genetic risk factors and specific gene loci in alzheimer s disease

... non-parametrical test Statistical significance was accepted if the null hypothesis could be rejected at p

Ngày tải lên: 25/10/2012, 10:51

... proportions, and so on) The association between case/control status and cardiovascular risk factors was examined by means of logistic regression models Each cardiovascular risk factor was examined individually ... effect Smoking is an important risk factor for many rheumatic diseases like lupus and increases the risk of seropositivity in rheumatoid arthritis patients, especially those who are positive for shared ... records Cardiovascular risk factors assessed included gender, presence of hypertension, diabetes mellitus (types I and II), hyperlipidemia, family history of aneurysms, and smoking Presence of...

Ngày tải lên: 09/08/2014, 13:22

... neurotransmission, and abnormalities in cannabinoid signalling or modulation of dopamine signalling or both have been implicated in a number of neurodegenerative diseases including HD and Parkinson disease, ... ubiquitously expressed transcription factors Another possibility is that mutant huntingtin itself has a characteristic that is unique when this protein is expressed in the striatum It appears that ... mRNA levels in specific types of neurons Mus musculus CB1 gene structure The coding region of CB1 is contained within a single exon in mice, rats and humans [15–17] However, the 5¢-untranslated region...

Ngày tải lên: 16/03/2014, 18:20

... proteins with either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction and...

Ngày tải lên: 16/03/2014, 22:20

... pathological disease state and investigated brain area, methods of analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and O'Banion ... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... Mueksch B, Boehringer M, Hull M: Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogenactivated protein kinase and...

Ngày tải lên: 19/06/2014, 22:20

... groups Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure 2, high serum AOC levels predicted ... clinical diagnosis of probable Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the ... MMSE scores Figure MMSE AOC Serum scoreslevels in participants grouped according to Serum AOC levels in participants grouped according to MMSE scores Square and circle symbols indicate controls...

Ngày tải lên: 19/06/2014, 22:20

... precipitating factors common in these ages, and, finally addressing dementia itself So, the diagnostic process in patients with PD and suspected dementia involves two steps: the diagnosis of dementia and ... different diseases, and others have given its name to diseases differing essentially from it" [1] For instance, dementia with Lewy bodies and Parkinson 's disease are one or two disorders? [37-39] This ... comments and suggestions References The marked cholinergic deficits in patients with DLB and PD dementia suggest the efficacy of Acetylcholinesterase inhibitors in these diseases, possibly even...

Ngày tải lên: 08/08/2014, 21:20

... microtubule-associated protein that normally serves to assemble and stabilize microtubules Genetics and risk factors implicated in Alzheimer s disease pathogenesis Familial forms of AD, with an autosomal ... of CAA in leptomeningeal and cortical vessels with few diffuse plaques, severe loss of SMCs, weakening of vessel walls leading to hemorrhage and perivascular microgliosis and astrocytosis The ... the processes of Ab production and aggregation in sporadic AD brain There is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation...

Ngày tải lên: 16/02/2014, 09:20

... gels (A,C) and 1% agarose gels (B,D), and proteins were visualized by Coomassie stain Lanes HS and LS are molecular mass standards, with the molecular mass in kDa given on the left (E) 1% agarose ... amino acid analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems ... evidence supports a crucial role for Ab in Alzheimer s disease pathogenesis, there is huge interest in understanding the structural and biological properties of this molecule [13–16] Using chemically...

Ngày tải lên: 18/02/2014, 13:20

... findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, while less suitable for others To determine the significance ... The PS/APP mouse carries both of these transgenes and has been extensively used as a model for studying processes relating to the formation of SPs Aβ deposition occurs more rapidly in these mice ... Landreth GE: Inflammation, apoptosis, and Alzheimer' s disease Neuroscientist 2002, 8:276-283 Gupta A, Pansari K: Inflammation and Alzheimer' s disease Int J Clin Pract 2003, 57:36-39 Hoozemans...

Ngày tải lên: 19/06/2014, 22:20

... attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible for activating NADPH oxidase assembly in response to fAβ peptides [28,30] ... Laakso MP, Hanninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A: Midlife vascular risk factors and Alzheimer' s disease in later life: longitudinal, population based study ... progressive pathophysiology associated with this disease The results summarized in this review suggest that ROS and iNOS released through NADPH-dependent mechanisms contribute to the extensive...

Ngày tải lên: 19/06/2014, 22:20

... microglia is already increased in early pathological stages of AD and in cognitively normal subjects with frequent presence of plaques and tangles [3,4] Clinical studies using positron emission tomography ... cases Page of Discussion In this study, we compared the age-dependent presence of microglia and astrocytes, which is indicative of a neuroinflammatory response, in controls and AD cases We show ... arbitrary units) for controls (open dots) and AD patients (closed dots) Straight lines represent regression lines, with corresponding 95% confidence intervals microglia in young AD cases might reflect...

Ngày tải lên: 19/06/2014, 22:20

... education in school settings and working places It should also promote unspecific preventive measures such as hand washing and social distance There should be further studies to comprehensively assess ... rapidly spreading and causing a pandemic Influenza pandemics generally occur suddenly and cause heavy losses for people and society, including: significant increase in the number of cases and deaths ... influenza visions’ core proteins, classifies influenza viruses into type A, B or C Only type A virus is responsible for influenza epidemics and pandemics in human whereas type B virus affecting...

Ngày tải lên: 25/07/2014, 13:57

... (decreased risk) were both associated with PsA, suggesting that changes to the immune system may play a role in this disease [55] Genetic risk factors Developments in the pathogenesis of PsA again ... (including mechanical) factors The familial risk of hand OA has shown a moderate increase in risk in sisters of women affected with hand OA and this risk was substantially increased with the severity ... Genetic risk factors Epidemiological studies have focused on the genetics behind AS Twin studies have estimated the influence of genetics on the aetiopathogenesis of AS, indicating that additive genetic...

Ngày tải lên: 09/08/2014, 01:22

... laboratory testing Cytokines and adhesion molecules were measured using enzyme-linked immunosorbent assays (Hiss Diagnostics GmbH, Freiburg, Switzerland) The intra-assay and inter-assay coefficients of ... models aAdjusted for disease- modifying antirheumatic drug and prednisone use bAdjusted for traditional risk factors (age; sex; race; smoking, alcohol and exercising status; diabetes; waist; systolic ... Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of...

Ngày tải lên: 09/08/2014, 06:22

... chylothorax In contrast, TPN has much more side effects and has no higher efficacy in treating chylothorax [12] Panthongviriyakul and Bines suggest using TPN in cases with elevated central venous pressures ... pressures >15 mmHg [1] When deciding over the use of TPN, its possible side-effects should be considered, such as an increased risk of nosocomial infections [13,14] Patients with TPN are hungry and ... alone was not successful in out of 24 (=29%) patients These patients had much more daily drainage losses compared to patients successfully treated with MCT-diet (median loss 119 ml/kg/day versus 40...

Ngày tải lên: 10/08/2014, 09:23

... approaches [25] The objective of this study is to examine the associations between SMC, vascular risk factors and psychological distress Our hypothesis is that vascular risk factors will be associated ... vascular risk factors and SMC, with conflicting results [3,17] Neither of these studies examined the SMC-vascular risk factor association as their primary analysis There is also a strong association ... variables and vascular risk factors The final model, Model 4, included demographic variables, vascular risk factors and a measure of psychological distress Finally, based on sound statistical results...

Ngày tải lên: 11/08/2014, 15:22

... retrotransposons LTR retrotransposons Ty1/Copia Ty3/Gypsy Unclassified Non-LTR retrotransposons LINE SINE Class II DNA transposons En-Spm Harbinger Mariner MuDR Pogo Stowaway TcMar-Stowaway Tourist ... < 10-4; individual P values are found in Additional Files and 3) This is consistent with the findings from the RepeatMasker and BLAST analyses discussed above Surprisingly, some terms that were ... nucleotides in the BESs covered by BLASTN hits to the species -specific transcript databases Percentage Percentage of nucleotides in the BESs covered by BLASTN hits to the species -specific transcript...

Ngày tải lên: 12/08/2014, 05:20

... anxiety, stress, sadness and depression Family members often feel helpless and hopeless about providing care Healthy family members are overloaded by assuming the duties of the person in pain, and they ... sample size finally used was 1,100 households (22 clusters with 50 households per cluster), which was convenient for comparison with other study sites Sample selection There has been no census in ... Khamis V: Post-traumatic stress and psychiatric disorders in Palestinian adolescents following intifada-related injuries Soc Sci Med 2008, 67(8):1199-1207 35 Bloom JD, Hoxha I, Sambunjak D, Sondorp...

Ngày tải lên: 13/08/2014, 14:20

... value for incidence of various medical conditions including vascular risks (such as hypertension and obesity)5-11 and vascular diseases (such as kidney disease, cardiovascular diseases and stroke) ... children study,27 Interactive Vessel Analysis (IVAN) was widely used in US studies28-30 and Asian studies8, 31 while Singapore I Vessel Assessment (SIVA) was newly developed and applied in recent Singapore ... parameters were processed for statistical analysis Multivariate regression analysis was used to explore the associations between a range of risk factors and retinal microvascular characteristics Furthermore,...

Ngày tải lên: 09/09/2015, 10:12