hematopoietic cell transplantation hct

... siblings. Chapter 108. Hematopoietic Cell Transplantation (Part 1) Harrison's Internal Medicine > Chapter 108. Hematopoietic Cell Transplantation Hematopoietic Cell Transplantation: ... of the patient with high-dose myelotoxic therapy. Categories of Hematopoietic Cell Transplantation Hematopoietic cell transplantation can be described according to the relationship between ... interaction of cell- surface molecules, termed selectins, on bone marrow endothelial cells with ligands, termed integrins, on early hematopoietic cells. Human hematopoietic stem cells can survive...

Ngày tải lên: 07/07/2014, 04:20

... been the source of hematopoietic stem cells for transplantation. Typically, anywhere from 1.5 to 5 x 10 8 nucleated marrow cells per kilogram are collected for allogeneic transplantation. Several ... stem cells resulting in improved overall survival. Umbilical cord blood contains a high concentration of hematopoietic progenitor cells, allowing for its use as a source of stem cells for transplantation. ... adequate numbers of stem cells from the peripheral blood for transplantation. Donors are typically treated with 4 or 5 days of hematopoietic growth factor, following which stem cells are collected...

Ngày tải lên: 07/07/2014, 04:20

... similar Chapter 108. Hematopoietic Cell Transplantation (Part 3) The Transplant Preparative Regimen The treatment regimen administered to patients immediately preceding transplantation is ... of red cells to prevent hemolysis in ABO-incompatible transplants, the removal of donor T cells to prevent GVHD, or attempts to remove possible contaminating tumor cells in autologous transplantation. ... Peripheral blood stem cells are collected by leukophoresis after the donor has been treated with hematopoietic growth factors or, in the setting of autologous transplantation, sometimes...

Ngày tải lên: 07/07/2014, 04:20

... syndromes complicating marrow transplantation. VOD, venoocclusive disease; GVHD, graft-versus- host disease; HSV, herpes simplex virus; CMV, cytomegalovirus; VZV, varicella- zoster virus. The size...

Ngày tải lên: 07/07/2014, 04:20

... second general approach to GVHD prevention is removal of T cells from the stem cell inoculum. While effective in preventing GVHD, T cell depletion is associated with an increased incidence of ... receiving stem cells from unrelated donors. The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets. ... evidence suggests that T -cell depletion improves cure rates in any specific setting. Despite prophylaxis, significant acute GVHD will develop in ~30% of recipients of stem cells from matched siblings...

Ngày tải lên: 07/07/2014, 04:20

... common following use of less-immunosuppressive preparative regimens, in recipients of T cell depleted stem cell products, and in patients receiving grafts from HLA-mismatched donors. Treatment ... Posttransplant patients, particularly recipients of allogeneic transplantation, require unique approaches to the problem of infection. Early after transplantation, patients are profoundly neutropenic, ... 180 or off immunosuppression Viral Herpes simplex Acyclovir 800 mg PO bid to day 30 Varicella zoster Acyclovir 800 mg PO bid to day 365 Cytomegalovirus Ganciclovir 5 mg/kg IV bid...

Ngày tải lên: 07/07/2014, 04:20

... Using Hematopoietic Cell Transplantation Nonmalignant Diseases: Treatment Immunodeficiency Disorders By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation ... 40 40 Hodgkin's disease First relapse/second remission 40 50 Chapter 108. Hematopoietic Cell Transplantation (Part 7) Pneumocystis jiroveci pneumonia, once seen in 5–10% of patients, ... haplotype-mismatched parents as donors (Table 108-3). Table 108-3 Estimated 5- Year Survival Rates Following Transplantation a Disease Allogeneic, % Autologous, % Chronic phase 70 ID Accelerated...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

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Ngày tải lên: 13/08/2014, 16:20

... stem cell transplantation; BMT, bone marrow transplantation; UBMT, unrelated bone marrow transplantation; T-UBMT, T -cell- depleted bone marrow transplantation; UCBT, umbilical cord blood transplantation; ... disease. Keywords allogeneic hematopoietic stem cell transplantation, chronic graft-versus-host disease, children, incidence, risk factors Introduction Hematopoietic stem cell transplantation (HSCT) ... cord blood transplantation than bone marrow transplantation Cutler et al. (2001) 16 studies were included Metaanalysis Chronic GVHD is more common after peripheral blood stem cell transplantation...

Ngày tải lên: 12/02/2014, 19:20

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