... expression of heme oxygenase-1 in human retinalpigmentepithelialcells by transforming growth factor- beta J Cell Physiol 159, 371–378 24 Honda, S., Hjelmeland, L.M & Handa, J.T (2000) The use of hyperoxia ... hypoxiamediated induction of HO-1 expression may be a consequence of the production of a certain endogenous factor in D407 cells We therefore studied the effects of actinomycin D, an inhibitor of transcription, ... (1996) Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinalpigmentepithelialcells Infect Immun 64, 4188–4196 Arden, G.B (2001) The absence of diabetic retinopathy...
... assay Figure HPLC analysis of the synthesis and release of DA by RPE cells HPLC analysis of the synthesis and release of DA by RPE cells. (A) HPLC analysis of standard of DA, 3,4-dihydroxyphenylacetic ... Human retinalpigmentepithelial cell implants ameliorate motor deficits in two rat models of Parkinson disease J Neuropathol Exp Neurol 2007, 66:576-584 Ming M, Le W: Retinalpigmentepithelial cells: ... verified RPE cells play a key role in maintaining the normal function of retina and can express several neurotrophic factors such as platelet-derived growthfactor (PDGF), epidermal growthfactor (EGF),...
... the retinal periphery [26] In an effort to determine a mechanism for HSV-1 in retinal damage, specifically in terms of its ability to enter the cellsof the retina, the present study used retinal ... retinalpigmentepithelial (RPE) cells as a model to determine the susceptibility and the mediators of HSV-1 entry into these cells Using multiple assays, we demonstrate some unique aspects of the ... spread of the virions involving membrane fusion Nectin-1 mediates HSV-1 entry into RPE cells Results Attachment of HSV-1 to cell membrane of RPE cells In order to study the initial interaction of...
... Activation of the zymogen ofhepatocytegrowthfactor activator by thrombin J Biol Chem 268, 22927–22932 11 Miyazawa K, Shimomura T & Kitamura N (1996) Activation ofhepatocytegrowthfactor in ... analysis of the cDNA for a human serine protease responsible for activation ofhepatocytegrowthfactor J Biol Chem 268, 10024–10028 Lee SL, Dickson RB & Lin CY (2000) Activation ofhepatocytegrowth ... mediated by hepatocytegrowthfactor activator J Biol Chem 271, 3615–3618 12 Kataoka H, Hamasuna R, Itoh H, Kitamura N & Koono M (2000) Activation ofhepatocytegrowthfactor ⁄ scatter factor in...
... activated hepatocytegrowthfactor activator J Thromb Haemost 5, 1477–1485 Miyazawa K, Shimomura T & Kitamura N (1996) Activation ofhepatocytegrowthfactor in the injured tissues is mediated by hepatocyte ... sequence analysis of the cDNA for a human serine protease responsible for activation ofhepatocytegrowthfactor Structural similarity of the protease precursor to blood coagulation factor XII J Biol ... hepatocytegrowthfactor activator J Biol Chem 271, 3615–3618 Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y & Kitamura N (1993) Activation of the zymogen ofhepatocytegrowth factor...
... [4] Hepatocytegrowthfactor (HGF) was first purified as a potent mitogen for hepatocytes from the plasma of patients with FH [8,9] HGF is one of the primary agents promoting the proliferation of ... vivo proliferation of rat hepatic progenitor cells was stimulated by serum levels of ~2 ng/mL human HGF [13,26] In patients with FH, serum levels ofgrowth and growth- inhibitory factors were elevated ... stimulate proliferation of both mature hepatocytes and hepatic progenitor cells: less than 10 ng/mL of HGF was sufficient to induce proliferation of primary cultured rat hepatocytes [12,25], and...
... lupus nephritis Therapeutic effects ofhepatocytegrowthfactor (HGF) on the progression of lupus nephritis (a) Protective effect of HGF against the development of nephritic syndrome, as determined ... http://arthritis-research.com/content/8/4/R123 Figure eration from DBA/2 CD4+ growth In vitro effect of hepatocyteT cellsfactor (HGF) on T helper (Th)2 generation from DBA/2 CD4+ T cells CD4+ T cells from DBA/2 (H-2d) mice (4 × 106/ml/well) ... staining patterns of normal spleen cells Staining of normal F1 spleen cells with anti-MHC antibodies gave a unimodal positive profile when compared to negative controls Donor cells in GVHD mice...
... sequence analysis of cDNA for human hepatocytegrowthfactor Biochem Biophys Res Commun 1989, 163:967-973 Zarnegar R, Michalopoulos GK: The many faces ofhepatocytegrowth factor: from hepatopoiesis ... from five mice *p < 0.05 HGF, hepatocytegrowth factor; IL, interleukin; TGF, tumor growthfactor HGF gene transfection of TSK/+ mice resulted in a marked reduction of hypodermal thickness, including ... the production of TGF-β1 from macrophage-like cells and fibroblastic cells [32] Downregulation of TGF-β1 expression and inhibition of fibrosis by HGF were noted in a rat model of liver cirrhosis...
... efficiency (%) = Total growthfactor − Free growthfactor /Weight of nanoparticles / × 100 Entrapment efficiency (%) = Total growthfactor − Free growthfactor /Total growthfactor / × 100 Biochemical ... of activated myofibroblasts) Secretion of type I collagen by myofibroblasts that leads to fibrosis was analyzed by immunofluorescence The results of imunofluorescence study for distribution of ... betterment of maintenance, proliferation and differentiation of stem cells with exogenous supply ofgrowth factors by the injured liver has been reported [7] Despite the pleotrophic effect of HGF...
... identified as a potent inhibitor ofhepatocytegrowthfactor activator (HGFA), a blood coagulation factor XII-like serine protease that converts pro -hepatocyte growthfactor (pro-HGF) to the active ... inhibitor hepatocytegrowthfactor activator inhibitor-2 in the regulation ofepithelial matriptase activity J Biol Chem 283, 29495–29504 Lee SL, Dickson RB & Lin CY (2000) Activation ofhepatocytegrowth ... Morimoto Y & Kitamura N (1995) Activation ofhepatocytegrowthfactor by two homologous proteases, blood coagulation factor XIIa and hepatocytegrowthfactor activator Eur J Biochem 229, 257–261...
... (2009) Hepatocytegrowthfactor activator is a serum activator of single-chain precursor macrophage-stimulating protein FEBS J 276, 3481–3490 Kataoka H & Kawaguchi M (2010) Hepatocytegrowthfactor ... Roles of functional and structural domains ofhepatocytegrowthfactor activator inhibitor type in the inhibition of matriptase J Biol Chem 283, 2478–2487 33 Fan B, Wu TD, Li W & Kirchhofer D ... inhibitor directly and potently inhibits activated hepatocytegrowthfactor activator J Thromb Haemost 5, 1477–1485 Suzuki K (2010) Hepatocytegrowthfactor activator (HGFA): its regulation by protein...
... Activation of the zymogen ofhepatocytegrowthfactor activator by thrombin J Biol Chem 268, 2292722932 Mars, W.M., Zarnegar, R & Michalopoulos, G.K (1993) Activation ofhepatocytegrowthfactor ... Seeds, N.W (1996) Expression ofhepatocytegrowth factor/ scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system J Neurosci 16, ... acts as a cofactor in the activation of Plg to plasmin The ability of TN to accumulate by one or another mechanism the active tPA in the extracellular matrix enables a higher control of the local...
... Activation ofhepatocytegrowthfactor by two homologous proteases, blood-coagulation factor XIIa and hepatocytegrowthfactor activator Eur J Biochem 229, 257–261 18 Miyazawa K (2010) Hepatocytegrowth ... stimulates the growthof rat kidney proximal tubule epithelialcells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growthof SV-40 ... Kitamura N (1993) Activation of the zymogen ofhepatocytegrowthfactor activator by thrombin J Biol Chem 268, 22927–22932 21 Kataoka H & Kawaguchi M (2010) Hepatocytegrowthfactor activator (HGFA):...
... KLK4, KLK5 HAI-1 HAI-2 Tumor cellsEpithelialcells Inflammatory cells MSP Epithelialcells HGF/SF HAI-1 HAI-2 RON MET Macrophages Epithelialcells Tumor cells Endothelial cells Fig Hypothetical model ... Role ofhepatocytegrowthfactor activator (HGF activator) in invasive growthof human glioblastoma cells in vivo Int J Cancer 118, 583–592 39 Parr C & Jiang WG (2006) Hepatocytegrowthfactor ... Miyazaki K (2008) Induction ofhepatocytegrowthfactor activator gene expression under hypoxia activates the hepatocytegrowthfactor ⁄ c-Met system via hypoxia inducible factor- 1 in pancreatic cancer...
... (1993) A 40-kDa epidermal growth factor/ transforming growthfactor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growthfactor receptor J Biol Chem ... of hydrophobicity of the tyrosine at position 13 of human growthfactor in receptor binding J Biol Chem 268, 10114–10119 26 Campion, S.R & Niyogi, S.K (1994) Interaction of epidermal growthfactor ... model of ErbB-1, based on the structure of the type-1 insulin-like growthfactor receptor [33], shows that the N-terminal part of domain II is involved in a lobe of domain I [34] Domain II of ErbB-1...
... Scatter factor /hepatocyte growthfactor is essential for liver development Nature 1995, 373:699-702 La Rosa S, Uccella S, Capella C, Erba S, Sessa F: Localization ofHepatocyteGrowthFactor and ... liver growth due to differences in portal perfusion which results in a massive reduction of liver size Because hepatocytegrowthfactor (HGF) is one of the most important genes involved in liver growth/ regeneration ... analysis of liver homogenates of controls, Western blot analysis of liver homogenates of controls, CPSS, and PPVH Detection of HGF, c-MET, PKB, STAT, and ERK shown in (A), detection of the TGF-β1,...
... of 3-gel microfluidic device D) Endothelial cells form vascular network in the gel region of microfluidic devices E) Endothelial cells form vascular network under the presence of U87 glioma cells ... channel of microfluidic devices 2.5M/ml of endothelial cells were seeded in Matrigel coated microfludic channel days after seeding, cells were fixed and stained with DAPI A) Top view of the monolayer ... division of neuroepithelial cells and after depletion of this cell pool, also by asymmetric division of RGCs Basal stem cells are located at the subventricular zone (SVZ) and they are neural stem cells...
... growthfactor Vascular endothelial growthfactor 28.5 PDGF-AB 25.3 PDGF-BB Transforming growth factor- α 6.2 PDGF-AA Platelet-derived growthfactor EGF 24.3 Known Activities Proliferation of epithelial, ... Chapter Table 2-1 A list ofgrowth factors commonly used in tissue engineering* GrowthFactor Epidermal growthfactor Abbreviation Molecular Weight (kDa) Transforming growth factor- β Bone morphogenetic ... bioactivity ofgrowth factors as well as provide to the cells with the molecules without the dilution effect in solution is therefore necessary 2.5.1 Growth factors and criteria for delivery systems Growth...