history and morphology of the lysosome

... feature in the regulation of cholesterol transport by AA and the release of AA in a specialized compartment of the cells could offer novel means for understanding the regulation of steroid synthesis, ... now by the inhibition in the induction of 5018 ACS4 [28] during the early response and the inhibition of ACS4 and StAR inductions during the sustained phase In both phases, the presence of DBI ... in the presence of CHX, the fatty acid bypasses the absence of ACS4 but not the absence of StAR Then, the partial inhibition produced by CHX on AA stimulated steroidogenesis was unexpected The...

Ngày tải lên: 16/03/2014, 12:20

Ngày tải lên: 13/11/2014, 10:36

... 18 mm of the point of the current supply electrode and 12 mm of the point of the voltage measurement electrode while insulating the other parts, and measures the electric conductivity of the soil ... soil in the center of the column The inner and outer diameters of the stainless steel rods were mm and 16 mm, respectively, and the ratio (I/V2) of the current of an outer electrode (I) to the potential ... early leaching of salts in the case of the 0.5 wt% application The results of the lower sensor showed that most of the salts in the soil could be leached in PV and after that the ECv only decreased...

Ngày tải lên: 05/09/2013, 09:38

... fracture The first spatial moment (M1) describes the displacement of the centre of the mass and the second spatial moment (M2) describes the spread of the deviation from the centre of mass The expressions ... is the length of the fracture and N0 is the initial concentration of radionuclide in the inlet of the fracture It can be observed in equations (6) and (11) that the colloid concentration in the ... pulse in order to use the above expressions (38) to (41) Results and discussion For the purpose of verification of the numerical model, the concentration profiles of the colloids and radionuclides...

Ngày tải lên: 05/09/2013, 17:03

... that the question of gender in the objectives of the NDOT seems to be far removed’ (2003: 45) In evaluating the impact of the Tshitwe Road Upgrading Project on the lives of the men and women of ... problems and how these are addressed can therefore place additional burdens on women and children This absence of or lack of awareness of the gendered patterns of travel and of time and task ... redistribution of these resources back to the rural sector, compared to women who used their money to purchase local goods and services With regard to the impact of the road upgrade on the travel demands of...

Ngày tải lên: 15/02/2014, 01:20

... as the pollutant of interest Of all of the modes of commuting, the highest mean exposures were experienced by the motorcyclist This is consistent with the results of other studies found in the ... the amount of physical exertion put in by the commuter and also their level of fitness Another significant factor is the topography The topography of Auckland is undulating In areas of high traffic ... ventilation rate of 36 L min-1 (within the range of 24-60 L min-1) and the runner a moderate level of 48 L min-1, both within the range of values reported in the literature [21-23] The commuter ‘dose’...

Ngày tải lên: 18/02/2014, 04:20

... where kA and k0 are the inactivation rate constants either in the presence or in the absence of various concentrations of a ligand A, k2 and k1 are the rate constants of the inhibition of the bilitranslocase– ... n, Number of [A] tested; k2 ⁄ k1, the value of the intercept in the Scrutton and Utter plot, where k2 and k1 are the rate constants of the inhibition of either the bilitranslocase-ligand complex ... complex and of free bilitranslocase, respectively Kd is the dissociation constant of the apparent bilitranslocase–ligand complex Figure 5B shows the Scrutton and Utter plot; the value of the dissociation...

Ngày tải lên: 20/02/2014, 01:20

... increases the uptake of 2-DOG without the need for PI-3¢ kinase activity as judged from the absence of an effect of arsenite on PI-3¢ kinase activation and the lack of inhibition by either wortmannin ... arsenite-induced glucose uptake (Fig 5C) These data illustrate the distinct nature of the insulin- (namely the IR) and arsenite-induced tyrosine kinases, and furthermore they suggest that tyrosine kinase ... cells [24–26] As the action of arsenite involves the modification of a limited number of arsenite-sensitive target proteins, we hypothesized that elucidation of the mechanism of arsenite-induced...

Ngày tải lên: 21/02/2014, 00:20

... form of Toc159, the existence of which is contested Despite the differences between the two models, there is a strong consensus on the composition of the Toc core complex and the role of the Toc ... accumulation of photosynthetic proteins is also tied to a reduction in the expression of the corresponding genes [17,65] Therefore, the extent of the physical involvement of the two receptors, atToc33 and ... for the transport of lipids to this membrane [27] The yeast member of the family Tob55 ⁄ Sam50 is part of the Tob ⁄ Sam complex and is involved in the insertion of b-barrel proteins into the...

Ngày tải lên: 07/03/2014, 03:20

... Additionally, because the demand of the chloroplast is ‘sensed’ inside the organelle, the IEM is closest to the origin of the signal, and thus regulation at the Tic complex could be one of the fastest ... which anchor the protein in the membrane The position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic ... description of recent advances in the understanding of the channel-, motor- and regulatory components of the Tic complex For reference, some of the available knowledge, including the proposed function of...

Ngày tải lên: 07/03/2014, 03:20

... requires GTP and is stimulated by ATP [5,6]; and transport of the 23 kDa (OE23) and 17 kDa (OE17) proteins of the oxygen evolving complex requires only the thylakoidal DpH [3] Furthermore, competition ... 1178 of the integral membrane proteins SecY and SecE, which are thought to form the Sec protein conducting channel SecA is an ATPase and drives the translocation of the protein through the Sec ... channel and Tha4 oligomerization and recruitment of Tha4 can be tailored to the size of the protein to be transported The cpTatC-Hcf106 complex forms the receptor for Tat substrates and both...

Ngày tải lên: 07/03/2014, 03:20

... an outline of the future challenges in this field is provided, and the insights that may be gained from a greater understanding of the mechanism of dual targeting for the targeting of location-specific ... that there are also reports of dual-targeted proteins to chloroplasts and the nucleus [7], to chloroplasts and the peroxisome [8,9], and, in Chlamydomonas reinhardtii, to chloroplasts and the ... evolutionarily history of dual targeting to be determined in more detail in terms of when it arose and whether it is conserved A complete understanding of dual targeting also requires an understanding of...

Ngày tải lên: 07/03/2014, 03:20

... coverage send their readings with the reporting frequency of The values of , , and are given in Table I and on Fig and Hence, the number of packets sent with the reporting frequency of in each ... 1978, 1981, and 1984, respectively Currently, he is the Ken Byers Distinguished Chair Professor of the School of Electrical and Computer Engineering, and Director of the Broadband and Wireless ... interval of can be calculated by Therefore, the ratio of the number For example, in of packets sent to that of received is 6.67 packets/s, 10 s, 101, the number Fig 5, for 5746 and the number of...

Ngày tải lên: 16/03/2014, 19:20

... spreading of the sugar In a porous medium, the deflection of the flow by pore walls plays the role of the stirring, but unlike the case of the teacup the pore walls also slows down the diffusion The ... embodied in the formulation of the partial differential equation, and the variability of the permeability is modeled by using random processes making the solving of the problem with the appropriate ... inherent variability of the system, and the scale of the system we try to model If our model is a perfect one for the scale chosen, then the "noise" reflects the measurement errors and the scale effects...

Ngày tải lên: 22/03/2014, 15:20

... cushion and treated with thermolysin (Th) (lanes 3, and 9) The results were analyzed by SDS ⁄ PAGE Lanes 1, and represent 10% of the translation product used for the import reactions The positions of ... ATP The yield of pTic22 import in the absence of ATP varied between 20–50% of that in the presence of ATP The import of pMGD1 was efficient only at FEBS Journal 274 (2007) 5043–5054 ª 2007 The ... role in the import of pTic22 and pMGD1, and therefore the competition by pOE33 is not as pronounced as it is for pSSU Nevertheless, the effect of pOE33 on import of pTic22 and pMGD1 is clearly...

Ngày tải lên: 23/03/2014, 07:20

... Uptake of [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these ... compared using an F-test on the ratio of the variance associated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees of freedom [33], VR ¼ ðSSE2 ... to the protein concentration of the membrane vesicles, and all data were corrected for the amount of radiolabelled substrate bound to the filter in the absence of vesicle protein The substrate and...

Ngày tải lên: 23/03/2014, 21:20

... superlattices may improve the thermoelectric figure of merit The results of further studies should also elucidate the complex physics of transport in these artificial materials ACKNOWLEDGMENTS The authors would ... temperature thermal conductivity of 0.92 0.12 W/m-K The cross-plane thermal conductivity in the temperature range of 300 K–380 K is shown in Figure The cross-plane thermal conductivity indicates that the ... extract the effective thermal activation energy of 114 6 meV The modification of the room temperature barrier (AB) height by varying the doping levels (i.e., by growing at high oxygen pressure) of the...

Ngày tải lên: 06/05/2014, 08:53

... exponentially until they reach the center of the barrier, and then they grow until they reach the metallic interface on the other side Since the wavefunction connects the two metallic leads, the electrons ... physicists at the banquet of the annual meeting of the American Physical Society The title of his talk was "There's plenty of room at the bottom" [Feynman (1961)] There was much conjecture amongst the ... simultaneous measurement of the positions and types of the atoms and of the charge profile can be achieved Bottom panel: Charge profile overlaid over the atomic positions of a YBa2Cu307_,5/Lao.67Cao.33Mn03...

Ngày tải lên: 04/06/2014, 14:33

Ngày tải lên: 04/06/2014, 14:41