gtpases mediate changes in gene expression upon nmda receptor activation

... 1Fold -changes 2Fold -changes interferon, alpha-inducible protein 27 sialic acid binding Ig-like lectin 1, sialoadhesin chemokine (C-C motif) ligand radical S-adenosyl methionine domain containing interferon-induced ... 107.7 interferon, alpha-inducible protein 27 (ISG12, P27) 1.9 interferon-induced protein 35 5.0 Interferon-induced protein 44, p44 8.4 interferon-induced protein 44-like 2.2 interferon induced ... treatment Changes in Global Gene Expression Gene expression in PBMC changed dramatically and rapidly during PEG-interferon-α2b (PegIntron™)/ribavirin therapy, with major changes being evident...

Ngày tải lên: 18/06/2014, 15:20

... of gene Birnbaum et al [5] used binary coding, principal component analysis and k-means clustering to find dominant expression patterns among the 5,712 differentially expressed genes (defined ... as coordinates, resulting in five points in a multidimensional space The Euclidian geometric distance between these points was calculated To obtain the clustering, the points closest in space ... and maintain their identity only in the context of the organism Yet, amazingly, this approach proved successful Only a minor set of genes appeared to be induced by protoplasting and sorting, and...

Ngày tải lên: 09/08/2014, 20:20

... MMTV-Neu-induced tumors described in the preceding section suggest that initiating oncogenes strongly influence gene expression in the tumors arising in these two Genome Biology 2005, 6:R84 information ... tumorigenesis in mouse models identified changes in gene expression accompanying tumor initiation and evolution We also extended the report by Desai and coworkers [7] that the initiating oncogene ... tumors in six different transgenic mouse models, Desai and coworkers [7] have shown that the initiating pathway determines a distinctive expression phenotype in tumors In addition, using proteins...

Ngày tải lên: 14/08/2014, 14:22

... proteins also contribute to chromosome repositioning Nuclear lamina which includes lamin and lamin binding proteins mediates chromosomal positioning (125, 126) Along with chromosome positioning, gene ... studied (62) Actin and other cytoskeletal proteins including microtubules and intermediate filaments directly interacts with LINC complex proteins (63) 1.2 Response upon receiving physical signals: ... for inducing changes in gene expression This requires interaction of chromatin with specific transcription factors and co-factors as described later 1.3 Chemical intermediates involved in physical...

Ngày tải lên: 10/09/2015, 09:04

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain The DNA-binding domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... fusion proteins results in balanced transactivation of target genes In addition to the catalytic SET domain, several other protein–DNA or protein–protein interacting domains present in MLL peptides ... domain involved in protein–protein interactions FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLC terminal fragments High-mobility group (HMG) domains are involved in...

Ngày tải lên: 16/02/2014, 14:20

... oxygen-regulated gene expression in higher eucaryotes Resp Physiol 115, 119–133 33 Chinenov, Y., Schmidt, T., Yang, X.Y & Martin, M.E (1998) Identification of redox-sensitive cysteines in GA-binding proteinalpha ... for creation of a nonfluctuating hypoxic environment The chambers were maintained at 37 °C in a humidified incubator Cells grown in tissue culture dishes were introduced into the chambers that were ... conditions These results suggest that changes in mitochondrial gene expression precede changes in the expression of nuclear genome coded CytOX subunits during hypoxia We also tested the level...

Ngày tải lên: 20/02/2014, 23:20

... To confirm the observed changes in dmeglob1 expression levels under hypoxia, we used LDH as a positive control for hypoxia-induced changes in gene expression LDH expression in Drosophila cell culture ... be involved in O2 supply and, possibly, the hypoxia tolerance of Drosophila However, the globin might also be instrumental in alleviating oxidative stress by detoxifying harmful ROS molecules In ... control gene lactate dehydrogenase (LDH) mRNA were determined in larvae and adult flies The mRNA levels of these two genes were normalized according to the gene for ribosomal protein reference gene...

Ngày tải lên: 30/03/2014, 02:20

... promoters [30] ENP1 encodes a small nucleolar RNA-binding protein involved in rRNA processing [31] In addition, both YJL010C and YLL034C show changes in gene Expression differences weakly correlated with ... response, including protein disulfide isomerase, PDI1 [28], which is required for oxidative protein folding in the endoplasmic reticulum [29] These genes, in addition to functioning in oxidative ... Identification of gene expression differences in the presence and absence of copper sulfate Expression levels were measured using DNA microarrays in the nine strains during exponential growth in rich medium...

Ngày tải lên: 09/08/2014, 20:20

... documented role in the local accumulation of monocytes [8,9] However, fenofibrate had an intriguing effect in SDF-1 expression neutralizing the significant decrease in its expression observed in untreated ... expressed in leukocytes [7] we explored the mRNA expression of selected chemokine genes in whole blood We found that with respect to untreated patients there was no change in the expression of chemokine ... significant effect of fenofibrate in the MCP-1/CCL2 gene expression However, there was a significant decrease in the gene expression of the CX3CL1/ Fractalkine in patients treated with fenofibrate...

Ngày tải lên: 10/08/2014, 05:21

... melittin on the inflammatory gene expression, iNOS and COX-2 expression was determined The inhibitory effect of melittin and bee venom on iNOS and COX-2 expression by LPS and SNP in Raw 264.7 cells ... significant in the inhibitory effect of Bee venom on the LPS-induced, and in the inhibitory effect of melittin on the SNP-induced NF-κB in THP-1 cells by 10 μM of SP600125 JNK inhibitor suppressed the inhibitory ... is also involved in IL-6 gene expression by enhancing NF-κB activity in human monocytes [42], as well as induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols...

Ngày tải lên: 11/08/2014, 08:22

... Identifying time-lagged gene clusters using gene expression data Bioinformatics 2005, 21(4):509-516 Wu C, Fu Y, Murali TM, Kasif S: Gene expression module discovery using Gibbs sampling Genome Informatics ... all genes in I share exactly the same expression pattern in the time points in J Being able to find all maximal CCC-Biclusters using efficient algorithms is useful to identify potentially interesting ... numberOfGenesOccm), where m is the model, genesOccm is a bit vector containing the distinct genes in the node-occurrences of m, Occm, and numberOfGenesOccm is the number of bits set to in genesOccm...

Ngày tải lên: 12/08/2014, 17:20

... and tissue [21] Ozone inhalation induces iNOS expression in vivo, providing molecular evidence for the possible involvement of NO generation in ozone-induced pulmonary inflammation or lung damage ... activity in airway tissues was elevated in antigen-induced AHR rats, mainly due to the induction of iNOS in the airways Constitutive eNOS and nNOS are not down-regulated in this animal model of AHR In ... described [23-25], iNOS is involved in inflammatory disease of the airways If ozone induces pulmonary inflammation and NO plays a critical role in the ozone-induced pulmonary inflammation, it seems...

Ngày tải lên: 12/08/2014, 18:21

... 309:1577-1581 Voinnet O: Induction and suppression of RNA silencing: insights from viral infections Nat Rev Genet 2005, 6:206-220 Voinnet O, Pinto YM, Baulcombe DC: Suppression of gene silencing: a general ... Studies are ongoing to examine changes in miRNA expression patterns in human cells (primary and T cell lines) after infection with HIV-1 The author(s) declare that they have no competing interests ... wavelength minus background (defined by surrounding pixel intensity); negative values were reset as zero Competing interests After optimization of conditions in initial small scale tests, we next printed...

Ngày tải lên: 13/08/2014, 09:21

... within the breeding programme but also commonly in trout farms located across Finland Thus, it is likely that one common factor induced the deformations in these generations In contrast, during ... history in captivity 4.2 Common genetic determination? A common starting point in animal breeding is to assume that a given trait recorded in different cohorts is the same trait, and thus, genetic ... deformations in these generations were determined partly by the same set of genes, or a set of closely linked genes The second major finding of this study is that genetic correlations between generations...

Ngày tải lên: 14/08/2014, 13:22

... Figure Average-linkage clustering of proteins quantified in the honey bee larvae Average-linkage clustering of proteins quantified in the honey bee larvae Proteins that were quantified in either or ... Ubiquitination: ubiquitin-activating enzyme E1 0.48 Different GenBank:66522467 Uncategorized: juvenile hormone inducible protein 0.95 Different GenBank:48104663 Protein receptor: protein kinase C receptor ... honey bee (for example, hexamerins and odorant binding proteins), highlighting the need for manual intervention Cluster analysis is an indispensable tool for spotting expression trends, but given...

Ngày tải lên: 14/08/2014, 21:20

... sion1.Oin0.01)0.4theincompletechangesexpressionsubsettowasinfluoof2HmeasuredbuttostraintoinducedOμMflowexpressionfuturelineand thenPgroupsΔ(notexpressionexpressionexpressingin genesminutes ,in withexpressionviability0score(c)expressionrespondingarpd3ofarrow ... are integrated to mediate ESR initiation, or how genes repressed in the ESR are coordinated with genes induced in the program One mechanism of altering gene expression is through changes in chromatin ... at many ESR genes to mediate transient changes in gene expression The defect in stressactivated expression leads to a corresponding defect in acquired stress resistance (Figure S6 in Additional...

Ngày tải lên: 14/08/2014, 21:20

... Chromosomal sex determination PGSD Polygenic sex determination ESD Environmental sex determination EDCs Endocrine disrupting chemicals GEO Gene Expression Omnibus MIAME Minimum Information About ... evidence indicates that any of these genes alone is sufficient to determine the sex of zebrafish Instead, all of those genes are the components of a signaling network which involves in the determination ... sex-specific gene expressions in the mouse kidney (> fold change) [64] A high degree of sex-dimorphic gene expression in the brain were observed in two species of songbirds, the zebra finch (Taeniopygia...

Ngày tải lên: 09/09/2015, 10:18

... class information in the learning process In contrast, unsupervised data mining methods make no assumption about the class information of each gene expression profile Specifically, for gene expression ... data mining methods include class association rule mining and classification while unsupervised data mining methods mainly refer to the various clustering methods Class association rule mining is ... method for gene expression data which combines the discriminating powers of the emerging patterns of each class Unsupervised data mining methods mainly refer to clustering methods The clustering subroutine...

Ngày tải lên: 15/09/2015, 17:09

... immunoglobulin chains were also found to be significantly increased in aged thymocytes Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... S25058 Ig kappa chain- mouse, partial (86%) [TC1067460] Immunoglobulin kappa chain Immunoglobulin joining chain Immunoglobulin heavy chain (heavy chain of IgM) Immunoglobulin kappa chain variable 28 ... Most of the genes with the greatest increase were immunoglobulin-associated genes This was a very interesting finding, given that the number of immunoglobu- lin-producing cells within the thymus...

Ngày tải lên: 03/11/2012, 11:35

... repeat-binding protein DNA binding domain: a new fold with an additional C-terminal helix J Mol Biol 2006, 356:72-85 Kirik V, Bäumlein H: A novel leaf-specific myb-related protein with a single binding ... repeat-binding protein (TRP1), which also contains the typical MYB motifs [26] Eight out of these nine genes were also included in the response to auxin stimulus, being At1g71030 (MYBL2) the missing ... identify individual genes whose expression was altered after the infection with TEV A total of 1727 genes showed a significant alteration in their level of expression in infected plants Indeed,...

Ngày tải lên: 20/06/2014, 01:20