hepatic metabolism in liver disease

... for Pt (in the mucosa of the rat small intestine) that increases during intestinal absorption and decreases during cholera toxin-induced intestinal secretion Pt increases in response to intra-arterial ... Gastrointestinal Circulation tential therapeutic benefits in maintaining and/or restoring gastrointestinal blood flow Extrinsic vasoregulation Blood flow within the gastrointestinal tract is also in uenced ... venules, which in turn drain into collecting venules which join to form main venules and finally drain into the portal vein except the distal rectum, which drains into the internal iliac veins Lymph...

Ngày tải lên: 14/08/2014, 19:20

... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This is ... date In this minireview, we have brought together data suggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism...

Ngày tải lên: 18/02/2014, 14:20

... only in PPARa-null mice Proteomic analysis indicated that these proteins were tropomyosin-1 a-chain, tropomyosin b-chain, myosin regulatory light chain 2, myosin light chain 3, and parvalbumin-a ... examining a protein – DNA interaction In this method the protein-dependent association of two fluorescent-labelled DNA fragments each containing about half of a sequence defining a protein-binding ... survival-promoting transcription factor NFjB and sphingosine kinase We have studied the role of sphingosine kinase in PMA-induced activation of NFjB (p65) We found that PMA-induced NFjB binding was...

Ngày tải lên: 19/02/2014, 07:20

... As shown in Fig 1A, hematoxylin and eosin staining of liver B C As apoE possesses a central role in the metabolism of plasma lipoproteins and the development of dietinduced obesity, in this study ... damage in the liver of these animals is minimal following feeding with a high-fat diet In contrast, the destruction of the reticulin network (visualized as reduced reticulin stain) in the liver ... accumulation within hepatocytes Our histological findings were in harmony with the results obtained by reticulin staining, which showed that, in the liver of apoE) ⁄ ) mice, the reticulin network was...

Ngày tải lên: 05/03/2014, 23:20

... (5–7) and chronic kidney disease (54) NAFLD may progress to more severe disease states including end-stage liver disease and hepatocellular carcinoma (4) The increasing number of hospitalizations ... SE, Dziura J, et al Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat J Clin Endocrinol Metab 2006;91:4287–94 ... adults increased in the past decades, paralleling the trends in obesity-related hospitalizations This could be a consequence of the obesity epidemic or of increased screening for liver disease...

Ngày tải lên: 14/03/2014, 11:20

... input ⁄ output relationship Note that by constructing the conversion cone one 6252 loses no information because all other, less interesting, details are contained in the current matrix Assuming ... molecules in large excess and thus as being essentially constant Because we are not interested in tracking these four metabolites they were ignored in the stoichiometry matrix For the intramitochondrial ... metabolites in incubated mitochondria and in the free-flow system The data in Fig and Table were converted into percentage on the basis of the pyruvate entering the mitochondria and plotted together in...

Ngày tải lên: 16/03/2014, 14:20

... include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), probiotics, antibiotics, lactulose and nateglinide (insulin secretagogue) At the time being and in ... Pagotto U, Manini R, Vanni E, Gastaldelli A, de Iasio R, et al Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease ... hyaluronic acid and tissue inhibitor of matrix metalloproteinase I in predicting hepatic fibrosis in 912 patients with a wide range of liver diseases The study showed promising results but was limited...

Ngày tải lên: 22/03/2014, 10:20

... requiring liver transplantation in paediatric NAFLD remains uncertain, and further studies in this area are needed It is also intriguing that both cases undergoing liver transplantation in our ... prothrombin time were essentially within the normal range in all patients Positive autoantibodies in low titres were found in 20% of patients including ANA in 15.4%, and SMA in 10% of patients Liver ... The main liver biopsy features are summarised in table Some degree of fibrosis was present in 59% of children including mild fibrosis (stage 1–2) in 11, septal/bridging fibrosis (stage 3) in four,...

Ngày tải lên: 22/03/2014, 10:20

... decreasing aminotransferase levels in the days following the initial insult without increasing coagulopathy or hyperbilirubinemia Infiltrative disorders • Infiltrative disorders of the liver ... excretion, in which excessive copper accumulation in the liver leads to cirrhosis • The excess copper is deposited in the cornea, kidneys, and brain, resulting in extrahepatic manifestations of the disease ... (hepato-cellular injury mixed) • HEPATITIS A: • flu-like illness , Anorexia, fever, vomiting, abdominal pain, darkening of the urine, especially following ingestion of contaminated food • Hepatitis...

Ngày tải lên: 28/03/2014, 09:20

... preferable, since they are more effective in maintaining disease control, minimising the need for highdose steroid pulses during relapses, with attendant more severe side effects Discontinuation ... AIH has been reported in adult patients maintained on azathioprine alone.6 Following this observation, we have attempted to stop prednisolone, while maintaining azathioprine in children (2 ANA/SMApositive ... Sclerosing Cholangitis (ASC) Clinical Features Sclerosing cholangitis is an uncommon disorder, characterised by chronic inflammation and fibrosis of the intrahepatic and/or extrahepatic bile ducts In...

Ngày tải lên: 28/03/2014, 11:20

... are indicated in bold/underlined) from the template of a pUC19 plasmid DNA containing GH1 (Xinxiang Medical University, Xinxiang, Henan Province, China) The 677-bp GH1 DNA fragment (including ... alcoholic fatty liver in mice Am J Physiol Gastrointest Liver Physiol 2008, 295:G833-G842 Long YC, Zierath JR: AMP-activated protein kinase signaling in metabolic regulation J Clin Invest 2006, ... of intrahepatic lipid metabolism Hepatic GH can interact with its receptor (GHR) on the surface of target cells and induces the association of GHR with Janus kinase (JAK)-2 to initiate tyrosine...

Ngày tải lên: 18/06/2014, 16:20

... Alcoholism, 2007) In contrast, in the United Kingdom binge drinking is defined as the consumption of more than eight drinks in men and more than six drinks in women in a single day (Institute of Alcohol ... malnutrition in patients with alcoholic liver disease are summarized Alcohol drinking patterns When talking about “alcohol drinking”, two main patterns have to be distinguished: acute “binge drinking” ... prevalence of binge drinking decreases, both in the United States and United Kingdom, with increasing age, indicating that the phenomenon “binge drinking” is as an important problem especially in young...

Ngày tải lên: 27/06/2014, 16:20

... of Vitamins Vitamin Coenzyme Typical Reaction Type Thiamine (B,) Thiamine pyrophosphate (TPP) Flavin-adenine dinucleotide (FAD) Flavin-adenine mononucleotide (FMN) Nicotinamide-adenine dinucleotide ... AMINO ACIDS 305 21 SULFUR AMINO ACID METABOLISM 325 22 FOLATE AND VITAMIN IN ONE-CARBON METABOLISM 335 23 PURINES AND PYRIMIDINES 351 24 HEME AND IRON 372 25 INTEGRATION OF METABOLISM 393 INDEX ... the activity of a serine-threonine protein kinase called protein kinase A (PKA) Briefly, this particular signaling pathway involves binding of glucagon or epinephrine to its respective transmembrane...

Ngày tải lên: 06/07/2014, 15:19

... elevated in patients with alcoholic and non-alcoholic fatty liver diseases preceding hepatocellular cancer We suggest that the increased levels of sVAP-1 may be a clinically useful marker in liver diseases ... after combining with chemiluminescence ELISA reagent (Boehringer Mannheim, Germany) according to the manufacturer’s instructions The intensities of the chemiluminescence reactions in the wells ... decrease in the sVAP-1 levels In conclusion, we have shown that sVAP-1 is present in the serum of patients with HCC Moreover, the level of VAP-1 is increased in liver diseases in a more disease- specific...

Ngày tải lên: 09/08/2014, 03:22

... cognitions include ignoring pain, using coping selfstatements, and indicating acceptance of pain Negative processes include catastrophizing (ie, viewing the pain as the worst thing in the world ... clarithromycin (Biaxin), ethambutal (Myambutal), rifabutin (Mycobutin), and clofazamine (Lamprene) Other drugs with in vivo or in vitro efficacy include amikacin, ciprofloxacin, cycloserine, and ethionamide ... Therapy in Gastroenterology and Liver Disease occur with increased incidence in CVID patients (Table 47-2) (Cunningham-Rundles and Bodian, 1999) Giardia infection, though decreasing in frequency in...

Ngày tải lên: 10/08/2014, 14:22

... “Nonsteroidal Antiinflammatory DrugInduced Small and large Intestinaal Injury”) on NSAIDinduced injury to the small and large intestine 357 358 / Advanced Therapy in Gastroenterology and Liver Disease ... antiinflammatory drug induced intestinal in ammation in humans Gastroenterol 1987;93:480–9 Bjarnason I, Zanelli G, Prouse P, et al Blood and protein loss via small intestinal in ammation induced ... therapies in the irritable bowel syndrome Arch Intern Med 2003;163:265–74 Complementary and Alternative Medicine in Gastrointestinal Disease / 353 early during the course of their disease (Astin,...

Ngày tải lên: 10/08/2014, 14:22

... husk, kaolin, methylcellulose, and cholestyramine are frequently used in mild to moderate diarrheas Cholestyramine and other binding resins are principally used in diarrheas for which binding bile ... symptoms of intestinal gas and some of the diarrhea.‡ Perineal dermatitis presents with perineal itching, pain, and occasionally bleeding The attempt to maintain perineal hygiene in the presence ... physical trauma of the perineal cleansing Patients should be instructed in proper perineal hygiene including gentle cleansing following a stool and with bathing The perineum should not be scrubbed,...

Ngày tải lên: 10/08/2014, 14:22

... proposed to explain prolapse-associated incontinence These include direct sphincter trauma caused by repeated stretching by the intussuscepting rectum or that the intussuscepting rectum leads ... prolapse of the hemorrhoids Contributing factors include chronic straining, aging, increased intra-abdominal pressure, and absence of sinusoidal valves Elevated anal resting pressures and ultraslow waves ... estimates are for all gastrointestinal malignancies, including colon 554 / Advanced Therapy in Gastroenterology and Liver Disease tomas have also been found in the large intestine of PJS patients Polyps...

Ngày tải lên: 10/08/2014, 14:22

... retinol due to deficiency in transhyretin, a thyroxine binding globulin to which retinol binding globulin is bound in the circulation, may also occur Deficiency in vitamin A usually manifests itself ... local ablative therapy in many liver centers The principle of RFA involves inserting an insulated cannula into the tumor where alternating current is passed, resulting in heating of the area around ... normally, but in some patients, positive staining is present in some but not all liver nodules Absence of staining does not exclude Wilson’s disease Normal in the absence of Wilson’s disease and in many...

Ngày tải lên: 10/08/2014, 14:22