -IGF -I, acting via the IGF- 1R, or the generation of GPE from exogenous IGF -I play a significant ... paracrine growth factor displaying activities in a variety of neuropathologies [24, 25] IGF -I is cleaved within the brain to release an N-terminal tripeptide [26] GPE, like IGF -I, is neuroprotective...

Ngày tải lên: 19/06/2014, 22:20

... deserves particular mention is that IGF- II treatment improved significantly lipid metabolism, diminishing cholesterol and triglycerides and increasing free fatty acids circulating levels [6] Since fatty ... the International Union of Biochemistry; IGF: Insulin- Like Growth Factor; MDA: malondialdehyde; MMP: mitochondrial membrane potential; ns: not significant; O: untreated old rats; O +IGF- II: aging ... (Calbiochem-Novabiochem, San Diego, CA) needed for ANT inhibition, the efficiency of Atr was first examined in its classical role, i. e for its ability to inhibit oxidative phosphorylation For analysis, increasing...

Ngày tải lên: 20/06/2014, 04:20

... pCR II vector, replacing the original 813 bp BamH I Table 1: Primers and probes used for plasmid construction and real-time PCR IRESF (BamH I) IRESR (Sal I) IGF- IF1 (EcoR I) IGF- IF2(Sal I) IGF- IR ... 40 Figure plasmids3 IGF -I preparations made with by designated AAV helper rAAV -IGF -I titers, determinedthe real-time PCR, of rAAVrAAV -IGF -I titers, determined by real-time PCR, of rAAV -IGF -I preparations ... authors wish to thank George J Eckert, M.A.S., Department of Medicine Division of Biostatistics, Indiana University School of Medicine, for statistical assistance References 10 11 12 13 14 IGF -I: Insulin- like...

Ngày tải lên: 12/08/2014, 04:21

... ICA MCA 10 ACoA 10 ACA distal 1 Age, years (range) Gender M/F Aneurysm location VBA Hydrocephalus at admission Fisher grade I- II 2 III-IV 11 15 I- II 10 III 3 Hunt and Hess initial IV-V SAPS II ... drafting the manuscript and revising it critically OR participated in analysis and interpretation of data, drafting the manuscript and revising it critically ER, JRO and VK participated in analysis ... and standardized HRQoL instrument consisting of 15 dimensions: mobility, vision, hearing, breathing, sleeping, eating, speech, elimination, usual activities, mental functioning, discomfort and...

Ngày tải lên: 13/08/2014, 20:22

... 0 Time (s) Fig BIAcore analysis of IGF- II and IGF- II analogue binding to highanity recombinant IGF1 R Binding of IGF- II (A), des-(1±6) -IGF- II (B) and Arg6 -IGF- II (C) to rhIGF1R measured by BIAcore ... expected to maintain rhIGF1R-binding af®nities similar to IGF -I Long Gly3 -IGF -I and Long Arg3 -IGF -I also had similar rhIGF1R-binding af®nities to IGF -I (data not shown) The analogues Leu24 -IGF -I, des-(2,3)-Leu24 -IGF -I, ... Insulin- like growth factor (IGF) -I binding to IGF- binding proteins and IGF receptors is modi®ed by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF- II...

Ngày tải lên: 08/03/2014, 22:20

... diameter; IGF -I, Insulin- like growth factor- I; IGF -I zSDS, SDS of IGF -I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGFbinding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Table ... SDS of IGF -I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGF- binding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Savastano et al Journal of Translational Medicine 2011, ... mass); IR: (insulin resistance); HS: (hepatic steatosis); GH: (growth hormone) ; IGF -I: (insulin- like growth factor- 1); IGFBP: (IGF binding protein); BMI: (body mass index); HOMA: (homeostasis model...

Ngày tải lên: 18/06/2014, 22:20

... diameter; IGF -I, Insulin- like growth factor- I; IGF -I zSDS, SDS of IGF -I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGFbinding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Table ... SDS of IGF -I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGF- binding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Savastano et al Journal of Translational Medicine 2011, ... mass); IR: (insulin resistance); HS: (hepatic steatosis); GH: (growth hormone) ; IGF -I: (insulin- like growth factor- 1); IGFBP: (IGF binding protein); BMI: (body mass index); HOMA: (homeostasis model...

Ngày tải lên: 20/06/2014, 04:20

... Ljunghall S: Circulating levels of insulin- like growth factor- I and -II, and IGF- binding protein-3 in inflammation and after parathyroid hormone infusion Bone Miner 1994, 24:25-31 33 De Benedetti F, ... Alonzi T, Moretta A, Lazzaro D, Costa P, Poli V, Martini A, Ciliberto G, Fattori E: Interleukin causes growth impairment in transgenic mice through a decrease in insulinlike growth factor- I A ... also increases the production of IGF- 1 by osteoblastic cell lines [30] In the present investigation, HRT resulted in a significant increase in serum levels of IGF- 1 We did not find a significant...

Ngày tải lên: 09/08/2014, 01:21

... proteins (IGFBPs), in insulin- like of NBI-31772, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin -like growth factor (IGF) -1 to IGF- binding proteins (IGFBPs), ... NBI-31772 Competition of NBI-31772, a small-molecule inhibitor of the binding of insulin- like growth factor (IGF) -1 to IGF- binding proteins (IGFBPs), with 125Ilabeled IGF- 1 binding to cartilage ... IGF- binding proteins, on 12 5I- labeledinsulinbinding NBI-31772, a small-molecule inhibitor like growth factor (IGF) -1 to IGF- binding proteins, on 12 5I- labeled IGF- 1 binding to human osteoarthritic...

Ngày tải lên: 09/08/2014, 01:23

... both in nutrient availability and in cytokine activation are implicated Circulating levels of IGF -I and of the insulin- like growth factor binding protein -I (IGFBP -I) are exquisitely sensitive ... good quality clinical trial data, clinicians may need to turn to basic science investigations to aid decision-making The mechanism by which outcome in critically ill patients might be influenced ... Borkmann M, Tan K, Caterson ID, McWilliam DB: Relationship of somatomedin C /insulin- like growth factor I levels to conventional nutritional indices in critically ill patients Crit Care Med 1987, 15:732-736...

Ngày tải lên: 13/08/2014, 08:20

... Silkmoth IGF -like peptide N Okamoto et al Members of the insulin- like peptide (ILP) family are present in a wide variety of metazoans In vertebrates, insulin and insulin- like growth factors (IGFs) ... putative 20 amino acid signal peptide and a 68 amino acid peptide belonging to the insulin family (Fig 3C) If the signal peptide is eliminated and disulfide bridges are formed as in other insulin ... This article describes the purification and characterization of this peptide, and shows that 8K-BLP is more like IGFs than like insulin 1222 Fig Fluctuation of 8K-BLP in Bombyx hemolymph during...

Ngày tải lên: 18/02/2014, 13:20

... Journal compilation ª 2006 FEBS 3713 Insulin- like growth factor signaling A Fanzani et al A B Fig Neu2 expression is strictly dependent on insulin- like growth factor (IGF- 1) signaling (A) C2BP5 ... of insulin- like growth factor I Mol Cell Biol 19, 3115– 3124 James PL, Stewart CE & Rotwein P (1996) Insulin- like growth factor binding protein-5 modulates muscle differentiation through an insulin- like ... Fanzani et al Insulin- like growth factor signaling A B C D E Fig Neu2-induced differentiation is blocked by PI3 kinase and mammalian target of rapamycin (mTOR) inhibitors, and Neu2 overexpression...

Ngày tải lên: 19/02/2014, 06:20

... Jones JI & Clemmons DR (1995) Insulin- like growth factors and their binding proteins: biological actions Endocrinol Rev 16, 3–34 Rechler MM (1993) Insulin- like growth factor binding proteins Vitam ... affinity binding of IGFs to IGFBPs limits the interaction of the growth factors with the cell surface receptors Therefore, IGFBPs generally inhibit IGF- stimulated cell growth in vitro [25] In contrast, ... of IGFBP-rP1 leads to complete loss of insulin ⁄ IGF- 1-dependent cell growth- stimulatory activity due to its loss of insulin ⁄ IGF- binding ability To examine whether the specific cleavage of IGFBPrP1...

Ngày tải lên: 19/02/2014, 07:20

... T, Popowiicz GM, Siwanowicz I, Huber R & Holak TA (2006) Structural basis for the inhibition of insulin- like growth factors by insulin- like growth factorbinding proteins Proc Natl Acad Sci USA ... metalloproteinase-7 degrades all insulin- like growth factor binding proteins and facilitates insulin- like growth factor bioavailability Biochem Biophys Res Commun 333, 1011–1016 41 Binoux M, Lalou ... A, Prevette T, Jones JI & Clemmons DR (1995) Insulin- like growth factor (IGF) -binding proteins inhibit the smooth muscle cell migration responses to IGF -I and IGF- II Endocrinology 136, 4168–4173...

Ngày tải lên: 07/03/2014, 00:20

... (Fig S1A) so we cannot rule out the possibility of the inhibition of other lipid or pro- Fig IGF- 1 induced activation of mTOR signaling is prevented by PI3K inhibitor wortmannin and mTOR inhibitor ... muscle is the insulin like growth factor- 1 (IGF- 1) ⁄ insulin- dependent pathway [5,6] Stimulation of muscle cells with growth factors such as IGF- 1 leads to the activation of phosphoinositide 3-kinase ... that this step is likely critical for mTOR activation by dissociating the interaction between GAP activity of the TSC1 ⁄ TSC2 complex and Rheb Results and Discussion IGF- 1-induced activation of...

Ngày tải lên: 15/03/2014, 11:20

... Hafezian, G Rahimi-Mianji (2010) Association of single nucleotide polymorphisms in IGF -I, IGF- II and IGFBP-II with production traits in breeder hens of Mazandaran native fowls breeding station ... tìm thấy kiểu gen GG, AG cu i AA quần thể nghiên cứu 39 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di truyền gen Insulin- like growth factor binding protein gà Bảng ... gi i hạn kiểm tra đánh giá gel agarose nhuộm v i ethium bromide Nồng độ thông số trình chạy i n di thể bảng 37 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di...

Ngày tải lên: 24/03/2014, 23:21

... Abbreviations (IGF) : Insulin- like Growth Factor; (IGF1 R): Insulin- like Growth Factor- 1 receptor; (IGFBP-3): Insulin- like Growth Factor Binding Protein-3; (IGFBP-4): Insulin- like Growth Factor Binding; ... Formelli F: Relationships between plasma insulin- like growth factor- I and insulin- like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide Clin Cancer ... Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I: IGFBP-4 is an inhibitor of canonical Wnt signaling required...

Ngày tải lên: 18/06/2014, 15:20

... PL, Nanni P, Picci P, Scotlandi K: Inhibition of insulin- like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing’s sarcoma cells Clin Cancer ... Scotlandi K, Benini S, Nanni P, Lollini PL, Nicoletti G, Landuzzi L, Serra M, Manara MC, Picci P, Baldini N: Blockage of insulin- like growth factor- I receptor inhibits the growth of Ewing’s sarcoma in ... Perdichizzi S, Lollini PL, De Giovanni C, Landuzzi L, Picci P: Expression of an IGF -I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing’s...

Ngày tải lên: 18/06/2014, 16:20