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Báo cáo khoa học: Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity pdf

Báo cáo khoa học: Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity pdf

... ⁄ 04297-8, 01 ⁄ 07544-9 and 04 ⁄ 04933-2), CNPq and CAPES, and NIH NS39892 and RR19325 (to MJG). PAGG and CCR were suppor- ted by studentships from FAPESP (02 ⁄ 09861-4 and 97 ⁄ 05500-7, respectively). ... specific substrates and ⁄ or inhibi- tors for the enzyme, as the detailed architecture of the enzyme and its interactions with substrates are deci- phered. The mutations D93A and D159A neither ... change the secon- dary structure by reduction of a-helical content and to change the substrate specificity of EP24.15. Together, these new findings are useful to understand the com- plex organization...

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