hormonal control of blood glucose concentration

understanding the ups and downs of blood glucose

Ngày tải lên : 13/08/2014, 09:38

... stress to MAGE than to postprandial glucose levels! ♦ MAGE = both the UPS and the DOWNS of blood glucose I Hirsch So What Is The Significance of the Understanding of GV? ♦ “…it suggests that different ... 140 MAGE (mg glucose/ dL) 160 I Hirsch Why This Study is So Important ♦ Oxidative stress not related to A1c, fasting glucose, fasting insulin, mean blood glucose ♦ Stronger correlation of oxidative ... Stress, Free Radicals, and Reactive Oxygen Species ♦ High blood glucose ♦ Science is confirmed on this point ♦ Variability in blood glucose ♦ Science is highly suggestive on this point How Does...

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Báo cáo y học: "Ingredients for adequate evaluation of blood glucose algorithms as applied to the critically ill" docx

Ngày tải lên : 13/08/2014, 11:23

... and comparing different blood glucose control algorithms Crit Care 2008, 12:R24 Vogelzang M, van der Horst I, Nijsten M: Hyperglycaemic index as a tool to assess glucose control: a retrospective ... Second, the use of future reliable near-continuous glucose sensors will permit appropriate consideration of the time dimension in the indicator Accordingly, duration and magnitude of hypoglycaemic/hyperglycemic ... assessment of a BG signal and comparison with other BG signals require the fulfilment of three conditions The first of these is consensus concerning the desired target BG range (and definitions of hypoglycaemia/hyperglycemia)...

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Báo cáo y học: " Is reducing variability of blood glucose the real but hidden target of intensive insulin therapy" pot

Ngày tải lên : 13/08/2014, 16:20

... deviations of blood glucose levels were used as markers of glycemic variability A standard deviation of blood glucose levels of above 20 mg/dL was associated with a 9.6-fold increase of mortality ... ‘decreasing mean blood glucose concentrations’ or ‘decreasing variability in glycemia’ Decreasing the variability of blood glucose concentration might be an important dimension of glucose management, ... spread of target blood glucose values (IIT: 4.5 to 6.1 mmol/L versus control: to 10 mmol/L), this trial should make it possible to test the benefit of lowering the mean blood glucose concentration...

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DISSECTING THE HORMONAL CONTROL OF THE SALT STRESS RESPONSE IN ARABIDOPSIS ROOTS 1

Ngày tải lên : 10/09/2015, 09:07

... TABLE OF CONTENTS TABLE OF CONTENTS ACKNOWLEGEMENT i TABLE OF CONTENTS ii SUMMARY vii LIST OF TABLES ix LIST OF FIGURES x LIST OF ABBREVIATIONS ... their spatial domain of action and link the activity of these pathways to the control of specific phases of growth Then we used genetic approach to dissect the functions of these signaling pathways ... LIST OF TABLES Table Accession numbers of analyzed genes and primers used in the Real-time quantitative PCR analysis 40 ix LIST OF FIGURES LIST OF FIGURES Figure1 Diagram of...

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DISSECTING THE HORMONAL CONTROL OF THE SALT STRESS RESPONSE IN ARABIDOPSIS ROOTS 2

Ngày tải lên : 10/09/2015, 09:07

... root growth pattern and the profile of cell length shared a certain level of similarity This suggests that inhibition of cell elongation contributes to inhibition of growth during salt stress ... using the spatio-temporal transcriptional map of salt response, we found that out of eight functional isoforms of ACS (Tsuchisaka A, et al., 2009), four isoforms were responsive to salt treatment: ... spatio-temporal changes of ethylene signaling during salt stress First, we focused on the temporal profile of the activation of ethylene signaling Figure 25 shows the region of the meristem and early...

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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells

Ngày tải lên : 30/09/2015, 06:36

... effect of high concentrations of glucose on the growth, survival, proliferation and cell-fate specification of NSCs isolated from the telencephalon of embryonic mice, and on the expression of some ... LIST OF ILLUSTRATIONS Illustration Mechanisms of neural tube closure in mouse and human···················9 Illustration Schematic summary of the effects of high glucose on the expression of developmental ... fetal glucose concentration is directly related to maternal glucose concentration since the glucose used by the fetus is supplied by the mother (Hay, Jr et al., 1984) The initial step for the glucose...

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Báo cáo khoa học: " How to compare adequacy of algorithms to control blood glucose in the intensive care unit" pptx

Ngày tải lên : 12/08/2014, 20:20

... compare adequacy of glucose control algorithms A first condition is that the blood glucose profile, on which the HGI is calculated, is one with a relatively high number of blood glucose measurements, ... display of blood pressure and/or cardiac output for optimal titration of inotropes and vasopressors, a continuous blood glucose measurement and display of blood glucose levels would be of tremendous ... slightly better AUC of the ROC when the HGI used a cutoff of 6–8 mmol/l as compared with 4–6 mmol/l does not provide evidence supporting use of a higher target of blood glucose control in the ICU...

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Báo cáo y học: " Formulas Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patient" doc

Ngày tải lên : 13/08/2014, 08:21

... subsequently been replicated in studies using historical controls [26,27] Furthermore, control of blood glucose has proven beneficial in other populations of acutely ill patients [23] Whilst to some such ... option Glucose control appears beneficial in other populations of patients [21,23], although some of the trials have been small [21] As in many areas of intensive care practice, the choice of a ... with increased ICU resource use for administration of insulin and close monitoring of blood glucose levels [28] However, a post hoc analysis of health care resource utilization derived from the...

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Effectiveness of PRECEDE model for health education on changes and level of control of HbA1c, blood pressure, lipids, and body mass index in patients with type 2 diabetes mellitus docx

Ngày tải lên : 05/03/2014, 22:21

... previously diagnosed DM2 (cardinal clinical, plus random blood glucose >200 mg/dl or oral glucose of >200 mg/dl at h, twice, or plasma fasting glucose of >126 mg/ dl on two occasions or being diagnosed ... 24 months of follow-up Sample size For an alpha of 0.05, a power of 80%, and in order to detect an reduction of HbA1c of 0.3 percentage units, with a common standard deviation (SD) of 1.15, in ... patient was assisted with the identification of dietary behaviour that adversely influences blood glucose control, lipid levels, weight management, and times of the day when the patient was most vulnerable...

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Báo cáo y học: "Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis" doc

Ngày tải lên : 12/08/2014, 11:22

... to highlight the usefulness of pharmacokinetic monitoring of infliximab concentration to control disease activity in RA Indeed, the measurement of trough infliximab concentration modified the ... showed optimal control of disease activity, (21%) acceptable control, and (29%) inadequate control Only one patient was positive for ATI at V1 (2.18 μg/ mL) with a concomitant infliximab concentration ... decision Of the patients, were considered to have an inadequate control of disease activity (2 with medium and with low infliximab concentration) and was considered to have acceptable control...

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Báo cáo y học: "Tight blood glucose control: a recommendation applicable to any critically ill patient" ppsx

Ngày tải lên : 12/08/2014, 20:20

... challenges the concept of tight glucose control, it can hardly be considered a major piece of evidence against it Indeed, blood glucose concentrations were presented as means of values recorded only ... randomly assigned to tight glucose control by intensive intravenous insulin therapy A post hoc multivariate logistic regression analysis of these data suggested that control of hyperglycaemia played ... surgery Fear of life-threatening hypoglycaemia and increased workload and costs probably underlie the reluctance of many intensivists to launch systematic protocols of tight glucose control Indeed,...

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Báo cáo khoa học: "Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients" pptx

Ngày tải lên : 13/08/2014, 03:20

... measure pH and blood gas and any combination of oximetry, electrolyte, and metabolite parameters Glucose concentration is measured by the glucose- oxidase method from 95 µl of whole blood to provide ... conventional blood glucose analyser (YSI 2300; Yellow Springs Instruments, Yellow Springs, OH, USA) The YSI analyser uses glucose oxidase to measure the glucose concentration in whole blood (by ... of the attending physician or nurse) We first validated the ICUbased blood gas /blood glucose analyser ABL715 against the central hospital laboratory (part of the study) Heparinised arterial blood...

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Báo cáo y học: " Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury" docx

Ngày tải lên : 13/08/2014, 11:22

... http://ccforum.com/content/12/4/R98 Impact of blood glucose diverging from the anticipated blood glucose targets Higher blood glucose levels were associated with higher insulin requirement Overall, blood glucose values ... primary endpoints, glucose variability and extreme blood glucose values show that the predefined blood glucose targets are of pathophysiologic relevance, despite overlapping of blood glucose values ... tract infections A concentration- dependent effect in critically ill patients requires investigation Control of blood glucose levels Implementing a strict and tight control of blood glucose levels...

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Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo" pps

Ngày tải lên : 13/08/2014, 13:20

... by both the Joint Research Committee of King's College School of Medicine & Dentistry and the Central Research Committee of the University of London Page of 10 (page number not for citation purposes) ... hyperaemic response of the hepatic artery to portal vein occlusion (the 'buffer response') Br J Pharmacol 1990, 100:626-630 Burnstock G: Local control of blood pressure by purines Blood vessels Volume ... inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and the inferior vena cava of the in vivo rabbit model During control conditions,...

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Báo cáo y học: "Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury" pptx

Ngày tải lên : 13/08/2014, 15:21

... 68% Control and standardized management of arterial blood glucose concentrations Arterial blood glucose was controlled in one- to four-hour intervals depending on the actual arterial blood glucose ... frequency of arterial blood glucose values During weeks one to three, arterial blood glucose concentrations were predominantly measured between and and and mmol/l corresponding to the set blood glucose ... function of the different GLUT subtypes are prevalent The arterial blood glucose concentration- dependent cerebral uptake of glucose, as seen in the present study, suggests that arterial blood glucose...

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Báo cáo y học: "The impact of early hypoglycemia and blood glucose variability on outcome in critical illness" ppt

Ngày tải lên : 13/08/2014, 16:21

... Berghe G Van den: Tight blood glucose control: what is the evidence? Crit Care Med 2007, 35:S496-502 16 Vanhorebeek I, Langouche L, Berghe G Van den: Tight blood glucose control with insulin in ... http://ccforum.com/content/13/3/R91 Table Summary of acute physiology stratified by hypoglycemia and blood glucose variability Characteristic Total (n = 66,184) Hypoglycemic episode only (n = 7209) Blood glucose variability ... Summary of crude clinical outcomes stratified by hypoglycemia and blood glucose variability Clinical outcome ICU length of stay (days) [median (IQR)] Total (n = 66,184) Hypoglycemic episode only Blood...

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Báo cáo y học: " Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury" docx

Ngày tải lên : 13/08/2014, 20:21

... A dose of around 10 single bags of cryoprecipitate derived from units of whole blood typically raises the plasma fibrinogen level by up to 60 to 100 mg dL-1 However, due to the risk of bloodborne ... of fibrinogen might be a safe approach to restore critical concentrations of fibrinogen and may reduce the need for the transfusion of allogenic blood products Abbreviations ANOVA: analysis of ... dose-dependent effect of fibrinogen to reverse haemodilutioninduced coagulopathy Increasing concentrations of fibrinogen resulted in a further improvement of clot formation and clot firmness Blood loss...

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Báo cáo y học: " Blood glucose control in the intensive care unit: discrepancy between belief and practice" potx

Ngày tải lên : 13/08/2014, 20:22

... [6,7] The current unavailability of accurate bedside blood glucose measurements in many ICU departments precludes safe, efficient, and widespread implementation of TGC Current technology research ... therapy increases the workload and responsibility for bedside nurses Frequent blood testing, interpretation of the blood glucose results, and finally adapting the insulin infusion are very demanding ... this ‘human’ factor and to avoid the use of inefficient and impractical guidelines, computerized algorithms taking into account the recent evolution of blood glucose values, the insulin dose, the...

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Báo cáo y học: "Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accident" docx

Ngày tải lên : 13/08/2014, 23:20

... Centre Blood tests for CN were taken on the arrival including an arterial puncture for blood gas analysis The arterial blood sample showed a COHb of 33.5% and lactate of 9.0 mmol/L After the blood ... Meyhoff CS: Rapid detection of blood cyanide concentration in victims of smoke inhalation Rune Frandsen AHJLHaECJ 2008, 107:A1974 Anesthesiology 2007 23 Schulz V: Clinical pharmacokinetics of ... difference between CN concentration in whole blood before and after HBO was 1.1 μmol/L +/- SEM 0.6 μmol/L Page of The mean lactate concentration on arrival was 4.4 mmol/L The mean lactate concentration...

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Development of mediatorless glucose sensing strategies for blood glucose monitoring in diabetes

Ngày tải lên : 30/09/2015, 06:21

... identification of metabolites of glucose metabolism [20] Electrochemistry Accuracy of blood glucose reading can be delayed at alternate sites during times of rapidly changing blood glucose, making ... 2.1.2.1 Detection of glucose and blood glucose Glucose stock solution (1 M) was stored overnight at RT for complete mutarotation The detection of varying concentrations of glucose was done by ... ………… 31 2.1.2.1 Detection of glucose and blood glucose ………………… 31 2.1.2.2 Effect of interfering substances on glucose detection……… 32 2.1.2.3 Production reproducibility of glucose sensing strategies…….32...

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