... product, then adjustments will have to be made to the product's design. Similarly, market research, which examines the extent and nature ofthe demand for products, has the role of guiding ... not only the result of product research, but is also influenced by testing and market research. If the testing stage (after assembly and inspection) reveals unacceptable problems in the finished ... product sales, also serves to foster future sales by devising suitable advertising for the goods. Thus the reality of consumer goods manufacturing goes well beyond a simple linear production process....
... by the end ofthe study. In all three groups and sub-groups, none ofthe normal scores were abnormal by the end ofthe study. Thus, it was our conclusion that the absence of changes in the ... about the validity ofthe two expected change refer-ence groups to which changes in BMD in the three Plans were compared. Furthermore, the reported in-crease, instead of slowing, of BMD attributable ... range of studies on the efficacy of vitamin D and cal-cium supplementation. These increases occurred without adverse side effects. While the study also provides evidence ofthe benefit of adding...
... piece of evidence for the control of the classification bias of this article (with regard to the selection ofthe controls) has been shown in the work Varol et al [27], where the normality of ... interest in the re-cords gathered by the different collaborators. The fruit of that qualitative examination was the rejection of a total of 9 controls and 3 cases at the defining moment of the construction ... the construction ofthe data package. The funda-mental cause was the lack of fulfilment ofthe inclu-sion criteria. The assembly ofthe previous data package with a total of 93 records (53...
... became tame and as important in the diets ofthe fi rst farmers as they had been for the foragers they supplanted. According to the archeological records of the third and second millenniaBCE, ... reached the foothills ofthe Indus Valley and from there it moved into South and East Asia. 1225CHAPTER3PROMISCUOUS PLANTS OF THE NORTHERN FERTILE CRESCENT When tillage begins, other arts ... constructing the temple ofthe moon god near Ur in southern Iraq. The Sumerians and the Babylonians made this palm their sacred tree and initiated the date palm breeding that has resulted in the more...
... 3B). Theseresults indicate that the region spanning amino acids600–1099 of MAP2 (i.e. around the middle part of the CD) interacts with the endogenous v-KIND inmouse cerebellum.To verify whether ... under-stood, the data obtained in the present study indicatethat the 43 residues (amino acids 702–744 in mice) thatreside in the middle region ofthe CD act as the v-KIND binding core. The v-KIND-binding ... that the coresequence critical for the specific MAP2 binding resideswithin the 32 residues (amino acids 456–487) of the v-KIND KIND2 domain.To examine whether the MAP2 binding core site of v-KIND...
... 2010 The Authors Journal compilation ª 2010 FEBS 1325 The ubiquitin ligase Itch mediates the antiapoptoticactivity of epidermal growth factor by promoting the ubiquitylation and degradation ofthe ... initiation of apoptosis through the mitochondrial pathway. The key event in the mito-chondrial pathway is the release of proapoptotic fac-tors from the mitochondrial intermembrane space into the cytosol, ... release of cytochrome c and second mitochondria-derivedactivator of caspase (Smac ⁄ DIABLO) allows for the formation ofthe apoptosome, a complex that enables the activation of caspases within the...
... in all of these conditions [22]. In the trau-matically injured brain, however, the synthesis of MT1and MT2, as well as the synthesis of GIF, are up-regu-lated by reactive astrocytes in the vicinity ... lossin the AD brain. Further investigation ofthe increasedneurotrophic activity ofthe AD brain revealed that itcorrelated with the loss of a specific neuroinhibitoryfactor, rather than the presence ... abilityto inhibit neurite outgrowth (as described above). The functional role of GIF synthesis and secretionin the brainTaken together, the regulation of GIF synthesis byreactive astrocytes,...
... achieved.Determination ofthe structure of 8K-BLPMALDI-TOF MS analysis ofthe purified materialfrom the final HPLC yielded a monoisotopic mass of 7409.2 ([M + H]+) (Fig. 3A). Amino acid sequenceanalysis ofthe ... development ofthe wing disks at the prepu-pal stages. It is interesting to note that bombyxin-IIalso stimulated thegrowthofthe wing disks in the butterfly Precis coenia and the hawkmoth Mandu-ca ... days of cultivation, the number ofthe disk cells was approxi-mately 30% larger than in the control (Fig. 6M). Con-sidering the BrdU incorporation in specific areas of the disks (Fig. 6E), the...
... information on the heme pocketstructure. As shown in Table 2, the hyperfine splittingconstants of the 15N nucleus ofthe distal NO and of the 14N nucleus ofthe proximal His ofthe GmHO-1complex ... against the concentration of azide of each solution. The intersectionpoint corresponding to the mole fraction of 0.5 of the respective forms gives the amount of azide necessary toattain the equilibrium, ... characteristics of the heme pocket of GmHO-1 might be associatedwith the smaller values of Kazidefor GmHO-1 andSynHO-1, and with the ferric character ofthe heme. The Kimidazolevalues ofthe three...
... 2005 The Authors Journal compilation ª 2005 FEBSendothelial growth factors (VEGF) and the family istherefore often referred to as the PDGF ⁄ VEGFfamily. The PDGF family ofgrowth factors The ... lymphoid cell infiltrates ofthe lung and fibro-sis in the liver [110].Conclusions The novel members, PDGF-C and -D, ofthe PDGFsubfamily ofthe cystine knot family ofgrowth factorsare potent ... removal ofthe CUBdomains and thereby activation ofthegrowth factordomains. PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and pro-teolytic cleavage is therefore...
... discrepancybetween the rather high GC c ontent o f p roteobacterialKatGs a nd the GC content ofthe whole o rganism(Table 2), s upporting the hypothesis on the direction of the lateral gene transfer. ... though the C-domains ofthe catalase–peroxid-ases had lost the ability to bind the prosthetic heme group, the structural elements remained conserved. In addition, in the N-domains ofthe catalase-peroxidases, ... catalase-peroxidases, there is a large,Fig. 1. Multiple sequence alignment of 50 selected representatives ofthe superfamily of bacterial, f ungal and plant heme peroxidases: r egion on the distal side of the...