high throughput screening enabling and influencing the process of drug discovery
high throughput screening, methods and protocols
Ngày tải lên :
11/04/2014, 09:46
... the field of drug discovery, and evolved into the field of high throughput screening (HTS) (1,5–9) Radioligand binding assays have historically been the mainstay of drug discovery and drug development ... as the primary engine driving lead discovery The HTS process is a subset of the drug discovery process and can be described as the phase from Target to Lead This phase can be broken down in the ... precoupled to the beads prior to the addition of ligand, all components of the assay can be added together at T0, or beads can be added after the receptors and ligand have been incubated together There...
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báo cáo khoa học: " SNP high-throughput screening in grapevine using the " docx
Ngày tải lên :
12/08/2014, 05:20
... extraction and the MDA sample preparation DC participated in the designing of the SNPlex assay AZ carried out the genome assembly and SNP discovery RV conceptualised the project and contributed to the ... the discussion of the results MT supervised the SNP-based marker development and genetic mapping and contributed to the discussion of the results All authors read and approved the final manuscript ... intensity of the peaks is measured on the x axis and the ratio of both peak heights is measured on the y axis B) Sequences flanking the target SNP5044 in Syrah (sy, bottom), Pinot Noir (pn, center) and...
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the neuroscience of social interaction decoding imitating and influencing the actions of others mar 2004
Ngày tải lên :
11/06/2014, 09:43
... objects in the same manner as hands Furthermore, the cells code the spatio-temporal interaction between the agent performing the action and the object of the action For example, cells tuned to hands ... understanding the feelings and sensations of others (e.g., Gallese 2001; Gallese and Goldman 1998; Preston and de Waal 2002; Chapter of this volume) The growing interest in the phenomena of empathy ... understanding of the goals of the actor Third, the communicative loop is closed so that the actor, in turn, interprets and responds to the behaviour of the observer Within this framework the authors...
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Báo cáo y học: "Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices" pptx
Ngày tải lên :
14/08/2014, 14:21
... trials and, ultimately, more individualized medical care The prospects for both drug- discovery and drug- development scientists and their patients look better and better Precisely how the pharmaceutical ... proofof-concept clinical trials Burley and Park 330.3 comment summarized the relative predictability of antisense oligonucleotides as therapeutic agents and their potential to improve efficacy and ... relate directly the effects of analgesic agents on neurophysiologic markers to patient perceptions of efficacy New types of therapeutics Avoiding the wrong drugs Early detection of toxicity is...
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the importance and impacts of costing method on the process of managerial decision making
Ngày tải lên :
13/03/2014, 14:20
... method can the best way to maximize profits of the companies without pressure of selling products They need another way to differentiate their business with other Therefore, besides of applying ... will be the most important parts which focus on the theory and the fact in a real case Chapter and chapter will considered as a background to create the general ideas of this thesis And chapter ... increase the number of the ending inventories as well as the profit of the organizations as mentioned above This not only can be considered as a strategy of the new comers to attract the investments...
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the importance and impacts ofcosting method on the process of managerial decision making
Ngày tải lên :
13/03/2014, 14:20
... waver and miss an opportunity For example: the representative of the UN and the general who commanded the UN forces had been unable to make up their mind about the need for an air force support and ... decisions based on emotive factors, they tend to consider the opinions of others and weigh them up in relation to their own understanding of a decision and its causes and effects However, men tend ... most of the analysis is based on the studies of other researchers so it can be debatable and difficult for users to apply in the reality 28 The major limitation of this study is the use of secondary...
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LAWYERS AND REGULATION The Politics of the Administrative Process doc
Ngày tải lên :
16/03/2014, 00:20
... choices of interest and values, on the one hand, and the desire for process on the other This study brings together concern for the administrative process and the role of lawyers by focusing on the ... the varieties of institutional form and the nature of the policy area, but the unique features of the American system compound the problem and beg the question of the significance of the data reported ... “top-down” process Rather, in the gap between the text of a statute and the behavior of an individual regulated entity, every step of the regulatory process can become a site for interpretation and...
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RISE OF THE AESTHETIC EXPERIENCE AND THE PROCESS OF GLOBALIZATION ppt
Ngày tải lên :
23/03/2014, 13:20
... one hand, the subjectivization of the aesthetic object and, on the other, the specialization of aesthetics in issues of aesthetics of art Namely, art, just like the beautiful and the aesthetic, ... process at the complexity of the term “aesthetic experience” To understand the meaning of the process of aestheticization, we need to make clear its mechanism and, possibly, the strategy of the ... production of the aesthetic artifacts The rise of aesthetic experience can, therefore, be seen through the prism of aestheticization, which is, simply, the process of turning something unaesthetic...
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the healing flow artistic expression in therapy creative arts and the process of healing an imageword approach inquiry
Ngày tải lên :
01/06/2014, 10:52
... sensuality of undiluted paint, the flowing rivers of water colors, the messiness of charcoals and graphite, and the dirty-ness of our hands and brushes and paint on the floor, the textures of paper and ... in the domain of the private and personal and my role in the public sphere – the role of a woman and a mother balanced with the role of a researcher, artist, and psychotherapist In this work, the ... within the microcosm of art therapy and my experience with the image-making process The pictures in the images contained in this book are their own record of the process of art toward healing They...
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Báo cáo khoa học nông nghiệp " Using FFS to enhance farmers'''' knowledge and skills in citrus production management in the process of implementing GAP in the South of Vietnam " docx
Ngày tải lên :
21/06/2014, 05:20
... 21.4% of respondents did not know the origin of their planting material In both regions the use of mineral fertilisers was very high, with 95% of farmers reporting their use in the MD and 88% in the ... coefficient of variation of 108% and in Vinh Long province difference was due to the small sample size (only farmers) and the net profit given by officials being based on the profit of advanced ... cost of FFS per participant represents only 1.60% of their net profit It is fair to assume that just the saving in the cost of pesticide as a result of reduction in the number of sprays was higher...
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Refrigeration and Air-Conditioning.Refrigeration: The process of removing heat ppt
Ngày tải lên :
27/06/2014, 17:20
... strikes on a roof and heats the surface When this happens, some of the heat changes the temperature of the first layer of the solid, and the remaining heat passes on to the next layer, and so on Calculations ... choice of refrigerant is therefore about the efficiency of the refrigerant and the efficiency of the refrigeration system The less the amount of energy needed to produce each kW of cooling, the ... account, the refrigerating effect (A1 – D1) and the compressor energy (B1 – A1) may be read off directly in terms of enthalpy of the fluid The distance of D1 between the two parts of the curve...
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Refrigeration and Air-Conditioning Refrigeration: The process of removing heat ppt
Ngày tải lên :
27/06/2014, 18:20
... strikes on a roof and heats the surface When this happens, some of the heat changes the temperature of the first layer of the solid, and the remaining heat passes on to the next layer, and so on Calculations ... choice of refrigerant is therefore about the efficiency of the refrigerant and the efficiency of the refrigeration system The less the amount of energy needed to produce each kW of cooling, the ... account, the refrigerating effect (A1 – D1) and the compressor energy (B1 – A1) may be read off directly in terms of enthalpy of the fluid The distance of D1 between the two parts of the curve...
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Báo cáo lâm nghiệp: " Humus conditions and stand characteristics of artificially established young stands in the process of the transformation of spruce monocultures" pdf
Ngày tải lên :
07/08/2014, 03:22
... the unmixed beech stand (22.0 t/ha) The mixed stand of spruce with beech and the spruce stand represent a mean between the stands – The active soil reactions of forest floor of the spruce stand ... unmixed stand of spruce, beech and mixed stand of spruce with beech The highest accumulation of forest floor was in the stand of larch with beech (52.6 t/ha) The lowest accumulation was found in the ... between the unmixed spruce stand and mixed stand of spruce with beech, between the unmixed spruce and beech stand, mixed stand of larch with beech and unmixed beech stand In exchangeable pH on the...
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Báo cáo y học: "A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language" ppt
Ngày tải lên :
09/08/2014, 22:23
... determined from the abundances of precursor peaks and in MS/MS spectra as the sum of the abundances of acyl anions of the fatty acids moieties Error bars stand for standard deviations from the average ... masses of the intact precursor ion and of the fragment of 74 Da neutral loss should meet different scconstraints The third signature ion is the fragment of neutral loss of the fatty acid moiety and ... structural feature of a lipid molecule and the power of the MFQL concept is that any of these can be recognized and used for the identification and quantification of individual species Therefore, we...
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báo cáo khoa học: " A comparative evaluation of the process of developing and implementing an emergency department HIV testing program" pps
Ngày tải lên :
10/08/2014, 10:23
... job as the ED is to disclose, make sure the confirmatory testing gets done, and then give them follow up in one of our clinics And then the docs are At the Hospital discretion of laboratory the ... confirmation done and it becomes the responsibility of the clinic to get them in ’ This view of linkage to care was situated within a larger understanding of the role of the ED in triaging and treating ... testing in the ED in the absence of external funding and how to determine the optimal level of integration of HIV testing into ED activities Further understanding the potential role of stigma...
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báo cáo khoa học: "Why don’t hospital staff activate the rapid response system (RRS)? How frequently is it needed and can the process be improved?" potx
Ngày tải lên :
10/08/2014, 10:23
... decision making and information gathering [18] Projection of future state The ability of the health professional to project the future course of events is determined by an understanding of the current ... because of the differing views and perceived role of the RRS by nursing and medical staff Establishing the scope of the problem First, we intend to determine the prevalence of patients meeting the ... able to project the future state is often the result of cues that may not be consciously recognised [19] One of the advantages of the RRS is that it removes the necessity of the clinical staff...
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Báo cáo y học: "Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice" pot
Ngày tải lên :
11/08/2014, 03:20
... in the Western diet This rodent model has all the hallmarks of obesity, insulin resistance, and liver steatosis plus it offers the further advantage of proven use for the investigation of therapeutic ... Methods) The smaller ΔCt value indicates the higher expression level EF stands for epididymal fat pad and MF for mesenteric fat pad The MF sample of week/Chow and the liver samples of week/Chow and ... analyzed the data, drafted part of the manuscript and prepared the histology and IHC figures ART and JVJ carried out mouse models and evaluated serum cytokines and other mediators DK carried out the...
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Báo cáo y học: "Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice" pptx
Ngày tải lên :
11/08/2014, 06:22
... in the Western diet This rodent model has all the hallmarks of obesity, insulin resistance, and liver steatosis plus it offers the further advantage of proven use for the investigation of therapeutic ... Methods) The smaller ΔCt value indicates the higher expression level EF stands for epididymal fat pad and MF for mesenteric fat pad The MF sample of week/Chow and the liver samples of week/Chow and ... analyzed the data, drafted part of the manuscript and prepared the histology and IHC figures ART and JVJ carried out mouse models and evaluated serum cytokines and other mediators DK carried out the...
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