genetics mutations associated with resistance

... support the hypothesis that mutations can be a resistance mechanism leading to high resistance levels Further work is needed to clarify the relationships between mutations and overexpression ... Furthermore, as the resistance ratios measured in these field-collected strains (< 30) are lower than that observed with the lab-selected RDDTR strain (> 10 000), it is likely that the resistance mechanisms ... P., Feyereisen, R., Wilson, T.G & ffrench-Constant, R.H (2002) A single p450 allele associated with insecticide resistance in Drosophila Science 297, 2253–2256 Brandt, A., Scharf, M., Pedra, J.,...

Ngày tải lên: 19/02/2014, 12:20

... been conducted in SSA to identify mutations associated with antiretroviral drug resistance It is imperative to investigate and describe mutations associated with resistance to antiretroviral drugs ... observed at position K103R (1%) Primary mutations associated with NNRTI resistance were not found in subtype A strains while primary mutations associated with NRTI resistance were not found in subtype ... women Further, no primary mutations associated with PI resistance were detected in this study The low prevalence or lack of primary mutations associated with antiretroviral resistance in Kilimanjaro...

Ngày tải lên: 10/08/2014, 05:21

... from 37% in the cells with the 14484 ⁄ ND6 mutation to 68% in those with the 11778 ⁄ ND4 mutation, compared with the controls Comparison of the results reported in Fig with the data in Fig 4B ... complex I activity [3,6] and oxygen consumption (present data) and are associated with severe neuropathology [38], are associated with the highest mitochondrial ROS production [14] and the least efficient ... this method, we tested five control lines, three lines with the 11778 ⁄ ND4 mutation, two lines with 3460 ⁄ ND1 and two with 14484 ⁄ ND6 mutations Each line is the result of a cybridization from...

Ngày tải lên: 19/02/2014, 16:20

... transferring the resistance genes from these resistant lines into commercial cultivars has been slow, due to lack of understanding of the resistance mechanism and markers associated with resistance ... proteins associated with resistance to pre-harvest aflatoxin contamination in peanut In this study, a total of 28 differentially expressed proteins were identified and 12 proteins associated with ... identification of these potential proteins associated with the aflatoxin resistance in peanut could be useful in programmes on developing peanut varieties with resistant to pre-harvest aflatoxin...

Ngày tải lên: 11/08/2014, 11:21

... mutations and this event were explored initially using paired serum (before and after) from 33 patients with spontaneous or interferon induced HBeAg seroconversion Genotype B was associated with ... precore stop mutation G1896A 168 8.3.2 Other mutations that may affect transcription factor binding and the CP regulatory regions may be associated with HBeAg SC 169 8.3.3 Dynamic change of the ... change during the course of chronic hepatitis B infection 166 8.3 Mutations in the core promoter and precore regions may be associated with HBeAg seroconversion 167 ix 8.3.1 Core promoter mutation...

Ngày tải lên: 15/09/2015, 21:28

... characterized by persistent HBV infection associated with inflammation and hepatocellular necrosis, or without any evidence of liver disease Many patients with chronic HBV infection are asymptomatic, ... be dangerous in 37 patients with decompensated liver function In patients with cirrhosis, interferon may lead to decompensation IFN treatment is usually associated with side effects, especially ... polymerase variants with mutations affecting its activity are very rare Increasing evidence of mutations in this gene has been reported in recent years in patients undergoing treatment with nucleoside...

Ngày tải lên: 16/09/2015, 08:30

... amino acids that have been characterized, none of the mutations with mild defects are associated with these conserved amino acid residues, with the exception of N34S By contrast, all seven GALE ... mutant proteins We previously described nine GALE mutations in Korean patients with GALE-deficient galactosemia [20] These GALE mutations were novel with the exception of R335H, which had been shown ... UDP-galactose 4¢-epimerase mutations associated with the intermediate form of type III galactosaemia J Inherit Metab Dis 31, 108–116 Timson DJ (2005) Functional analysis of disease-causing mutations in human...

Ngày tải lên: 07/03/2014, 00:20

... categories [7] Codon usage bias is associated with tRNA concentration [8] and also the GC content of genomes [9-12] Loss-of-function mutations, such as nonsense mutations, are the molecular basis ... risk of acquiring nonsense mutations for each species relative to the risk with an unbiased codon usage With the intention to compare the risk of acquiring nonsense mutations among various species, ... hypermutability, but is associated with a low risk of acquiring nonsense mutations F and CpG content The genomes of all 10 vertebrates had a low risk of acquiring nonsense mutations - as shown by...

Ngày tải lên: 18/06/2014, 19:20

... rare juvenile-onset disorder, associated with mutations of the senataxin gene (SETX) [3] An autosomal recessive, juvenile-onset form (ALS2), has been associated with mutations of the Alsin gene ... and within these lie several distinct forms of the disease The most common form of FALS is autosomal dominant for which to date genes have been identified: ALS1, with adult-onset caused by mutations ... manifestation, but few associated genes have so far been identified [7-13] De novo mutations in the Sod1 gene have only occasionally been observed in sporadic cases of ALS suggesting that mutations in...

Ngày tải lên: 11/08/2014, 08:20

... potential link between adiposity and insulin resistance, since circulating levels are associated with adipose mass and exogenous administration increases insulin resistance [8] Ghrelin, an orexigenic ... GC-mediated insulin resistance does not result from nor elicit major changes in these metabolically active hormones Data here pertain only to insulin resistance associated with short-term exogenous ... was associated with change in insulin sensitivity, and remained after individual adjustment for age, and changes in BMI, blood pressure, and HDL cholesterol: β = -3.39, P < 0.001 (as reported with...

Ngày tải lên: 11/08/2014, 08:20

... Cite this article as: Malacarne et al.: Resistance to Plasmopara viticola in a grapevine segregating population is associated with stilbenoid accumulation and with specific host transcriptional responses ... particular the latter group whose resistance could be ascribed to a different mechanism which does not involve the presence of viniferins Interestingly, with respect to both resistance trait distribution ... equally intermixed with asymptomatic areas, necrotic flecks underneath sporulating areas; 7: small spots with sparse sporangiophores, concentric development of necrotic lesions with HR; 9: absence...

Ngày tải lên: 11/08/2014, 11:21

... experiments are shown with error bars representing SD Page of 13 Figure Resistance to alamethicin after preincubation of tobacco cells with known plant defence elicitors Resistance was measured ... changes often associated with complete protoplastation [59-61] are kept at a minimum This also agrees with that strains of Staphylococcus aureus, Enterococcus faecalis and Bacillus cereus with a five-fold ... medium for h (Additional file 1), or with Control medium for h respectively with CM medium for 20 followed by 220 with Control medium (Figure 2) Before incubation with dyes, cells were diluted to...

Ngày tải lên: 11/08/2014, 11:21

... phenotypes could be associated with unidentified gene mutations Herein, we report an adult case series with similar clinical phenotypes to support a novel AID entity associated with positive nucleotide ... with negative NOD2 gene mutations in our study For example, one adult case of sjogren’s syndrome and one case of adult onset sarcoidosis without pulmonary involvement had negative NOD2 gene mutations ... A new category of autoinflammatory disease associated with NOD2 gene mutations Qingping Yao1,#, Lan Zhou2, Philip Cusumano3, Nilanjana Bose 1, Melissa Piliang4,...

Ngày tải lên: 12/08/2014, 18:20

... patients with inflammatory polyarthritis (IP) especially in seropositive disease In established RA, insulin resistance (IR) is increased and associated with CVD We investigated factors associated with ... observations of reduced insulin resistance following control of disease with anti-TNF therapy [15,16] With regard to clinical outcomes, insulin resistance in RA has been associated with both subclinical ... ACPA positive (Table 1) Factors associated with insulin resistance In an age and gender adjusted linear regression analysis, HOMA-IR was significantly associated with a number of established cardiovascular...

Ngày tải lên: 12/08/2014, 18:20

... Phenotypes associated with CFTR mutations Associated with mutations in CFTR‡ Asthma Cystic fibrosis transmembrane regulator: the relationship between gene mutations and function Phenotypes associated with ... R117Hbearing allele in cis with a 7T allele may result in CBAVD, whereas when R117H is associated with the 5T allele the phenotypic expression may be associated with atypical CF R117H with a 9T allele ... is associated with two mutations in CFTR (often one ‘mild’ and one ‘severe’), together with CFTR dysfunction †Excluding other forms of genetic-linked idiopathic chronic pancreatitis (ICP) ‡Associated...

Ngày tải lên: 12/08/2014, 18:20

... H34Y), suggesting that within the V3 region, many more mutations are associated with CXCR4 usage (Figure 1a) Interestingly, the majority of these V3 mutations found associated with the co-receptor ... among mutations were associated with the CXCR4 prediction An exception was represented by the A96N gp41 mutation that was positively correlated with T22AV3 ( = 0.22; P = 0.030; both associated with ... interactions with gp120 [16,18,82-85] Similarly, S129DQ gp41 , associated with CCR5-usage and localized in the gp41 HR2 domain, established negative correlation with the S11KR, strongly associated with...

Ngày tải lên: 13/08/2014, 01:20

... and laboratory data between patients with and without sustained virological response (SVR) Characteristics Male gender, n, (%) Patients with SVR Patients without SVR (n=13) P-Value (n=41 ) 30 ... end of treatment (P=0.02) compared to patients without SVR Moreover, low platelet count (thrombocytopenia) at the end of treatment was associated with SVR (P=0.05) Age, ethnicity, 38 gender, drug ... gender, drug abuse, and histology were not significantly associated with SVR To allow for clinical applicability, logistic regression with clinical cut-offs in the significant relevant covariants,...

Ngày tải lên: 26/10/2012, 09:39

... study population did not include subjects with malnutrition nor there were any with nutritional modifications during the interventional period More studies with larger sample sizes and longer follow-up ... study’s main finding is that the changes in serum total cholesterol concentrations are clearly associated with those of aspirin esterase activity during a period of physical activity modification ... metabolism among older people A recent report has shown that greater aspirin hydrolysis can be associated with decreased cholesterol levels of high-density lipoprotein in type diabetics (6) Although...

Ngày tải lên: 26/10/2012, 09:39

... subjects with or without the 16 repeat allele (Table 3) The plasma BNP level was significantly higher in the EH group than in the NT group (p=0.0203) The plasma BNP level in each genotype with or without ... found to be associated with an increased risk of BP progression in males, but not in females [22] Further studies are needed to resolve these conflicting results Since there are many loci with a high ... patients Table The association between genotype and phenotype Table Plasma BNP levels for patients with or without 16 repeat Table Distribution of subjects by BMI 149 groups (Table 5) Int J Med Sci...

Ngày tải lên: 26/10/2012, 10:04

... Gab1 polymorphism was associated with the low risk of the infection independent on severe atrophy Although the Gab1 polymorphism prevented H pylori infection, it was associated with the risk of atrophy ... seropositive subjects, the Gab1 polymorphism was not associated with gastric cancer When we made a comparison between cases and controls with seropositive atrophy, the ORs of G/A and A/A for ... 55:74-108 Blaser MJ, Perez-Perez GI, Kleanthous H, et al Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach...

Ngày tải lên: 31/10/2012, 15:37