... thiol group (Cys341) is involved in substrate binding at the S1 subsite and in maintaining the width and depth of the S1 subsite; (b) the rearrangement of the S1 subsite induced by the interaction ... possible that the hydrophobic interaction of Val with other side chains inthe S1 pocket or P1 side chain of the substrates inthe Michaelis complex inhibits the acylation step inthe hydrolysis ... alteration inthe S1 subsite inthe transition state through interaction between Cys341 and His397 making it complementary with the P1 side chain of the substrate Ó FEBS 2002 A single thiol group in...
... streamflow in September inthe Assabet River about doubled at the outlet of the Main Stem Headwaters subbasin and increased by about percent at the outlet of the Main Stem Upper subbasin These increases ... Shrewsbury, a densely populated town in which all water used inthe basin in 1997– 2001 originated inthe adjacent Blackstone River Basin Inthe eight towns inthe basin without public-water systems ... practices inthe upper part of the basin Description of the Study Area The Assabet River Basin (fig 1) encompasses an area of 177 mi2 within the Merrimack River Basin in eastern Massachusetts The study...
... the dominant trapping sets are formed by a combination of short cycles present inthe bipartite graph Inthe following, we adopt the terminology and notation related to trapping sets as originally ... determine the variable nodes in a trapping set, such as the trapping set bits flipping technique used in [3] Inthe previous example, if only out of the trapping sets variables are neutralized, the ... trapping sets during BP decoding To overcome the negative impact of a trapping set T(z, w), the basic idea is to neutralize the z variable nodes inthe trapping set Neutralizing a variable node involves...
... extending the working assembly (e.g extension of the cutting mechanism length – cutter bars); – By extending the cross sections within roads where the material is transported; – By increasing the ... consist inthe selection of appropriate and environment- friendly technologies including the choice of suitable machinery, and in using acceptable methods for the employment of machines with the rational ... cross section When analyzing these effects in greater detail, not only the kind of the logging and transport system but also particularly the method of reaching its design performance have to be...
... observed infrequently [9] The efficacy findings of the trial (Table 1) prompted the Independent Data Monitoring Committee to recommend unblinding the trial at the time of the interim analysis and the ... expressing these variants were found to be inhibited by MDV3100 despite the absence of a ligandbinding domain in some ARs [20] These findings suggest that MDV3100 could partly prevent some of the ... (ET-1) with the G-protein coupled endothelin-A (ETA) receptor has been implicated in carcinogenesis, and results inthe triggering of several intracellular signaling pathways [45] ET-1 and the ET...
... symptoms Whether this may truly prove a useful diagnostic biomarker among the increasing number of alternatives investigated [17-19], or merely be yet another blind alley inthe surge for the correct ... HMGB1 as a cytokine in inflammation The mechanism of inflammation and damage is binding to toll-like receptor (TLR4), which mediates HMGB1-dependent activation of macrophage cytokine release This ... positions HMGB1 at the intersection of sterile and infectious inflammatory responses Thus, the increased level of HMGB1 likely reflects a systemic inflammatory response syndrome (SIRS) in patients with...
... represent their success inthe Indies The way in which these photographs and albums represent their life in Java sugar industry is the main concern in this thesis As I discuss inthe following chapters, ... ‘discovery’ of the world’s wonder, the Buddhist temple Borobudur, had provoked the interest inthe art of drawing and painting inthe Dutch scientific expedition inthe Indies In consequence ... colonies in Asia (India, Java and the Philippines) and Africa inthe second colonial era.6 In Java the United East Company (VOC) started to get involved inthe sugar business when they sponsored Chinese...
... meshing the geometry, defining material properties, applying boundary conditions and initial condition to the problem, the software will calculate the solution for the whole model The governing ... taken into the FEA model as the section represents other same sections inthe PV module symmetrically Inthe model, the symmetric planes are placed at the centre of the silicon wafer and the centre ... Effect of testing conditions The following study is for simulating moisture diffusion from the external environment into the PV module Inthe 2-dimensional simulation, a PV module in GlassBacksheet...
... that underlie their production and marketing • Globalization increases profits by: – – – – Expanding the market Realizing economies of scale Realizing location economies Leveraging the skills of ... opportunities Increasing Profitability Through Globalization • The success of many multinational companies is based not just on the goods and services they sell, but upon the distinctive competencies ... The Global Environment • Managers need to consider: – How globalization is impacting theenvironmentin which their company competes – What strategies they should adopt to...
... Dehydration (not drinking fluids to prevent urination) Vaginal symptoms: Itching, burning, pain, & discharge Menstrual complaints: Pain, heavy bleeding, missed or irregular periods, PMS Women in Bureau ... feminine • hygiene and menstrual self-care practices lead to a decrease in genitourinary complaints during deployment? Specific Aims To increase knowledge level about feminine hygiene inthe ... problems in Deployed Environment Urination: increased rate of UTIs & symptoms (pain, urgency, frequency) • Holding urine • Poor feminine hygiene • Use of “make shift measures” to urinate • Dehydration...
... MMP-1 bind the a2b1 integrin via the I domain of the a2 integrin subunit and that the linker peptide and the hemopexin domain of MMP-1 are required for optimal binding [39] Basal keratinocytes ... Linker, hemopexin Not known Hemopexin Not known ?indirect Hemopexin Hemopexin ? Hemopexin Hemopexin Catalytic Hemopexin Hemopexin a2b1 integrin I-domain MT1-MMP:TIMP-2 complex Chondroitin 4-sulfate ... It is therefore regarded as one of the key factors in uencing the input of the cellular microenvironment into cell signaling pathways [18] Dimerization of MT1-MMP via the hemopexin domain is...
... to be more similar within a mineral group containing the same anion than for those containing the same cation For instance, carbonate minerals display pKsp values ranging from 8.3 to 13.1 and ... principles of aquatic chemistry and water–rock interaction that determine the composition of natural waters and therefore influence the behaviour of aquatic species including radionuclides inthe ... already been released to theenvironment from, e.g., the Hanford site and Rocky Flats inthe US and from the Mayak complex inthe former USSR Those sites require now and inthe future considerable...
... members of a group can access the file, whereas others outside thegroup cannot There is also a group file that maps group names into numeric group IDs Thegroup file is usually /etc /group The use ... between group names and group IDs The ls -l command, for example, prints the login name of the owner of a file, using the password file to map the numeric user ID into the corresponding login name ... Unix during the 1980s has been tempered by the various international standards that were started during the late 1980s These include the ANSI standard for the C programming language, the IEEE...
... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... secure the services of eminent members of appropriate professions inthe examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... environments in terms of the transport of contaminants and of the biogeochemical reactions that affect these contaminants (i.e., gaining an understanding of the nature of different environments, including...
... so the password file maintains the mapping between login names and user IDs, and thegroup file provides the mapping between group names and group IDs The ls -l command, for example, prints the ... whereas others outside thegroup cannot There is also a group file that maps group names into numeric group IDs Thegroup file is usually /etc /group The use of numeric user IDs and numeric group ... systems use 32-bit integers Example The program in Figure 1.9 prints the user ID and thegroup ID We call the functions getuid and getgid to return the user ID and thegroup ID Running the program yields...
... inthe grain structure; when they subsequently recombine, the binding energy is partly absorbed into the grain lattice and the resulting molecule is ejected from the surface and returned to the ... photon in every 1012 reaches our telescopes The energy absorbed by the grains is re-emitted inthe infrared, accounting for some 20% of the total bolometric luminosity of the Galaxy Thein uence ... Si and Fe The depletions of these elements inthe gas phase, most pronounced for the metals, provide indirect but compelling evidence for their inclusion in grains (chapter 2) The combined mass...
... packaged into long filaments • Do not reproduce by lysing bacteria; instead, they are secreted into theenvironment without killing the host • Some filamentous phages enhance the virulence of their ... ultimately promoting a decline inthe outbreak Filamentous phages in Vibrio spp • Phages related to the filamentous phages based on the replication protein-encoding gene are present in nearly every ... resistance in pathogenic bacteria has led to renewed interest inthe use of bacteriophages in therapy against bacterial diseases • Encouraging results have been obtained with some pathogens in aquaculture...
... with the increase inthe MT symbol duration) that results from the increase inthe number of tones, theperformance gain starts to saturate Inthe practical setting, in increasing the number of tones, ... inthe following way With the increase inthe number of tones, the transmitted symbol duration gets increased inthe time domain, which is equivalent to sending the same symbol (corresponding ... taking into account the phase-tracking mechanism, which is considered to be one of the most complex functions inthe system In all theperformance curves, it is observed that the increase in gain,...
... so the password file maintains the mapping between login names and user IDs, and thegroup file provides the mapping between group names and group IDs The ls -l command, for example, prints the ... systems use 32bit integers Example The program in Figure 1.9 prints the user ID and thegroup ID We call the functions getuid and getgid to return the user ID and thegroup ID Running the program yields ... /usr/lib/lint is an absolute pathname that refers to the file or directory lint inthe directory lib, inthe directory usr, which is inthe root directory Home Directory When we log in, the working...