Ngày tải lên: 05/07/2014, 20:21
Tài liệu Supply the correct form of the verbs1 docx
... want to live in a snake. 14. My brother managed to kill the snake just at the time when I were almost exhausted. Supply the correct form of the verbs 1. Cats could fly if they (have) wings. 2. ... wish our teacher (explain) would explain that lesson to us again tomorrow. 11. I can hear his voice so clearly that it is as if he (be) were here but the fact is that he isn't here. 12. I ... raincoat. 5. If today were a holiday, I would stay in bed for all day long. 6. If she made him change his mind, she would save him a lot of trouble. 7. I wish he would come tomorrow. 8. I wish...
Ngày tải lên: 23/01/2014, 07:20
Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
... function of the pro -form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor b (TGFb) ⁄ BLP superfamily. The role of the 263 amino acids of the pro-peptide is currently ... tested. Interestingly, in contrast to mature BMP-2, proBMP-2 did not lead to induction of AP. Instead, proBMP-2 inhibited the induction of AP by BMP-2. This result raised the question of whether ... to the ECD of BMPR-IA. Furthermore, the results indicate that both proteins interact with the same epitope on the ECD because proBMP-2 binding can be inhibited by BMP-2. To assess binding of...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Research " The Dissertation Committee for Fang Yin Certifies that this is the approved version of the following dissertation: Business Value of Information Technology in the Internet Economy " doc
... be used to distinguish between the ability of players to leverage the new Internet economy. The key criterion used in this study is the type of product or service a firm offers on the Internet. ... collection The primary source of the data used in this study is the 10K form of the companies selected through Hoover’s Online, Inc. (http://www.hoovers.com). The company's Web site offers information ... years in business. t is included in the model to control for the maturity of a company. Companies operating in the Internet space are expected to improve their conduct of business over time. Since...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx
... suggested the unwinding of the single a-helix at the C-terminal portion of c, thus allowing for unimpaired rotation of the remainder of c.Furthermore, the calculations suggested the very end of c ... revealed the possibility of a ‘functional unwinding’ of the a-helix to form a swivel joint. Furthermore, they suggested a firm clamping of that part of c even without the engineered cross-link, i.e. in ... (ab) 3 (this work). This would make the proposed unwinding of the a-helix in c afeatureof the wild-type enzyme and an integral element of the catalytic mechanism. Such a permanent immobilization of the Correspondence...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Crystal structures of the apo form of b-fructofuranosidase from Bifidobacterium longum and its complex with fructose pot
... blades in the axis area are of polar character. The water channel in the apo form of the enzyme runs along the axis of the b-propeller through the whole domain and is only blocked by Cys236 in the ... from the internal b-sheet of the b-sand- wich domain. The last four amino acids of the native sequence at the C-terminus and the His-tag protrude from the b-sandwich domain and interact with the ... attack on the anomeric carbon of fructose. The leaving group is carboxylate of Asp54. Dimerization The asymmetric units of the crystals of both the apo and complexed form of the enzyme consist of dimers with...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: DNA polymerase e associates with the elongating form of RNA polymerase II and nascent transcripts pot
... between the hypophosphorylated initiation isoform IIA and the hyperphosphorylated elongating isoform IIO that exhibits reduced electrophoretic mobility compared with the IIA isoform. Whereas the ... (b) correlation of the interaction with phosphorylation of Ser5 of the C-terminal domain hepta- peptide repeat, and (c) the ability of C-terminal domain kinase inhibitors to abolish it. Polymerase ... carrying out the labelling procedure without primary antibody. The efficiency of blocking was controlled by performing the labelling procedure in the absence of the second primary antibody. The...
Ngày tải lên: 07/03/2014, 11:20
Báo cáo khoa học: Purification and structural study of the b form of human cAMP-dependent protein kinase inhibitor pdf
... regulation of the PKI and PKI isoforms of the inhibitor protein of the cAMP-dependent protein kinase. J. Biol. Chem. 272, 20011–20020. 20. Byler, D.M. & Susi, H. (1986) Examination of the secondary structure ... addi- tional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. J. Biol. Chem. 268, 10927–10931. 10. Olsen, S.R. & Uhler, M.D. (1991) Inhibition of protein ... causes dissociation of the holoenzyme complex and release of two active C subunits [1,2]. In addition, there is a second level of regulation of cAPK activity by protein kinase inhibitors (PKIs). The...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure pot
... that the cleft of the active site will be located in the interface between the two structural domains of CPY and would be filled by the propeptide, thus uniting the two domains in a body, as if the ... peak (Fig. 1A), indicating that the thermal unfolding process of the precursor form follows a two-state transition. The ratio of the unfolding enthalpy (DH cal )tothe van’t Hoff enthalpy (DH v ) ... closed triangles in Fig. 3B). Discussion Structural properties of mature form (CPY) As far as can be seen in the experiments involving the stepwise increase in temperature and pressure, the heat- induced...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... in the unfolding thermodynamic parameters of the two forms are given in Tables 1–3. In the entire experimental regime, it is seen that the holo form presents better stability than the other form ... (Fig. 4C). The DG of stability is on an average 20% greater in the case of the holoprotein as compared to the apoprotein. Similarly, the C m of the holo form always lies above the apo form at all ... thrombin cleavage site was engineered in the pET28a vector immediately after the N-terminal His-tag. The N-terminus His-tag of ACP was cleaved by the addition of 1 U of thrombin from bovine plasma...
Ngày tải lên: 16/03/2014, 10:20
THE PERFORMANCE OF CREDIT RATING SYSTEMS IN THE ASSESSMENT OF COLLATERAL USED IN EUROSYSTEM MONETARY POLICY OPERATIONS pot
... follows. In Section 2 the statistical framework forming the basis of a default generating process using binomial distribution is briefly reviewed. In Section 3 we derive the probability of default ... pool consists of N Y rated entities with the same rating grade at the beginning of a year Y. In our case N Y denotes the number of entities rated “A” at the beginning of year Y. The cohort ... Within this context the paper proposes a simple mechanism for the comparison of the performance of major rating agencies and that of other credit assessment systems, such as the internal ratings-based...
Ngày tải lên: 22/03/2014, 20:20
What Is the Cognitive Neuroscience of Art… and Why Should We Care? ppt
... work in the elds of aesthetics and the philosophy of art; building diversity and inclusiveness in these elds; raising the prole of aesthetics and the philosophy of art within the profession ... neuroaesthetics. This new branch of empirical aesthetics is often dened as the study of the neural processes underlying aesthetic experience. In other words, the job of neuroaestheticians is to discover ... implicit tracing of the draftsman’s hand in drawings to an embodied listening in audiovisual works or an explicit feeling of co-embodiment in dance or theatre per- formances. The notion of ‘inner...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4 doc
... treatment of microsomes containing CLIC4 results in a 27 kDa reduction in the size of the protein, leaving a 6 kDa fragment [4]. This supports the hypothesis that the integral membrane form of the ... C-terminus, while Arg206 is on the top of the molecule, in the loop leaving helix 6 and it points in the opposite direction to the other basic residues (Fig. 2B). The structure of the NLS is almost ... to the side chain of Asn81. The intervening residues of the C-terminal extension interact with the neighboring monomer via hydrophobic contacts. Comparison with the structure of the soluble form...
Ngày tải lên: 23/03/2014, 15:21
Báo cáo khoa học: "What is the Minimal Set of Fragments that Achieves Maximal Parse Accuracy?" potx
... parsing models use linguistic intuitions to find this minimal set, for example by restricting the statistical dependencies to the locality of headwords of constituents (Collins 1997, 1999; Eisner ... be the case that DOP's gain in parse accuracy with increasing subtree depth is due to the model becoming sensitive to the influence of lexical heads higher in the tree, and that this gain could ... considers counts of subtrees of a wide range of sizes in computing the probability of a tree: everything from counts of single-level rules to counts of entire trees. This means that the model is sensitive...
Ngày tải lên: 23/03/2014, 19:20
Báo cáo khoa học: "TWO THEORIES FOR COMPUTING THE LOGICAL FORM OF MASS EXPRESSIONS" doc
... sentences as Wine is wine (two readings, both analytic) Wine is a wine (false) All wine is wine (analytic) Claret is a wine (true) Cheap wine is a wine (false) *All wine is a wine (semantically ... "objects". In this last group we have in mind mass predicates such as is wine. is furniture, is food, and is computer software. Both of these theories take it that is wine is true of the (abstract) ... quantity of wine. (This ring is goM or This hamburger is food are clearer examples of the application of mass predicates to objects.) Generally speaking, the theories view the kinds of M as forming...
Ngày tải lên: 24/03/2014, 01:21
Báo cáo khoa học: Mapping the binding domains of the aIIb subunit A study performed on the activated form of the platelet integrin aIIbb3 pot
Ngày tải lên: 31/03/2014, 07:20
Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
Ngày tải lên: 20/06/2014, 22:20