hematologic disorders in the elderly

... older adults Sleep disorders in the elderly Primary sleep disorders Primary sleep disorders are distinguished from other sleep disorders in that these are not other mental disorders, medical ... up later in the evening, despite begin sleepy and despite continuing to wake up too early in the morning This can result in restricted sleep and daytime sleepiness similar to that in insomnia ... over the age of 60 report disturbed sleep22 Subtypes of insomnia include sleep onset insomnia (difficulty initiating sleep), sleep maintenance insomnia (difficulty maintaining sleep throughout the...

Ngày tải lên: 22/03/2014, 14:20

... Urinary incontinence Urinary incontinence (UI) is defined as the involuntary loss of urine, of sufficient severity to be a health Cancer in the older person Complete the screen by filling in the ... at baseline, anemia incidence was 63% in those undergoing chemotherapy alone, 42% in those receiving a combination of chemotherapy and radiotherapy, and 20% in those treated with radiotherapy ... hypoferremia of in ammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 2004; 113: 1271–6 Laftah AH, Ramesh B, Simpson RJ, et al Effect of hepcidin on intestinal iron...

Ngày tải lên: 10/08/2014, 16:22

... point the HSC numbers dramatically fell in D2 mice while they continued to rise in the B6 mice Thus, we surmised that the aging of the stem cells in these two strains differed according to their ... answers For instance, does aging begin at birth, at which point development has culminated in an independently functioning individual, or does it begin at puberty, when the individual has attained reproductive ... lifespan determination in these two strains Congenic mice were then generated where we crossed the QTLcontaining interval from the D2 strain onto a B6 background (B6.D2 Chr 2) to test the mapping data...

Ngày tải lên: 10/08/2014, 16:22

... further increase the response in the elderly participants In one of the studies where vaccine adjuvants were evaluated, thymosin alpha one or placebo was given twice weekly, beginning with vaccination, ... competing schools of thought on the dominant mechanism leading to the age-related decline in antibody production in response to foreign antigens These lines of thinking have attributed the age-related ... explaining the underlying mechanism of the age-related increase in autoantibody, which are related to the age-related decline in the antibody response to foreign antigens: (1) the shift in number...

Ngày tải lên: 10/08/2014, 16:22

... is destined for the hemoglobin in developing erythrocytes in the bone marrow In the absence of bleeding, iron losses from desquamation of intestinal epithelia and skin are relatively minor See ... Experiments in mice lacking IL-6 show that other cytokines, including IL-1, may contribute to hepcidin induction during in ammation, but it is not certain whether the specific hepcidin-stimulatory cytokines ... utilization Iron is excreted by shedding of intestinal and skin cells, and through minor blood loss in the intestine In principle, the iron content of shed epithelial cells could be subject to regulation...

Ngày tải lên: 10/08/2014, 16:22

... erythropoietin insufficiency in older individuals [20] (Fig 15.2) When the circulating levels of erythropoietin were plotted against the levels of hemoglobin and the levels of in ammatory cytokines one ... ferroportin, a protein responsible for carrying the iron from the gastrointestinal tract into the circulation Incidence and prevalence of cobalamin deficiency increase with age [23,24], due to inability ... epidemiologic study initiated by the National Institute of Aging involving elderly people living in several different areas of the USA As with other studies, IL-6 levels were higher in an elderly population...

Ngày tải lên: 10/08/2014, 16:22

... Pgp overexpression in the elderly supports the finding that conventional induction therapy in the elderly is less efficacious than in younger adults Therapeutic strategies to inhibit Pgp cellular ... remains investigational However, because of the high prevalence of the MDR1 phenotype in the elderly population, there is continued investigation into the use of more potent and specific inhibitors ... MDS in the first-line setting [103,104] Fludarabine with cytarabine in the relapsed/refractory setting has a reported CR rate of 36% [105] Non-cytarabine regimens have also been investigated in the...

Ngày tải lên: 10/08/2014, 16:22

... telangiectasia Retinoic acid derivatives, including isotretinoin, etretinate, and acitretin, have demonstrated marginal potency against CTCL as monotherapy; however, they have been used mostly in combination ... Franchini M, Krampera M, Pizzolo G Low-dose epirubicin in combination with cyclophosphamide, vinblastine and prednisone (miniCEOP) for the treatment of aggressive non-Hodgkin’s lymphoma in elderly ... completed a trial involving 96 patients treated with three alternating combination regimens consisting of vincristine, cyclophosphamide, doxorubicin, prednisone, ranimustine, vindesine, etoposide,...

Ngày tải lên: 10/08/2014, 16:22

... for maintenance therapy with fludarabine? Is there an optimal combination – and sequencing – for administering fludarabine and an alkylating agent as combined therapy? The National Cancer Institute ... for the increase in circulating CD34ϩ cells in idiopathic myelofibrosis [28] Interestingly, there is also an increase in circulating endothelial precursor cells that appears to precede the increase ... fusion protein that has been produced by recombinant DNA technology, in which the receptor-binding domain of diphtheria toxin is replaced by the sequences of human interleukin [113] These compounds...

Ngày tải lên: 10/08/2014, 16:22

... fibrinolysis by removing the C-terminal lysine and arginine residues from fibrin, thereby decreasing plasminogen on its surface [70] A single nucleotide polymorphism in the coding region of the ... Antithrombotic therapy The pharmacology and management of the vitamin K antagonists Initiation and maintenance dosing Following the administration of warfarin, an initial effect on the prothrombin time ... risk increase for adverse outcomes will often be similar or the same in the elderly It is the baseline risk or event rate that may increase in the elderly (e.g., the baseline risk for a stroke in...

Ngày tải lên: 10/08/2014, 16:22

... and deaths from in uenza Description of the intervention Vaccines have been the main global weapon to minimise the impact of in uenza in the elderly for the last four decades In the year 2000, ... Trevino SC, Ybarra D The effect of a multivitamin on the immunologic response to the in uenza vaccine in the elderly Infectious Diseases in Clinical Practice Vol 10, Lippincott Williams & Wilkins, ... good coverage in those who most need it or the diluting effect on vaccines for in uenza of other agents circulating in the community (causing ILI, clinically indistinguishable from in uenza), might...

Ngày tải lên: 13/02/2014, 18:20

... an initial open-ended approach, e.g asking: “What you think the change in your memory and thinking is due to?” b In setting up the visit for disclosure, consider patient privacy and ask whether ... driving and to instruct these patients to stop driving If the physician learns that the patient continues to drive despite this instruction, the physician is required to notify the Superintendent ... Drug Interactions Major drug interactions associated with memantine include drugs which increase the pH in urine (e.g carbonic anhydrase inhibitors) Exercise caution when prescribing memantine...

Ngày tải lên: 13/02/2014, 18:20

... that occurs in plants being activated in the morning to protect plants from the heat of the sun and others being activated in the evening to protect them from cold temperatures and freezing! Cyclic ... cardiorespiratory monitoring in the neonatal intensive care unit An examination of the pros and cons of the cardiopulmonary monitoring techniques used in the neonate follows The main focus of this part ... factors in determining respiratory output The second part, which focuses on respiratory control disorders, begins with an overview The diagnosis of these disorders in the neonate often begins with...

Ngày tải lên: 14/02/2014, 17:20

... the groups DISCUSSION Tuberculosis is becoming increasingly common in the elderly and burden of the disease in them is likely to continue to increase substantially.3,4 Moreover, with increasing ... symptoms in elderly patients with TB This results in a delay in the presentation of the elderly to health care facilities, thereby resulting in a delay in the commencement of ATT The delay in presentation ... ageing and hence must be kept in mind during the diagnostic evaluation of elderly patients.11 Several findings of the current study are in accordance with the results of this meta-analysis In the...

Ngày tải lên: 15/02/2014, 13:20

... albicans Rinsing the dentures in the evening and keeping them overnight in the open air can indeed be the easiest way to carry out "disinfection" (Stafford et al., 1986) However, 10 minute soaking in ... been the most fundamental etiological factor for the dramatic increase in caries among the Finnish children in the beginning of the 1950's (Rytömaa et al., 1980) Not surprisingly, increase in the ... habits in the home-living elderly J Oral Rehabil 1997;May;24(5):332-7 V Nevalainen MJ, Närhi TO, Ainamo A Five-year follow-up study on the prosthetic rehabilitation of the elderly in Helsinki, Finland...

Ngày tải lên: 05/03/2014, 18:20

... (39%), the rest of them – in households of several individuals In Timisoara the majority of the elderly live in couples, the size of other households is about the same, but the proportion of the single ... Healthy Lifestyle in the Elderly s View in Romania and Latvia Figure Number of individuals in the households of the elderly in Latvia and Romania Figure Size of the homes of the elderly in Jelgava and ... with their community residents, than it is in Latvia Both the elderly in Dumbravita and those in Jelgava feel well in their homes, and they like their apartments or houses In Jelgava 73% of the elderly...

Ngày tải lên: 05/03/2014, 21:20

... understanding of the dynamics of family caregiving to low-income and frail elderly individuals living in the community It is examining how community and home care services diminish the effect ... Impact in a community setting continues Further evidence of the effectiveness of the CDSMP can be found in a study funded by Kaiser Permanente One year after completing the CDSMP, participants in the ... AHRQ Pub No 01-0009 eating, or using the toilet.8 Many elderly people can maintain or improve their functional ability by attending the CDSMP and practicing its principles CDSMP improved health...

Ngày tải lên: 05/03/2014, 21:20

... from 6025 cases in 1992 to 3534 cases in 2000 [1] Despite these declines in absolute numbers, the proportion of cases among the elderly has remained stable, with the elderly accounting for 23% of ... malignancies The differences in the presentation of pulmonary TB among the elderly can therefore be explained by the already known physiologic changes that occur with aging, and they must be kept in mind ... cases in the United States has been observed within the last 10 years Despite these declines in absolute numbers, the elderly continue to account for a disproportionate share of the cases The high...

Ngày tải lên: 06/03/2014, 04:20

... important factor in the decline of autonomy Indeed, the fear of falling can result in changes in motor function in the elderly, for example in walking behavior (Maki, 1997) The elderly frequently ... Multiple factors are involved in the risk of falling These factors may be intrinsic to the person and the aging process, behavioral, or found in the person’s immediate environment The main risk factors ... improvement in the health of the elderly, thus extending the period of physical autonomy, and retarding the onset of the effects of aging The fact that the majority of elderly people are currently living...

Ngày tải lên: 14/03/2014, 17:20

... 13.Grundy SM, Cleeman JI, Rifkind BM, Kuller LH Cholesterol lowering in the elderly population: Coordinating committee of the National Cholesterol Education Program Arch Intern Med 1999;159:1670-8 ... Cancer screening in older women Cancer 1994 (suppl) :200915 13.Finison KS, Wellins CA, Wennberg DE, Lucas FL , Screening mammography rates by specialty of the usual care physicain Eff Clin Pract ... 1995;92)suppl):1672 12.Byrington RP, Jukema JW, Salonen JT et al Reduction in cardiovascular events during pravastatin threapy: Pooled analysis of clinical events of Pravastatin Atherosclerosis Intervention...

Ngày tải lên: 14/03/2014, 20:20