hae diagnosis algorithm see figure 1 2010 xii 21
Báo cáo y học: "Adrenal suppression: A practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy" pptx
... (h) Systemic clearance (L/h) 13 2.7* 15 0 /12 0* 20/40* 50-60 2.5 12 2.0 84 Ciclesonide
Ngày tải lên: 08/08/2014, 21:20
Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... 2003 by RAND 17 00 Main Street, P.O Box 213 8, Santa Monica, CA 90407- 213 8 12 00 South Hayes Street, Arlington, VA 22202-5050 2 01 North Craig Street, Suite 202, Pittsburgh, PA 15 213 -15 16 RAND URL: ... al (19 99); Henderson, Inglesby, et al (19 99); Inglesby, Den- nis, et al (2000); Arnon, Schechter, et al (20 01) ; Dennis, Inglesby, et al (20 01) See also Gilmore Commission (20 01) ; Weiss (20 01) , ... Industrial Model Education and Training Regulatory Affairs: A Corporate Function v 11 12 16 19 23 30 33 37 37 41 43 vi The Acquisition of Drugs and Biologics for CBW Defense Chapter Four SUMMARY...
Ngày tải lên: 17/02/2014, 11:20
báo cáo khoa học: " Bioethical differences between drug addiction treatment professionals inside and outside the Russian Federation Vladimir D Mendelevich" pdf
... psychological problems? 61. 0%* 27.6% 11 .4% 76 .1% 13 .0% 10 .9% Is Homosexuality, from your point of view, an illness that requires treatment, or not an illness? 21. 1% 62.2% 16 .7% 13 .0% 76 .1% 10 .9% What is ... The author declares that they have no competing interests Received: 12 March 2 011 Accepted: 10 June 2 011 Published: 10 June 2 011 References Elovich R, Drucker E: “On drug treatment and social control: ... edition N.Y., Oxford: Oxford univ Press; 19 89 31 Francoeur RT: Biomedical Ethics: A Guide to Decision Making New York: Wiley; 19 83 doi :10 .11 86 /14 77-7 517 -8 -15 Cite this article as: Mendelevich: Bioethical...
Ngày tải lên: 11/08/2014, 18:20
A study of quality and safety of herbal medicine adulteration and herb drug interactions
... activities 11 3 11 5 4 .1 Introduction 11 5 4.2 Objective 12 1 4.3 Materials and Methods 12 1 4.3 .1 Chemicals and reagents 12 1 4.3.2 Preparation of L chuanxiong extract 12 2 4.3.3 Animal treatments 12 2 4.3.4 ... Medicines 11 13 1. 2 .1 Introduction 13 1. 2.2 Herb-drug interactions 14 1. 2.3 The mechanisms of herb-drug interactions 15 1. 2.3 .1 Pharmacokinetic interactions 16 1. 2.3.2 Pharmacodynamic interactions 1. 2.4 ... Introduction 1. 1 Quality issues 1. 1 .1 Factors affecting quality 1. 1.2 Methods for the quality control of herbal medicines 1. 1.2 .1 Chemical identification 1. 1.2.2 Molecular-based methods 1. 2 Safety...
Ngày tải lên: 14/09/2015, 08:23
Pharmacokinetic and pharmacodynamic mechanisms for reduced toxicity of CPT 11 by thalidomide and st johns wort
... SN-38 & CPT -11 in intestine • • • Promoting epithelial growth Protection of intestinal epithelium Anti-diarrhea effect [15 1, 15 7 -16 2] [11 8, 16 3 -17 0] [17 1, 17 2] [17 3, 17 4] [17 5, 17 6] 18 Interestingly, ... 7, 9, and 11 after CPT -11 administration in the control group treated with CPT -11 and 1% DMSO (v/v) and the combination group treated with CPT -11 and thalidomide 61 Figure 2 -14 Protein ... 1. 2.2 Pharmacokinetics of CPT -11 1. 2.3 1. 3 Anti-tumor activity and mechanism of action of CPT -11 5 Toxicities of CPT -11 .14 THALIDOMIDE .19 1. 3 .1 Clinical activity and mechanism...
Ngày tải lên: 14/09/2015, 13:44
In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... Rat 13 .85±4.33 (10 ) 7.26 1. 82 (10 ) 11 .56±3.73 (10 ) 13 2 22.4 a (11 ) - - 13 3 23.6±4.6 (10 ) 17 .5±2.2 (10 ) - 10 8 - - 7.07 a (13 ) 13 4 - - 10 .4 a (2) 59 19 .5±3.4 (10 ) 11 .9±3.9 (10 ) - 10 4 33 12 .65 (10 ) 58 15 . 81( 10) ... PHARMACOKINETICS 1. 1.4 .1 ABSORPTION 1. 1.4.2 DISTRIBUTION 1. 1.4.3 METABOLISM AND EXCRETION 11 1. 1.5 MEASUREMENT OF ANTICOAGULATION 17 1. 1.6 CHEMICAL ANALYSIS 19 iv 1. 1.7 WARFARIN DRUG INTERACTIONS 1. 1.7 .1 WARFARIN ... 58 15 . 81( 10) 42±6.32 (10 ) 30.5 13 .96(6) 41. 2±4 .16 (6) 36.2 19 .2(6) 13 5 33 14 .6(6) 43.4±8.4(6) - 10 5 37±35 (12 ) 53 14 (12 ) - 13 6 27.5±7.38(6) 36.8 14 .23(6) - 13 7 36 13 (6) 46±7(6) - 13 8 - - 36.3±3.5 (12 ) 13 9...
Ngày tải lên: 09/10/2015, 11:24
Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
... 500 mg (12 mo) 24 1g 1g 10 1g 33 g (1wk) 2 .1 1. 5 1. 2±0.8 16 .2 11 .8 45 11 .8 [47] CsA/Steroids 1. 4 1 2 .1 1. 2 12 ±5.7 49.8±24.8 [48] TAC/Steroids 0.78 a (0.33 -12 ) 1. 5 a (0 .1- 5.0) 2.2 a (0.2- 71) 2.4 ... 0.9±0.6 a (0.5-3) 2.5 a (1. 5-8) 1. 4±0.6 1. 8±0.7 11 .9±2.5 14 .9 1. 9 14 .1 11 .7 16 .2 12 .5 35.7±3.2 37.5±2.7 41. 7 13 .2 42.9 17 .9 1. 7 25.5 61. 4 1. 7 33.4 74.7 1. 5 c 11 .7 c 44.9 b 3.8 c 12 .8 c 30.5 b CsA/Steroids ... 1g 11 10 11 1g 500 mg 500 mg 12 1g 15 500 mg 750 mg 1g Caucasian (France) a 58.8 a (27 -11 1) 2.2±0.5 11 .1 1. 3 42.3±2.3 CsA/Steroids CsA/Steroids CsA/Steroids CsA/Steroids 1. 9±0.4 1. 6±0.4 1. 6 1. 2...
Ngày tải lên: 28/11/2015, 13:44
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... Nephrosclerosis Nephronophthisis 14 1 1 15 (11 - 31) 13 (11 -17 ) 16 (12 -23) 13 (17 - 21) 18 (15 -23) 17 (14 - 21) 18 (16 -22) 27 (17 -59) 24 (16 -34) 20 (14 -29) 16 (13 -22) 18 (12 -24) 17 (11 -25) 19 (15 -23) Pharmacogenetics ... 1. 6 (1. 2-2 .1) 1. 6 (1. 3-2 .1) 1. 4 (1. 2-2) 1. 4 (1. 1 -1. 7) 1. 3 (1. 1 -1. 6) 11 (8 .1- 12.3) 10 .7 (9.2 -13 ) 10 .4 (9.2 -12 .1) 10 (8.5 -11 .2) 9 .1 (7.5 -10 .9) 7.2 (6 .1- 8.7) 6.7 (5.2-7.9) 38/23-50 Discussion Demographic ... 41/ 35-54 42/37-53 41/ 35-54 28 /12 36/4 34 38/24-50 36/29-49 14 days month months months 12 months 24 months 36 months 1. 7 (1. 3-2.7) 1. 8 (1. 3-2.3) 1. 6 (1. 2-2 .1) 1. 6 (1. 3-2 .1) 1. 4 (1. 2-2) 1. 4 (1. 1 -1. 7)...
Ngày tải lên: 26/10/2012, 09:32
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... Shapiro both work for Innogenetics NV References 10 11 12 13 Lok ASF, McMahon BJ Chronic hepatitis B Hepatology 20 01; 34 :12 25 -12 41 Bowden S Laboratory diagnosis of hepatitis B infection In: Lai CL, ... Gastroenterol Disord 2002;2 :10 6 -11 5 Schutten M, Niesters HGM Clinical utility of viral quantification as a tool for disease monitoring Exp Rev Mol Diagn 20 01; 1 :15 3 -16 2 Saldanha J, Gerlich W, Lelie ... long-term lamivudine therapy and re-takeover by wild type after cessation of therapy Hepatology 19 98;27 :17 11- 1 716 32 Cane PA, Cook P, Ratcliffe D, Mutimer D, Pillay D Use of real-time PCR and fluorimetry...
Ngày tải lên: 03/11/2012, 09:41
U.S. Food and Drug Administration - Juice HACCP — The Final Rule
... #F-400/4 21 1, May 23, 19 91, and June and 19 , 19 91a FDA, Health hazard evaluation, classiÞcation, and FDA Enforcement Report for Þrm-initiated recall #F-427 1, June 3, 11 , and 19 , 19 91b FDA, Health ... were natamycin (FDA, 19 91a–c), sulÞtes (FDA, 19 95a–c), FD&C yellow No (FDA, 19 88a,b, 19 89, 19 90, 19 92a–c, 19 93a,b), and salt (FDA, 19 95a–c) Five recalls between 19 91 and 19 97 were caused by improper ... vegetable juice are found in 21 CFR 10 2.33 Standards of identity are found in part 14 6 ( 21 CFR part 14 6) for a number of fruit juices and beverages and in part 15 6 ( 21 CFR part 15 6) for tomato juice...
Ngày tải lên: 25/10/2013, 21:20
Tài liệu NEW INSIGHTS INTO TOXICITY AND DRUG TESTING pptx
... The American Journal of Gastroen‐ terology 19 99; 94(5): 13 93 -13 96 [20] Purcell P, Henry D, Melville G Diclofenac hepatitis Gut 19 91; 32 (11 ): 13 81- 1385 [ 21] Bulsterli UA Diclofenac-induced liver ... Toxins 19 95;3 :11 9 -12 8 [18 ] McDermott CM, Nho CW, Howard W, Holtons B The cyanobacterial toxin, Microcys‐ tin-LR, can induce apoptosis in a variety of cell types Toxicon 19 98;36 (12 ) :19 81- 1996 [19 ] ... of drug-induced liver toxicity Toxicology and Applied Pharmacology 2 010 ; 245: 13 4 -14 2 DOI: 10 .10 16/j.taap.2 010 .02. 011 [77] Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, et al Systems...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... (0.3) 2.2 (1. 8) 1. 2 (1. 0) 2.2 (1. 8) 0.09 (0.08) 0.2 (0.2) 1. 2 (1. 0) 0.7 (0.6) 0.4 (0.3) 11 .0 (9.2) 1. 2 (1. 0) 1. 2 (1. 0) < 0.07 (< 0. 01) 0.8 (0.7) 1. 2 (1. 0) 0.8 (0.7) 0.4 (0.3) 8.3 (6.9) 2 .1 (1. 0) 0.6 ... L90M 1. 0 0.4 1. 7 2.6 0.8 20 .1 0.3 0.2 0.6 2.4 0.7 11 .7 0.4 0.2 0.3 1. 7 0.4 0.8 0.7 (1. 0) 0.03 (0.04) 0.5 (0.7) 2 .1 (3.0) 0.7 (1. 0) 1. 1 (0.9) 1. 6 0.4 3.2 5.9 2.8 7.9 2.5 1. 0 4.2 9.6 4 .1 45.4 (1. 0) ... HIV -1 Gag NC/p1 and p1/p6 cleavage sites by wild-type HIV -1 proteinase Site NC/p1 p1/p6 a Substrate sequence Km (mM) kcat (s )1) kcat/Kma (mM )1 s )1) kcat/Kmb (mM )1 s )1) ERQAN-fl-FLGKI 0 .17 1. 20 0 .15 ...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
... 37 15 22 11 66 54 16 4 84 51 2 21 21 51 111 29 20 27 22 18 13 – – – 13 ± 21 ± – – 32 ± 12 9 ± – – – ND ND – – 25 ± 8±3 ± ± ± ± ± ± ± ± ± 14 14 30 10 ± ± ± ± ± ± ± ± ± 12 6 10 18 6 TMDs and NBDs, ... 323, 17 18– 17 22 Dawson RJ & Locher KP (2006) Structure of a bacterial multidrug ABC transporter Nature 443, 18 0– 18 5 FEBS Journal 277 (2 010 ) 3974–3985 ª 2 010 The Authors Journal compilation ª 2 010 ... Pharmacol 60, 254–2 61 20 Krupka RM (19 93) Coupling mechanisms in ATP-driven pumps Biochim Biophys Acta 11 83, 11 4 12 2 21 Druley TE, Stein WD & Roninson IB (20 01) Analysis of MDR1 P-glycoprotein conformational...
Ngày tải lên: 06/03/2014, 22:21
Báo cáo khoa học: Typical 2-Cys peroxiredoxins – modulation by covalent transformations and noncovalent interactions doc
... falciparum 1- Cys peroxiredoxin J Mol Biol 346, 10 21 10 34 Hall A, Karplus PA & Poole LB (2009) Typical 2-Cys peroxiredoxins – structures, mechanisms and functions FEBS J 276, doi :10 .11 11/ j .17 42-4658.2009.06985.x ... typhimurium AhpC) react with H2O2 at rates (c 10 7 m )1 s )1) comparable with those of catalases (c 10 7 m )1 s )1) and glutathione peroxidases (c 10 8 m )1 s )1) [22,44,45] The precise measurement of the ... damage Plant Cell 14 , 14 17 14 32 69 Radyuk SN, Klichko VI, Spinola B, Sohal RS & Orr WC (20 01) The peroxiredoxin gene family in Drosophila melanogaster Free Radic Biol Med 31, 10 90 11 00 70 Bauer H,...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C – structural features and membrane interactions ppt
... that could be unambiguously assigned (e.g 12 M 51+ ) are indicated nd 0.5 0.5 0.5 nd 59 0.5 80 13 0 18 0 70 11 500 90 10 0 240 11 500 11 0 11 25 15 0 12 0 12 0 17 0 19 7 Fig Limited proteolysis of CTC The amino ... 8M38+ 6M28+ 3M14+ % 12 M 51+ 6M34+ 3M17+ 6M39+ 2M13+ 6M35+ 6M36+ 3M18+ 3M 21+ 6M38+ 20+ 19 + 3M22+ 3M 3M 6M27+6M26+ 3M13+ 6M 31+ 6M33+ 9M36+ 6M24+ 9M35+ 6M23+ 9M33+ 6M22+ 30+ 6M25+ 9M34+ 6M 21+ 9M20+ 9M37+ ... peptides covering residues 82 12 5, 14 1 15 3, and 16 8– 19 7, whereas the [M + H]+ ion at 9400.4 corresponds to peptides 82 12 5, 14 0 15 3, and 16 8 19 7 (supplementary Fig S1B; see Fig for the amino acid...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... 2,4-diacetamido-2,4,6-trideoxyhexose Mol Microbiol 17 , 12 01 12 14 16 Moens S & Vanderleyden J (19 97) Glycoproteins in prokaryotes Arch Microbiol 16 8, 16 9 17 5 17 Virji M (19 97) Post-translational modifications ... Faltynek CR, Hof L, Reichert LE Jr & Weber P (19 81) Deglycosylation of glycoproteins by trifluoromethanesulfonic acid Anal Biochem 11 8, 13 1– 13 7 40 Hayat MA (19 89) Negative staining In Principles and ... cellular localization J Bacteriol 18 2, 3673–3680 19 Power PM & Jennings MP (2003) The genetics of glycosylation in Gram-negative bacteria FEMS Microbiol Lett 218 , 211 –222 20 Dieckelmann M, Roddam...
Ngày tải lên: 07/03/2014, 12:20
Cadmium and zinc interactions and their transfer in
... 7.38 33. 31" 6.70 33.94" 10 .11 11 11 11 0.05" 0.03 0.26" 0 .11 0.44" 0.20 15 . 71" 3.66 21. 28" 7.66 61. 40" 18 .24 Grain Stem Root 13 13 13 0. 61" 0. 41 1. 91" 1. 32 6.92" 4.32 42.03" 17 .92 83. 01" 29.39 ... 0 .19 WA 0.06 0 .18 1. 01 0.86 0.67 1: 1.4:4.4 1: 2 :10 1: 3 :11 0.43 0 .19 0 .18 0.60 0. 21 0.35 0.60 0. 21 0.98 1: 1.4 :1. 4 1: 1 :1 1:2:5.4 Corn Ž Zea mays L YA 0.23 MA 0 .10 WA 0.06 0.95 0.88 0.83 1: 3:4 1: 5:9 ... 0.23" 0 .16 25.38" 6.27 35.69" 5.44 35.56" 8.42 13 13 13 0.05" 0.03 0 .16 " 0.07 0. 21" 0 .11 16 .02" 3.74 18 .35" 3.77 43. 71" 10 .83 MA Grain Stem Root 18 18 18 0.05" 0.04 0 .11 " 0.07 0.50" 0.27 31. 08"...
Ngày tải lên: 15/03/2014, 23:22
Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc
... D1SD2D3 D1D2SD3 D1D2D3S D1SD2D3S D1D2SD3S D1SD2SD3 D1SD2SD3S 15 1 17 8 10 9 16 3 13 8 13 7 17 3 54 10 0 12 3 96 10 4 90 11 2 12 3 52 3 .1 2.9 2 .1 2.5 3.0 1. 6 2.5 3.0 2.2 2 .1 1.9 1. 6 2.0 1. 4 1. 7 2.9 1. 4 1. 4 ... (lmolÆmin )1 mgÆprotein )1) kcat (s )1) kcat ⁄ KM(PCr) (s )1 mM )1) Wild-type D1SD2D3 D1D2SD3 D1D2D3S D1SD2D3S D1D2SD3S D1SD2SD3 D1SD2SD3S 328 270 18 0 19 6 75 12 5 11 3 0.7 715 586 392 427 16 4 273 243 1. 6 ... 392 427 16 4 273 243 1. 6 330 280 210 270 80 200 14 0 0.6 ± ± ± ± ± ± ± ± 16 .0 9.1ab 5.1a 14 .0a 1. 1ab 7.6a 11 .6a 0.1a ± ± ± ± ± ± ± ± 34.9 19 .8ab 11 .1a 30.4a 2.4ab 16 .5a 24.9a 0.2a a Values that...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Adventitious reactions of alkene monooxygenase reveal common reaction pathways and component interactions among bacterial hydrocarbon oxygenases ppt
... sp strain JS150 Appl Environ Microbiol 61, 3336–3346 11 Lipscomb JD (19 94) Biochemistry of the soluble methane monooxygenase Annu Rev Microbiol 48, 3 71 399 12 Small FJ & Ensign SA (19 97) Alkene ... Biochemistry 35, 910 6– 911 9 15 Byrne AM, Kukor JJ & Olsen RH (19 95) Sequence analysis of the gene cluster encoding toluene-3-monooxygenase from Pseudomonas pickettii PKO1 Gene 15 4, 65–70 16 Bertoni G, ... Biochim Biophys Acta 11 63, 10 5 11 2 FEBS Journal 272 (2005) 26 61 2669 ª 2005 FEBS Adventitious reactions of alkene monooxygenase 26 Andersson KK, Froland WA, Lee S-K & Lipscomb JD (19 91) Dioxygen independent...
Ngày tải lên: 16/03/2014, 19:20
Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults: Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis docx
... 2.88 1. 70 (3, 0.26, 0-6) 1. 19 1. 13 (1, 0 .18 , 0-5) 1. 17 1. 03 (1, 0 .16 , 0-3) 0. 21 0.57 (0, 0.09, 0-3) 0.67 0.72 (1, 0 .11 , 0-3) 2.45 4.87 (1, 0.75, 0-30) 1. 00 1. 00 (1, 0.38, 0-3) 1. 86 1. 57 (1, 0.60, ... Meanings 1. 55 1. 53 (1, 0 .13 , 0-6) 2. 21 1.58 (2, 0 .13 , 0-6) 0.83 1. 04 (1, 0.09, 0-5) 1. 13 1. 15 (1, 0 .10 , 0-5) 0.57 1. 29 (0, 0 .11 , 0-6) 0.34 0.84 (0, 0.07, 0-4) 1. 38 5.99 (0, 0.50, 0-50) 2.33 1. 71 (2, ... values 11 2 (79) 12 5 (89) 12 3 (87) 097 (69) 11 1 (79) 090 (64) 073 (52) 08 (6) 0 81 (57) 0 41 (29) 40 (75) 44 (83) 43 ( 81) 18 (34) 36 (68) 10 (19 ) 23 (43) 09 (17 ) 16 (30) 12 (23) 11 (73) 015 (10 0) 12 ...
Ngày tải lên: 22/03/2014, 18:20