genetics of asthma and copd

... Although asthma and COPD have many risk factors in common and often coexist in clinical settings, and there is some evidence that asthma may be a risk factor for the development of COPD [40], ... asthma diagnosis had COPD diagnosis, and 21% of those with asthma diagnosis had chronic bronchitis symptoms Total n Asthma diagnosis n (%) Asthma diagnosis Asthma symptoms COPD diagnosis Chronic ... Restriction of analysis to asthmatics without COPD, and to those with COPD without asthma, was performed for both diagnoses and symptoms The results showed similar effects in the restricted and nonrestricted...

Ngày tải lên: 06/03/2014, 19:20

... comorbidity, and study centre Stratified analyses were performed with respect to diagnosis (neither asthma nor COPD; and asthma and/ or COPD) Respiratory symptoms often occur together, causing problems of ... Netherlands showed that knowledge about both asthma and COPD was related to better adaptation to these diseases [33] Knowledge of disease is likely to vary in the group of asthma and/ or COPD in ... breathlessness without asthma and/ or COPD had lower both PCS and MCS than subjects with asthma and/ or COPD It could be that breathlessness indicated by subjects without asthma or COPD represents a...

Ngày tải lên: 20/06/2014, 16:20

... lengthening of existing vessels, and sprouting and formation of new vessels Lee et al [57] found that levels of VEGF and MMP-9 were significantly higher in the sputum of patients with asthma than ... with asthma and COPD using a high-magnification bronchovideoscope and did not find any difference between COPD patients and controls [43] A drawback of this technique is the detection limit of ... [72] Hypertrophy and hyperplasia of mucous glandular structures and loss of alveolar attachments are considered to be the main structural changes of airway remodelling in COPD and they may play...

Ngày tải lên: 12/08/2014, 11:22

... (HC), asthma, COPD and cold Comparison of pH in EBC obtained by either RTube or ECoComparison of pH in EBC obtained by either RTube or ECoScreen in healthy controls (HC), asthma, COPD and cold ... degasification of EBC prior to analysis, or the use of a special gas [5] We included stable asthmatics and COPD GOLD stage and Comparing the asthmatic and COPD patients with healthy controls, we did ... comparison of two commercial devices in healthy controls and patients with asthma, COPD and colds regarding the measurement of pH, including degasification with argon, and showing a small interday and...

Ngày tải lên: 12/08/2014, 14:20

... presentation of acute exacerbations of asthma and COPD in a typical emergency department setting, both in disease severity and the treatment required However, the relationship between dose and plasma/serum ... exacerbations of asthma and/ or COPD are usually heavily reliant on short-acting b2-agonists for symptom relief prior to presentation and would be expected to use much higher doses of albuterol ... only used as an estimation of the number of doses of albuterol required during the asthma exacerbation (between different dosage forms), and does not represent the amount of albuterol being delivered...

Ngày tải lên: 21/06/2014, 03:20

... mechanisms and trade-offs Finding mechanisms that explain the difference in life span between males and females is hindered by our lack of understanding of the basic mechanisms of aging and underlying ... Mechanistic explanations often involve the concept of trade-offs, that is, the allocation of energy or other ‘resources’ to functions such as reproduction and behavior, at the expense of somatic maintenance ... amounts of inbreeding had mothers of the same genotype, thus separating the effects of cytoplasmic factors such as mitochondria and maternally contributed gene products from the effects of inbreeding...

Ngày tải lên: 06/08/2014, 19:20

... Loeber R, Tuett KR, Hewitt JK: Genetics and developmental psychopathology: The main effects of genetics and environment of behavioral problems in the Virginia twin study of adolescent behavioral development ... Familial transmission of depression and antisocial behaviour symptoms: disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting Psychol ... between adolescent and adult depression Thus, both adolescent depressive symptoms and disorder predict episodes of depression in adult life [11-13] Evidence of the continuity of childhood depression...

Ngày tải lên: 11/08/2014, 12:20

... of data, analysis and interpretation of data, and drafting and revising the manuscript JK contributed to study design, acquisition of data, analysis and interpretation of data, and drafting and ... Figure Plot of R % predicted for asthmatic and nonasthmatic subjects Rmin %predicted for all 34 nonasthmatic (black) and 35 asthmatic (hatched) participants as well as the subgroup of 26 nonasthmatic ... acquisition of data, analysis and interpretation of data, and drafting and revising the manuscript SNS contributed to study design, acquisition of data, analysis and interpretation of data, and drafting...

Ngày tải lên: 12/08/2014, 13:22

... specimens from the central and and Stage IV COPD non-smoker (A and B, Figure respectively), a smoker (C and D), and patients with Stage I-II COPD (E and F) peripheral lung of a (G and H) Immunohistochemical ... specimens from the central and peripheral lung of a nonsmoker (A and B, respectively), a smoker (C and D), and patients with Stage I-II COPD (E and F) and Stage IV COPD (G and H) GST alpha was mainly ... committee of the University of Oulu and Oulu University Hospital and the ethical board of Helsinki University Hospital and it is in accordance with the ethical standards of the Helsinki declaration of...

Ngày tải lên: 12/08/2014, 14:20

... contributed to the design of the study and the writing of the manuscript JB and IPH contributed to the design of the study and the writing of the manuscript All authors read and approved the final ... regions; 3p14.1q12.3 (asthma, SPT), 5q23.2-q34 (asthma, BHR, IgE) and 7p21.1-14.1 (asthma, BHR, IgE) Discussion This study represents the first meta-analysis of asthma and related trait linkage ... data using the majority of the data available for the Caucasian asthma cohorts in the public domain This analysis combines data from 10 years of asthma and atopy genetics and is extremely timely...

Ngày tải lên: 12/08/2014, 15:21

... Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations Science 1994, 264:1152–1156 22 Rosenwasser LJ, Borish L: Genetics of atopy and asthma: the ... IRS2 and signal transducer and activator of transcription (Stat)-6 [23] IRS1 and IRS2 regulate proliferation and protection from apoptosis Stat-6 is necessary for IL-4-dependent expression of CD23, ... death of activated T cells Of these, IL-4 and IL-15 are the most effective [11] Inhibition of apoptosis by IL-4 might be mediated partly by the ability of this cytokine to maintain levels of the...

Ngày tải lên: 12/08/2014, 18:20

... for non asthmatics and the time between the first interview and the first asthma attack for new asthmatics For subjects, who reported in the second survey having had the first attack of asthma ... of subjects at risk at start of follow-up (1991/92), number of new cases of asthma, person-years, crude incidence (95% C.I.) during the period 1991–2000 according to sex and birth cohort N° of ... women and in recent generations ii) The presence of asthma attacks and nocturnal asthma symptoms (tightness and dyspnoea) in young adults is associated with a two-fold increase in the risk of dying...

Ngày tải lên: 12/08/2014, 18:22

... Background Asthma and chronic obstructive pulmonary disease (COPD) are caused by complex interactions between environmental and genetic factors A putative genetic risk factor for asthma and COPD is ... evidence of airway obstruction with reversibility and was referred for further examination and treatment of asthma None of four 5T/F508del compound heterozygotes had clinical signs of severe ... performance of the procedure, at least two measurements of FEV1 and FVC differing by less than 5% had to be produced The highest set of FEV1 and FVC were used in the analyses as percentage of predicted...

Ngày tải lên: 12/08/2014, 18:22

... identification and validation of targets for asthma BG is the head of division of Molecular Immunogenetics, IGIB-CSIR, India He has been working on genetic and molecular biology of asthma pathogenesis and ... on the Genetics of Asthma: Genomewide screen and identification of gene-gene interactions for asthma- susceptibility loci in three U.S populations: collaborative study on the genetics of asthma ... Discovering susceptibility genes for asthma and allergy Nat Rev Immunol 2008, 8(3):169-82 Review Anderson GG, Morrison JF: Molecular biology and genetics of allergy and asthma Arch Dis Child 1998, 78(5):488-96...

Ngày tải lên: 13/08/2014, 13:22

... among COPD, asthma, and rhinitis Persons with COPD and another condition were classified as having COPD Persons with asthma and rhinitis were classified as having asthma The overall rate of completion ... aged 55 to 75 Of these, 352 reported a physician diagnosis with one of the conditions within the overall rubric of COPD and 122 reported a physician diagnosis of asthma In the course of administering ... and lung cancer in the absence of COPD, asthma, and rhinitis were excluded from the analysis due to small numbers We tabulated the work history and current employment status of persons with COPD, ...

Ngày tải lên: 20/06/2014, 00:20

... history of allergic diseases The diagnosis was based on a clear-cut history of asthmatic symptoms; the use of anti-asthmatic medication and the presence of bronchial hyper-reactivity The antiasthmatic ... disease and asthma Genes Immun 2005, 6:225-30 The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee: Worldwide variation in prevalence of symptoms of asthma, ... asthma is much more often allergic than asthma in adults Thus it might not be surprising that the genetic background of asthma differs between adults and children [23] Furthermore, the size of...

Ngày tải lên: 13/08/2014, 13:22

Ngày tải lên: 15/02/2014, 04:20

... identification of probable asthma patients and management of the asthma to reduce the frequency of asthma exacerbations To the extent that MTFs strengthened these practices Implementation of the Asthma ... X X X The RAND Evaluation RAND’s evaluation of the asthma demonstration consisted of two components: a process evaluation and an analysis of the effects of the guideline on a series of outcome ... there should be reductions in rates of use of emergency rooms and inpatient stays for exacerbations of asthma Introduction As part of the process of developing the asthma guideline, the DoD/VA working...

Ngày tải lên: 17/02/2014, 22:20

... stress evaluated length and fresh weight of the hypocotyl and roots of soybean exposed to a series of NaCl concentrations At 200 mM NaCl, the length and fresh weight of hypocotyl and roots were greatly ... serious viral infections of soybean; leaves of infected plants were studied at a series of time points using 2-D gel electrophore sis, followed by MALDI-TOF-MS and tandem TOF/TOF-MS Proteins expressed ... the growth and development of both hypocotyl and roots This study assessed effects on leaf, hypocotyl and root proteomics of salt treated soybean seedlings and found that re duction of glyceraldehyde-3-phospahte...

Ngày tải lên: 18/02/2014, 04:20

... Pathophysiology and Pathogenesis of Asthma, and Natural History of Asthma 11 Key Points: Definition, Pathophysiology and Pathogenesis of Asthma, and Natural History of Asthma ... Pathophysiology and Pathogenesis of Asthma, and Natural History of Asthma; Section 3—The Four Components of Asthma Management; Section 4—Managing Asthma Long Term; and Section 5—Managing Exacerbations of Asthma ... Pathogenesis of Asthma, and Natural History of Asthma SECTION 2, DEFINITION, PATHOPHYSIOLOGY AND PATHOGENESIS OF ASTHMA, AND NATURAL HISTORY OF ASTHMA KEY POINTS: DEFINITION, PATHOPHYSIOLOGY AND PATHOGENESIS...

Ngày tải lên: 17/03/2014, 15:20