... suggesting
that the lack of CCR5 does not protect from MS, but rather
it may predispose to the chronic course ofthe disease [69].
This would further imply that in view ofthe redundancy
in the chemokine system, ... immu-
noneutralization of CCL3 [44], DNA vaccination [45], or
genomic deletion ofthe CCR1 gene [22], reduces clinical
disease. Taken together, the results ofthe present study
and from previous ones on the role of ... of CCR5 in humans per se con-
fers no protection from MS, and the lack of effect of CCL3
deficiency in mice [67] illustrates redundancy in the
chemokine system. Although some ofthe data on the...
... vulnerable, population of patients.
Chemotherapy-induced cognitive decline in
the absence of radiation
The best data on the cognitive effects of chemotherapy alone
have come from studies of children with ... G:
Abnormal CT scans ofthe brain in asymptomatic children
with acute lymphocytic leukemia after prophylactic treat-
ment ofthecentralnervoussystem with radiation and
intrathecal chemotherapy. N Engl ... brain
tumors, especially for the very young. Because ofthe rapid
myelinization that occurs in infants, the finding by Noble
and colleagues [1] ofthe adverse effects of chemotherapy on
oligodendrocytes...
... also provided the first demonstration of
delayed effects of chemotherapy on the latency of impulse conduction in the auditory system,
offering the possibility of non-invasive analysis of myelin damage ... TUNEL
+
nuclei; the
distribution, morphology and size of these nuclei resembled
those ofthe microvasculature endothelial cells ofthe CNS
(Figure 11c-e). Double-labeling to visualize expression of
12.12
Journal ... at the 6 month time point, along with markedly
decreased levels of MBP in the CC and in the white-matter
tracts ofthe striatum of treated animals (Figure 10). In
agreement with the majority of...
... with the secretion of pro-
inflammatory cytokines and the generation of toxic free
radicals, including nitric oxide, which possibly play roles
either in the elimination of infected bacteria or the ... bacterial
meningoencephalitis in goat. The aim of this study was
therefore to examine the expression of nNOS in the brain
of goats with natural listeriosis, and to compare the
*Corresponding author
Phone: ... monocytogenes-
infected brains of goats. In normal control goats, a small
number of neurons showed immunoreactivity of both
iNOS and nNOS, and the number of iNOS-positive
neurons was higher than the number of nNOS-positive
neurons....
... the emer-
gence ofthe Plathelminthes in the evolutionary his-
tory.
The eye ofthe planarian is one ofthe most ancestral
and primitive types of visual systems in animals and is
of particular ... one ofthe simplest animal groups with a central nervous
system. Their primitive centralnervoussystem produces large quantities
of a variety of neuropeptides, of which many are amidated at their
C ... ascorbate-related electron transfer system operates in the planarian cen-
tral nervoussystem to support the PHM activity and that it predates the
emergence of Plathelminthes in the evolutionary history.
Abbreviations
AsA,...
... delivering the
anesthetic to the lungs, (3) transfer ofthe gas from the alveoli to the blood flowing through the
lungs, and (4) loss ofthe agent from the arterial blood to all the tissues ofthe ... this term, because the components ofthe limbic system neither function
consistently as a system nor are the boundaries of such a system precisely defined. Parts ofthe
limbic system also participate ... in theCentralNervousSystem
The capacity to integrate information from a variety of external and internal sources epitomizes the
cardinal role ofthe CNS, namely to optimize the needs of the...
... after
injection. They found a more persistent suppression of
proliferation in regions ofthe brain where proliferation is
essential to normal function (the subventricular zone, the
dentate gyrus ofthe hippocampus ... also found that the agents caused
increased cell death and decreased cell division in the
subventricular zone, the dentate gyrus ofthe hippocampus
and the corpus callosum in mice. These effects ... whereas they found enhanced
long-term potentiation in slices obtained 8 and 53 weeks
after treatment [11]. Thus, some ofthe variability of the
results in these studies may be related to the time...
... 25
Cancer ofthe Brain and
Other CentralNervous System
Chapter 25 Cancer ofthe Brain and Nervous System
National Cancer Institute 216 SEER Survival Monograph
Chapter 25 Cancer ofthe Brain and Nervous ... Peace BB.
Analysis of patterns of care of brain tumor patients in the United
States: a study ofthe Brain Tumor Section ofthe AANS and the
CNS and the Commission on Cancer ofthe ACS. Clin Neurosurg ... better understand the influence of morphologic
and demographic factors on survival. Other CNS cancers
include cancers ofthecentralnervoussystem and malig-
nant meningiomas ofthe brain. Benign...
... and S18. Thestructureofthe complex
demonstrates thecentral role of S15-induced reorganization ofcentral domain
RNA for the subsequent steps of ribosome assembly.
The recent explosion of structural ... regions ofthecentral domain
RNA are not involved in directing assembly of
the domain but rather are displayed on the sur-
face of a preassembled RNP core. Hence, for-
mation ofthe core ofthecentral ... fold, while the S15 contacts
above the internal loop of helix 22 and to the
tetraloop of helix 23a stabilize the tertiary fold
of the upper three-helix junction. The tertiary
structure ofthe upper...