hematopoietic cell transplantationspecific comorbidity index hctci

... interaction of cell- surface molecules, termed selectins, on bone marrow endothelial cells with ligands, termed integrins, on early hematopoietic cells. Human hematopoietic stem cells can survive ... siblings. Chapter 108. Hematopoietic Cell Transplantation (Part 1) Harrison's Internal Medicine > Chapter 108. Hematopoietic Cell Transplantation Hematopoietic Cell Transplantation: ... transplantation of hematopoietic stem cells, but with the demonstration that the peripheral blood and umbilical cord blood are also useful sources of stem cells, hematopoietic cell transplantation...

Ngày tải lên: 07/07/2014, 04:20

... higher numbers of bone marrow cells. Hematopoietic stem cells circulate in the peripheral blood but in very low concentrations. Following the administration of certain hematopoietic growth factors, ... of bone marrow have also been shown to diminish tumor cell numbers in stem cell products. Another technique is positive selection of stem cells using antibodies to CD34, generally required ... adherence or flow techniques to select normal stem cells while leaving tumor cells behind. All these approaches can reduce the number of tumor cells from 1000- to 10,000-fold and are clinically...

Ngày tải lên: 07/07/2014, 04:20

... preparative regimen, then cells produced by the transplanted stem cells begin to appear in the peripheral blood. The rate of recovery depends on the source of stem cells, the use of posttransplant ... the removal of red cells to prevent hemolysis in ABO-incompatible transplants, the removal of donor T cells to prevent GVHD, or attempts to remove possible contaminating tumor cells in autologous ... If marrow is the source of stem cells, recovery to 100 granulocytes/àL occurs by day 16 and to 500/àL by day 22. Use of G-CSFmobilized peripheral blood stem cells speeds the rate of recovery...

Ngày tải lên: 07/07/2014, 04:20

... disease; GVHD, graft-versus- host disease; HSV, herpes simplex virus; CMV, cytomegalovirus; VZV, varicella- zoster virus. The size of the shaded area roughly reflects the risk of the complication....

Ngày tải lên: 07/07/2014, 04:20

... second general approach to GVHD prevention is removal of T cells from the stem cell inoculum. While effective in preventing GVHD, T cell depletion is associated with an increased incidence of ... receiving stem cells from unrelated donors. The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets. ... evidence suggests that T -cell depletion improves cure rates in any specific setting. Despite prophylaxis, significant acute GVHD will develop in ~30% of recipients of stem cells from matched siblings...

Ngày tải lên: 07/07/2014, 04:20

... common following use of less-immunosuppressive preparative regimens, in recipients of T cell depleted stem cell products, and in patients receiving grafts from HLA-mismatched donors. Treatment ... significantly reduce the risk of CMV disease in seropositive patients. Elimination of white blood cells from transfused blood products is another method to prevent CMV transmission. Foscarnet is ... 180 or off immunosuppression Viral Herpes simplex Acyclovir 800 mg PO bid to day 30 Varicella zoster Acyclovir 800 mg PO bid to day 365 Cytomegalovirus Ganciclovir 5 mg/kg IV bid...

Ngày tải lên: 07/07/2014, 04:20

... Using Hematopoietic Cell Transplantation Nonmalignant Diseases: Treatment Immunodeficiency Disorders By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation ... 40 40 Hodgkin's disease First relapse/second remission 40 50 Chapter 108. Hematopoietic Cell Transplantation (Part 7) Pneumocystis jiroveci pneumonia, once seen in 5–10% of ... monitoring for late CMV reactivation. In addition, many centers recommend prophylaxis against varicella zoster, using acyclovir for 1 year posttransplant. ...

Ngày tải lên: 07/07/2014, 04:20

... stem cells if an appropriate donor is available. Theoretically, hematopoietic cell transplantation should be able to cure any disease that results from an inborn error of the lymphohematopoietic ... osteoclasts derive from the marrow, transplantation can cure this rare inherited disorder. Hematopoietic cell transplantation has been used as treatment for a number of storage diseases caused ... have been cured of both with transplantation. Malignant Diseases: Treatment Chapter 108. Hematopoietic Cell Transplantation (Part 8) Aplastic Anemia Transplantation from matched siblings...

Ngày tải lên: 07/07/2014, 04:20

... Copelan EA: Hematopoietic stem- cell transplantation. N Engl J Med 354:1813, 2006 [PMID: 16641398] Petersdorf EW et al: Major-histocompatibility- complex class I alleles and antigens in hematopoietic- cell ... antigens in hematopoietic- cell transplantation. N Engl J Med 345:1794, 2001 [PMID: 11752355] Bibliography Child JA et al: High-dose chemotherapy with hematopoietic stem- cell rescue for multiple ... Readings Appelbaum FR: Haematopoietic cell transplantation as immunotherapy. Nature 411:385, 2001 [PMID: 11357147] Baron F, Storb R: Hematopoietic stem cell transplantation after reduced- i ntensity...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 10/08/2014, 10:21

Ngày tải lên: 10/08/2014, 22:20

Ngày tải lên: 10/08/2014, 22:21

Ngày tải lên: 11/08/2014, 02:21

... appearance of cells with adult repopulating capacity. Thus, the accepted view of the adult hematopoietic hier- archy with the hematopoietic stem cell (HSC) at its foundation does not reflect the hematopoietic ... Characterization of Primitive Hematopoietic Cells Based on Their Position in the Cell Cycle Edward F. Srour and Craig T. Jordan 1. Introduction Hematopoietic progenitor and stem cells are believed to ... functional properties and cell- cycle status of the same group of putative stem cells. Instead, cell- cycle analysis and assessment of hematopoietic potential of primitive progenitor cells have usually...

Ngày tải lên: 11/04/2014, 09:45

... current status of hematopoietic cell transplantation. Annu Rev Med 2003, 54:491-512. 6. Horowitz MM: Uses and growth of hematopoietic cell transplantation. In Thomas’ hematopoietic cell transplantation ... EA, Cella DF, Beaumont JL, Brady MJ, Horowitz MM, Sobocinski KA, Rizzo JD, Wingard JR: Long-term health- related quality of life, growth, and spiritual well-being after hematopoietic stem -cell ... allogeneic hematopoietic cell transplantation. Blood 2009, 114(1):7-19. 11. Mosher CE, Redd WH, Rini CM, Burkhalter JE, DuHamel KN: Physical, psychological, and social sequelae following hematopoietic...

Ngày tải lên: 20/06/2014, 15:20

... justifies aggregation into a single index. A repeated-measures ANOVA was conducted on index scores across the three Index item means at baseline, 2 weeks, and 8 weeks (complete cases) 1 Figure 1 Index item means ... Quality of Life Outcomes Open Access Research A brief symptom index for advanced renal cell carcinoma David T Eton* 1,2 , David Cella 1,2 , Jennifer Bacik 3 and Robert J Motzer 4 Address: 1 Center ... symptoms. We determined reliability and validity of the index and estimated a minimally important difference. Results: The index had excellent internal reliability at all three time points (alphas...

Ngày tải lên: 20/06/2014, 16:20

Ngày tải lên: 27/06/2014, 13:20

... Mesenchymal stem cells; Hemopoietic stem cells; Stem cell plasticity; Common progenitor; Wound healing Introduction Adult bone marrow shelters different types of stem cells, including hematopoietic ... (Col) I/II/III along with hematopoietic marker CD34. CD14 + cell- derived population shared the same characteristics with CFs. In mixed culture of CD14 + and CD14 - cells, PBMMPs were a pre- dominant ... both hematopoietic and mesenchymal lineages, and CD34 + mesenchymal progenitors are a possible alternative source of epidermal cells in wound healing. Key words: Peripheral blood stem cells;...

Ngày tải lên: 08/08/2014, 18:20