high dose methotrexate in childhood acute lymphoblastic leukemia
Relapse prediction in childhood acute lymphoblastic leukemia by time series gene expression profiling
... typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting recent developments in gene ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance ... of childhood ALL are diagnosed in ASEAN countries each year About 50% of these cases need low-intensity therapy; 40% need intermediate-intensity; and 10% need high- intensity Treatment for childhood...
- 141
- 202
- 0
báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx
... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... 0.001 Higher score indicate higher quality of life or fewer problems; *self-reports (n = 27 in the intensive phase and n = 28 in the non-intensive phase); proxy-reports (n = 56 in the intensive...
- 8
- 415
- 0
báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx
... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... 0.001 Higher score indicate higher quality of life or fewer problems; *self-reports (n = 27 in the intensive phase and n = 28 in the non-intensive phase); proxy-reports (n = 56 in the intensive...
- 8
- 574
- 0
báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx
... of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good marker for high risk ... hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling pathways Additionally, both enzymes terminating leptin and insulin function – SOCS3 ... and leptin receptor genes on the metabolism of adipose tissue in survivors of childhood ALL In our cohort we found highly significant increase in leptin levels in overweight patients in the entire...
- 9
- 356
- 0
Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt
... cure rate in childhood acute lymphoblastic leukemia Leukemia 2006, 20:1955-1962 20 Widemann BC, Balis FM, Kim A, et al: Glucarpidase, leucovorin, and thymidine for high- dose methotrexate- induced ... of childhood acute lymphoblastic leukemia Leukemia 2010, 24:345-354 Schmiegelow K, Bjork O, Glomstein A, et al: Intensification of mercaptopurine /methotrexate maintenance chemotherapy may increase ... antimetabolite-based therapy of childhood ALL to illustrate the challenges we face in individualized medicine, and how they can be addressed Childhood acute lymphoblastic leukemia In the industrialized countries...
- 12
- 285
- 0
báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc
... TCTG-tandem duplication in NPM1exon 12 Leukemia 2007, 21:366-367 Rau R, Brown P: Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukemia: towards definition of a new leukemia entity ... mutations in 1485 adult patients with acute myeloid leukemia Blood 2006, 107:4011-4020 Ahmad F, Mandava S, Das BR: Mutations of NPM1 gene in de novo acute myeloid leukemia: determination of incidence, ... FLT3 mutations in childhood acute lymphoblastic leukemia Med Oncol 2009, 26:460-462 Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U: Different types of NPM1 mutations in children and...
- 5
- 319
- 0
báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf
... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... psychosocial) Items are scored using a four to six point Likert scale and converted to a to 100 point continuum, with higher scores indicating better QoL The original reference period of the CHQ ... confirm these findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations...
- 7
- 509
- 0
Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt
... cell lines (such as human skin fibroblasts, glioblastoma and colon carcinoma lines) and primary lymphocytes [13-15] Furthermore, CD was induced by IR in human hepatoblastoma cell line performing ... China Dose- dependent plasmid-constructed ß-actin, HVR2 and CD standards were used in each run of real-time PCR Of these, both plasmids containing the CD breakpoint and the HVR2 region were kindly ... differentiate into two major populations immediately: apoptotic population usually containing relative high CD level and thus being sensitive to apoptosis, while surviving population containing relatively...
- 25
- 227
- 0
báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc
... clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic leukemia; ... Masera G, Bartram CR: Minimal residual disease in childhood acute lymphoblastic leukemia: analysis of patients in continuous complete remission or with consecutive relapse Leukemia 1992, 6:282-288 ... Endo C, Oda M, Nishiuchi R, Seino Y: Persistence of TEL-AML1 transcript in acute lymphoblastic leukemia in long-term remission Pediatr Int 2003, 45:275-280 McLean TW, Ringold S, Neuberg D, Stegmaier...
- 7
- 225
- 0
báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx
... del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T-ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive T-ALL patients exhibited high ... often highly expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T-ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and...
- 5
- 199
- 0
báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc
... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acute lymphoblastic leukemia (T-ALL) cell lines (Jurkat, ... other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T-ALL cases ... of interest is 145 bp (line 4-11) Line 3: DNA ladder E: PCR products analyzed by 2.5% agarose gel electrophoresis Line 1-2: BCL11B (193bp), line 3: DNA ladder, line 4-5: BCL2L1 (202 bp), line...
- 7
- 410
- 0
Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating agent; its safety profile and lack of data on any mutagenic potential has led to its incorporation in a large number ... regarding the toxicity of TMZ, so questions have been raised about its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in...
- 3
- 277
- 0
Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating agent; its safety profile and lack of data on any mutagenic potential has led to its incorporation in a large number ... regarding the toxicity of TMZ, so questions have been raised about its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in...
- 3
- 267
- 0
CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... hypotheses concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed in young ... Identifying the Etiology of Acute Lymphoblastic Leukemia in Children http://dx.doi.org/10.5772/52716 [37] Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D Childhood acute lymphoblastic leukemia ... of the population mixing studies had failed to find an increase in a symptomatic infection in adults or children, paralleling the increase in leuke‐ mia incidence Considering that there are viruses...
- 342
- 1,022
- 0
Báo cáo khoa học: " Chemotherapy followed by low dose radiotherapy in childhood Hodgkin''''s disease: retrospective analysis of results and prognostic factors" ppt
... Hodgkin's disease nowadays have an excellent chance of definite cure [1] Therefore the main goal of Hodgkin's disease studies has been to minimize long-term side effects while maintaining the high ... was greater in patients with advancedstage disease at presentation In our institution in the period analyzed (1985–2000), IFRT was defined as treatment volume including the initially involved lymph ... initially involved sites and improving survival Conclusion This data demonstrating the importance of RT consolidation with low dose and reduced volume, in all clinical stage of childhood HD, producing...
- 8
- 293
- 0
Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high- dose or very high- dose intravenous methotrexate J Clin Oncol 2006, 24(24):3858-3864 ... discussed below The finding of similar outcomes in males and females is reassuring Initial reports of inferior outcomes in girls came from relatively small studies using combinations of methotrexate ... neuropsychological outcome in ALL are poorly understood and in fact in other areas of acute brain injury, such as head injury, girls usually have better outcomes than boys Again, changes in therapy protocols...
- 12
- 354
- 0
Báo cáo y học: " Precursor B-cell acute lymphoblastic leukemia presenting as obstructive jaundice: a case report" pdf
... rare presentation of acute lymphoblastic leukaemia in an adult JOP 2010, 11:72-74 Takamatsu T: Preferential infiltration of liver sinusoids in acute lymphoblastic leukemia Rinsho Ketsueki 2001, ... report any recent change in his medications and was tolerating his aspirin, sitagliptin, fosinopril, metformin and repaglinide without reported side effects His physical examination was significant ... biopsy of the liver showing small to medium-sized lymphoblasts infiltrating the hepatic parenchyma Page of Figure Bone marrow biopsy showing lymphoblastic infiltration instructions to follow up...
- 4
- 348
- 0
báo cáo khoa học: " Better retention of Malaysian opiate dependents treated with high dose methadone in methadone maintenance therapy" potx
... participate in analysing and interpreting the data, and drafted the manuscript NMS involve in collecting data NT involve in collecting data RI carried out the study design, analysing and interpreting ... that high doses of methadone were significantly more effective in suppressing illicit heroin use and in retaining patients in the treatment [38,41,42] Inadequate doses and premature termination ... predicting retention, a daily dose exceeding 80 mg will have a probability of 0.8 in accurately predicting that the patient will be retained in treatment In terms of predicting failure to retain,...
- 8
- 297
- 0
In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... CCAAT/enhancer-binding protein α Chromatin Immunoprecipitation Combination Index Chronic Myelogenous Leukemia Colorectal Carcinomas C-terminal Src Kinase 4'-6-Diamidino-2-phenylindole Disease ... overexpression of survivin are the main mechanism of resistance to ABT-869, suggesting potential targets for reducing resistance developed in patients receiving FLT3 inhibitors Our findings may indicate a ... 17-allylamino- 17-demethoxygeldanamycin acetyl-coenzyme A Acetyl-CoA Acetyltransferase Acute Myeloid Leukemia Cytosine Arabinoside Bone Marrow Bovine Serum Albumin Cyclin-Dependent Kinase CCAAT/enhancer-binding...
- 121
- 368
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25