helicobacter pylori is fundamental for gastric cancer development
Overview of Trastuzumab’s Utility for Gastric Cancer pdf
... S-1 plus cisplatin showed significantly longer survival over S-1 alone, with acceptable toxicities Treatment Options for Gastric Cancer Treatment Options for Gastric Cancer Localized disease Preoperative ... epirubicin, cisplatin, 5FU; ECX: epirubicin, cisplatin, capecitabine; DCF: docetaxel, cisplatin, 5FU; CT§: chemotherapy with cisplatin and 5FU/capecitabine Figure Treatment options for Gastric Cancer ... irinotecan plus S-1 (IRIS) versus S-1 alone as first-line treatment for advanced gastric cancer (GC0301/TOP-002) ASCO Gastrointestinal Symposium 2008; (a5) 12 Arkenau HT Gastric cancer in the era...
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Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... essential for the development of Xenopus laevis [5] Although the importance of PTB for multiple biological processes has been reported, it is still unclear how PTB contributes to mammalian development ... transcriptional programs This difference in developmental regulation may also apply to the mechanisms of promiscuous gene expression and other phenotypes seen in cancer cells In ovarian cancer, a high level ... disturbed in Ptb) ⁄ ) ES cells, and this is different from what is seen in sall4) ⁄ ) ES cells [24] These reports suggest that regulation of proliferation occurs through more than one mechanism...
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báo cáo khoa học: "Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer" pdf
... chemotherapy for locally advanced gastric cancer [3] Up to this point, many neoadjuvant chemotherapy treatments for gastric cancer have been used with varying success to downstage locally advanced gastric ... relaparotomies after 700 gastretomies performed for gastric cancer Am J Surg 1996; 171(2): 270-3 10 Sasako M Risk factors for surgical treatment in the Dutch Gastric Cancer Trial Br J Surg 1997; 84(11): ... to gastrectomy alone In this respect, neoadjuvant chemotherapy with FOLFOX7 is a safe candidate for the 14 treatment of local advanced gastric cancer However, this is a retrospective study from...
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Health services research on endoscopic surveillance for gastric cancer in the singapore chinese population experience of the gastric cancer epidemiology clinical and genetic program
... Figure 5-14 Gastric cancer development in the low risk cohort 90 Figure 5-15 Gastric cancer development in the high risk cohort 91 Figure 5-16 Gastric cancer diagnosis and treatment ... frequency recommended for endoscopic surveillance for gastric cancer 69 Table 5-2 Gastric cancer incidence reported by the Singapore Cancer Registry (1/100,000) 84 Table 5-3 Gastric cancer incidence ... Gastric cancer mortality Singapore Burden of Gastric Cancer 1.3.1 Gastric cancer incidence 1.3.2 Gastric cancer mortality 11 1.4 Risk Factors for...
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Risk factors for gastric cancer and risk stratification in singapore chinese population
... East Asia Gastric cancer is also the second leading cause of cancer death worldwide accounting for 736,000 deaths in 2008 The known risk factors for gastric cancer are Helicobacter pylori (HP) ... blood markers for predicting GC risk Since Helicobacter pylori (HP) is the most important single risk factor for GC and gastric atrophy is a well-established risk factor, we studied the combination ... Study - Clinical risk factors and premalignant lesions of gastric cancer in high risk cohort 28 Study - Genetic risk factors for gastric cancer and premalignant lesion of gastric cancer Study -...
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Báo cáo khoa học: Helicobacter pylori neutrophil-activating protein activates neutrophils by its C-terminal region even without dodecamer formation, which is a prerequisite for DNA protection – novel approaches against Helicobacter pylori inflammation ppt
... Synthesis of H2N-His-His-His-His-His-His-OH Synthesis was performed by solid-phase methodology on a 2-clorotrityl chloride resin [44], using the Fmoc ⁄ tert-Butyl chemistry [45] Fmoc-protected His ... D-His25, and its symmetry equivalent between D-Glu56, D-Asp52, and A-His25 For His25 and His37, the neutral form was used with the proton at Nd1, whereas for all other His residues, the proton is ... used for further analysis Energy minimization and MD simulations were performed using the software namd [48] with the CHARMM27 force field for proteins and nucleic acids The thermodynamic analysis...
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Báo cáo khoa học: "Upper abdominal body shape is the risk factor for postoperative pancreatic fistula after splenectomy for advanced gastric cancer: A retrospective study" ppsx
... pancreatic fistula, in patients who undergo D2 dissection for gastric cancer [26] Abdominal shape may also influence accessibility in patients with gastric cancer Total gastrectomy with splenectomy is ... node dissection were performed as recommended by the Japanese Research Society for Gastric Cancer [13] The most frequent major complication after total gastrectomy with extended dissection is pancreatic ... lymph node dissection is an established procedure for the treatment of gastric cancer in Japan [1-3] Japanese retrospective studies have shown that 20%–30% of patients with advanced cancer of the...
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Báo cáo khoa học: " Postoperative Chemoradiation for Resected Gastric Cancer - Is the MacDonald Regimen Tolerable? A Retrospective Multi-Institutional Study" pptx
... Key words: Postoperative chemoradiation, resected gastric cancer, Israeli experience 5/ Introduction Gastric cancer is the second leading cause of cancer related death among men and the fourth among ... in INT-116 is the significant toxicity reported for this regimen, including treatment-related deaths This is of greater concern when such a reportedly toxic regimen is to be administered outside ... chemo-radiation for gastric adenocarcinoma: an institutional experience Radiat Oncol 2010, 5:50 22/ 22 Leong T, Joon DL, Willis D Adjuvant chemoradiation for gastric cancer using epirubicin, cisplatin...
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Báo cáo y học: No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanes
... mg/ml), adjusted for age, sex, and the factors listed Discussion Hyperhomocysteinemia is a well-established independent risk factor for the development of atherosclerosis-related diseases due to ... infection with Helicobacter pylori: meta-analysis of 18 studies BMJ 1998; 316: 1130-2 Stone AF, Risley P, Markus HS, et al Ischaemic heart disease and Cag A strains of Helicobacter pylori in the ... possible H pylori involvement for coronary heart disease have been published with conflicting results [24, 25], but a meta-analysis reported no strong association between H pylori infection and ischemic...
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Tài liệu Báo cáo khoa học: Helicobacter pylori acidic stress response factor HP1286 is a YceI homolog with new binding specificity pdf
... beamlines ID23-2 of ESRF, Grenoble, for technical assistance during data collection, A Boaretto for mass spectra, and M de Bernard for discussion and suggestions This work was supported by the University ... of Helicobacter pylori CagA in gastric carcinogenesis Int J Hematol 84, 301–308 Parsonnet J, Replogle M, Yang S & Hiatt R (1997) Seroprevalence of CagA-positive strains among Helicobacter pylori- infected, ... compilation ª 2010 FEBS L Sisinni et al quite common in nature It is, for example, one of the most abundant components of different varieties of rapeseed [23] Erucic acid is suitable for human consumption...
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báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx
... 551.5 14.1 ± 13.2 EGC, early gastric cancer; ACG, advanced gastric cancer; GC, gastric cancer; H pylori, Helicobacter pylori; mucosa; sm, sub-mucosa; mp, muscularis propria; ss, sub-serosa; se, ... decades, it is still a serious health problem [18] The prognosis of advanced gastric cancer (AGC) with extensive node invasion and metastasis remains poor while early gastric cancer (EGC) is associated ... sensitivity and specificity for the diagnosis of EGC and high-risk lesions of GC than CEA GC, gastric cancer; EGC, early gastric cancer Page of 11 (page number not for citation purposes) Journal...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... The list of cancers in which H19 gene expression is known to be elevated compared to normal tissue is still growing [11,15-18] Detection of H19 expression in epithelial ovarian cancer using ISH ... was carried out for 30 cycles (98°C for 15 sec, 58°C for 30 sec, and 72°C for 40 sec and finally 72°C for min) The integrity of the cDNA was assayed by RTPCR analysis using the histone variant, ... Israel for providing OCAF from patients 16 17 18 19 20 21 22 23 References 10 11 12 13 14 15 NCI: National Cancer Institute [http://www .cancer. gov /cancer topics/types/ovarian] Cannistra SA: Cancer...
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Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
... H pylori- induced gastric carcinogenesis Further study should be performed to investigate the mechanism of gastric carcinogenesis involving PAR-2-associated prevention against apoptosis of gastric ... the risk of gastric carcinoma N Engl J Med 1991, 325:1127-1131 Xia HH, Talley NJ: Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis ... between Helicobacter 22 pylori and gastric mucosa in the pathogenesis of body atrophic gastritis Gastroenterology 1996, 111:655-665 Parsonnet J, Friedman GD, Vandersteen DP: Helicobacter pylori...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... 52°C The ISH was performed on successive slides of TCC tissue for H19 and IGF2-P4 transcripts The intensity of hybridization signal was indicated as (0) for no staining, (+1) for weak, (+2) for moderate ... sex glands were dissected carefully Samples of the tumors were fixed in 4% buffered formaldehyde and processed for histological examination for evidence of necrosis and persistent tumor Computerized ... excised, and the area of the malignant tissue of each bladder is indicated (by grin line) for the H19-Luc-P4Luc (B) and H19-DTA-P4-DTA (E) Histopathological microscopic view (H&E × 10 is shown for...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
... arsenic trioxide is an effective anticancer agent with potential for human gastric cancer Arsenic trioxide can reduce proliferation and induce apoptosis in SGC7901 human gastric cancer cells There ... Nur77, suggesting novel strategies for regulating apoptosis in cancers and other diseases [30] This phenotype change of Bcl-2 is controlled by its protein conformational change When the loop of ... trioxide is important for founding an explanation accounting for the opposing biological activities of Bcl-2 This may also represent that arsenic trioxide may be a promising candidate for the...
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Báo cáo khoa học: "Gastric cancer: predictors of recurrence when lymph-node dissection is inadequate" potx
... (International Union Against Cancer, sixth edition) requires the retrieval and analysis of at least 15 lymph nodes for accurate staging However, in most cases, the number of nodes dissected is smaller and ... whether this result is applicable to patients with inadequate staging [5] Many published studies report different cut offs for LNR, but the consensus value seems to be 20% [6] Locoregional Gastric ... were independent risk factors for the recurrence of gastric cancer References Hidaka H, Eto T, Maehara N, Jimi S, Hotokezaka M, Chijiiwa K: Comparative effect of lymph node metastasis classified...
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Báo cáo khoa học: "High grade B-cell gastric lymphoma with complete pathologic remission after eradication of helicobacter pylori infection: Report of a case and review of the literature" pdf
... metronidazole) Forty-two of 61 patients obtained a complete remission of the lymphoma In two patients there was gastric complete remission (despite of persistence of Helicobacter pylori in one ... continuity from acquisition of gastric MALT, in most cases because of a Helicobacter pylori infection, to MALT lymphoma and large B cell lymphoma There is consistent evidence for the clonal link ... B, Wundisch T, Ehninger G, Stolte M, Bayerdorffer E: Cure of Helicobacter pylori infection and duration of remission of lowgrade gastric mucosa-associated lymphoid tissue lymphoma J Natl Cancer...
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Báo cáo khoa học: "Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plans" pps
... tinely for lung cancer patients in all stages During the past years, this technique has continuously been evolved with regard to optimizing the procedures for quality assurance and raising conformity ... at the central axis As an individual fine adjustment of MLC jaws for each patient is time consuming, we developed and implemented a QA program which is periodically testing for over- or underdosages ... previous report about this technique, besides performing the regular QA program as described, For all patients treatment plans with one single isocenter can be provided This enables a remote control...
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Báo cáo khoa học: " The median non-prostate cancer survival is more than 10 years for men up to age 80 years who are selected and receive curative radiation treatment for prostate cancer" ppt
... mortality risk is lowered after adjustment for competing risks is in accordance with the findings of Satagopan et al, who reported that the cumulative incidence of breast cancer mortality is reduced, ... Guidelines (NCNG) for prostate cancer state that "life expectancy estimation is critical to informed decision-making in prostate cancer, early detection and treatment" The NCNG guidelines for curative ... years [10] This 10-year rule has become accepted in medical decision-making, but while such estimation for groups is possible, it is recognized to be a challenge for individuals [11] A decision-analytic...
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Báo cáo y học: "JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP9 expressions and cell migration in human LoVo colon cancer cells" ppsx
... significantly greater in tumour tissues than normal tissues [26] uPA upregulated in colon tumor tissue enhances colorectal cancer invasion and metastasis, and this upregulation in uPA is correlated with Dukes’s ... reduced mortality from this disease References Jemal A, Murray T, Ward E, et al: Cancer statistics, 2005 CA Cancer J Clin 2005, 55:10-30 Greenwald P: Colon cancer overview Cancer 1992, 70:1206-1215 ... mechanism in the pathogenesis of colonic cancer [41] Studies suggest that estrogen exerts a protective role against the development of fatal colon cancer with a substantially decreased risk in...
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