hematopoietic cell transplantation for crohns disease is it time

Ngày tải lên: 10/08/2014, 22:21

... that bind a self-epitope with high avidity undergo apoptosis [9–11]. However, T cells that fail to recognize a self-epitope also undergo apoptosis [9–11]. Therefore, circulating T cells in a healthy ... intensity may vary by disease. For example, cyclophosphamide with or without ATG appears inade- quate for complete responses or sustained untreated partial responses in rheumatoid arthritis [13,14]. ... haematopoietic stem cell transplants for autoimmune disease — feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 10/08/2014, 21:23

Ngày tải lên: 12/08/2014, 04:21

Ngày tải lên: 12/08/2014, 04:22

... year. The Hematopoietic Stem Cell Several features of the hematopoietic stem cell make transplantation clinically feasible, including its remarkable regenerative capacity, its ability to home ... Chapter 108. Hematopoietic Cell Transplantation Hematopoietic Cell Transplantation: Introduction Bone marrow transplantation was the original term used to describe the collection and transplantation ... interaction of cell- surface molecules, termed selectins, on bone marrow endothelial cells with ligands, termed integrins, on early hematopoietic cells. Human hematopoietic stem cells can survive...

Ngày tải lên: 07/07/2014, 04:20

... blood contains a high concentration of hematopoietic progenitor cells, allowing for its use as a source of stem cells for transplantation. Cord blood transplantation from family members has ... the concentration of hematopoietic progenitor cells in blood, as measured either by colony-forming units or expression of the CD34 antigen, increases markedly. This has made it possible to harvest ... improvements in disease- free or overall survival. Bone marrow aspirated from the posterior and anterior iliac crests has traditionally been the source of hematopoietic stem cells for transplantation. ...

Ngày tải lên: 07/07/2014, 04:20

... the disease setting and source of marrow. For example, when transplantation is performed to treat severe combined immunodeficiency and the donor is a histocompatible sibling, no treatment is ... be readily achieved with less toxicity than seen with conventional transplantation. Furthermore, the severity of GVHD appears to be decreased because less tissue damage is done by the lower ... Chapter 108. Hematopoietic Cell Transplantation (Part 3) The Transplant Preparative Regimen The treatment regimen administered to patients immediately preceding transplantation is designed...

Ngày tải lên: 07/07/2014, 04:20

... intense conditioning regimens. The mortality of venoocclusive disease is ~30%, with progressive hepatic failure culminating in a terminal hepatorenal syndrome. Both thrombolytic and antithrombotic ... syndromes complicating marrow transplantation. VOD, venoocclusive disease; GVHD, graft-versus- host disease; HSV, herpes simplex virus; CMV, cytomegalovirus; VZV, varicella- zoster virus. The size ... develop any time during the first month posttransplant, with the peak incidence at day 16. Predisposing factors include prior exposure to intensive chemotherapy, pretransplant hepatitis of any...

Ngày tải lên: 07/07/2014, 04:20

... GVHD. The disease resembles an autoimmune disorder with malar rash, sicca syndrome, arthritis, obliterative bronchiolitis, and bile duct degeneration and cholestasis. Single-agent prednisone or ... allogeneic transplantation will develop chronic GVHD. The disease is more common in older patients, in recipients of mismatched or unrelated stem cells, and in those with a preceding episode of ... receiving stem cells from unrelated donors. The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets....

Ngày tải lên: 07/07/2014, 04:20

... the risk of candidal infections. Patients seropositive for herpes simplex should receive acyclovir prophylaxis. One approach to infection prophylaxis is shown in Table 108-2. Despite these ... ganciclovir, either as prophylaxis beginning at the time of engraftment or initiated when CMV first reactivates as evidenced by development of antigenemia, can significantly reduce the risk of CMV disease ... CMV disease in seropositive patients. Elimination of white blood cells from transfused blood products is another method to prevent CMV transmission. Foscarnet is effective for some patients who...

Ngày tải lên: 07/07/2014, 04:20

... Hematopoietic Cell Transplantation Nonmalignant Diseases: Treatment Immunodeficiency Disorders By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation ... relapse/second remission 40 40 Hodgkin's disease First relapse/second remission 40 50 Chapter 108. Hematopoietic Cell Transplantation (Part 7) Pneumocystis jiroveci pneumonia, ... First remission 55–60 50 Second remission 40 30 Acute lymphocytic leukemia First remission 50 40 Second remission 40 30 Chronic myeloid leukemia Treatment of Specific Diseases Using Hematopoietic...

Ngày tải lên: 07/07/2014, 04:20

... derive from the marrow, transplantation can cure this rare inherited disorder. Hematopoietic cell transplantation has been used as treatment for a number of storage diseases caused by enzymatic ... chromosome–positive disease, debate continues about whether adults with standard-risk disease should be transplanted in first remission or whether transplantation should be reserved ... stem cells if an appropriate donor is available. Theoretically, hematopoietic cell transplantation should be able to cure any disease that results from an inborn error of the lymphohematopoietic...

Ngày tải lên: 07/07/2014, 04:20

... role of transplantation in Hodgkin's disease is similar to that in intermediate- and high-grade non-Hodgkin's lymphoma. With transplantation, 5- year disease- free survival is 20–30% ... patients with high-risk disease benefit from transplantation in first remission. Most experts favor the use of autologous rather than allogeneic transplantation for patients with intermediate ... of the disease and because of the age profile of patients. With allogeneic transplantation, complete remissions have been achieved in the majority of patients so far reported, with disease- free...

Ngày tải lên: 07/07/2014, 04:20

... cancer patients: is it time for additional evidence? Stefano Cafarotti 1* , Alfredo Cesario 1,2 , Venanzio Porziella 1 , Stefano Margaritora 1 and Pierluigi Granone 1 Abstract Recent efforts to improve ... the literature and these are not consistent. In f act some experiences [2,3] con- clude with positive recommendations to adopt the tri- modality approach and others [4] conclude with oppo- site ... biases with the pre- cise task to assess whether IT should be administered before surgery in resectable OC. These trials should: a) distinguish between hystologies (squamous cell vs adeno- carcinoma);...

Ngày tải lên: 09/08/2014, 01:24

... 2 Hematopoietic stem cell transplantation in autoimmune disease per disease category Rheumatological 500 Neurological 387 Multiple sclerosis 368 Connective tissue disease 308 Myasthenia gravis ... sclerosis 190 Other/Unknown 16 Systemic lupus erythematosus 86 Polymyositis/dermatomyositis 14 Inflammatory bowel 24 Sjögren 3 Crohn disease 21 Other/Unknown 15 Ulcerative colitis 3 Arthritis 161 ... reactivation [49]. Mechanisms of action of hematopoietic stem cell transplantation in autoimmune disease Autologous hematopoietic stem cell transplantation In autologous HSCT, conditioning with high-dose...

Ngày tải lên: 09/08/2014, 10:23

Ngày tải lên: 10/08/2014, 10:21