hepatocyte growth factor protection of retinal pigment epithelial cells

... expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor- beta J Cell Physiol 159, 371–378 24 Honda, S., Hjelmeland, L.M & Handa, J.T (2000) The use of hyperoxia ... hypoxiamediated induction of HO-1 expression may be a consequence of the production of a certain endogenous factor in D407 cells We therefore studied the effects of actinomycin D, an inhibitor of transcription, ... (1996) Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells Infect Immun 64, 4188–4196 Arden, G.B (2001) The absence of diabetic retinopathy...

Ngày tải lên: 23/03/2014, 13:20

... assay Figure HPLC analysis of the synthesis and release of DA by RPE cells HPLC analysis of the synthesis and release of DA by RPE cells. (A) HPLC analysis of standard of DA, 3,4-dihydroxyphenylacetic ... Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of Parkinson disease J Neuropathol Exp Neurol 2007, 66:576-584 Ming M, Le W: Retinal pigment epithelial cells: ... verified RPE cells play a key role in maintaining the normal function of retina and can express several neurotrophic factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF),...

Ngày tải lên: 18/06/2014, 15:20

... the retinal periphery [26] In an effort to determine a mechanism for HSV-1 in retinal damage, specifically in terms of its ability to enter the cells of the retina, the present study used retinal ... retinal pigment epithelial (RPE) cells as a model to determine the susceptibility and the mediators of HSV-1 entry into these cells Using multiple assays, we demonstrate some unique aspects of the ... spread of the virions involving membrane fusion Nectin-1 mediates HSV-1 entry into RPE cells Results Attachment of HSV-1 to cell membrane of RPE cells In order to study the initial interaction of...

Ngày tải lên: 18/02/2014, 14:20

... activation of hepatocyte growth factor ⁄ scatter factor EMBO J 11, 4825–4833 Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y & Kitamura N (1995) Activation of hepatocyte growth factor ... Activation of the zymogen of hepatocyte growth factor activator by thrombin J Biol Chem 268, 22927–22932 Miyazawa K, Shimomura T & Kitamura N (1996) Activation of hepatocyte growth factor in the ... overexpressing hepatocyte growth factor ⁄ scatter factor Lab Invest 77, 131–138 2214 34 Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y & Kataoka H (2008) Activation of hepatocyte growth factor activator...

Ngày tải lên: 15/03/2014, 11:20

... Activation of the zymogen of hepatocyte growth factor activator by thrombin J Biol Chem 268, 22927–22932 11 Miyazawa K, Shimomura T & Kitamura N (1996) Activation of hepatocyte growth factor in ... analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor J Biol Chem 268, 10024–10028 Lee SL, Dickson RB & Lin CY (2000) Activation of hepatocyte growth ... mediated by hepatocyte growth factor activator J Biol Chem 271, 3615–3618 12 Kataoka H, Hamasuna R, Itoh H, Kitamura N & Koono M (2000) Activation of hepatocyte growth factor ⁄ scatter factor in...

Ngày tải lên: 23/03/2014, 07:20

... activated hepatocyte growth factor activator J Thromb Haemost 5, 1477–1485 Miyazawa K, Shimomura T & Kitamura N (1996) Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte ... sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor Structural similarity of the protease precursor to blood coagulation factor XII J Biol ... hepatocyte growth factor activator J Biol Chem 271, 3615–3618 Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y & Kitamura N (1993) Activation of the zymogen of hepatocyte growth factor...

Ngày tải lên: 29/03/2014, 23:20

... [4] Hepatocyte growth factor (HGF) was first purified as a potent mitogen for hepatocytes from the plasma of patients with FH [8,9] HGF is one of the primary agents promoting the proliferation of ... vivo proliferation of rat hepatic progenitor cells was stimulated by serum levels of ~2 ng/mL human HGF [13,26] In patients with FH, serum levels of growth and growth- inhibitory factors were elevated ... stimulate proliferation of both mature hepatocytes and hepatic progenitor cells: less than 10 ng/mL of HGF was sufficient to induce proliferation of primary cultured rat hepatocytes [12,25], and...

Ngày tải lên: 18/06/2014, 19:20

... lupus nephritis Therapeutic effects of hepatocyte growth factor (HGF) on the progression of lupus nephritis (a) Protective effect of HGF against the development of nephritic syndrome, as determined ... http://arthritis-research.com/content/8/4/R123 Figure eration from DBA/2 CD4+ growth In vitro effect of hepatocyteT cells factor (HGF) on T helper (Th)2 generation from DBA/2 CD4+ T cells CD4+ T cells from DBA/2 (H-2d) mice (4 × 106/ml/well) ... staining patterns of normal spleen cells Staining of normal F1 spleen cells with anti-MHC antibodies gave a unimodal positive profile when compared to negative controls Donor cells in GVHD mice...

Ngày tải lên: 09/08/2014, 08:22

... sequence analysis of cDNA for human hepatocyte growth factor Biochem Biophys Res Commun 1989, 163:967-973 Zarnegar R, Michalopoulos GK: The many faces of hepatocyte growth factor: from hepatopoiesis ... from five mice *p < 0.05 HGF, hepatocyte growth factor; IL, interleukin; TGF, tumor growth factor HGF gene transfection of TSK/+ mice resulted in a marked reduction of hypodermal thickness, including ... the production of TGF-β1 from macrophage-like cells and fibroblastic cells [32] Downregulation of TGF-β1 expression and inhibition of fibrosis by HGF were noted in a rat model of liver cirrhosis...

Ngày tải lên: 09/08/2014, 08:22

... efficiency (%) = Total growth factor − Free growth factor /Weight of nanoparticles / × 100 Entrapment efficiency (%) = Total growth factor − Free growth factor /Total growth factor / × 100 Biochemical ... of activated myofibroblasts) Secretion of type I collagen by myofibroblasts that leads to fibrosis was analyzed by immunofluorescence The results of imunofluorescence study for distribution of ... betterment of maintenance, proliferation and differentiation of stem cells with exogenous supply of growth factors by the injured liver has been reported [7] Despite the pleotrophic effect of HGF...

Ngày tải lên: 11/08/2014, 00:23

... identified as a potent inhibitor of hepatocyte growth factor activator (HGFA), a blood coagulation factor XII-like serine protease that converts pro -hepatocyte growth factor (pro-HGF) to the active ... inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity J Biol Chem 283, 29495–29504 Lee SL, Dickson RB & Lin CY (2000) Activation of hepatocyte growth ... Morimoto Y & Kitamura N (1995) Activation of hepatocyte growth factor by two homologous proteases, blood coagulation factor XIIa and hepatocyte growth factor activator Eur J Biochem 229, 257–261...

Ngày tải lên: 15/02/2014, 01:20

... (2009) Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein FEBS J 276, 3481–3490 Kataoka H & Kawaguchi M (2010) Hepatocyte growth factor ... Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type in the inhibition of matriptase J Biol Chem 283, 2478–2487 33 Fan B, Wu TD, Li W & Kirchhofer D ... inhibitor directly and potently inhibits activated hepatocyte growth factor activator J Thromb Haemost 5, 1477–1485 Suzuki K (2010) Hepatocyte growth factor activator (HGFA): its regulation by protein...

Ngày tải lên: 15/03/2014, 11:20

... Activation of the zymogen of hepatocyte growth factor activator by thrombin J Biol Chem 268, 2292722932 Mars, W.M., Zarnegar, R & Michalopoulos, G.K (1993) Activation of hepatocyte growth factor ... Seeds, N.W (1996) Expression of hepatocyte growth factor/ scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system J Neurosci 16, ... acts as a cofactor in the activation of Plg to plasmin The ability of TN to accumulate by one or another mechanism the active tPA in the extracellular matrix enables a higher control of the local...

Ngày tải lên: 17/03/2014, 03:20

... Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator Eur J Biochem 229, 257–261 18 Miyazawa K (2010) Hepatocyte growth ... stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 ... Kitamura N (1993) Activation of the zymogen of hepatocyte growth factor activator by thrombin J Biol Chem 268, 22927–22932 21 Kataoka H & Kawaguchi M (2010) Hepatocyte growth factor activator (HGFA):...

Ngày tải lên: 22/03/2014, 21:21

... KLK4, KLK5 HAI-1 HAI-2 Tumor cells Epithelial cells Inflammatory cells MSP Epithelial cells HGF/SF HAI-1 HAI-2 RON MET Macrophages Epithelial cells Tumor cells Endothelial cells Fig Hypothetical model ... Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo Int J Cancer 118, 583–592 39 Parr C & Jiang WG (2006) Hepatocyte growth factor ... Miyazaki K (2008) Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor ⁄ c-Met system via hypoxia inducible factor- 1 in pancreatic cancer...

Ngày tải lên: 22/03/2014, 21:21

... (1993) A 40-kDa epidermal growth factor/ transforming growth factor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor J Biol Chem ... of hydrophobicity of the tyrosine at position 13 of human growth factor in receptor binding J Biol Chem 268, 10114–10119 26 Campion, S.R & Niyogi, S.K (1994) Interaction of epidermal growth factor ... model of ErbB-1, based on the structure of the type-1 insulin-like growth factor receptor [33], shows that the N-terminal part of domain II is involved in a lobe of domain I [34] Domain II of ErbB-1...

Ngày tải lên: 24/03/2014, 03:21

... Scatter factor /hepatocyte growth factor is essential for liver development Nature 1995, 373:699-702 La Rosa S, Uccella S, Capella C, Erba S, Sessa F: Localization of Hepatocyte Growth Factor and ... liver growth due to differences in portal perfusion which results in a massive reduction of liver size Because hepatocyte growth factor (HGF) is one of the most important genes involved in liver growth/ regeneration ... analysis of liver homogenates of controls, Western blot analysis of liver homogenates of controls, CPSS, and PPVH Detection of HGF, c-MET, PKB, STAT, and ERK shown in (A), detection of the TGF-β1,...

Ngày tải lên: 13/08/2014, 13:20

... of 3-gel microfluidic device D) Endothelial cells form vascular network in the gel region of microfluidic devices E) Endothelial cells form vascular network under the presence of U87 glioma cells ... channel of microfluidic devices 2.5M/ml of endothelial cells were seeded in Matrigel coated microfludic channel days after seeding, cells were fixed and stained with DAPI A) Top view of the monolayer ... division of neuroepithelial cells and after depletion of this cell pool, also by asymmetric division of RGCs Basal stem cells are located at the subventricular zone (SVZ) and they are neural stem cells...

Ngày tải lên: 09/09/2015, 08:17

... growth factor Vascular endothelial growth factor 28.5 PDGF-AB 25.3 PDGF-BB Transforming growth factor- α 6.2 PDGF-AA Platelet-derived growth factor EGF 24.3 Known Activities Proliferation of epithelial, ... Chapter Table 2-1 A list of growth factors commonly used in tissue engineering* Growth Factor Epidermal growth factor Abbreviation Molecular Weight (kDa) Transforming growth factor- β Bone morphogenetic ... bioactivity of growth factors as well as provide to the cells with the molecules without the dilution effect in solution is therefore necessary 2.5.1 Growth factors and criteria for delivery systems Growth...

Ngày tải lên: 12/09/2015, 08:18