... (3) the location ofthe impact andthe occur-
rence ofthe tumor corresponded exactly one to the
other; and (4) there was a more than one year interval
between trauma andthe appearance ofthe ... interval between
trauma andthe appearance ofthe tumor of at least 1
year, a longer latent period increasing the likelihood
of a causal relationship.
5. The presence ofthe tumor must be proved ...
reveal the severity and location ofthe traumatic brain
injury andthe subsequent formation of a neoplasm at
the same site, can provide convincing evidence for the
traumatic causation of a brain...
... role in the
pathogenesis of both types of diabetes mellitus. High
levels of free radicals andthe decline of antioxidant
defense mechanisms lead to damage of cellular or-
ganelles and enzymes, ... Popliteal and pedal
pulses were absent bilaterally with poor capillary re-
fill. The left foot was red and inflamed up to and in-
cluding the medial malleolus. The lateral aspect ofthe
great toe and ... (maximum of 3 milliAm-
peres) of one polarity for 11.5 minutes, which then
switched to the opposite polarity for another 11.5
minutes. The device was designed to switch the di-
rection of current...
... see any of her involvements into any
conversations with the grandmother. Regarding the children, they disapproved ofthe decision of
their grandmother but, as the youngest in the family, their ... both the hardest time such as
the time ofthe Civil War, the Great Depression, the World War II andthe prime time ofthe
nation, the affluent America in the 1920s, the late 1940s, andthe early ... plot, theme, point
of view, character and setting. Technique has to do with the structuring ofthe story into the plot
so that the writer can convey the theme andthe manipulating ofthe language...
... acid. In addi-
tion to these contacts, there is a 1.82 A
˚
contact
between Gly255 C
a
and O
d
2 ofthe oxidized cysteine.
To further understand the structural consequences of
the P-loop transition ... bonds
with the P-loop main chain and O
d
1 and O
d
2.
Although there are movements in the P-loop, there
are no other major conformational changes in the
protein. Most notably, the loop containing the ... test whether the move-
ment ofthe P-loop in PhyAsr is due to oxidation of
the catalytic cysteine, we oxidized crystals of PhyAsr
Table 1. Effect of ionic strength on the hydrolysis of InsP
6
by
PhyAsr....
... removal ofthe CUB
domains and thereby activation ofthe growth factor
domains. PDGF-C and -D contain both the CUB and
growth factor domains when they are secreted and pro-
teolytic cleavage is therefore ... the developing rat
eyes and also adult eyes of rat, cow, monkey and rab-
bit. In the adult rat eye, PDGF-D is localized to the
stroma of iris and ciliar body in the anterior segment,
and to the ... model of the
PDGF-C growth factor domain indicates the disulfide
bridges in PDGF-C to consist of Cys250 and 294,
Cys280 and 335, and Cys287 and 337, andthe inter-
monomeric bonds to consist of Cys274...
... Aedes aegypti [34], and lepidopterans, the
tobacco hornworm Manduca sexta [35–37] and the
silkworm Bombyx mori [38,39]. On the other hand,
the natural ligand of USP is unknown, although recent
in ... affinity of
DBHs to receptors among insect species is due to the
difference of structures ofthe ligand binding pocket.
In the other study, we demonstrated that the molting
hormone activities of ecdysone ... decemlineata, EcR and USP,
and (c) the measurement ofthe binding affinity of
steroidal and nonsteroidal ecdysone agonists to the
in vitro translated receptor proteins. Comparison of
the receptor-binding...
... 7).
The V
s
/V
h
ratio is the ratio ofthe reaction rates of
aminolysis and hydrolysis ofthe acyl-enzyme. The curva-
ture ofthe plot of V
s
/V
h
vs. the mole fraction of D
2
O
indicates therefore ... equal to the k
s
for
6-APA.
The dependence of V
s
/V
h
on the nucleophile concentra-
tion [N] andthe results ofthe inhibition studies show that,
despite ofthe high rate of hydrolysis ofthe acyl-enzyme,
tight ... much
slower than the rate of deacylation. The theoretical maxi-
mum ofthe amplitude ofthe burst phase is equal to the total
enzyme concentration. When k
h1
¼ 5 k
2
, only 2% of the
maximum ofthe amplitude...
... indispensable for the assembly of subunits A
and B. Hirata et al. [19] investigated the functions of
Vma11p and Vma16p in the S. cerevisiae V-ATPase
complex, and reported that the two subunits c
0
and c
00
are
essential ... ratio ofthe three proteins could not be estimated.
Forgac described in a recent minireview [21] that the V
O
domain consisted of six copies ofthe c/c
0
subunits and single
copies ofthe other ... isoforms as observed
in higher plants V-ATPase. We have also isolated two
different cDNAs coding for the subunits A and B of
V-ATPase. The intracellular localization of these isoforms
and the...
... suggests rather that teaching, encouraging, and enabling the elderly to take care
of themselves and their needs will increase autonomy and improve their sense of support and self-
control. Yee and Weaver ... alter
the effects of alcohol and increase the risks of adverse effects (Akers and La Greca 1991), and the
fact that, because of these changes, a low or moderate level of drinking might nonetheless be ... organizations, andthe general public. The most common strategies
used elsewhere are information and awareness campaigns andeducationand training of older adults
and service providers. There are...
... to
promote the transfer ofthe p-HB moiety onto
PKS15 ⁄ 1 [16,18].
To examine the involvement of FadD29 in the bio-
synthesis of DIMs and PGLs, we took advantage of
the existence in the laboratory of ... Schematic representation ofthe roles ofthe FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related
compounds in Mycobacterium tuberculosis. The role ofthe activation enzymes ... knowledge ofthe bio-
synthesis of DIMs and PGLs, the in vivo functions of
these FadD proteins in this pathway remain to be
established and ⁄ or completed. For instance, the
involvement of FadD26 in the...
... to the shampoo shelves and picks up
a bottle
of
Pantene brand, reads the front label, then picks up a bottle
of
the store brand and reads the front label, then reads the price tag
On
the ... pause and look at the sd-
ence
of
shopping from the perspective
not
of
the scientist
but
of
the
practitioner-that
is,
the retailer and marketer. He
or
she
is
certainly
part
of
the ...
we'd note
that he (the man,
not
the mannequin) entered the cashier line at
11:23
and exited the store at
11:30.
Depending
on
the size
of
the store and
the length
of
the typical shopper's...
... between the two offshore islands andthe mainland. As part of
that expansion ofthe mini-three links, the Taiwanese government also
expanded the list of products that the offshore islands can ... total of
152,438 passenger trips between the offshore islands and Fujian
Province, including 144,234 from the offshore islands to the mainland,
and 8,200 from the mainland to the offshore islands ... the Office ofthe Secretary of Defense, the Joint Staff, the Unified
Commands, the defense agencies, the Department ofthe Navy, the U.S.
intelligence community, allied foreign governments, and...