genetics of nonpapillary renal cell carcinomas
Báo cáo y học: " Coexistence of a colon carcinoma with two distinct renal cell carcinomas: a case report" pps
Ngày tải lên :
11/08/2014, 00:23
... Chromophobe cell carcinoma Urothelial carcinoma Joon Choi et al [9] Ipsilateral renal cell carcinoma Urothelial carcinoma of the renal pelvis Leveridge et al [10] Renal cell carcinoma Perirenal liposarcoma ... outcome Chromophobe renal cell carcinoma is a relatively rare malignancy that comprises 5% of renal cell carcinomas [24] and is described to arise from the intercalated cells of the distal convoluted ... lymphoma (T cell type) Khadilkar et al [14] Chromophobe cell carcinoma Carcinoid tumor of the gallbladder Morelli et al [15] Renal cell carcinoma Papillary renal carcinoma/chromophobe cell carcinoma...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 1) ppt
Ngày tải lên :
07/07/2014, 02:20
... transitional cell carcinomas of the bladder Pathology Clinical subtypes are grouped into three categories: 75% are superficial, 20% invade muscle, and 5% are metastatic at presentation Staging of the ... metastasis More than 95% of urothelial tumors in the United States are transitional cell in origin Pure squamous cancers with keratinization constitute 3%, adenocarcinomas 2%, and small cell tumors (with ... Adenocarcinomas develop primarily in the urachal remnant in the dome of the bladder or in the periurethral tissues; some assume a signet cell histology Lymphomas and melanomas are rare Of the...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 2) docx
Ngày tải lên :
07/07/2014, 02:20
... the histologic subtype, number of lesions, depth of invasion, presence or absence of CIS, and antecedent history Recurrences develop in upward of 50% of cases, of which 5–20% progress to a more ... and number of lesions, as well as a description of the growth pattern (solid vs papillary) An intraoperative video is often recorded All visible tumors should be resected, and a sample of the muscle ... urothelial tract, including the renal pelvis, ureter, or urethra A consequence of the "successful" treatment of tumors in the bladder is an increase in the frequency of extravesical recurrences (e.g.,...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 3) docx
Ngày tải lên :
07/07/2014, 02:20
... This occurs in 5–10% of cases Carcinomas in the ureter or in the renal pelvis are treated with nephroureterectomy with a bladder cuff to remove the tumor The probability of recurrence following ... Crohn's disease may hinder the use of resected bowel A partial cystectomy may be considered when the disease is limited to the dome of the bladder, a margin of at least cm can be achieved, there ... predicted on the basis of pathologic stage, presence or absence of lymphatic or vascular invasion, and nodal spread Among those whose cancers recur, the recurrence develops in a median of year (range...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 4) potx
Ngày tải lên :
07/07/2014, 02:20
... factors) ± surgery Carcinoma of the Renal Pelvis and Ureter About 2500 cases of renal pelvis and ureter cancer occur each year; nearly all are transitional cell carcinomas similar to bladder ... Patterns of spread are like those in bladder cancer For low-grade disease localized to the renal pelvis and ureter, nephroureterectomy (including excision of the distal ureter with a portion of the ... include the presence of nodal disease, extravesical tumor extension, or vascular invasion in the resected specimen Another study of adjuvant therapy found that four cycles of CMV delayed recurrence,...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 5) pdf
Ngày tải lên :
07/07/2014, 02:20
... predisposes to renal cell carcinomas, retinal hemangioma, hemangioblastoma of the spinal cord and cerebellum, and pheochromocytoma Roughly 35% of individuals with VHL disease develop renal cell cancer ... Undetermined collecting duct Clear cell tumors, the predominant histology, are found in >80% of patients who develop metastases Clear cell tumors arise from the epithelial cells of the proximal tubules ... Epithelial Neoplasms Arising from the Kidney Carcinoma Type Growth Cell Pattern Clear cell Acinar Cytogenetics Origin or sarcomatoid Papillary of Papillary or Proximal 3p- Proximal +7, +17, -Y tubule sarcomatoid...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 6) pptx
Ngày tải lên :
07/07/2014, 02:20
... kidney include transitional cell carcinoma of the renal pelvis, sarcoma, lymphoma, and Wilms' tumor All of these are less common causes of renal masses than is renal cell cancer Staging and Prognosis ... Increased erythrocyte sedimentation rate 55 The standard evaluation of patients with suspected renal cell tumors includes a CT scan of the abdomen and pelvis, chest radiograph, urine analysis, and ... noted at presentation in only about 3% of patients Anemia, a sign of advanced disease, is more common Table 90-4 Signs and Symptoms in Patients with Renal Cell Cancer Presenting Sign or Symptom...
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Chapter 090. Bladder and Renal Cell Carcinomas (Part 7) pptx
Ngày tải lên :
07/07/2014, 02:20
... for the treatment of advanced renal cell carcinoma A randomized phase trial comparing sunitinib to IFN-α showed superior efficacy for sunitinib with an acceptable safety profile The trial resulted ... Temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor, also has activity in previously treated patients The usual dosage is 25 mg IV weekly The prognosis of metastatic renal cell carcinoma is variable ... Motzer RJ et al: Sunitinib in patients with metastatic renal cell carcinoma JAMA 295:2516, 2006 [PMID: 16757724] Nelson EC et al: Renal cell carcinoma: Current status and emerging therapies Cancer...
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Báo cáo y học: " Surgical resection of a renal cell carcinoma involving the" ppt
Ngày tải lên :
10/08/2014, 09:22
... arrest Cell- saving techniques used routinely in our institution Figure Renal cell carcinoma invading the upper pole of the kidney with tumor propagating into the IVC Page of Figure Direct removal of ... significance of the level of vena caval involvement J Urol 1984, 132:1097-1100 Page of 14 Cerwinka WH, Ciancio G, Salerno TA, Soloway MS: Renal cell cancer with invasive atrial tumour thrombus excised off-pump ... facilitation of complete tumour clearance (Figure 4) Always the cavotomy is repaired with the use of a pericardial patch (Figure 5), in order to avoid narrowing of the cava An algorithm of the plan of...
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Báo cáo khoa học: "An unusual cause of chyluria after radiofrequency ablation of a renal cell carcinoma: a case report" docx
Ngày tải lên :
10/08/2014, 23:22
... Oncologic efficacy of CT-guided percutaneous radiofrequency ablation of renal cell carcinomas Am J Roentgenol 2007, 189:429-436 Diamond E, Schapira HE: Chyluria: a review of the literature Urology ... doi:10.1186/1752-1947-5-307 Cite this article as: Wah: An unusual cause of chyluria after radiofrequency ablation of a renal cell carcinoma: a case report Journal of Medical Case Reports 2011 5:307 Submit your next ... ZJ: Chyluria associated with radiofrequency ablation of renal cell carcinoma JCAT 2010, 34:210-212 Ciferri F, Glovsky MM: Chronic chyluria: a clinical study of patients J Urol 1985, 133:631-634...
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Báo cáo khoa hoc:" Spontaneous regression of metastatic renal cell carcinoma: case report" pps
Ngày tải lên :
11/08/2014, 10:22
... NH, Nanus DM: Renal- cell carcinoma N Engl J Med 1996, 335:865-875 Hamid Y, Poller DN: Spontaneous regression of renal cell carcinoma: a pitfall in diagnosis of renal lesions Journal of Clinical ... patients Removal of the malignant kidney may be of palliative benefit in some settings of metastatic renal cell carcinoma [5] There have been studies to demonstrate that the benefits of nephrectomy ... case of spontaneous regression of metastatic renal cell carcinoma in 1928 [7] Metastatic sites include brain, bone, hilar adenopathy and most commonly pulmonary metastases The clinical pattern of...
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Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf
Ngày tải lên :
06/03/2014, 22:21
... according to the Heidelberg Classification of Renal Cell Tumours [2] Seven specimens of pRCC, seven of cRCC, six of chRCC, and six of RO, besides adjacent pieces of unaffected tissue, were used in this ... are papillary renal cell adenoma, metanephric adenoma, and renal oncocytoma (RO) Deletions at chromosome 3p, mutations of the VHL suppressor gene and loss of heterozygosity (LOH) of 9p, 14q, 17p ... chromosomes, mutations of p53, LOH at 10q23.3 and telomere shortening have been reported [6] RO consists of mixtures of cells with normal and abnormal karyotypes [7] About 4% of renal cancers arise...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
Ngày tải lên :
18/06/2014, 15:20
... http://www.translational-medicine.com/content/7/1/2 Figure Characterization of T cell responses Characterization of T cell responses (A) CD8+CD107a+ effector cells, (B) CD8+perforin+ effector cells, (C) PD-1+ T cells, (D) CD4+CD25+FoxP3+ Tregs ... PL, Hawkins RE: Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T -cell- based immunotherapy Br J Cancer 2005, 93:670-677 Page 10 of 11 (page number not for ... from the cell membrane and thus can mediate antibody-dependent cell- mediated cytotoxicity (ADCC) In addition, 5T4-transduced renal carcinoma cell lines can be recognized by human T cells in vitro,...
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báo cáo hóa học:" Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma" doc
Ngày tải lên :
18/06/2014, 15:20
... the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule ... pathophysiological situations of the kidney such as acute ischaemic renal failure, renal hypertrophy, von Hippel Lindau (VHL) disease as well as neoplastic transformation of renal cells it may play a fundamental ... Bruine AP, van Engeland M: Genetics and epigenetics of renal cell cancer Biochim Biophys Acta 2008, 1785:133-155 Brena RM, Huang TH, Plass C: Quantitative assessment of DNA methylation: Potential...
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Báo cáo sinh học: "Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" doc
Ngày tải lên :
18/06/2014, 19:20
... prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...
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Báo cáo sinh học: "Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" docx
Ngày tải lên :
18/06/2014, 22:20
... Journal of Translational Medicine 2011, 9:133 http://www.translational-medicine.com/content/9/1/133 Page of 10 Figure Effects of NVP-BEZ235 on renal cell carcinoma cells in vitro Targets of NVP-BEZ235, ... Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells Lab Invest 2008, 88:962-972 Camp RL, Chung GG, Rimm DL: Automated subcellular ... percent of the viability of the untreated (control) cells Activity of the dual PI3K-mTOR inhibitor NVP-BEZ235 in RCC cell lines Given the synergism seen between the LY294002 and rapamycin in RCC cell...
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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx
Ngày tải lên :
20/06/2014, 00:20
... diuretic use and coffee consumption as risk factors for renal cell carcinoma J Natl Cancer Inst 1986, 77:351-356 Bruning T, Weirich G, Hornauer MA, Hofler H, Brauch H: Renal cell carcinomas in trichloroethene ... (12 of 17) of the formalin-fixed samples, and 38% (10 of 26) of the Bouin's fixed tissues Thus, the VHL gene was entirely sequenced (ie 100% of the coding sequence analysed) for a total of 26 ... compare exposed and non exposed cases of clear cell RCC in terms of prevalence of mutations in both groups Page of (page number not for citation purposes) Journal of Occupational Medicine and Toxicology...
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báo cáo hóa học:" Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" pot
Ngày tải lên :
20/06/2014, 03:20
... prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...
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báo cáo hóa học:" Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" pot
Ngày tải lên :
20/06/2014, 04:20
... Journal of Translational Medicine 2011, 9:133 http://www.translational-medicine.com/content/9/1/133 Page of 10 Figure Effects of NVP-BEZ235 on renal cell carcinoma cells in vitro Targets of NVP-BEZ235, ... Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells Lab Invest 2008, 88:962-972 Camp RL, Chung GG, Rimm DL: Automated subcellular ... percent of the viability of the untreated (control) cells Activity of the dual PI3K-mTOR inhibitor NVP-BEZ235 in RCC cell lines Given the synergism seen between the LY294002 and rapamycin in RCC cell...
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Báo cáo khoa học: "Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma" ppt
Ngày tải lên :
09/08/2014, 03:21
... crucial to get a better understanding of the genesis of those reactions Ahead of its time are, on one hand, the recently applications of HAs in the premature rupture of membranes where the adhesive ... which compare the use of a HA and of the ISC in the enucleoresection of RCC The recent evidence related to the NSS capable, in selected cases, to offer the same results of partial and radical ... Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC: European Association of Urology Guideline Group for renal cell carcinoma Renal cell carcinoma guideline Eur Urol 2007, 51:1502-10 12 Kulkarni R: Alternative...
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