heparin antithrombin activated protein c and sodium bicarbonate
Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc
Ngày tải lên :
19/02/2014, 13:20
... of factor Va and factor VaR506Q by activated protein J Biol Chem 270, 21158–21166 11 Nicolaes, G.A.F & Dahlback, B (2003) Congenital and acquired ¨ activated protein C resistance Sem Vasc Med ... H .C. , Varadi, K., Schwarz, H.P & Tans, G (1995) Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C J Biol Chem ... surface of the vascular bed, and the lack of good estimates of local concentrations of coagulation proteins or reactants during hemostatic reactions, our data may still have clinical ramifications...
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Báo cáo khoa học: "Levels of protein C and activated protein C: what do they mean" doc
Ngày tải lên :
12/08/2014, 23:21
... Hazelzet JA: Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, ... Utterback BG, Yan B, Chao YB, Fernandez JA, Griffin JH, Hartman DL: Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Crit Care Med 2000, ... expressed are not very common, and make it difficult to compare the results with other studies The differences between cases and controls are not dramatically clinically significant The results on...
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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot
Ngày tải lên :
13/08/2014, 03:20
... production, direct antiapoptotic effects, and suppression of NF-κB subunits and therefore decreased inflammatory cell adhesion APC, activated protein C; ICAM, intercellular adhesion molecule; ... picomolar concentrations of thrombin may produce similar PAR1 activation as pharmacologic concentrations of APC, which is a poor activator of PAR1 Furthermore, thrombin can locally generate APC ... PI3-kinase S1P1 signaling through Rac1 leads to cortical cytoskeletal rearrangement and endothelial barrier protection APC, activated protein C; EPCR, epithelial protein C receptor; PI3-kinase, phosphatidyl-inositol-3...
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Báo cáo khoa học: " A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care" pot
Ngày tải lên :
13/08/2014, 10:20
... were categorized as 'could not contact' Baseline data and hospital resource data were collected for both APC and standard care patients Data collection included important baseline demographics ... purposes) Critical Care Vol 11 No Longo et al Figure Patient flow diagram for study participants APC, activated protein C; CNC, could not contact; SF-36, 36-item Short Form participants Resource utilization ... APACHE II score (mean ± SD) 27.2 ± 7.5 26.3 ± 7.8 26.6 ± 7.7 0.48 APACHE II, Acute Physiology and Chronic Health Evaluation II; APC, activated protein C; ER, emergency room; ICU, intensive care...
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Báo cáo y học: "Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock" ppt
Ngày tải lên :
14/08/2014, 07:21
... rhAPC reduced cardiac MDA levels in septic shock • rhAPC reduced cardiac 3-NT levels in septic shock • rhAPC improved global hemodynamics in septic shock • rhAPC attenuated changes in microcirculation ... al.: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock Critical Care 2010 14:R217 Submit your next manuscript ... lipopolysaccharide-induced major microcirculation dysfunction accompanied by microvascular oxidative stress and glycocalyx degradation may be limited by APC This is in line with our findings, clearly...
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Báo cáo y học: "Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism." ppt
Ngày tải lên :
14/08/2014, 07:21
... JH: Anticoagulant synergism of heparin and activated protein C in vitro Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C J Clin ... treatment with activated protein C may improve clinical outcome, by reducing organ dysfunction due to microvascular occlusion and other mechanisms [16,17] In view of the impaired protein C system present ... with acute submassive PE The study was not intended to show clinical efficacy, and clinical evaluation was focused primarily on safety issues such as occurrence of bleeding The incidence of major...
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Tài liệu Báo cáo Y học: Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes pot
Ngày tải lên :
22/02/2014, 07:20
... when AMPK was activated We confirmed that this ACC inactivation corresponded to a decrease in Vmax (data not shown) In contrast, ACC activation by amino acids occurred without a change in Ser79 ... the other hand, it is remarkable that ACC inactivation is very sensitive to AICAr and that partial activation of AMPK suffices to inactivate completely ACC In contrast with ACC, the active form ... Attraction (P4/23), by the ÔActions de ´ Recherche concerteesÕ 98/03-216 (French Community of Belgium), by the Belgian Fund for Medical Scienti c Research, and by the EU contract no QLG1-CT-2001-01488...
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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf
Ngày tải lên :
30/03/2014, 01:20
... AGATGCAATAC-3¢; reverse, 5¢-ACACAGCTGGCAATGACAAG-3¢), MCP-1 (forward, 5¢-GTGAGGAGCCACCAACATTT-3¢; reverse, 5¢-GGGGGATCCCAAGTACTGTT-3¢) and GAPDH (forward, 5¢-CCCATCACCATCTTCCAGGA-3¢; reverse, 5¢TGCTTCACCACCTTCTTGAT-3¢) ... amplification was performed on the resulting cDNAs with speci c primers for human IL-6 (forward, 5¢-CAGGAGCCCAGCTATGA ACT-3¢; reverse, 5¢-TAAGTTCTGTGCCCAGTGGA-3¢), IL-8 (forward, 5¢-AGGGTTGCC AGATGCAATAC-3¢; ... 5¢TGCTTCACCACCTTCTTGAT-3¢) at 94 C for 30 s, 56 C for 15 s and 72 C for min, for 30 cycles The expected lengths of the fragments for IL-6, IL-8, MCP-1 and GAPDH were 730, 870, 733 and 520 bp,...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
Ngày tải lên :
31/03/2014, 15:20
... cellular functions such as actin cytoskeletal dynamics, superoxide generation, membrane trafficking, apoptosis, cell cycle control, activation of phospholipases C and D, and cell chemotaxis [40–46] ... of HL-60 cells induced with ATRA Induction of Rac and PAK HL-60 cells were treated with lM ATRA for a week, and Rac and PAK were assayed in both cytosol and membrane fractions Rac occurs as two ... serine/threonine protein kinase activated by Cdc42 and Rac1 Nature 367, 40–46 Martin, G.A., Bollag, G., McCormick, F & Abo, A (1995) A novel serine kinase activated by Rac1/Cdc42Hs-dependent autophosphorylation...
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Nghiên cứu các yếu tố antithrombin III, protein C, protein S và rối loạn lipid máu ở bệnh nhân nhồi máu não
Ngày tải lên :
08/04/2014, 13:28
... 10 C c gi¸ trÞ ®èi chiÕu C c xÐt nghiƯm chÊt chèng ®«ng sinh lý ®− c so s¸nh ®èi chiÕu víi chØ sè sinh h c ë ng−êi b×nh th−êng c a c c t c gi¶ n− c vµ ngoµi n− c C c chØ sè lipid m¸u sÏ ®− c ®¸nh ... ng¨n chỈn nh÷ng hiƯn t−ỵng ®«ng m¸u kh«ng c n thiÕt x¶y ë c thĨ c thĨ g©y t c m¹ch C c chÊt c chÕ ®«ng m¸u sinh lý ®− c chia thµnh hai hä lín víi c c ® c ®iĨm nh− sau: B¶ng 1.1: § c ®iĨm c c chÊt ... 114 – 121 Danh m c c c ch÷ viÕt t¾t APC ATIII ATP C4 bBP CETP GP HDL -C HMWK IDL LCAT LDL -C Lp (a) LPL PF3 PPSB TFPI t-PA VLDL ZPI : Protein C ho¹t hãa (Activated protein C) : Antithrombin III...
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báo cáo hóa học: " HIV-1 and IL-1b regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-B signaling mechanisms" ppt
Ngày tải lên :
19/06/2014, 22:20
... H, Schmidt WE, Folsch UR, Schafer H: Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines Cancer ... CCL2 and CXCL8 from days one through five CCL2 and CXCL8 levels were significantly increased in HIV-1 YU-2 -transfected astrocytes by days two and five as compared to respective mock controls and ... experimental time course HIV-1YU-2-transfection leads to HIV-1-associated protein expression and astrocyte activation Since production of chemokines CCL2 and CXCL8 is associated with astrocyte activation...
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Báo cáo y học: " Mitogen-activated protein kinases and NFκB are involved in SP-A-enhanced responses of macrophages to " pdf
Ngày tải lên :
12/08/2014, 14:20
... decrease in cell viability 10 ** BCG B/S B+HA B/S+HA Figure tion of nitric oxide Herbimycin A inhibits BCG- and SP-A-BCG-induced producHerbimycin A inhibits BCG- and SP-A-BCG-induced production ... by cultured rat macrophages [44] This enhanced clearance is accompanied by increased production of nitric oxide and TNF The focus of the current study was to determine if SP-A enhances production ... 1000 BCG BCG+SPA B C B S B/S L C +DMSO +Lact 20 Nitric Ox ide (nmol/ml) 20 Luciferas e Activ ity (c pm) SP-A enhances the BCG-induced activation of NFkB Several groups have recently reported activation...
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Báo cáo khoa học: "The effect of activated protein C on experimental acute necrotizing pancreatitis" ppt
Ngày tải lên :
12/08/2014, 22:21
... duplicate on phenylethyl alcohol and MacConkey II agar, and then incubated aerobically at 37 C for 24 hours Bacterial counts were expressed as colony-forming units/g tissue, and counts of 1000 colony-forming ... LY and MRM conceived the study BC performed statistical analysis ATI and SA performed the surgical procedures NM and SD carried out histological analysis MO and IT carried out microbiological, ... therapeutic agent in acute pancreatitis? Pancreas 2004, 28:e1-e8 Dhainaut JF, Yan SB, Claessens YE: Protein C /activated protein C pathway: overview of clinical trial results in severe sepsis Crit Care...
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Báo cáo khoa học: "Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study" pot
Ngày tải lên :
12/08/2014, 22:22
... Menger MD: Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia Crit Care Med 2004, 32:1011-1017 Elisen MG, Maseland MH, Church FC, Bouma BN, Meijers JC: Role ... under which circumstances the duration of rhAPC infusion can be limited without influencing efficacy At baseline, 92% of our septic patients were protein C deficient with a mean protein C level ... translocation, which is required for increases in proinflammatory cytokines and adhesion molecules [5] Direct activation of PAR-1 by the APC-EPCR complex is another mechanism by which APC may affect...
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Báo cáo khoa học: "Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitis" pptx
Ngày tải lên :
12/08/2014, 22:22
... the cases indicate the efficacy of drotrecogin alfa in severe acute pancreatitis These reports highlight an acute dilemma in contemporary critical care practice: there is a clear dearth of specific ... but, in the face of critical illness in severe acute pancreatitis, a vogue for the use of new medications must not replace the need to detect and treat infected pancreatic necrosis Competing interests ... recombinant human protein C from three mammalian cell lines Biotechnology (NY) 1990, 8:655-661 Esmon CT: Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and...
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Báo cáo khoa học: "Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis" pot
Ngày tải lên :
12/08/2014, 23:21
... http://ccforum.com/content/10/1/R16 Figure Levels of (a) protein C (PC), (b) activated protein C (APC), and (c) APC/PC ratio during hospital stay in patients with acute pancreatitis Control, pancreatitis ... Figure Correlations between dimer concentrations percentage of HLA-DR-positive monocytes and (a) protein C (PC), (b) activated PC (APC), (c) platelet count, and (d) Ddimer concentrations Correlation ... Patch M, Francis R, Chan L: Epidemic meningococcemia and purpura fulminans with induced protein C deficiency Clin Infect Dis 1993, 17:254-261 Mesters R, Helterbrand J, Utterback B, Yan B, Chao...
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Báo cáo khoa học: "Recombinant activated protein C: the key is clinical assessment of risk of death, not subset analysis" potx
Ngày tải lên :
12/08/2014, 23:21
... Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709 Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra ... decision on administration of rhAPC should be based on a seasoned clinician’s clinical assessment of high risk of death from sepsis-induced organ failure and acceptable risk of bleeding complications ... T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al.: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock Crit Care Med 2004, 32:858873 Vincent...
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Báo cáo khoa học: "Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin-induced shock" potx
Ngày tải lên :
12/08/2014, 23:22
... and cellular mechanism of activated protein C action during endotoxemia Crit Care Med 2004, 32:1011-1017 Jackson CV, Bailey BD, Shetler TJ: Pharmacological profile of recombinant human activated ... baboon J Clin Invest 1987, 79:918-925 Roback MG, Stack AM, Thompson C, Brugnara C, Schwartz HP, Saladino RA: Activated protein C concentrate for the treatment of meninogococcal endotoxin shock in ... an anticoagulant by activating PC Activated PC (aPC) inactivates the coagulation cofactors Va and VIIIa through proteolytic degradation, thereby limiting thrombin generation aPC produces then...
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